메뉴 건너뛰기




Volumn 540, Issue 7634, 2016, Pages 552-558

Early dissemination seeds metastasis in breast cancer

(27)  Hosseini, Hedayatollah a   Obradovic, Milan M S a,h   Hoffmann, Martin b   Harper, Kathryn L c   Sosa, Maria Soledad c   Werner Klein, Melanie a   Nanduri, Lahiri Kanth a,i   Werno, Christian b   Ehrl, Carolin a   Maneck, Matthias a   Patwary, Nina a   Haunschild, Gundula a   Guzvic, Miodrag a   Reimelt, Christian a   Grauvogl, Michael a   Eichner, Norbert a   Weber, Florian a   Hartkopf, Andreas D d   Taran, Florin Andrei d   Brucker, Sara Y d   more..


Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2;

EID: 85010855064     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature20785     Document Type: Article
Times cited : (540)

References (55)
  • 1
    • 84875173347 scopus 로고    scopus 로고
    • Metastasis awakening: Targeting dormant cancer
    • Aguirre-Ghiso, J. A., Bragado, P., Sosa, M. S. Metastasis awakening: Targeting dormant cancer. Nat. Med. 19, 276-277 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 276-277
    • Aguirre-Ghiso, J.A.1    Bragado, P.2    Sosa, M.S.3
  • 2
    • 84875183611 scopus 로고    scopus 로고
    • Metastasis awakening: The challenges of targeting minimal residual cancer
    • Polzer, B., Klein, C. A. Metastasis awakening: The challenges of targeting minimal residual cancer. Nat. Med. 19, 274-275 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 274-275
    • Polzer, B.1    Klein, C.A.2
  • 3
    • 0035963938 scopus 로고    scopus 로고
    • Polychemotherapy for early breast cancer: An overview of the randomised clinical trials with quality-adjusted survival analysis
    • Cole, B. F., Gelber, R. D., Gelber, S., Coates, A. S., Goldhirsch, A. Polychemotherapy for early breast cancer: An overview of the randomised clinical trials with quality-adjusted survival analysis. Lancet 358, 277-286 (2001).
    • (2001) Lancet , vol.358 , pp. 277-286
    • Cole, B.F.1    Gelber, R.D.2    Gelber, S.3    Coates, A.S.4    Goldhirsch, A.5
  • 4
    • 79952041937 scopus 로고    scopus 로고
    • Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial
    • Gianni, L., et al. Treatment with trastuzumab for 1 year after adjuvant chemotherapy in patients with HER2-positive early breast cancer: A 4-year follow-up of a randomised controlled trial. Lancet Oncol. 12, 236-244 (2011).
    • (2011) Lancet Oncol. , vol.12 , pp. 236-244
    • Gianni, L.1
  • 5
    • 0037206022 scopus 로고    scopus 로고
    • Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer
    • Klein, C. A., et al. Genetic heterogeneity of single disseminated tumour cells in minimal residual cancer. Lancet 360, 683-689 (2002).
    • (2002) Lancet , vol.360 , pp. 683-689
    • Klein, C.A.1
  • 6
    • 0038271868 scopus 로고    scopus 로고
    • From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression
    • Schmidt-Kittler, O., et al. From latent disseminated cells to overt metastasis: Genetic analysis of systemic breast cancer progression. Proc. Natl Acad. Sci. USA 100, 7737-7742 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 7737-7742
    • Schmidt-Kittler, O.1
  • 7
    • 63049102497 scopus 로고    scopus 로고
    • Parallel progression of primary tumours and metastases
    • Klein, C. A. Parallel progression of primary tumours and metastases. Nat. Rev. Cancer 9, 302-312 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 302-312
    • Klein, C.A.1
  • 8
    • 37349079197 scopus 로고    scopus 로고
    • Systemic spread is an early step in breast cancer
    • Hüsemann, Y., et al. Systemic spread is an early step in breast cancer. Cancer Cell 13, 58-68 (2008).
    • (2008) Cancer Cell , vol.13 , pp. 58-68
    • Hüsemann, Y.1
  • 9
    • 84856088337 scopus 로고    scopus 로고
    • EMT and dissemination precede pancreatic tumor formation
    • Rhim, A. D., et al. EMT and dissemination precede pancreatic tumor formation. Cell 148, 349-361 (2012).
    • (2012) Cell , vol.148 , pp. 349-361
    • Rhim, A.D.1
  • 10
    • 77953225810 scopus 로고    scopus 로고
    • Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma
    • Eyles, J., et al. Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma. J. Clin. Invest. 120, 2030-2039 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 2030-2039
    • Eyles, J.1
  • 11
    • 84856233963 scopus 로고    scopus 로고
    • Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast
    • Banys, M., et al. Hematogenous and lymphatic tumor cell dissemination may be detected in patients diagnosed with ductal carcinoma in situ of the breast. Breast Cancer Res. Treat. 131, 801-808 (2012).
    • (2012) Breast Cancer Res. Treat. , vol.131 , pp. 801-808
    • Banys, M.1
  • 12
    • 80052970594 scopus 로고    scopus 로고
    • Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ
    • Sänger, N., et al. Disseminated tumor cells in the bone marrow of patients with ductal carcinoma in situ. Int. J. Cancer 129, 2522-2526 (2011).
    • (2011) Int. J. Cancer , vol.129 , pp. 2522-2526
    • Sänger, N.1
  • 13
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan, S., Weinberg, R. A. Tumor metastasis: Molecular insights and evolving paradigms. Cell 147, 275-292 (2011).
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 14
    • 14744301796 scopus 로고    scopus 로고
    • Revealing progesterone's role in uterine and mammary gland biology: Insights from the mouse
    • Fernandez-Valdivia, R., et al. Revealing progesterone's role in uterine and mammary gland biology: Insights from the mouse. Semin. Reprod. Med. 23, 22-37 (2005).
    • (2005) Semin. Reprod. Med. , vol.23 , pp. 22-37
    • Fernandez-Valdivia, R.1
  • 15
    • 0042693019 scopus 로고    scopus 로고
    • Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform
    • Mulac-Jericevic, B., Lydon, J. P., DeMayo, F. J., Conneely, O. M. Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform. Proc. Natl Acad. Sci. USA 100, 9744-9749 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 9744-9749
    • Mulac-Jericevic, B.1    Lydon, J.P.2    DeMayo, F.J.3    Conneely, O.M.4
  • 16
    • 23044500236 scopus 로고    scopus 로고
    • Progesterone receptor isoforms A and B: Temporal and spatial differences in expression during murine mammary gland development
    • Aupperlee, M. D., Smith, K. T., Kariagina, A., Haslam, S. Z. Progesterone receptor isoforms A and B: Temporal and spatial differences in expression during murine mammary gland development. Endocrinology 146, 3577-3588 (2005).
    • (2005) Endocrinology , vol.146 , pp. 3577-3588
    • Aupperlee, M.D.1    Smith, K.T.2    Kariagina, A.3    Haslam, S.Z.4
  • 17
    • 84878258729 scopus 로고    scopus 로고
    • Progesterone signalling in breast cancer: A neglected hormone coming into the limelight
    • Brisken, C. Progesterone signalling in breast cancer: A neglected hormone coming into the limelight. Nat. Rev. Cancer 13, 385-396 (2013).
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 385-396
    • Brisken, C.1
  • 18
    • 34548569038 scopus 로고    scopus 로고
    • Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity
    • Liao, M. J., et al. Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res. 67, 8131-8138 (2007).
    • (2007) Cancer Res. , vol.67 , pp. 8131-8138
    • Liao, M.J.1
  • 19
    • 54049096261 scopus 로고    scopus 로고
    • HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion
    • Korkaya, H., Paulson, A., Iovino, F., Wicha, M. S. HER2 regulates the mammary stem/progenitor cell population driving tumorigenesis and invasion. Oncogene 27, 6120-6130 (2008).
    • (2008) Oncogene , vol.27 , pp. 6120-6130
    • Korkaya, H.1    Paulson, A.2    Iovino, F.3    Wicha, M.S.4
  • 20
    • 35848955428 scopus 로고    scopus 로고
    • ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome
    • Ginestier, C., et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1, 555-567 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 555-567
    • Ginestier, C.1
  • 21
    • 0030460355 scopus 로고    scopus 로고
    • Estrogen-induced transcription of the progesterone receptor gene does not parallel estrogen receptor occupancy
    • Lee, Y. J., Gorski, J. Estrogen-induced transcription of the progesterone receptor gene does not parallel estrogen receptor occupancy. Proc. Natl Acad. Sci. USA 93, 15180-15184 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 15180-15184
    • Lee, Y.J.1    Gorski, J.2
  • 22
    • 84861576201 scopus 로고    scopus 로고
    • The landscape of cancer genes and mutational processes in breast cancer
    • Stephens, P. J., et al. The landscape of cancer genes and mutational processes in breast cancer. Nature 486, 400-404 (2012).
    • (2012) Nature , vol.486 , pp. 400-404
    • Stephens, P.J.1
  • 23
    • 33747893501 scopus 로고    scopus 로고
    • A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation
    • Fehm, T., et al. A concept for the standardized detection of disseminated tumor cells in bone marrow from patients with primary breast cancer and its clinical implementation. Cancer 107, 885-892 (2006).
    • (2006) Cancer , vol.107 , pp. 885-892
    • Fehm, T.1
  • 24
    • 84918593578 scopus 로고    scopus 로고
    • Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes
    • Gužvić, M., et al. Combined genome and transcriptome analysis of single disseminated cancer cells from bone marrow of prostate cancer patients reveals unexpected transcriptomes. Cancer Res. 74, 7383-7394 (2014).
    • (2014) Cancer Res. , vol.74 , pp. 7383-7394
    • Gužvić, M.1
  • 25
    • 79551643707 scopus 로고    scopus 로고
    • Framework models of tumor dormancy from patient-derived observations
    • Klein, C. A. Framework models of tumor dormancy from patient-derived observations. Curr. Opin. Genet. Dev. 21, 42-49 (2011).
    • (2011) Curr. Opin. Genet. Dev. , vol.21 , pp. 42-49
    • Klein, C.A.1
  • 26
    • 84946215072 scopus 로고    scopus 로고
    • Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets
    • Brastianos, P. K., et al. Genomic characterization of brain metastases reveals branched evolution and potential therapeutic targets. Cancer Discov. 5, 1164-1177 (2015).
    • (2015) Cancer Discov. , vol.5 , pp. 1164-1177
    • Brastianos, P.K.1
  • 27
    • 0034653649 scopus 로고    scopus 로고
    • Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling
    • Brisken, C., et al. Essential function of Wnt-4 in mammary gland development downstream of progesterone signaling. Genes Dev. 14, 650-654 (2000).
    • (2000) Genes Dev. , vol.14 , pp. 650-654
    • Brisken, C.1
  • 28
    • 61349178831 scopus 로고    scopus 로고
    • The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse
    • Fernandez-Valdivia, R., et al. The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse. Dev. Biol. 328, 127-139 (2009).
    • (2009) Dev. Biol. , vol.328 , pp. 127-139
    • Fernandez-Valdivia, R.1
  • 29
    • 33746709476 scopus 로고    scopus 로고
    • Steroid hormone receptor status of mouse mammary stem cells
    • Asselin-Labat, M. L., et al. Steroid hormone receptor status of mouse mammary stem cells. J. Natl. Cancer Inst. 98, 1011-1014 (2006).
    • (2006) J. Natl. Cancer Inst. , vol.98 , pp. 1011-1014
    • Asselin-Labat, M.L.1
  • 30
    • 77953388315 scopus 로고    scopus 로고
    • Progesterone induces adult mammary stem cell expansion
    • Joshi, P. A., et al. Progesterone induces adult mammary stem cell expansion. Nature 465, 803-807 (2010).
    • (2010) Nature , vol.465 , pp. 803-807
    • Joshi, P.A.1
  • 31
    • 78649821635 scopus 로고    scopus 로고
    • Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression
    • Mukherjee, A., et al. Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression. FASEB J. 24, 4408-4419 (2010).
    • (2010) FASEB J. , vol.24 , pp. 4408-4419
    • Mukherjee, A.1
  • 32
    • 84965092320 scopus 로고    scopus 로고
    • Breast cancer mortality after a diagnosis of ductal carcinoma in situ
    • Narod, S. A., Iqbal, J., Giannakeas, V., Sopik, V., Sun, P. Breast cancer mortality after a diagnosis of ductal carcinoma in situ. JAMA Oncol. 1, 888-896 (2015).
    • (2015) JAMA Oncol. , vol.1 , pp. 888-896
    • Narod, S.A.1    Iqbal, J.2    Giannakeas, V.3    Sopik, V.4    Sun, P.5
  • 33
    • 20244374263 scopus 로고    scopus 로고
    • Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary arcinoma
    • Astolfi, A., et al. Gene expression analysis of immune-mediated arrest of tumorigenesis in a transgenic mouse model of HER-2/neu-positive basal-like mammary arcinoma. Am. J. Pathol. 166, 1205-1216 (2005).
    • (2005) Am. J. Pathol. , vol.166 , pp. 1205-1216
    • Astolfi, A.1
  • 34
    • 79251548904 scopus 로고    scopus 로고
    • HER2-positive circulating tumor cells in breast cancer
    • Ignatiadis, M., et al. HER2-positive circulating tumor cells in breast cancer. PLoS One 6, e15624 (2011).
    • (2011) PLoS One , vol.6 , pp. e15624
    • Ignatiadis, M.1
  • 35
    • 34548069945 scopus 로고    scopus 로고
    • Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern
    • Hafner, C., et al. Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern. Proc. Natl Acad. Sci. USA 104, 13450-13454 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13450-13454
    • Hafner, C.1
  • 36
    • 78650582977 scopus 로고    scopus 로고
    • Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors
    • Hafner, C., et al. Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors. Proc. Natl Acad. Sci. USA 107, 20780-20785 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 20780-20785
    • Hafner, C.1
  • 37
    • 0037228055 scopus 로고    scopus 로고
    • High frequency of BRAF mutations in nevi
    • Pollock, P. M., et al. High frequency of BRAF mutations in nevi. Nat. Genet. 33, 19-20 (2003).
    • (2003) Nat. Genet. , vol.33 , pp. 19-20
    • Pollock, P.M.1
  • 38
    • 2342527930 scopus 로고    scopus 로고
    • Activation of Akt-1 (PKB-) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion
    • Hutchinson, J. N., Jin, J., Cardiff, R. D., Woodgett, J. R., Muller, W. J. Activation of Akt-1 (PKB-) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res. 64, 3171-3178 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 3171-3178
    • Hutchinson, J.N.1    Jin, J.2    Cardiff, R.D.3    Woodgett, J.R.4    Muller, W.J.5
  • 39
    • 84861592850 scopus 로고    scopus 로고
    • MYC suppresses cancer metastasis by direct transcriptional silencing of V and 3 integrin subunits
    • Liu, H., et al. MYC suppresses cancer metastasis by direct transcriptional silencing of V and 3 integrin subunits. Nat. Cell Biol. 14, 567-574 (2012).
    • (2012) Nat. Cell Biol. , vol.14 , pp. 567-574
    • Liu, H.1
  • 40
    • 79955615205 scopus 로고    scopus 로고
    • Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres
    • VerMilyea, M. D., et al. Transcriptome asymmetry within mouse zygotes but not between early embryonic sister blastomeres. EMBO J. 30, 1841-1851 (2011).
    • (2011) EMBO J. , vol.30 , pp. 1841-1851
    • VerMilyea, M.D.1
  • 41
    • 0031710033 scopus 로고    scopus 로고
    • A third-generation lentivirus vector with a conditional packaging system
    • Dull, T., et al. A third-generation lentivirus vector with a conditional packaging system. J. Virol. 72, 8463-8471 (1998).
    • (1998) J. Virol. , vol.72 , pp. 8463-8471
    • Dull, T.1
  • 42
    • 0033854421 scopus 로고    scopus 로고
    • Transformation of mortal human fibroblasts and activation of a growth inhibitory pathway by the bovine papillomavirus E5 oncoprotein
    • Petti, L. M., Ray, F. A. Transformation of mortal human fibroblasts and activation of a growth inhibitory pathway by the bovine papillomavirus E5 oncoprotein. Cell Growth Differ. 11, 395-408 (2000).
    • (2000) Cell Growth Differ. , vol.11 , pp. 395-408
    • Petti, L.M.1    Ray, F.A.2
  • 43
    • 0344375083 scopus 로고    scopus 로고
    • Lentivirus-delivered stable gene silencing by RNAi in primary cells
    • Stewart, S. A., et al. Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA 9, 493-501 (2003).
    • (2003) RNA , vol.9 , pp. 493-501
    • Stewart, S.A.1
  • 44
    • 43249109372 scopus 로고    scopus 로고
    • Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Chapter 3, Unit 3.22
    • Thery, C., Amigorena, S., Raposo, G., Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Current Protoc. Cell Biology Chapter 3, Unit 3.22 (2006).
    • (2006) Current Protoc. Cell Biology
    • Thery, C.1    Amigorena, S.2    Raposo, G.3    Clayton, A.4
  • 45
    • 84896705478 scopus 로고    scopus 로고
    • A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation
    • Dueck, A., Eichner, A., Sixt, M., Meister, G. A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation. FEBS Lett. 588, 632-640 (2014).
    • (2014) FEBS Lett. , vol.588 , pp. 632-640
    • Dueck, A.1    Eichner, A.2    Sixt, M.3    Meister, G.4
  • 46
    • 84875404794 scopus 로고    scopus 로고
    • The UCSC genome browser database: Extensions and updates 2013
    • Meyer, L. R., et al. The UCSC genome browser database: Extensions and updates 2013. Nucleic Acids Res. 41, D64-D69 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , pp. D64-D69
    • Meyer, L.R.1
  • 48
    • 1342294092 scopus 로고    scopus 로고
    • Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation
    • Yang, Y. H., et al. Normalization for cDNA microarray data: A robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30, e15 (2002).
    • (2002) Nucleic Acids Res. , vol.30 , pp. e15
    • Yang, Y.H.1
  • 49
    • 28344444255 scopus 로고    scopus 로고
    • A stepwise framework for the normalization of array CGH data
    • Khojasteh, M., Lam, W. L., Ward, R. K., MacAulay, C. A stepwise framework for the normalization of array CGH data. BMC Bioinformatics 6, 274 (2005).
    • (2005) BMC Bioinformatics , vol.6 , pp. 274
    • Khojasteh, M.1    Lam, W.L.2    Ward, R.K.3    MacAulay, C.4
  • 50
    • 0242333835 scopus 로고    scopus 로고
    • Normalization of cDNA microarray data
    • Smyth, G. K., Speed, T. Normalization of cDNA microarray data. Methods 31, 265-273 (2003).
    • (2003) Methods , vol.31 , pp. 265-273
    • Smyth, G.K.1    Speed, T.2
  • 51
    • 84926507971 scopus 로고    scopus 로고
    • Limma powers differential expression analyses for RNA-sequencing and microarray studies
    • Ritchie, M. E., et al. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. e47
    • Ritchie, M.E.1
  • 52
    • 42949174747 scopus 로고    scopus 로고
    • Breaking the waves: Improved detection of copy number variation from microarray-based comparative genomic hybridization
    • Marioni, J. C., et al. Breaking the waves: Improved detection of copy number variation from microarray-based comparative genomic hybridization. Genome Biol. 8, R228 (2007).
    • (2007) Genome Biol. , vol.8 , pp. R228
    • Marioni, J.C.1
  • 53
    • 34147104969 scopus 로고    scopus 로고
    • A faster circular binary segmentation algorithm for the analysis of array CGH data
    • Venkatraman, E. S., Olshen, A. B. A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics 23, 657-663 (2007).
    • (2007) Bioinformatics , vol.23 , pp. 657-663
    • Venkatraman, E.S.1    Olshen, A.B.2
  • 54
    • 79955166265 scopus 로고    scopus 로고
    • GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers
    • Mermel, C. H., et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12, R41 (2011).
    • (2011) Genome Biol. , vol.12 , pp. R41
    • Mermel, C.H.1
  • 55
    • 0033551238 scopus 로고    scopus 로고
    • Comparative genomic hybridization, loss of heterozygosity, DNA sequence analysis of single cells
    • Klein, C. A., et al. Comparative genomic hybridization, loss of heterozygosity, DNA sequence analysis of single cells. Proc. Natl Acad. Sci. USA 96, 4494-4499 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 4494-4499
    • Klein, C.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.