Tauro-β-muricholic acid restricts bile acid-induced hepatocellular apoptosis by preserving the mitochondrial membrane potential

Biochemical and Biophysical Research Communications

Volumn 424, Issue 4, 2012, Pages 758-764

  Denk, Gerald Ulrich ^a   Kleiss, Carl Philipp ^a   Wimmer, Ralf ^a   Vennegeerts, Timo ^a   Reiter, Florian Paul ^a   Schulz, Sabine ^b   Zischka, Hans ^b   Rust, Christian ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Apoptosis; Bile acid; Cholestasis; Mitochondrial membrane potential

Indexed keywords

BILE ACID; CASPASE 3; CASPASE 7; CHOLIC ACID DERIVATIVE; GLYCOCHENODEOXYCHOLIC ACID; PALMITIC ACID; PROTEIN BAX; TAURO BETA MURICHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ASSAY; FLUOROMETRY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; LIVER CELL DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; QUANTITATIVE ANALYSIS; RAT;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BILE ACIDS AND SALTS; CYTOPROTECTION; GLYCOCHENODEOXYCHOLIC ACID; HEP G2 CELLS; HEPATOCYTES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA, LIVER; TAUROCHOLIC ACID;

RATTUS;

EID: 84864815555     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.029     Document Type: Article

References (32)

1. Maillette de Buy Wenniger L., Beuers U. Bile salts and cholestasis. Dig. Liver Dis. 2010, 42:409-418.
2. Rust C., Karnitz L.M., Paya C.V., Moscat J., Simari R.D., Gores G.J. The bile acid taurochenodeoxycholate activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 2000, 275:20210-20216.
3. Patel T., Bronk S.F., Gores G.J. Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes. J. Clin. Invest. 1994, 94:2183-2192.
4. EASL Clinical Practice Guidelines: management of cholestatic liver diseases, J. Hepatol. 51 (2009) 237-267.
5. Corpechot C., Abenavoli L., Rabahi N., Chretien Y., Andreani T., Johanet C., Chazouilleres O., Poupon R. Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis. Hepatology 2008, 48:871-877.
6. Corpechot C., Carrat F., Bahr A., Chretien Y., Poupon R.E., Poupon R. The effect of ursodeoxycholic acid therapy on the natural course of primary biliary cirrhosis. Gastroenterology 2005, 128:297-303.
7. Chapman R., Fevery J., Kalloo A., Nagorney D.M., Boberg K.M., Shneider B., Gores G.J. Diagnosis and management of primary sclerosing cholangitis. Hepatology 2010, 51:660-678.
8. Lindor K.D., Kowdley K.V., Luketic V.A., Harrison M.E., McCashland T., Befeler A.S., Harnois D., Jorgensen R., Petz J., Keach J., Mooney J., Sargeant C., Braaten J., Bernard T., King D., Miceli E., Schmoll J., Hoskin T., Thapa P., Enders F. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 2009, 50:808-814.
9. Hofmann A.F., Hagey L.R., Krasowski M.D. Bile salts of vertebrates: structural variation and possible evolutionary significance. J. Lipid Res. 2010, 51:226-246.
10. Sacquet E., Parquet M., Riottot M., Raizman A., Nordlinger B., Infante R. Metabolism of beta-muricholic acid in man. Steroids 1985, 45:411-426.
11. Montet J.C., Parquet M., Sacquet E., Montet A.M., Infante R., Amic J. Beta-muricholic acid; potentiometric and cholesterol-dissolving properties. Biochim. Biophys. Acta 1987, 918:1-10.
12. Wang D.Q., Tazuma S. Effect of beta-muricholic acid on the prevention and dissolution of cholesterol gallstones in C57L/J mice. J. Lipid Res. 2002, 43:1960-1968.
13. Milkiewicz P., Roma M.G., Elias E., Coleman R. Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways. Gut 2002, 51:113-119.
14. Katagiri K., Nakai T., Hoshino M., Hayakawa T., Ohnishi H., Okayama Y., Yamada T., Ohiwa T., Miyaji M., Takeuchi T. Tauro-beta-muricholate preserves choleresis and prevents taurocholate-induced cholestasis in colchicine-treated rat liver. Gastroenterology 1992, 102:1660-1667.
15. Botham K.M., Boyd G.S. The metabolism of chenodeoxycholic acid to beta-muricholic acid in rat liver. Eur. J. Biochem. 1983, 134:191-196.
16. Hohenester S., Gates A., Wimmer R., Beuers U., Anwer M.S., Rust C., Webster C.R. Phosphatidylinositol-3-kinase p110gamma contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J. Hepatol. 2010, 53:918-926.
17. Glasova H., Berghaus T.M., Kullak-Ublick G.A., Paumgartner G., Beuers U. Tauroursodeoxycholic acid mobilizes alpha-PKC after uptake in human HepG2 hepatoma cells. Eur. J. Clin. Invest. 2002, 32:437-442.
18. Denk G.U., Hohenester S., Wimmer R., Bohland C., Rust C., Beuers U. Role of mitogen-activated protein kinases in tauroursodeoxycholic acid-induced bile formation in cholestatic rat liver. Hepatol. Res. 2008, 38:717-726.
19. Rust C., Bauchmuller K., Bernt C., Vennegeerts T., Fickert P., Fuchsbichler A., Beuers U. Sulfasalazine reduces bile acid induced apoptosis in human hepatoma cells and perfused rat livers. Gut 2006, 55:719-727.
20. Rust C., Wild N., Bernt C., Vennegeerts T., Wimmer R., Beuers U. Bile acid-induced apoptosis in hepatocytes is caspase-6-dependent. J. Biol. Chem. 2009, 284:2908-2916.
21. Botla R., Spivey J.R., Aguilar H., Bronk S.F., Gores G.J. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: a mechanism of UDCA cytoprotection. J. Pharmacol. Exp. Therap. 1995, 272:930-938.
22. Malhi H., Guicciardi M.E., Gores G.J. Hepatocyte death: a clear and present danger. Physiol. Rev. 2010, 90:1165-1194.
23. Corpechot C., Chazouilleres O., Poupon R. Early primary biliary cirrhosis: biochemical response to treatment and prediction of long-term outcome. J. Hepatol. 2011, 55:1361-1367.
24. Kanai S., Ohta M., Kitani K., Sato Y. Tauro beta-muricholate is as effective as tauroursodeoxycholate in preventing taurochenodeoxycholate-induced liver damage in the rat. Life Sci. 1990, 47:2421-2428.
25. Ohiwa T., Katagiri K., Hoshino M., Hayakawa T., Nakai T. Tauroursodeoxycholate and tauro-beta-muricholate exert cytoprotection by reducing intrahepatocyte taurochenodeoxycholate content. Hepatology 1993, 17:470-476.
26. -: umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology 2012, 55:173-183.
27. Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat. Med. 2000, 6:513-519.
28. Zamzami N., Marchetti P., Castedo M., Hirsch T., Susin S.A., Masse B., Kroemer G. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis. FEBS Lett. 1996, 384:53-57.
29. Rodrigues C.M., Steer C.J. Mitochondrial membrane perturbations in cholestasis. J. Hepatol. 2000, 32:135-141.
30. Marzo I., Brenner C., Zamzami N., Jurgensmeier J.M., Susin S.A., Vieira H.L., Prevost M.C., Xie Z., Matsuyama S., Reed J.C., Kroemer G. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998, 281:2027-2031.
31. Feldstein A.E., Canbay A., Guicciardi M.E., Higuchi H., Bronk S.F., Gores G.J. Diet associated hepatic steatosis sensitizes to Fas mediated liver injury in mice. J. Hepatol. 2003, 39:978-983.
32. Malhi H., Bronk S.F., Werneburg N.W., Gores G.J. Free fatty acids induce JNK-dependent hepatocyte lipoapoptosis. J. Biol. Chem. 2006, 281:12093-12101.