Urinary Tract Infection: Which Conformation of the Bacterial Lectin FimH Is Therapeutically Relevant?

Journal of Medicinal Chemistry

Volumn 60, Issue 13, 2017, Pages 5646-5662

  Mayer, Katharina ^a   Eris, Deniz ^a   Schwardt, Oliver ^a   Sager, Christoph P ^a   Rabbani, Said ^a   Kleeb, Simon ^a   Ernst, Beat ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO 4 IODO PHENYL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 2',3 DICHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 2',3,4' TRICHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 2,'3',4' TRICHLORO BIPHENYL 4 YL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 2' METHOXY BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 2' METHYL BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 3' (TRIFLUOROMETHYL)BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 3' METHYL BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 3' NITRO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 4' (TRIFLUOROMETHYL)BIPHENYL 4 YL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 4' (TRIFLUOROMETHYL)BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 4' METHOXY BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 4' METHYL BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO 4' NITRO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO BIPHENYL 4 YL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 3 CHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3' CHLORO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 3 CARBONITRIL; 3' CHLORO 4' (ALPHA DEXTRO MANNOPYRANOSYLOXY)BIPHENYL 4 CARBONITRIL; 3,3' DICHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3,3',4' TRICHLORO BIPHENYL 4 YL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 3,3',4' TRICHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3,4' DICHLORO 3' (TRIFLUOROMETHYL)BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 3,4' DICHLORO BIPHENYL 4 YL 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO MANNOPYRANOSIDE; 3,4' DICHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; 4' ACETYL 3 CHLORO BIPHENYL 4 YL ALPHA DEXTRO MANNOPYRANOSIDE; BACTERIAL LECTIN FIMH; BIPHENYL DERIVATIVE; LECTIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; ADHESIN; ANTIINFECTIVE AGENT; ARTIFICIAL MEMBRANE; FIMBRIA PROTEIN; FIMH PROTEIN, E COLI;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; DRUG BINDING; DRUG SYNTHESIS; INTESTINE ABSORPTION; LIPOPHILICITY; NONHUMAN; PHYSICAL CHEMISTRY; RENAL CLEARANCE; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI; UROTHELIUM; ANTAGONISTS AND INHIBITORS; ARTIFICIAL MEMBRANE; CHEMISTRY; DRUG EFFECTS; ESCHERICHIA COLI; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR MODEL; PERMEABILITY; PROTEIN CONFORMATION; URINARY TRACT INFECTIONS;

ADHESINS, ESCHERICHIA COLI; ANTI-BACTERIAL AGENTS; ESCHERICHIA COLI; FIMBRIAE PROTEINS; HUMANS; MEMBRANES, ARTIFICIAL; MODELS, MOLECULAR; PERMEABILITY; PROTEIN CONFORMATION; URINARY TRACT INFECTIONS;

EID: 85023752836     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.7b00342     Document Type: Article

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