PDK1-dependent metabolic reprogramming dictates metastatic potential in breast cancer

Cell Metabolism

Volumn 22, Issue 4, 2015, Pages 577-589

  Dupuy, Fanny ^a,b   Tabariès, Sébastien ^a,c   Andrzejewski, Sylvia ^a,b   Dong, Zhifeng ^a,c   Blagih, Julianna ^a,b   Annis, Matthew G ^a,c   Omeroglu, Atilla ^d   Gao, Dongxia ^e   Leung, Samuel ^e   Amir, Eitan ^f   Clemons, Mark ^g   Aguilar Mahecha, Adriana ^h   Basik, Mark ^h   Vincent, Emma E ^a,b   St Pierre, Julie ^a,b   Jones, Russell G ^a,b   Siegel, Peter M ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g OTTAWA REGIONAL CANCER CENTRE   (Canada)

^h MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; FRUCTOSE BISPHOSPHATE ALDOLASE; GLUCOSE; GLUCOSE 6 PHOSPHATE ISOMERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LACTATE DEHYDROGENASE; LACTIC ACID; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE DEHYDROGENASE KINASE 1; UNCLASSIFIED DRUG; CARBON; GLUTAMINE; PROTEIN SERINE THREONINE KINASE; PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING) KINASE; SMALL INTERFERING RNA;

AEROBIC METABOLISM; ANIMAL CELL; ARTICLE; BREAST METASTASIS; CANCER CELL; CELL POPULATION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GLUCOSE INTAKE; HUMAN; HUMAN CELL; LIVER METASTASIS; METABOLIC STRESS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; NUTRIENT LIMITATION; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; BREAST TUMOR; CELL HYPOXIA; CHEMISTRY; GENETICS; GLYCOLYSIS; LIVER TUMOR; MASS FRAGMENTOGRAPHY; METABOLIC ENGINEERING; METABOLISM; METABOLOME; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; RNA INTERFERENCE; SECONDARY; TUMOR CELL LINE;

ANIMALS; BREAST NEOPLASMS; CARBON ISOTOPES; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTAMINE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LIVER NEOPLASMS; METABOLIC ENGINEERING; METABOLOME; MICE; MICE, INBRED BALB C; OXIDATIVE PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84943392673     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.08.007     Document Type: Article

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