Metabolic shifts toward glutamine regulate tumor growth, invasion and bioenergetics in ovarian cancer

Molecular Systems Biology

Volumn 10, Issue 5, 2014, Pages

  Yang, Lifeng ^a,b   Moss, Tyler ^c   Mangala, Lingegowda S ^c   Marini, Juan ^d   Zhao, Hongyun ^a,b   Wahlig, Stephen ^a,c   Armaiz Pena, Guillermo ^c   Jiang, Dahai ^c   Achreja, Abhinav ^a,b   Win, Julia ^a,b   Roopaimoole, Rajesha ^c   Rodriguez Aguayo, Cristian ^c   Mercado Uribe, Imelda ^c   Lopez Berestein, Gabriel ^c   Liu, Jinsong ^c   Tsukamoto, Takashi ^e   Sood, Anil K ^c   Ram, Prahlad T ^c   Nagrath, Deepak ^a,b  

^a RICE UNIVERSITY   (United States)

^b Rice University   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d BAYLOR COLLEGE OF MEDICINE   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

cancer metabolism; glutamine dependence; glutaminolysis; invasion; ovarian cancer

Indexed keywords

ACONITATE HYDRATASE; ASPARTATE AMINOTRANSFERASE ISOENZYME 1; ASPARTATE AMINOTRANSFERASE ISOENZYME 2; CITRATE SYNTHASE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; JANUS KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PYRUVATE CARBOXYLASE; PYRUVATE DEHYDROGENASE; SMALL INTERFERING RNA; STAT3 PROTEIN; SUCCINATE DEHYDROGENASE; TRACER; TRICARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; BIOSYNTHESIS; CANCER GROWTH; CANCER MODEL; CANCER PATIENT; CANCER PROGNOSIS; CANCER SURVIVAL; CARBOXYLATION; CELL ADHESION; CELL ENERGY; CELL MIGRATION; CELL PROLIFERATION; CELL RESPIRATION; CELLULAR PARAMETERS; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; EXTRACELLULAR ACIDIFICATION RATE; FEMALE; GENE EXPRESSION; GLUTAMINE ANABOLISM; GLUTAMINE CATABOLISM; GLUTAMINE SYNTHESIS; GLUTAMINOLYSIS; GLYCOLYSIS; HUMAN; HUMAN CELL; LIPID METABOLISM; METABOLISM; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OVARIAN CANCER CELL LINE; OVARY CANCER; OXYGEN CONSUMPTION RATE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR INVASION; CELL CYCLE; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; OVARY TUMOR; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE;

CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; ENERGY METABOLISM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMINE; HUMANS; OVARIAN NEOPLASMS; PROGNOSIS; SIGNAL TRANSDUCTION;

EID: 84901624185     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1002/msb.20134892     Document Type: Article

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