The mechanism of long non-coding RNA MEG3 for neurons apoptosis caused by hypoxia: Mediated by miR-181b-12/15-LOX signaling pathway

Frontiers in Cellular Neuroscience

Volumn 10, Issue SEP2016, 2016, Pages

  Liu, Xiaomin ^a   Hou, Lijing ^b   Huang, Weiwei ^a   Gao, Yuan ^a   Lv, Xin ^a   Tang, Jiyou ^a  

^a SHANDONG UNIVERSITY   (China)

^b Shandong Academy of Chinese Medicine   (China)

Author keywords

12 15 LOX; Infarct; MCAO; MEG3; miR 181b

Indexed keywords

ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; LONG UNTRANSLATED RNA; LONG UNTRANSLATED RNA MEG3; MESSENGER RNA; MICRORNA; MICRORNA 181B; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EDEMA; BRAIN HYPOXIA; BRAIN INFARCTION; BRAIN INFARCTION SIZE; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING;

EID: 84988662474     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2016.00201     Document Type: Article

References (25)

1. Balik, V., Srovnal, J., Sulla, I., Kalita, O., Foltanova, T., Vaverka, M., et al. (2013). MEG3: a novel long noncoding potentially tumour-suppressing RNA in meningiomas. J. Neurooncol. 112, 1-8. doi: 10.1007/s11060-012-1038-6
2. Chen, J., Venkat, P., Zacharek, A., and Chopp, M. (2014). Neurorestorative therapy for stroke. Front. Hum. Neurosci. 8:382. doi: 10.3389/fnhum.2014.00382
3. Chou, V. P., Ko, N., Holman, T. R., and Manning-Bog, A. B. (2014). Gene-environment interaction models to unmask susceptibility mechanisms in Parkinson’s disease. J. Vis. Exp. 83:e50960. doi: 10.3791/50960
4. Dharap, A., Bowen, K., Place, R., Li, L. C., and Vemuganti, R. (2009). Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J. Cereb. Blood Flow Metab. 29, 675-687. doi: 10.1038/jcbfm.2008.157
5. Dharap, A., Pokrzywa, C., and Vemuganti, R. (2013). Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. ASN Neuro 5, 283-289. doi: 10.1042/AN20130029
6. Han, J., Sun, L., Xu, Y., Liang, H., and Cheng, Y. (2015). Activation of PPARgamma by 12/15-lipoxygenase during cerebral ischemia-reperfusion injury. Int. J. Mol. Med. 35, 195-201. doi: 10.3892/ijmm.2014.1998
7. Hutchison, E. R., Kawamoto, E. M., Taub, D. D., Lal, A., Abdelmohsen, K., Zhang, Y., et al. (2013). Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes. Glia 61, 1018-1028. doi: 10.1002/glia.22483
8. Jung, J. E., Karatas, H., Liu, Y., Yalcin, A., Montaner, J., Lo, E. H., et al. (2015). STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke. J. Cereb. Blood Flow Metab. 35, 2043-2051. doi: 10.1038/jcbfm.2015.169
9. Mehta, S. L., Kim, T., and Vemuganti, R. (2015). Long noncoding RNA FosDT promotes ischemic brain injury by interacting with REST-associated chromatin-modifying proteins. J. Neurosci. 35, 16443-16449. doi: 10.1523/JNEUROSCI.2943-15.2015
10. Ouyang, Y. B., Lu, Y., Yue, S., Xu, L. J., Xiong, X. X., White, R. E., et al. (2012). miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo. Neurobiol. Dis. 45, 555-563. doi: 10.1016/j.nbd.2011.09.012
11. Ouyang, Y. B., Xu, L., Yue, S., Liu, S., and Giffard, R. G. (2014). Neuroprotection by astrocytes in brain ischemia: importance of microRNAs. Neurosci. Lett. 565, 53-58. doi: 10.1016/j.neulet.2013.11.015
12. Peng, W., Si, S., Zhang, Q., Li, C., Zhao, F., Wang, F., et al. (2015). Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate gastric cancer progression. J. Exp. Clin. Cancer Res. 34, 79. doi: 10.1186/s13046-015-0197-7
13. Peng, Z., Li, J., Li, Y., Yang, X., Feng, S., Han, S., et al. (2013). Downregulation of miR-181b in mouse brain following ischemic stroke induces neuroprotection against ischemic injury through targeting heat shock protein A5 and ubiquitin carboxyl-terminal hydrolase isozyme L1. J. Neurosci. Res. 91, 1349-1362. doi: 10.1002/jnr.23255
14. Praticò, D., Zhukareva, V., Yao, Y., Uryu, K., Funk, C. D., Lawson, J. A., et al. (2004). 12/15-lipoxygenase is increased in Alzheimer’s disease: possible involvement in brain oxidative stress. Am. J. Pathol. 164, 1655-1662. doi: 10.1016/S0002-9440(10)63724-8
15. Rodriguez-Ortiz, C. J., Baglietto-Vargas, D., Martinez-Coria, H., LaFerla, F. M., and Kitazawa, M. (2014). Upregulation of miR-181 decreases c-Fos and SIRT-1 in the hippocampus of 3xTg-AD mice. J. Alzheimer Dis. 42, 1229-1238. doi: 10.3233/JAD-140204
16. Sun, L., Xu, Y. W., Han, J., Liang, H., Wang, N., and Cheng, Y. (2015). 12/15-Lipoxygenase metabolites of arachidonic acid activate PPARgamma: a possible neuroprotective effect in ischemic brain. J. Lipid Res. 56, 502-514. doi: 10.1194/jlr.M053058
17. Sun, Y., Gui, H., Li, Q., Luo, Z. M., Zheng, M. J., Duan, J. L., et al. (2013). MicroRNA-124 protects neurons against apoptosis in cerebral ischemic stroke. CNS Neurosci. Ther. 19, 813-819. doi: 10.1111/cns.12142
18. Tao, Y. H., Sharif, N., Zeng, B. H., Cai, Y. Y., and Guo, Y. X. (2015). Lateral ventricle injection of orexin-A ameliorates central precocious puberty in rat via inhibiting the expression of MEG3. Int. J. Clin. Exp. Pathol. 8, 12564-12570.
19. Tasca, C. I., Dal-Cim, T., and Cimarosti, H. (2015). In vitro oxygen-glucose deprivation to study ischemic cell death. Methods Mol. Biol. 1254, 197-210. doi: 10.1007/978-1-4939-2152-2_15
20. Tay, Y., Rinn, J., and Pandolfi, P. P. (2014). The multilayered complexity of ceRNA crosstalk and competition. Nature 505, 344-352. doi: 10.1038/nature12986
21. van Spronsen, M., van Battum, E. Y., Kuijpers, M., Vangoor, V. R., Rietman, M. L., Pothof, J., et al. (2013). Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures. PLoS ONE 8:e74907. doi: 10.1371/journal.pone.0074907
22. Wang, P., Ren, Z., and Sun, P. (2012). Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. J. Cell. Biochem. 113, 1868-1874. doi: 10.1002/jcb.24055
23. Zhang, J., Yuan, L., Zhang, X., Hamblin, M. H., Zhu, T., Meng, F., et al. (2015). Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp. Neurol. 277, 162-170. doi: 10.1016/j.expneurol.2015.12.014
24. Zheng, W. X., Cao, X. L., Wang, F., Wang, J., Ying, T. Z., Xiao, W., et al. (2015). Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity. Eur. J. Pharmacol. 767, 201-210. doi: 10.1016/j.ejphar.2015.10.027
25. Zhi, F., Wang, Q., Deng, D., Shao, N., Wang, R., Xue, L., et al. (2014). MiR-181b-5p downregulates NOVA1 to suppress proliferation, migration and invasion and promote apoptosis in astrocytoma. PLoS ONE 9:e109124. doi: 10.1371/journal.pone.0109124