The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists

Biochemical Journal

Volumn 474, Issue 12, 2017, Pages 2027-2038

  Vollmer, Stefan ^a   Strickson, Sam ^a   Zhang, Tinghu ^b   Gray, Nathanael ^b   Lee, Katherine L ^c   Rao, Vikram R ^d   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b HARVARD UNIVERSITY   (United States)

^c Pfizer Worldwide Research   (United States)

^d Inflammation and Immunology Research Unit   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN P105; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR AGONIST; IL1B PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 1BETA; IRAK1 PROTEIN, HUMAN; IRAK4 PROTEIN, HUMAN; LIPOPEPTIDE; MYD88 PROTEIN, HUMAN; NUCLEAR PROTEIN; PAM(3)CSK(4) PEPTIDE; PELI1 PROTEIN, HUMAN; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1CC PROTEIN, HUMAN; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR; UBIQUITIN PROTEIN LIGASE;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CELL DIFFERENTIATION; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; HEK293 CELL LINE; HUMAN; HUMAN CELL; INTRINSIC ACTIVITY; MACROPHAGE; MONOCYTE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; AGONISTS; AMINO ACID SUBSTITUTION; CELL CULTURE; CELL LINE; CHEMISTRY; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENETICS; IMMUNOLOGY; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN PROCESSING;

AMINO ACID SUBSTITUTION; CELL LINE; CELLS, CULTURED; DIMERIZATION; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-1BETA; LIPOPEPTIDES; MACROPHAGES; MONOCYTES; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; TOLL-LIKE RECEPTORS; UBIQUITIN-PROTEIN LIGASES;

EID: 85020725081     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20170097     Document Type: Article

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