Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice

Gastroenterology

Volumn 152, Issue 1, 2017, Pages 176-192.e5

  Popp, Vanessa ^a   Gerlach, Katharina ^a   Mott, Stefanie ^a   Turowska, Agnieszka ^b   Garn, Holger ^c   Atreya, Raja ^a   Lehr, Hans Anton ^d   Ho, I Cheng ^e   Renz, Harald ^c   Weigmann, Benno ^a   Neurath, Markus F ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b sterna biologicals GmbH Co & KG ^*  (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d Institute of Pathology   (Germany)

^e BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

DNA Cleavage; Gene Regulation; Immune Response; Mouse Model

Indexed keywords

DEOXYRIBOZYME; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 9; MESSENGER RNA; OXAZOLONE; TRANSCRIPTION FACTOR GATA 3; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2; CYTOKINE; GATA3 PROTEIN, HUMAN; GATA3 PROTEIN, MOUSE; HGD40 DNAZYME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL SPECIFICITY; COLON; CONTROLLED STUDY; CROHN DISEASE; DRUG DISTRIBUTION; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE; IN VIVO STUDY; INFLAMMATORY BOWEL DISEASE; INTESTINE ENDOSCOPY; KNOCKOUT GENE; LAMINA PROPRIA; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; MOUSE; MOUSE MODEL; NONHUMAN; OXAZOLONE-INDUCED COLITIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPLENIC T CELL; TRINITROBENZENE SULFONIC ACID-INDUCED COLITIS; ULCERATIVE COLITIS; ADOLESCENT; ADULT; AGED; ANIMAL; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CHEMICALLY INDUCED; CHEMISTRY; CHILD; COLITIS; DISEASE MODEL; FEMALE; GENETICS; INTESTINE MUCOSA; KNOCKOUT MOUSE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; RECTAL DRUG ADMINISTRATION; T LYMPHOCYTE; YOUNG ADULT;

ADMINISTRATION, RECTAL; ADOLESCENT; ADULT; AGED; ANIMALS; CASE-CONTROL STUDIES; CHILD; COLITIS; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; CYTOKINES; DISEASE MODELS, ANIMAL; DNA, CATALYTIC; FEMALE; GATA3 TRANSCRIPTION FACTOR; HUMANS; INTESTINAL MUCOSA; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; OXAZOLONE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; RNA, MESSENGER; T-LYMPHOCYTES; TRINITROBENZENESULFONIC ACID; YOUNG ADULT;

EID: 85006321452     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2016.09.005     Document Type: Article

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