Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 39, 2013, Pages 15530-15537

  Schwartz, Drew J ^a   Kalas, Vasilios ^a   Pinkner, Jerome S ^a   Chen, Swaine L ^b,c   Spaulding, Caitlin N ^a   Dodson, Karen W ^a   Hultgren, Scott J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Dept Medicine Endocrinol Diabet   (Singapore)

^c GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

Chronic cystitis; Microbial pathogenesis; Protein conformations; Protein dynamics

Indexed keywords

FIMH PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ALLELE; ARTICLE; ASYMPTOMATIC BACTERIURIA; BACTERIAL COLONIZATION; BACTERIAL VIRULENCE; BACTERIUM ISOLATE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CYSTITIS; IN VITRO STUDY; MIXED INFECTION; MULTIDRUG RESISTANCE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; PYELONEPHRITIS; URINARY TRACT INFECTION; UROPATHOGENIC ESCHERICHIA COLI;

CHRONIC CYSTITIS; MICROBIAL PATHOGENESIS; PROTEIN CONFORMATIONS; PROTEIN DYNAMICS;

ADHESINS, ESCHERICHIA COLI; ALLELES; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; CHRONIC DISEASE; COINFECTION; CYSTITIS; ESCHERICHIA COLI; FIMBRIAE PROTEINS; HUMANS; MANNOSE; MICE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; URINARY TRACT; URINARY TRACT INFECTIONS; VIRULENCE;

EID: 84884645556     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1315203110     Document Type: Article

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