Fumaric acid esters promote neuronal survival upon ischemic stress through activation of the Nrf2 but not HIF-1 signaling pathway

Neuropharmacology

Volumn 105, Issue , 2016, Pages 228-240

  Lin Holderer, Jiemeng ^a   Li, Lexiao ^a   Gruneberg, Daniel ^a   Marti, Hugo H ^a   Kunze, Reiner ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Dimethyl fumarate; Fumaric acid esters; HIF; Ischemia; Monomethyl fumarate; Nrf2

Indexed keywords

FUMARIC ACID DIMETHYL ESTER; FUMARIC ACID METHYL ESTER; HYDROXYCARBOXYLIC ACID RECEPTOR 2; HYPOXIA INDUCIBLE FACTOR 1; PROPIDIUM IODIDE; RECEPTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; ESTER; FUMARIC ACID DERIVATIVE; GLUCOSE; NFE2L2 PROTEIN, MOUSE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CELL LINE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE SILENCING; HIPPOCAMPUS; HT 22 CELL LINE; MOUSE; NERVE CELL; NERVE CELL NECROSIS; NEUROPROTECTION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SH SY5Y CELL LINE; SIGNAL TRANSDUCTION; TISSUE CULTURE; ANIMAL; C57BL MOUSE; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENETICS; HUMAN; HYPOXIA; PATHOLOGY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; BRAIN ISCHEMIA; CELL LINE; CELL SURVIVAL; ESTERS; FUMARATES; GLUCOSE; HIPPOCAMPUS; HUMANS; HYPOXIA; HYPOXIA-INDUCIBLE FACTOR 1; MICE; MICE, INBRED C57BL; NEURONS; NF-E2-RELATED FACTOR 2; SIGNAL TRANSDUCTION;

EID: 84961383063     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.01.023     Document Type: Article

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