Enhanced Rate of Acquisition of Point Mutations in Mouse Intestinal Adenomas Compared to Normal Tissue

Cell Reports

Volumn 19, Issue 11, 2017, Pages 2185-2192

  Lugli, Natalia ^a   Dionellis, Vasilis S ^a,b   Ordóñez Morán, Paloma ^c   Kamileri, Irene ^a   Sotiriou, Sotirios K ^a   Huelsken, Joerg ^c   Halazonetis, Thanos D ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^c EPFL   (Switzerland)

Author keywords

adenomas; APC; mutational signatures; organoids; precancerous lesions

Indexed keywords

HISTONE H2AX; HISTONE H2AX GAMMA; UNCLASSIFIED DRUG;

ADENOMA; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL AGING; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA SEQUENCE; GENE FREQUENCY; GENETIC VARIABILITY; GENOMIC INSTABILITY; HETEROZYGOSITY LOSS; HIGH THROUGHPUT SEQUENCING; HOMOZYGOSITY; IN VITRO STUDY; IN VIVO STUDY; INTESTINAL ADENOMA; INTESTINE TUMOR; MALE; MOUSE; MUTATION RATE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE SUBSTITUTION; SINGLE NUCLEOTIDE VARIANT; WHOLE EXOME SEQUENCING; ANIMAL; C57BL MOUSE; GENETICS; INTESTINE; METABOLISM;

ADENOMA; ANIMALS; INTESTINES; MALE; MICE; MICE, INBRED C57BL; POINT MUTATION;

EID: 85020754993     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2017.05.051     Document Type: Article

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