Lipoxygenase inhibitors protect acute lymphoblastic leukemia cells from ferroptotic cell death

Biochemical Pharmacology

Volumn 140, Issue , 2017, Pages 41-52

  Probst, Lukas ^a   Dächert, Jasmin ^a   Schenk, Barbara ^a   Fulda, Simone ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Acute leukemia; Cell death; Ferroptosis; Redox; ROS

Indexed keywords

ANTIOXIDANT; BAICALEIN; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FERROSTATIN 1; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; NORDIHYDROGUAIARETIC ACID; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; REACTIVE OXYGEN METABOLITE; RSL 3; UNCLASSIFIED DRUG; ALOX12 PROTEIN, HUMAN; ALOX15 PROTEIN, HUMAN; ALPHA TOCOPHEROL; ANTINEOPLASTIC AGENT; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE; CARBOLINE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE; FADD PROTEIN, HUMAN; FERROSTATIN-1; FLAVANONE DERIVATIVE; GLUTATHIONE PEROXIDASE; PHENYLENEDIAMINE DERIVATIVE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; RSL3 COMPOUND; TUMOR PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EXPOSURE; FERROPTOSIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID PEROXIDATION; PRIORITY JOURNAL; ANTAGONISTS AND INHIBITORS; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KINETICS; METABOLISM; OXIDATIVE STRESS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR CELL LINE;

ALPHA-TOCOPHEROL; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; CARBOLINES; CELL DEATH; CELL LINE, TUMOR; CYCLOHEXYLAMINES; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FLAVANONES; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTATHIONE PEROXIDASE; HUMANS; KINETICS; LIPID PEROXIDATION; LIPOXYGENASE INHIBITORS; MASOPROCOL; NEOPLASM PROTEINS; OXIDATIVE STRESS; PHENYLENEDIAMINES; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REACTIVE OXYGEN SPECIES;

EID: 85021811196     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2017.06.112     Document Type: Article

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