메뉴 건너뛰기




Volumn 18, Issue 6, 2017, Pages

Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction

Author keywords

Adiponectin; Endothelial dysfunction; Obesity; Type 2 diabetes

Indexed keywords

ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; SYNAPTOPHYSIN; ADIPONECTIN; ADIPOQ PROTEIN, HUMAN;

EID: 85021065617     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms18061321     Document Type: Review
Times cited : (858)

References (129)
  • 1
    • 85047287739 scopus 로고    scopus 로고
    • Adiponectin: Probe of the molecular paradigm associating diabetes and obesity
    • Ghoshal, K., Bhattacharyya, M. Adiponectin: Probe of the molecular paradigm associating diabetes and obesity. World J. Diabetes 2015, 6, 151-166.
    • (2015) World J. Diabetes , vol.6 , pp. 151-166
    • Ghoshal, K.1    Bhattacharyya, M.2
  • 2
    • 0028787490 scopus 로고
    • Novel serum protein similar to c1q, produced exclusively in adipocytes
    • Scherer, P.E., Williams, S., Fogliano, M., Baldini, G., Lodish, H.F. A novel serum protein similar to c1q, produced exclusively in adipocytes. J. Biol. Chem. 1995, 270, 26746-26749.
    • (1995) J. Biol. Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.5
  • 3
    • 0029980285 scopus 로고    scopus 로고
    • CDNA cloning and expression of a novel adipose specific collagen-like factor, apm1 (Adiposemost abundant gene transcript 1)
    • Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y., Matsubara, K. cDNA cloning and expression of a novel adipose specific collagen-like factor, apm1 (adiposemost abundant gene transcript 1). Biochem. Biophys. Res. Commun. 1996, 221, 286-289.
    • (1996) Biochem. Biophys. Res. Commun , vol.221 , pp. 286-289
    • Maeda, K.1    Okubo, K.2    Shimomura, I.3    Funahashi, T.4    Matsuzawa, Y.5    Matsubara, K.6
  • 4
    • 0029836585 scopus 로고    scopus 로고
    • Isolation and characterization of gbp28, a novel gelatin-binding protein purified from human plasma
    • Nakano, Y., Tobe, T., Choi-Miura, N.-H., Mazda, T., Tomita, M. Isolation and characterization of gbp28, a novel gelatin-binding protein purified from human plasma. J. Biochem. 1996, 120, 803-812.
    • (1996) J. Biochem , vol.120 , pp. 803-812
    • Nakano, Y.1    Tobe, T.2    Choi-Miura, N.-H.3    Mazda, T.4    Tomita, M.5
  • 8
  • 9
    • 18144408371 scopus 로고    scopus 로고
    • Adipose tissue, adipokines, and inflammation
    • Fantuzzi, G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005, 115, 911-919.
    • (2005) J. Allergy Clin. Immunol , vol.115 , pp. 911-919
    • Fantuzzi, G.1
  • 11
    • 17544382289 scopus 로고    scopus 로고
    • Adipoq is a novel adipose-specific gene dysregulated in obesity
    • Hu, E., Liang, P., Spiegelman, B.M. Adipoq is a novel adipose-specific gene dysregulated in obesity. J. Biol. Chem. 1996, 271, 10697-10703.
    • (1996) J. Biol. Chem , vol.271 , pp. 10697-10703
    • Hu, E.1    Liang, P.2    Spiegelman, B.M.3
  • 12
    • 0037356826 scopus 로고    scopus 로고
    • The role of the novel adipocyte-derived hormone adiponectin in human disease
    • Díez, J.J., Iglesias, P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur. J. Endocrinol. 2003, 148, 293-300.
    • (2003) Eur. J. Endocrinol , vol.148 , pp. 293-300
    • Díez, J.J.1    Iglesias, P.2
  • 15
    • 9444285912 scopus 로고    scopus 로고
    • Induction of adiponectin in skeletal muscle by inflammatory cytokines: In vivo and in vitro studies
    • Delaigle, A.L.M., Jonas, J.-C., Bauche, I.B., Cornu, O., Brichard, S.M. Induction of adiponectin in skeletal muscle by inflammatory cytokines: In vivo and in vitro studies. Endocrinology 2004, 145, 5589-5597.
    • (2004) Endocrinology , vol.145 , pp. 5589-5597
    • Delaigle, A.L.M.1    Jonas, J.-C.2    Bauche, I.B.3    Cornu, O.4    Brichard, S.M.5
  • 16
    • 55949118111 scopus 로고    scopus 로고
    • Circulating serum adiponectin levels in patients with coronary artery disease: Relationship to atherosclerotic burden and cardiac function
    • Patel, J.V., Abraheem, A., Dotsenko, O., Creamer, J., Gunning, M., Hughes, E.A., Lip, G.Y.H. Circulating serum adiponectin levels in patients with coronary artery disease: Relationship to atherosclerotic burden and cardiac function. J. Intern. Med. 2008, 264, 593-598.
    • (2008) J. Intern. Med , vol.264 , pp. 593-598
    • Patel, J.V.1    Abraheem, A.2    Dotsenko, O.3    Creamer, J.4    Gunning, M.5    Hughes, E.A.6    Lip, G.Y.H.7
  • 21
    • 0036230486 scopus 로고    scopus 로고
    • Genome-wide search for type 2 diabetes in japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p
    • Mori, Y., Otabe, S., Dina, C., Yasuda, K., Populaire, C.L., Lecoeur, C.C., Vatin, V., Durand, E., Hara, K., Okada, T. Genome-wide search for type 2 diabetes in japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. Diabetes 2002, 51, 1247-1255.
    • (2002) Diabetes , vol.51 , pp. 1247-1255
    • Mori, Y.1    Otabe, S.2    Dina, C.3    Yasuda, K.4    Populaire, C.L.5    Lecoeur, C.C.6    Vatin, V.7    Durand, E.8    Hara, K.9    Okada, T.10
  • 24
    • 34547911845 scopus 로고    scopus 로고
    • Recent advances in the measurement of adiponectin isoform distribution
    • Magkos, F., Sidossis, L.S. Recent advances in the measurement of adiponectin isoform distribution. Curr. Opin. Clin. Nutr. Metab. Care 2007, 10, 571-575.
    • (2007) Curr. Opin. Clin. Nutr. Metab. Care , vol.10 , pp. 571-575
    • Magkos, F.1    Sidossis, L.S.2
  • 25
    • 11144355637 scopus 로고    scopus 로고
    • Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity
    • Pajvani, U.B., Hawkins, M., Combs, T.P., Rajala, M.W., Doebber, T., Berger, J.P., Wagner, J.A., Wu, M., Knopps, A., Xiang, A.H. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J. Biol. Chem. 2004, 279, 12152-12162.
    • (2004) J. Biol. Chem , vol.279 , pp. 12152-12162
    • Pajvani, U.B.1    Hawkins, M.2    Combs, T.P.3    Rajala, M.W.4    Doebber, T.5    Berger, J.P.6    Wagner, J.A.7    Wu, M.8    Knopps, A.9    Xiang, A.H.10
  • 26
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis, J., Tsao, T.-S., Javorschi, S., Ebbets-Reed, D., Erickson, M.R.S., Yen, F.T., Bihain, B.E., Lodish, H.F. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. USA 2001, 98, 2005-2010.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.-S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.S.5    Yen, F.T.6    Bihain, B.E.7    Lodish, H.F.8
  • 27
    • 34248197560 scopus 로고    scopus 로고
    • Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention
    • Wang, Z.V., Schraw, T.D., Kim, J.-Y., Khan, T., Rajala, M.W., Follenzi, A., Scherer, P.E. Secretion of the adipocyte-specific secretory protein adiponectin critically depends on thiol-mediated protein retention. Mol. Cell. Biol. 2007, 27, 3716-3731.
    • (2007) Mol. Cell. Biol , vol.27 , pp. 3716-3731
    • Wang, Z.V.1    Schraw, T.D.2    Kim, J.-Y.3    Khan, T.4    Rajala, M.W.5    Follenzi, A.6    Scherer, P.E.7
  • 28
    • 34347338702 scopus 로고    scopus 로고
    • Adiponectin secretion is regulated by sirt1 and the endoplasmic reticulum oxidoreductase ero1-lα
    • Qiang, L., Wang, H., Farmer, S.R. Adiponectin secretion is regulated by sirt1 and the endoplasmic reticulum oxidoreductase ero1-lα. Mol. Cell. Biol. 2007, 27, 4698-4707.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4698-4707
    • Qiang, L.1    Wang, H.2    Farmer, S.R.3
  • 30
    • 70350018290 scopus 로고    scopus 로고
    • Succination of thiol groups in adipose tissue proteins in diabetes succination inhibits polymerization and secretion of adiponectin
    • Frizzell, N., Rajesh, M., Jepson, M.J., Nagai, R., Carson, J.A., Thorpe, S.R., Baynes, J.W. Succination of thiol groups in adipose tissue proteins in diabetes succination inhibits polymerization and secretion of adiponectin. J. Biol. Chem. 2009, 284, 25772-25781.
    • (2009) J. Biol. Chem , vol.284 , pp. 25772-25781
    • Frizzell, N.1    Rajesh, M.2    Jepson, M.J.3    Nagai, R.4    Carson, J.A.5    Thorpe, S.R.6    Baynes, J.W.7
  • 32
    • 3142761477 scopus 로고    scopus 로고
    • T-cadherin is a receptor for hexameric and high-molecular-weight forms of acrp30/adiponectin
    • Hug, C., Wang, J., Ahmad, N.S., Bogan, J.S., Tsao, T.-S., Lodish, H.F. T-cadherin is a receptor for hexameric and high-molecular-weight forms of acrp30/adiponectin. Proc. Natl. Acad. Sci. USA 2004, 101, 10308-10313.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10308-10313
    • Hug, C.1    Wang, J.2    Ahmad, N.S.3    Bogan, J.S.4    Tsao, T.-S.5    Lodish, H.F.6
  • 33
    • 40449133794 scopus 로고    scopus 로고
    • T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model
    • Hebbard, L.W., Garlatti, M.L., Young, L.J.T., Cardiff, R.D., Oshima, R.G., Ranscht, B. T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. Cancer Res. 2008, 68, 1407-1416.
    • (2008) Cancer Res , vol.68 , pp. 1407-1416
    • Hebbard, L.W.1    Garlatti, M.L.2    Young, L.J.T.3    Cardiff, R.D.4    Oshima, R.G.5    Ranscht, B.6
  • 38
    • 3543025954 scopus 로고    scopus 로고
    • The BAR-domain family of proteins: A case of bending and binding?
    • Habermann, B. The BAR-domain family of proteins: A case of bending and binding? EMBO Rep. 2004, 5, 250-255.
    • (2004) EMBO Rep , vol.5 , pp. 250-255
    • Habermann, B.1
  • 39
    • 1342331452 scopus 로고    scopus 로고
    • Bar domains go on a bender
    • Lee, M.C.S., Schekman, R. Bar domains go on a bender. Science 2004, 303, 479-480.
    • (2004) Science , vol.303 , pp. 479-480
    • Lee, M.C.S.1    Schekman, R.2
  • 40
    • 33645129695 scopus 로고    scopus 로고
    • The bar domain proteins: Molding membranes in fission, fusion, and phagy
    • Ren, G., Vajjhala, P., Lee, J.S., Winsor, B., Munn, A.L. The bar domain proteins: Molding membranes in fission, fusion, and phagy. Microbiol. Mol. Biol. Rev. 2006, 70, 37-120.
    • (2006) Microbiol. Mol. Biol. Rev , vol.70 , pp. 37-120
    • Ren, G.1    Vajjhala, P.2    Lee, J.S.3    Winsor, B.4    Munn, A.L.5
  • 41
    • 33748964289 scopus 로고    scopus 로고
    • Bar domain proteins: A role in tubulation, scission and actin assembly in clathrin-mediated endocytosis
    • Dawson, J.C., Legg, J.A., Machesky, L.M. Bar domain proteins: A role in tubulation, scission and actin assembly in clathrin-mediated endocytosis. Trends Cell Biol. 2006, 16, 493-498.
    • (2006) Trends Cell Biol , vol.16 , pp. 493-498
    • Dawson, J.C.1    Legg, J.A.2    Machesky, L.M.3
  • 44
    • 33751239461 scopus 로고    scopus 로고
    • Appl1, appl2, akt2 and foxo1a interact with fshr in a potential signaling complex
    • Nechamen, C.A., Thomas, R.M., Dias, J.A. Appl1, appl2, akt2 and foxo1a interact with fshr in a potential signaling complex. Mol. Cell. Endocrinol. 2007, 260, 93-99.
    • (2007) Mol. Cell. Endocrinol , vol.260 , pp. 93-99
    • Nechamen, C.A.1    Thomas, R.M.2    Dias, J.A.3
  • 45
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein acrp30 enhances hepatic insulin action
    • Berg, A.H., Combs, T.P., Du, X., Brownlee, M., Scherer, P.E. The adipocyte-secreted protein acrp30 enhances hepatic insulin action. Nat. Med. 2001, 7, 947-953.
    • (2001) Nat. Med , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 46
    • 80053370831 scopus 로고    scopus 로고
    • Appl1 mediates adiponectin-induced lkb1 cytosolic localization through the PP2A-PKCzeta signaling pathway
    • Deepa, S.S., Zhou, L., Ryu, J., Wang, C., Mao, X., Li, C., Zhang, N., Musi, N., DeFronzo, R.A., Liu, F. Appl1 mediates adiponectin-induced lkb1 cytosolic localization through the PP2A-PKCzeta signaling pathway. Mol. Endocrinol. 2011, 25, 1773-1785.
    • (2011) Mol. Endocrinol , vol.25 , pp. 1773-1785
    • Deepa, S.S.1    Zhou, L.2    Ryu, J.3    Wang, C.4    Mao, X.5    Li, C.6    Zhang, N.7    Musi, N.8    Defronzo, R.A.9    Liu, F.10
  • 47
    • 84940587459 scopus 로고    scopus 로고
    • Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses
    • Zhao, L., Fu, Z., Wu, J., Aylor, K.W., Barrett, E.J., Cao, W., Liu, Z. Globular adiponectin ameliorates metabolic insulin resistance via AMPK-mediated restoration of microvascular insulin responses. J. Physiol. 2015, 593, 4067-4079.
    • (2015) J. Physiol , vol.593 , pp. 4067-4079
    • Zhao, L.1    Fu, Z.2    Wu, J.3    Aylor, K.W.4    Barrett, E.J.5    Cao, W.6    Liu, Z.7
  • 48
    • 78650795768 scopus 로고    scopus 로고
    • Appl1 mediates adiponectin-stimulated p38 mapk activation by scaffolding the tak1-mkk3-p38 mapk pathway
    • Xin, X., Zhou, L., Reyes, C.M., Liu, F., Dong, L.Q. Appl1 mediates adiponectin-stimulated p38 mapk activation by scaffolding the tak1-mkk3-p38 mapk pathway. Am. J. Physiol. Endocrinol. Metab. 2011, 300, E103-E110.
    • (2011) Am. J. Physiol. Endocrinol. Metab , vol.300 , pp. E103-E110
    • Xin, X.1    Zhou, L.2    Reyes, C.M.3    Liu, F.4    Dong, L.Q.5
  • 49
    • 34248147538 scopus 로고    scopus 로고
    • Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by appl1 in endothelial cells
    • Cheng, K.K.Y., Lam, K.S.L., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C., Xu, A. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by appl1 in endothelial cells. Diabetes 2007, 56, 1387-1394.
    • (2007) Diabetes , vol.56 , pp. 1387-1394
    • Cheng, K.K.Y.1    Lam, K.S.L.2    Wang, Y.3    Huang, Y.4    Carling, D.5    Wu, D.6    Wong, C.7    Xu, A.8
  • 51
    • 0345167800 scopus 로고    scopus 로고
    • Tsc2 mediates cellular energy response to control cell growth and survival
    • Inoki, K., Zhu, T., Guan, K.-L. Tsc2 mediates cellular energy response to control cell growth and survival. Cell 2003, 115, 577-590.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 52
    • 0036713778 scopus 로고    scopus 로고
    • Tsc2 is phosphorylated and inhibited by akt and suppresses mtor signalling. Nat
    • Inoki, K., Li, Y., Zhu, T., Wu, J., Guan, K.-L. Tsc2 is phosphorylated and inhibited by akt and suppresses mtor signalling. Nat. Cell Biol. 2002, 4, 648-657.
    • (2002) Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 55
    • 0034074153 scopus 로고    scopus 로고
    • 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes pepck and glucose-6-phosphatase
    • Lochhead, P.A., Salt, I.P., Walker, K.S., Hardie, D.G., Sutherland, C. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes pepck and glucose-6-phosphatase. Diabetes 2000, 49, 896-903.
    • (2000) Diabetes , vol.49 , pp. 896-903
    • Lochhead, P.A.1    Salt, I.P.2    Walker, K.S.3    Hardie, D.G.4    Sutherland, C.5
  • 56
    • 22744449914 scopus 로고    scopus 로고
    • Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc
    • Liao, Y., Takashima, S., Maeda, N., Ouchi, N., Komamura, K., Shimomura, I., Hori, M., Matsuzawa, Y., Funahashi, T., Kitakaze, M. Exacerbation of heart failure in adiponectin-deficient mice due to impaired regulation of AMPK and glucose metabolism. Cardiovasc. Res. 2005, 67, 705-713.
    • (2005) Res , vol.67 , pp. 705-713
    • Liao, Y.1    Takashima, S.2    Maeda, N.3    Ouchi, N.4    Komamura, K.5    Shimomura, I.6    Hori, M.7    Matsuzawa, Y.8    Funahashi, T.9    Kitakaze, M.10
  • 57
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats
    • Ye, J.-M., Doyle, P.J., Iglesias, M.A., Watson, D.G., Cooney, G.J., Kraegen, E.W. Peroxisome proliferator-activated receptor (PPAR)-α activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats. Diabetes 2001, 50, 411-417.
    • (2001) Diabetes , vol.50 , pp. 411-417
    • Ye, J.-M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 58
  • 59
    • 12944302597 scopus 로고    scopus 로고
    • Globular adiponectin increases glut4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells
    • Ceddia, R.B., Somwar, R., Maida, A., Fang, X., Bikopoulos, G., Sweeney, G. Globular adiponectin increases glut4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 2005, 48, 132-139.
    • (2005) Diabetologia , vol.48 , pp. 132-139
    • Ceddia, R.B.1    Somwar, R.2    Maida, A.3    Fang, X.4    Bikopoulos, G.5    Sweeney, G.6
  • 61
    • 31644443192 scopus 로고    scopus 로고
    • Ceramides in insulin resistance and lipotoxicity
    • Summers, S.A. Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 2006, 45, 42-72.
    • (2006) Prog. Lipid Res , vol.45 , pp. 42-72
    • Summers, S.A.1
  • 62
    • 0033965158 scopus 로고    scopus 로고
    • The p38 signal transduction pathway activation and function
    • Ono, K., Han, J. The p38 signal transduction pathway activation and function. Cell. Signal. 2000, 12, 1-13.
    • (2000) Cell. Signal , vol.12 , pp. 1-13
    • Ono, K.1    Han, J.2
  • 63
    • 33750578279 scopus 로고    scopus 로고
    • Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of amp-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor α
    • Yoon, M.J., Lee, G.Y., Chung, J.-J., Ahn, Y.H., Hong, S.H., Kim, J.B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of amp-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor α. Diabetes 2006, 55, 2562-2570.
    • (2006) Diabetes , vol.55 , pp. 2562-2570
    • Yoon, M.J.1    Lee, G.Y.2    Chung, J.-J.3    Ahn, Y.H.4    Hong, S.H.5    Kim, J.B.6
  • 64
    • 17744363472 scopus 로고    scopus 로고
    • Adenosine 50-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes
    • Pelletier, A.L., Joly, E.R., Prentki, M., Coderre, L. Adenosine 50-monophosphate-activated protein kinase and p38 mitogen-activated protein kinase participate in the stimulation of glucose uptake by dinitrophenol in adult cardiomyocytes. Endocrinology 2005, 146, 2285-2294.
    • (2005) Endocrinology , vol.146 , pp. 2285-2294
    • Pelletier, A.L.1    Joly, E.R.2    Prentki, M.3    Coderre, L.4
  • 65
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-an inflammatory disease
    • Ross, R. Atherosclerosis-an inflammatory disease. N. Engl. J. Med. 1999, 340, 115-126.
    • (1999) N. Engl. J. Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 68
    • 24644447505 scopus 로고    scopus 로고
    • Adiponectin: Protection of the endothelium
    • Lam, K.S.L., Xu, A. Adiponectin: Protection of the endothelium. Curr. Diabetes Rep. 2005, 5, 254-259.
    • (2005) Curr. Diabetes Rep , vol.5 , pp. 254-259
    • Lam, K.S.L.1    Xu, A.2
  • 69
    • 3142616447 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling
    • Shibata, R., Ouchi, N., Kihara, S., Sato, K., Funahashi, T., Walsh, K. Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling. J. Biol. Chem. 2004, 279, 28670-28674.
    • (2004) J. Biol. Chem , vol.279 , pp. 28670-28674
    • Shibata, R.1    Ouchi, N.2    Kihara, S.3    Sato, K.4    Funahashi, T.5    Walsh, K.6
  • 72
    • 41149113524 scopus 로고    scopus 로고
    • Adiponectin inhibits the production of cxc receptor 3 chemokine ligands in macrophages and reduces t-lymphocyte recruitment in atherogenesis
    • Okamoto, Y., Folco, E.J., Minami, M., Wara, A.K., Feinberg, M.W., Sukhova, G.K., Colvin, R.A., Kihara, S., Funahashi, T., Luster, A.D. Adiponectin inhibits the production of cxc receptor 3 chemokine ligands in macrophages and reduces t-lymphocyte recruitment in atherogenesis. Circ. Res. 2008, 102, 218-225.
    • (2008) Circ. Res , vol.102 , pp. 218-225
    • Okamoto, Y.1    Folco, E.J.2    Minami, M.3    Wara, A.K.4    Feinberg, M.W.5    Sukhova, G.K.6    Colvin, R.A.7    Kihara, S.8    Funahashi, T.9    Luster, A.D.10
  • 74
    • 0346463030 scopus 로고    scopus 로고
    • Adiponectin stimulates angiogenesis by promoting cross-talk between amp-activated protein kinase and akt signaling in endothelial cells
    • Ouchi, N., Kobayashi, H., Kihara, S., Kumada, M., Sato, K., Inoue, T., Funahashi, T., Walsh, K. Adiponectin stimulates angiogenesis by promoting cross-talk between amp-activated protein kinase and akt signaling in endothelial cells. J. Biol. Chem. 2004, 279, 1304-1309.
    • (2004) J. Biol. Chem , vol.279 , pp. 1304-1309
    • Ouchi, N.1    Kobayashi, H.2    Kihara, S.3    Kumada, M.4    Sato, K.5    Inoue, T.6    Funahashi, T.7    Walsh, K.8
  • 75
    • 2942720979 scopus 로고    scopus 로고
    • Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin
    • Kobayashi, H., Ouchi, N., Kihara, S., Walsh, K., Kumada, M., Abe, Y., Funahashi, T., Matsuzawa, Y. Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin. Circ. Res. 2004, 94, e27-e31.
    • (2004) Circ. Res , vol.94 , pp. e27-e31
    • Kobayashi, H.1    Ouchi, N.2    Kihara, S.3    Walsh, K.4    Kumada, M.5    Abe, Y.6    Funahashi, T.7    Matsuzawa, Y.8
  • 79
    • 40949149409 scopus 로고    scopus 로고
    • Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes
    • Ikeda, Y., Ohashi, K., Shibata, R., Pimentel, D.R., Kihara, S., Ouchi, N., Walsh, K. Cyclooxygenase-2 induction by adiponectin is regulated by a sphingosine kinase-1 dependent mechanism in cardiac myocytes. FEBS Lett. 2008, 582, 1147-1150.
    • (2008) FEBS Lett , vol.582 , pp. 1147-1150
    • Ikeda, Y.1    Ohashi, K.2    Shibata, R.3    Pimentel, D.R.4    Kihara, S.5    Ouchi, N.6    Walsh, K.7
  • 86
    • 84870452496 scopus 로고    scopus 로고
    • Adiponectin: Key player in the adipose tissue-liver crosstalk
    • Moschen, A.R., Wieser, V., Tilg, H. Adiponectin: Key player in the adipose tissue-liver crosstalk. Curr. Med. Chem. 2012, 19, 5467-5473.
    • (2012) Curr. Med. Chem , vol.19 , pp. 5467-5473
    • Moschen, A.R.1    Wieser, V.2    Tilg, H.3
  • 88
    • 57049107346 scopus 로고    scopus 로고
    • Endocrine functions of adipose tissue: Focus on adiponectin
    • Sowers, J.R. Endocrine functions of adipose tissue: Focus on adiponectin. Clin. Cornerstone 2008, 9, 32-40.
    • (2008) Clin. Cornerstone , vol.9 , pp. 32-40
    • Sowers, J.R.1
  • 89
    • 24744457984 scopus 로고    scopus 로고
    • Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation
    • Fu, Y., Luo, N., Klein, R.L., Garvey, W.T. Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation. J. Lipid Res. 2005, 46, 1369-1379.
    • (2005) J. Lipid Res , vol.46 , pp. 1369-1379
    • Fu, Y.1    Luo, N.2    Klein, R.L.3    Garvey, W.T.4
  • 91
    • 9144263120 scopus 로고    scopus 로고
    • A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity
    • Combs, T.P., Pajvani, U.B., Berg, A.H., Lin, Y., Jelicks, L.A., Laplante, M., Nawrocki, A.R., Rajala, M.W., Parlow, A.F., Cheeseboro, L. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004, 145, 367-383.
    • (2004) Endocrinology , vol.145 , pp. 367-383
    • Combs, T.P.1    Pajvani, U.B.2    Berg, A.H.3    Lin, Y.4    Jelicks, L.A.5    Laplante, M.6    Nawrocki, A.R.7    Rajala, M.W.8    Parlow, A.F.9    Cheeseboro, L.10
  • 93
    • 0032797852 scopus 로고    scopus 로고
    • Regulation of glucose production by the liver
    • Nordlie, R.C., Foster, J.D., Lange, A.J. Regulation of glucose production by the liver. Ann. Rev. Nutr. 1999, 19, 379-406.
    • (1999) Ann. Rev. Nutr , vol.19 , pp. 379-406
    • Nordlie, R.C.1    Foster, J.D.2    Lange, A.J.3
  • 94
    • 0035663963 scopus 로고    scopus 로고
    • Endogenous glucose production is inhibited by the adipose-derived protein ACRP30
    • Combs, T.P., Berg, A.H., Obici, S., Scherer, P.E., Rossetti, L. Endogenous glucose production is inhibited by the adipose-derived protein ACRP30. J. Clin. Investig. 2001, 108, 1875-1881.
    • (2001) J. Clin. Investig , vol.108 , pp. 1875-1881
    • Combs, T.P.1    Berg, A.H.2    Obici, S.3    Scherer, P.E.4    Rossetti, L.5
  • 95
    • 0037984387 scopus 로고    scopus 로고
    • Structure-function studies of the adipocyte-secreted hormone acrp30/adiponectin implications for metabolic regulation and bioactivity
    • Pajvani, U.B., Du, X., Combs, T.P., Berg, A.H., Rajala, M.W., Schulthess, T., Engel, J.R., Brownlee, M., Scherer, P.E. Structure-function studies of the adipocyte-secreted hormone acrp30/adiponectin implications for metabolic regulation and bioactivity. J. Biol. Chem. 2003, 278, 9073-9085.
    • (2003) J. Biol. Chem. , vol.278 , pp. 9073-9085
    • Pajvani, U.B.1    Du, X.2    Combs, T.P.3    Berg, A.H.4    Rajala, M.W.5    Schulthess, T.6    Engel, J.R.7    Brownlee, M.8    Scherer, P.E.9
  • 96
    • 33646346627 scopus 로고    scopus 로고
    • Ice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor Î3 agonists
    • Nawrocki, A.R., Rajala, M.W., Tomas, E., Pajvani, U.B., Saha, A.K., Trumbauer, M.E., Pang, Z., Chen, A.S., Ruderman, N.B., Chen, H. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor Î3 agonists. J. Biol. Chem. 2006, 281, 2654-2660.
    • (2006) J. Biol. Chem , vol.281 , pp. 2654-2660
    • Nawrocki, A.R.1    Rajala, M.W.2    Tomas, E.3    Pajvani, U.B.4    Saha, A.K.5    Trumbauer, M.E.6    Pang, Z.7    Chen, A.S.8    Ruderman, N.B.9    Chen, H.10
  • 97
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • Xu, A., Wang, Y., Keshaw, H., Xu, L.Y., Lam, K.S.L., Cooper, G.J.S. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Investig. 2003, 112, 91-100.
    • (2003) J. Clin. Investig , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 99
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler, M.C., Hardie, D.G. AMP-activated protein kinase in metabolic control and insulin signaling. Circ. Res. 2007, 100, 328-341.
    • (2007) Circ. Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 100
    • 19444366098 scopus 로고    scopus 로고
    • Inverse correlation between serum adiponectin concentration and hepatic lipid content in japanese with type 2 diabetes
    • Maeda, K., Ishihara, K., Miyake, K., Kaji, Y., Kawamitsu, H., Fujii, M., Sugimura, K., Ohara, T. Inverse correlation between serum adiponectin concentration and hepatic lipid content in japanese with type 2 diabetes. Metabolism 2005, 54, 775-780.
    • (2005) Metabolism , vol.54 , pp. 775-780
    • Maeda, K.1    Ishihara, K.2    Miyake, K.3    Kaji, Y.4    Kawamitsu, H.5    Fujii, M.6    Sugimura, K.7    Ohara, T.8
  • 101
    • 14144249423 scopus 로고    scopus 로고
    • Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study
    • Vuppalanchi, R., Marri, S., Kolwankar, D., Considine, R.V., Chalasani, N. Is adiponectin involved in the pathogenesis of nonalcoholic steatohepatitis? A preliminary human study. J. Clin. Gastroenterol. 2005, 39, 237-242.
    • (2005) J. Clin. Gastroenterol , vol.39 , pp. 237-242
    • Vuppalanchi, R.1    Marri, S.2    Kolwankar, D.3    Considine, R.V.4    Chalasani, N.5
  • 104
    • 54449085766 scopus 로고    scopus 로고
    • Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury
    • Zhou, M., Xu, A., Tam, P.K.H., Lam, K.S.L., Chan, L., Hoo, R.L.C., Liu, J., Chow, K.H.M., Wang, Y. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology 2008, 48, 1087-1096.
    • (2008) Hepatology , vol.48 , pp. 1087-1096
    • Zhou, M.1    Xu, A.2    Tam, P.K.H.3    Lam, K.S.L.4    Chan, L.5    Hoo, R.L.C.6    Liu, J.7    Chow, K.H.M.8    Wang, Y.9
  • 105
    • 0035798713 scopus 로고    scopus 로고
    • The mechanisms by which both heterozygous peroxisome proliferator-activated receptor î3 (Pparî3) deficiency and pparî3 agonist improve insulin resistance
    • Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K. The mechanisms by which both heterozygous peroxisome proliferator-activated receptor î3 (pparî3) deficiency and pparî3 agonist improve insulin resistance. J. Biol. Chem. 2001, 276, 41245-41254.
    • (2001) J. Biol. Chem , vol.276 , pp. 41245-41254
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Murakami, K.4    Motojima, K.5    Komeda, K.6    Ide, T.7    Kubota, N.8    Terauchi, Y.9    Tobe, K.10
  • 106
  • 109
    • 59649117072 scopus 로고    scopus 로고
    • Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice
    • Xu, A., Wang, H., Hoo, R.L.C., Sweeney, G., Vanhoutte, P.M., Wang, Y., Wu, D., Chu, W., Qin, G., Lam, K.S.L. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology 2009, 150, 625-633.
    • (2009) Endocrinology , vol.150 , pp. 625-633
    • Xu, A.1    Wang, H.2    Hoo, R.L.C.3    Sweeney, G.4    Vanhoutte, P.M.5    Wang, Y.6    Wu, D.7    Chu, W.8    Qin, G.9    Lam, K.S.L.10
  • 110
    • 84898821021 scopus 로고    scopus 로고
    • Zataria multiflora increases insulin sensitivity and pparî3 gene expression in high fructose fed insulin resistant rats
    • Mohammadi, A., Gholamhoseinian, A., Fallah, H. Zataria multiflora increases insulin sensitivity and pparî3 gene expression in high fructose fed insulin resistant rats. Iran. J. Basic Med. Sci. 2014, 17, 263-270.
    • (2014) Iran. J. Basic Med. Sci , vol.17 , pp. 263-270
    • Mohammadi, A.1    Gholamhoseinian, A.2    Fallah, H.3
  • 112
    • 41149155892 scopus 로고    scopus 로고
    • Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance
    • Li, M., Kim, D.H., Tsenovoy, P.L., Peterson, S.J., Rezzani, R., Rodella, L.F., Aronow, W.S., Ikehara, S., Abraham, N.G. Treatment of obese diabetic mice with a heme oxygenase inducer reduces visceral and subcutaneous adiposity, increases adiponectin levels, and improves insulin sensitivity and glucose tolerance. Diabetes 2008, 57, 1526-1535.
    • (2008) Diabetes , vol.57 , pp. 1526-1535
    • Li, M.1    Kim, D.H.2    Tsenovoy, P.L.3    Peterson, S.J.4    Rezzani, R.5    Rodella, L.F.6    Aronow, W.S.7    Ikehara, S.8    Abraham, N.G.9
  • 113
    • 84958763341 scopus 로고    scopus 로고
    • L-cysteine supplementation increases adiponectin synthesis and secretion, and glut4 and glucose utilization by upregulating disulfide bond a-like protein expression mediated by mcp-1 inhibition in 3t3-l1 adipocytes exposed to high glucose
    • Achari, A.E., Jain, S.K. L-cysteine supplementation increases adiponectin synthesis and secretion, and glut4 and glucose utilization by upregulating disulfide bond a-like protein expression mediated by mcp-1 inhibition in 3t3-l1 adipocytes exposed to high glucose. Mol. Cell. Biochem. 2016, 414, 105-113.
    • (2016) Mol. Cell. Biochem , vol.414 , pp. 105-113
    • Achari, A.E.1    Jain, S.K.2
  • 114
    • 85009247551 scopus 로고    scopus 로고
    • Manganese supplementation increases adiponectin and lowers icam-1 and creatinine blood levels in zucker type 2 diabetic rats, and downregulates icam-1 by upregulating adiponectin multimerization protein (DSBA-l) in endothelial cells
    • Burlet, E., Jain, S.K. Manganese supplementation increases adiponectin and lowers icam-1 and creatinine blood levels in zucker type 2 diabetic rats, and downregulates icam-1 by upregulating adiponectin multimerization protein (DSBA-l) in endothelial cells. Mol. Cell. Biochem. 2017, 429, 1-10.
    • (2017) Mol. Cell. Biochem , vol.429 , pp. 1-10
    • Burlet, E.1    Jain, S.K.2
  • 116
    • 0038818552 scopus 로고    scopus 로고
    • Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension
    • Furuhashi, M., Ura, N., Higashiura, K., Murakami, H., Tanaka, M., Moniwa, N., Yoshida, D., Shimamoto, K. Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 2003, 42, 76-81.
    • (2003) Hypertension , vol.42 , pp. 76-81
    • Furuhashi, M.1    Ura, N.2    Higashiura, K.3    Murakami, H.4    Tanaka, M.5    Moniwa, N.6    Yoshida, D.7    Shimamoto, K.8
  • 118
    • 0242288690 scopus 로고    scopus 로고
    • Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross-sectional and interventional studies
    • Gavrila, A., Chan, J.L., Yiannakouris, N., Kontogianni, M., Miller, L.C., Orlova, C., Mantzoros, C.S. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: Cross-sectional and interventional studies. J. Clin. Endocrinol. Metab. 2003, 88, 4823-4831.
    • (2003) J. Clin. Endocrinol. Metab , vol.88 , pp. 4823-4831
    • Gavrila, A.1    Chan, J.L.2    Yiannakouris, N.3    Kontogianni, M.4    Miller, L.C.5    Orlova, C.6    Mantzoros, C.S.7
  • 120
    • 11344295032 scopus 로고    scopus 로고
    • Adiponectin is altered after maximal exercise in highly trained male rowers
    • Jürimäe, J., Purge, P., Jürimäe, T. Adiponectin is altered after maximal exercise in highly trained male rowers. Eur. J. Appl. Physiol. 2005, 93, 502-505.
    • (2005) Eur. J. Appl. Physiol , vol.93 , pp. 502-505
    • Jürimäe, J.1    Purge, P.2    Jürimäe, T.3
  • 122
    • 78751646291 scopus 로고    scopus 로고
    • Influence of acute aerobic exercise on adiponectin oligomer concentrations in middle-aged abdominally obese men
    • Numao, S., Katayama, Y., Hayashi, Y., Matsuo, T., Tanaka, K. Influence of acute aerobic exercise on adiponectin oligomer concentrations in middle-aged abdominally obese men. Metabolism 2011, 60, 186-194.
    • (2011) Metabolism , vol.60 , pp. 186-194
    • Numao, S.1    Katayama, Y.2    Hayashi, Y.3    Matsuo, T.4    Tanaka, K.5
  • 123
    • 79953236112 scopus 로고    scopus 로고
    • Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus
    • Hernandez, A.V., Usmani, A., Rajamanickam, A., Moheet, A. Thiazolidinediones and risk of heart failure in patients with or at high risk of type 2 diabetes mellitus. Am. J. Cardiovasc. Drugs 2011, 11, 115-128.
    • (2011) Am. J. Cardiovasc. Drugs , vol.11 , pp. 115-128
    • Hernandez, A.V.1    Usmani, A.2    Rajamanickam, A.3    Moheet, A.4
  • 124
    • 0033754530 scopus 로고    scopus 로고
    • Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: A 6-month randomized placebo-controlled dose-response study
    • Aronoff, S., Rosenblatt, S., Braithwaite, S., Egan, J.W., Mathisen, A.L., Schneider, R.L. Pioglitazone hydrochloride monotherapy improves glycemic control in the treatment of patients with type 2 diabetes: A 6-month randomized placebo-controlled dose-response study. The pioglitazone 001 study group. Diabetes Care 2000, 23, 1605-1611.
    • (2000) The Pioglitazone 001 Study Group. Diabetes Care , vol.23 , pp. 1605-1611
    • Aronoff, S.1    Rosenblatt, S.2    Braithwaite, S.3    Egan, J.W.4    Mathisen, A.L.5    Schneider, R.L.6
  • 126
    • 33847629923 scopus 로고    scopus 로고
    • Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—A meta-analysis
    • Vestergaard, P. Discrepancies in bone mineral density and fracture risk in patients with type 1 and type 2 diabetes—A meta-analysis. Osteoporos. Int. 2007, 18, 427-444.
    • (2007) Osteoporos. Int , vol.18 , pp. 427-444
    • Vestergaard, P.1
  • 128
    • 0346219295 scopus 로고    scopus 로고
    • Effect of thiazolidinediones on body weight in patients with diabetes mellitus
    • Fonseca, V. Effect of thiazolidinediones on body weight in patients with diabetes mellitus. Am. J. Med. 2003, 115, 42-48.
    • (2003) Am. J. Med , vol.115 , pp. 42-48
    • Fonseca, V.1
  • 129
    • 0021263352 scopus 로고
    • Macular EDEMA. A complication of diabetic retinopathy
    • Ferris, F.L., Patz, A. Macular EDEMA. A complication of diabetic retinopathy. Surv. Ophthalmol. 1984, 28, 452-461.
    • (1984) Surv. Ophthalmol , vol.28 , pp. 452-461
    • Ferris, F.L.1    Patz, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.