Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke

Stroke

Volumn 43, Issue 9, 2012, Pages 2430-2436

  Wang, Zhifei ^a   Tsai, Li Kai ^a,c   Munasinghe, Jeeva ^b   Leng, Yan ^a   Fessler, Emily Bame ^a   Chibane, Fairouz ^a   Leeds, Peter ^a   Chuang, De Maw ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

angiogenesis; cerebral ischemia; hypoxia inducible factor 1; matrix metalloproteinase; MRI; valproate; vascular endothelial growth factor

Indexed keywords

ANGIOGENIC FACTOR; GELATINASE A; GELATINASE B; HISTONE H3; HISTONE H4; HYPOXIA INDUCIBLE FACTOR 1ALPHA; VALPROIC ACID; VASCULOTROPIN;

ACETYLATION; ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PERFUSION; CELL PROLIFERATION; CONTROLLED STUDY; CONVALESCENCE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; GELATIN ZYMOGRAPHY; IMMUNOHISTOCHEMISTRY; LOCOMOTION; LONG TERM CARE; MALE; MENTAL PERFORMANCE; MICROVESSEL DENSITY; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; REPERFUSION; ROTAROD TEST; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING; ZYMOGRAPHY;

ANIMALS; ANTICONVULSANTS; BLOTTING, WESTERN; BRAIN ISCHEMIA; CEREBRAL INFARCTION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; LOCOMOTION; MAGNETIC RESONANCE IMAGING; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; NEOVASCULARIZATION, PHYSIOLOGIC; POSTURAL BALANCE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; STROKE; VALPROIC ACID;

EID: 84865595109     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.112.652545     Document Type: Article

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