-
1
-
-
0019935804
-
Plaques, tangles and dementia. A quantitative study
-
Wilcock, G. K. & Esiri, M. M. Plaques, tangles and dementia. A quantitative study. J. Neurol. Sci. 56, 343-356 (1982).
-
(1982)
J. Neurol. Sci
, vol.56
, pp. 343-356
-
-
Wilcock, G.K.1
Esiri, M.M.2
-
2
-
-
84923043538
-
Frontotemporal dementia caused by microtubule-Associated protein tau gene (MAPT) mutations: A chameleon for neuropathology and neuroimaging
-
Ghetti, B. et al. Frontotemporal dementia caused by microtubule-Associated protein tau gene (MAPT) mutations: A chameleon for neuropathology and neuroimaging. Neuropathol. Appl. Neurobiol. 41, 24-46 (2015).
-
(2015)
Neuropathol. Appl. Neurobiol
, vol.41
, pp. 24-46
-
-
Ghetti, B.1
-
3
-
-
37049048544
-
Paired helical filaments in electron microscopy of Alzheimers disease
-
Kidd, M. Paired helical filaments in electron microscopy of Alzheimers disease. Nature 197, 192-193 (1963).
-
(1963)
Nature
, vol.197
, pp. 192-193
-
-
Kidd, M.1
-
4
-
-
77957103117
-
The fine structure of neurofibrillary tangles in Alzheimers disease
-
Terry, R. D. The fine structure of neurofibrillary tangles in Alzheimers disease. J. Neuropathol. Exp. Neurol. 22, 629-642 (1963).
-
(1963)
J. Neuropathol. Exp. Neurol
, vol.22
, pp. 629-642
-
-
Terry, R.D.1
-
5
-
-
0019470087
-
Reappraisal of the fine structure of Alzheimers neurofibrillary tangles
-
Yagishita, S., Itoh, Y., Nan, W. & Amano, N. Reappraisal of the fine structure of Alzheimers neurofibrillary tangles. Acta Neuropathol. 54, 239-246 (1981).
-
(1981)
Acta Neuropathol
, vol.54
, pp. 239-246
-
-
Yagishita, S.1
Itoh, Y.2
Nan, W.3
Amano, N.4
-
6
-
-
0025977281
-
Straight and paired helical filaments in Alzheimer disease have a common structural unit
-
Crowther, R. A. Straight and paired helical filaments in Alzheimer disease have a common structural unit. Proc. Natl Acad. Sci. USA 88, 2288-2292 (1991).
-
(1991)
Proc. Natl Acad. Sci. USA
, vol.88
, pp. 2288-2292
-
-
Crowther, R.A.1
-
7
-
-
0024044195
-
Structural characterization of the core of the paired helical filament of Alzheimer disease
-
Wischik, C. M. et al. Structural characterization of the core of the paired helical filament of Alzheimer disease. Proc. Natl Acad. Sci. USA 85, 4884-4888 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 4884-4888
-
-
Wischik, C.M.1
-
8
-
-
0042307302
-
Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure
-
Berriman, J. et al. Tau filaments from human brain and from in vitro assembly of recombinant protein show cross-β structure. Proc. Natl Acad. Sci. USA 100, 9034-9038 (2003).
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 9034-9038
-
-
Berriman, J.1
-
9
-
-
84994614108
-
Potential pathways of abnormal Tau and α-synuclein dissemination in sporadic Alzheimers and Parkinsons diseases
-
Braak, H. & Del Tredici, K. Potential pathways of abnormal Tau and α-synuclein dissemination in sporadic Alzheimers and Parkinsons diseases. Cold Spring Harb. Perspect. Biol. 8, a023630 (2016).
-
(2016)
Cold Spring Harb. Perspect. Biol
, vol.8
, pp. a023630
-
-
Braak, H.1
Del Tredici, K.2
-
10
-
-
84955101086
-
Short fibrils constitute the major species of seed-competent Tau in the brains of mice transgenic for human P301S Tau
-
Jackson, S. J. et al. Short fibrils constitute the major species of seed-competent Tau in the brains of mice transgenic for human P301S Tau. J. Neurosci. 36, 762-772 (2016).
-
(2016)
J. Neurosci
, vol.36
, pp. 762-772
-
-
Jackson, S.J.1
-
11
-
-
0024745894
-
Multiple isoforms of human microtubule-Associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimers disease
-
Goedert, M., Spillantini, M. G., Jakes, R., Rutherford, D. & Crowther, R. A. Multiple isoforms of human microtubule-Associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimers disease. Neuron 3, 519-526 (1989).
-
(1989)
Neuron
, vol.3
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
12
-
-
0033850080
-
Abnormal tau-containing filaments in neurodegenerative diseases
-
Crowther, R. A. & Goedert, M. Abnormal tau-containing filaments in neurodegenerative diseases. J. Struct. Biol. 130, 271-279 (2000).
-
(2000)
J. Struct. Biol
, vol.130
, pp. 271-279
-
-
Crowther, R.A.1
Goedert, M.2
-
13
-
-
84999766500
-
Unique pathological tau conformers from Alzheimers brains transmit tau pathology in nontransgenic mice
-
Guo, J. L. et al. Unique pathological tau conformers from Alzheimers brains transmit tau pathology in nontransgenic mice. J. Exp. Med. 213, 2635-2654 (2016).
-
(2016)
J. Exp. Med
, vol.213
, pp. 2635-2654
-
-
Guo, J.L.1
-
14
-
-
84942909501
-
Peptide dimer structure in an Aβ (1-42) fibril visualized with cryo-EM
-
Schmidt, M. et al. Peptide dimer structure in an Aβ (1-42) fibril visualized with cryo-EM. Proc. Natl Acad. Sci. USA 112, 11858-11863 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 11858-11863
-
-
Schmidt, M.1
-
15
-
-
84982685920
-
Atomic resolution structure of monomorphic Aβ 42 amyloid fibrils
-
Colvin, M. T. et al. Atomic resolution structure of monomorphic Aβ 42 amyloid fibrils. J. Am. Chem. Soc. 138, 9663-9674 (2016).
-
(2016)
J. Am. Chem. Soc
, vol.138
, pp. 9663-9674
-
-
Colvin, M.T.1
-
16
-
-
84884217594
-
Molecular structure of β-Amyloid fibrils in Alzheimers disease brain tissue
-
Lu, J.-X. et al. Molecular structure of β-Amyloid fibrils in Alzheimers disease brain tissue. Cell 154, 1257-1268 (2013).
-
(2013)
Cell
, vol.154
, pp. 1257-1268
-
-
Lu, J.-X.1
-
17
-
-
84983638394
-
Atomic-resolution structure of a disease-relevant Aβ (1-42) amyloid fibril
-
Wlti, M. A. et al. Atomic-resolution structure of a disease-relevant Aβ (1-42) amyloid fibril. Proc. Natl Acad. Sci. USA 113, E4976-E4984 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E4976-E4984
-
-
Wälti, M.A.1
-
18
-
-
84961718093
-
Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
-
Tuttle, M. D. et al. Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. Nat. Struct. Mol. Biol. 23, 409-415 (2016).
-
(2016)
Nat. Struct. Mol. Biol
, vol.23
, pp. 409-415
-
-
Tuttle, M.D.1
-
19
-
-
0026595846
-
Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms
-
Goedert, M., Spillantini, M. G., Cairns, N. J. & Crowther, R. A. Tau proteins of Alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms. Neuron 8, 159-168 (1992).
-
(1992)
Neuron
, vol.8
, pp. 159-168
-
-
Goedert, M.1
Spillantini, M.G.2
Cairns, N.J.3
Crowther, R.A.4
-
20
-
-
85009774848
-
Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation
-
McEwan, W. A. et al. Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation. Proc. Natl Acad. Sci. USA 114, 574-579 (2017).
-
(2017)
Proc. Natl Acad. Sci. USA
, vol.114
, pp. 574-579
-
-
McEwan, W.A.1
-
21
-
-
85013460627
-
Helical reconstruction in RELION
-
He, S. & Scheres, S. H. W. Helical reconstruction in RELION. J. Struct. Biol. 198, 163-176 (2017).
-
(2017)
J. Struct. Biol
, vol.198
, pp. 163-176
-
-
He, S.1
Scheres, S.H.W.2
-
22
-
-
84875871051
-
Atomic structure and hierarchical assembly of a cross-β amyloid fibril
-
Fitzpatrick, A. W. P. et al. Atomic structure and hierarchical assembly of a cross-β amyloid fibril. Proc. Natl Acad. Sci. USA 110, 5468-5473 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 5468-5473
-
-
Fitzpatrick, A.W.P.1
-
23
-
-
0025785076
-
Identification of 3-And 4-repeat tau isoforms within the PHF in Alzheimers disease
-
Jakes, R., Novak, M., Davison, M. & Wischik, C. M. Identification of 3-And 4-repeat tau isoforms within the PHF in Alzheimers disease. EMBO J. 10, 2725-2729 (1991).
-
(1991)
EMBO J
, vol.10
, pp. 2725-2729
-
-
Jakes, R.1
Novak, M.2
Davison, M.3
Wischik, C.M.4
-
24
-
-
0003986552
-
Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease
-
Wischik, C. M. et al. Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease. Proc. Natl Acad. Sci. USA 85, 4506-4510 (1988).
-
(1988)
Proc. Natl Acad. Sci. USA
, vol.85
, pp. 4506-4510
-
-
Wischik, C.M.1
-
25
-
-
84954385047
-
Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau
-
Taniguchi-Watanabe, S. et al. Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau. Acta Neuropathol. 131, 267-280 (2016).
-
(2016)
Acta Neuropathol
, vol.131
, pp. 267-280
-
-
Taniguchi-Watanabe, S.1
-
26
-
-
85005814219
-
Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimers disease brain
-
Dan, A. et al. Extensive deamidation at asparagine residue 279 accounts for weak immunoreactivity of tau with RD4 antibody in Alzheimers disease brain. Acta Neuropathol. Commun. 1, 54 (2013).
-
(2013)
Acta Neuropathol. Commun
, vol.1
, pp. 54
-
-
Dan, A.1
-
27
-
-
33746005851
-
Structure of polyglycine II
-
Crick, F. H. C. & Rich, A. Structure of polyglycine II. Nature 176, 780-781 (1955).
-
(1955)
Nature
, vol.176
, pp. 780-781
-
-
Crick, F.H.C.1
Rich, A.2
-
28
-
-
0030936599
-
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
-
Jicha, G. A., Bowser, R., Kazam, I. G. & Davies, P. Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J. Neurosci. Res. 48, 128-132 (1997).
-
(1997)
J. Neurosci. Res
, vol.48
, pp. 128-132
-
-
Jicha, G.A.1
Bowser, R.2
Kazam, I.G.3
Davies, P.4
-
29
-
-
81755177762
-
The dynamic structure of filamentous tau
-
Bibow, S. et al. The dynamic structure of filamentous tau. Angew. Chem. Int. Edn Engl. 50, 11520-11524 (2011).
-
(2011)
Angew. Chem. Int. Edn Engl
, vol.50
, pp. 11520-11524
-
-
Bibow, S.1
-
30
-
-
12644260802
-
The structural basis of monoclonal antibody Alz50s selectivity for Alzheimers disease pathology
-
Carmel, G., Mager, E. M., Binder, L. I. & Kuret, J. The structural basis of monoclonal antibody Alz50s selectivity for Alzheimers disease pathology. J. Biol. Chem. 271, 32789-32795 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 32789-32795
-
-
Carmel, G.1
Mager, E.M.2
Binder, L.I.3
Kuret, J.4
-
31
-
-
0036771837
-
An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype
-
Poorkaj, P. et al. An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype. Ann. Neurol. 52, 511-516 (2002).
-
(2002)
Ann. Neurol
, vol.52
, pp. 511-516
-
-
Poorkaj, P.1
-
32
-
-
0036198120
-
Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation
-
Hayashi, S. et al. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann. Neurol. 51, 525-530 (2002).
-
(2002)
Ann. Neurol
, vol.51
, pp. 525-530
-
-
Hayashi, S.1
-
33
-
-
84878723720
-
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
-
Clavaguera, F. et al. Brain homogenates from human tauopathies induce tau inclusions in mouse brain. Proc. Natl Acad. Sci. USA 110, 9535-9540 (2013).
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 9535-9540
-
-
Clavaguera, F.1
-
34
-
-
0031592945
-
Common core structure of amyloid fibrils by synchrotron X-ray diffraction
-
Sunde, M. et al. Common core structure of amyloid fibrils by synchrotron X-ray diffraction. J. Mol. Biol. 273, 729-739 (1997).
-
(1997)
J. Mol. Biol
, vol.273
, pp. 729-739
-
-
Sunde, M.1
-
35
-
-
2942616602
-
Evidence for assembly of prions with left-handed b-helices into trimers
-
Govaerts, C., Wille, H., Prusiner, S. B. & Cohen, F. E. Evidence for assembly of prions with left-handed b-helices into trimers. Proc. Natl Acad. Sci. USA 101, 8342-8347 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 8342-8347
-
-
Govaerts, C.1
Wille, H.2
Prusiner, S.B.3
Cohen, F.E.4
-
36
-
-
84939574467
-
Folding of the Tau protein on microtubules
-
Kadavath, H. et al. Folding of the Tau protein on microtubules. Angew. Chem. Int. Edn Engl. 54, 10347-10351 (2015).
-
(2015)
Angew. Chem. Int. Edn Engl
, vol.54
, pp. 10347-10351
-
-
Kadavath, H.1
-
37
-
-
33746377894
-
Protein misfolding, functional amyloid, and human disease
-
Chiti, F. & Dobson, C. M. Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem. 75, 333-366 (2006).
-
(2006)
Annu. Rev. Biochem
, vol.75
, pp. 333-366
-
-
Chiti, F.1
Dobson, C.M.2
-
38
-
-
0034625060
-
Assembly of t protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming b structure
-
von Bergen, M. et al. Assembly of t protein into Alzheimer paired helical filaments depends on a local sequence motif (306VQIVYK311) forming b structure. Proc. Natl Acad. Sci. USA 97, 5129-5134 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 5129-5134
-
-
Von Bergen, M.1
-
39
-
-
84942502608
-
Identification of key amino acids responsible for the distinct aggregation properties of microtubule-Associated protein 2 and tau
-
Xie, C. et al. Identification of key amino acids responsible for the distinct aggregation properties of microtubule-Associated protein 2 and tau. J. Neurochem. 135, 19-26 (2015).
-
(2015)
J. Neurochem
, vol.135
, pp. 19-26
-
-
Xie, C.1
-
40
-
-
34249290108
-
Atomic structures of amyloid cross-b spines reveal varied steric zippers
-
Sawaya, M. R. et al. Atomic structures of amyloid cross-b spines reveal varied steric zippers. Nature 447, 453-457 (2007).
-
(2007)
Nature
, vol.447
, pp. 453-457
-
-
Sawaya, M.R.1
-
41
-
-
0028027088
-
Domains of tau protein and interactions with microtubules
-
Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E. M. & Mandelkow, E. Domains of tau protein and interactions with microtubules. Biochemistry 33, 9511-9522 (1994).
-
(1994)
Biochemistry
, vol.33
, pp. 9511-9522
-
-
Gustke, N.1
Trinczek, B.2
Biernat, J.3
Mandelkow, E.M.4
Mandelkow, E.5
-
42
-
-
84997417099
-
Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo
-
Kaufman, S. K. et al. Tau prion strains dictate patterns of cell pathology, progression rate, and regional vulnerability in vivo. Neuron 92, 796-812 (2016).
-
(2016)
Neuron
, vol.92
, pp. 796-812
-
-
Kaufman, S.K.1
-
43
-
-
33845661120
-
B-rolls, b-helices, and other b-solenoid proteins
-
Kajava, A. V. & Steven, A. C. b-rolls, b-helices, and other b-solenoid proteins. Adv. Protein Chem. 73, 55-96 (2006).
-
(2006)
Adv. Protein Chem
, vol.73
, pp. 55-96
-
-
Kajava, A.V.1
Steven, A.C.2
-
44
-
-
40849120669
-
Amyloid fibrils of the HET-s(218-289) prion form a b solenoid with a triangular hydrophobic core
-
Wasmer, C. et al. Amyloid fibrils of the HET-s(218-289) prion form a b solenoid with a triangular hydrophobic core. Science 319, 1523-1526 (2008).
-
(2008)
Science
, vol.319
, pp. 1523-1526
-
-
Wasmer, C.1
-
45
-
-
85016000058
-
The activities of amyloids from a structural perspective
-
Riek, R. & Eisenberg, D. S. The activities of amyloids from a structural perspective. Nature 539, 227-235 (2016).
-
(2016)
Nature
, vol.539
, pp. 227-235
-
-
Riek, R.1
Eisenberg, D.S.2
-
46
-
-
84938703713
-
Structure-based drug design identifies polythiophenes as antiprion compounds
-
Herrmann, U. S. et al. Structure-based drug design identifies polythiophenes as antiprion compounds. Sci. Transl. Med. 7, 299ra123 (2015).
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 299ra123
-
-
Herrmann, U.S.1
-
47
-
-
69249100953
-
Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses
-
Aslund, A. et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. ACS Chem. Biol. 4, 673-684 (2009).
-
(2009)
ACS Chem. Biol
, vol.4
, pp. 673-684
-
-
Aslund, A.1
-
49
-
-
37549052418
-
The tauopathy associated with mutation + 3 in intron 10 of Tau: Characterization of the MSTD family
-
Spina, S. et al. The tauopathy associated with mutation + 3 in intron 10 of Tau: characterization of the MSTD family. Brain 131, 72-89 (2008).
-
(2008)
Brain
, vol.131
, pp. 72-89
-
-
Spina, S.1
-
50
-
-
84920901644
-
Conformation determines the seeding potencies of native and recombinant Tau aggregates
-
Falcon, B. et al. Conformation determines the seeding potencies of native and recombinant Tau aggregates. J. Biol. Chem. 290, 1049-1065 (2015).
-
(2015)
J. Biol. Chem
, vol.290
, pp. 1049-1065
-
-
Falcon, B.1
-
51
-
-
85014129582
-
MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy
-
Zheng, S. Q. et al. MotionCor2: Anisotropic correction of beam-induced motion for improved cryo-electron microscopy. Nat. Methods 14, 331-332 (2017).
-
(2017)
Nat. Methods
, vol.14
, pp. 331-332
-
-
Zheng, S.Q.1
-
52
-
-
84955216953
-
Real-Time CTF determination and correction
-
Zhang, K. Gctf: Real-Time CTF determination and correction. J. Struct. Biol. 193, 1-12 (2016).
-
(2016)
J. Struct. Biol
, vol.193
, pp. 1-12
-
-
Zhang, K.1
Gctf2
-
53
-
-
84880607763
-
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
-
Chen, S. et al. High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy. Ultramicroscopy 135, 24-35 (2013).
-
(2013)
Ultramicroscopy
, vol.135
, pp. 24-35
-
-
Chen, S.1
-
54
-
-
77949535720
-
Features and development of Coot
-
Emsley, P., Lohkamp, B., Scott, W. G. & Cowtan, K. Features and development of Coot. Acta Crystallogr. D Biol. Crystallogr. 66, 486-501 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr
, vol.66
, pp. 486-501
-
-
Emsley, P.1
Lohkamp, B.2
Scott, W.G.3
Cowtan, K.4
-
55
-
-
0030924992
-
Refinement of macromolecular structures by the maximum-likelihood method
-
Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D Biol. Crystallogr. 53, 240-255 (1997).
-
(1997)
Acta Crystallogr. D Biol. Crystallogr
, vol.53
, pp. 240-255
-
-
Murshudov, G.N.1
Vagin, A.A.2
Dodson, E.J.3
-
56
-
-
0034622579
-
A closer look at the active site of γ-class carbonic anhydrases: High-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila
-
Iverson, T. M., Alber, B. E., Kisker, C., Ferry, J. G. & Rees, D. C. A closer look at the active site of γ-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila. Biochemistry 39, 9222-9231 (2000).
-
(2000)
Biochemistry
, vol.39
, pp. 9222-9231
-
-
Iverson, T.M.1
Alber, B.E.2
Kisker, C.3
Ferry, J.G.4
Rees, D.C.5
-
57
-
-
74549178560
-
MolProbity: All-Atom structure validation for macromolecular crystallography
-
Chen, V. B. et al. MolProbity: All-Atom structure validation for macromolecular crystallography. Acta Crystallogr. D Biol. Crystallogr. 66, 12-21 (2010).
-
(2010)
Acta Crystallogr. D Biol. Crystallogr
, vol.66
, pp. 12-21
-
-
Chen, V.B.1
|