Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner

Journal of Biological Chemistry

Volumn 289, Issue 15, 2014, Pages 10865-10875

  Cushing, Leah ^a   Stochaj, Wayne ^a   Siegel, Marshall ^b   Czerwinski, Robert ^a   Dower, Ken ^a   Wright, Quentin ^a   Hirschfield, Margaret ^a   Casanova, Jean Laurent ^c,d,e,f,h   Picard, Capucine ^f,g,h   Puel, Anne ^c,f,h   Lin, Lih Ling ^a   Rao, Vikram R ^a  

^a PFIZER INC   (United States)

^b Pfizer Chemical Technologies Section   (United States)

^c St Giles Laboratory of Human Genetics of Infectious Diseases   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

^e Pediatric Hematology Immunology Unit   (France)

^f IMAGINE INSTITUTE   (France)

^g HÔPITAL NECKER ENFANTS MALADES   (France)

^h UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE;

AUTOPHOSPHORYLATION; CYTOKINES; DERMAL FIBROBLASTS; HUMAN CELLS; HUMAN MONOCYTES; INTERLEUKIN-1;

ENZYMES;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; SERINE 346; STRESS ACTIVATED PROTEIN KINASE 1; SYNAPTOPHYSIN; THREONINE; THREONINE 342; THREONINE 345; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FIBROBLAST; HUMAN; HUMAN CELL; MONOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

INNATE IMMUNITY; INTERLEUKIN 1 (IL-1); INTERLEUKIN RECEPTOR-ASSOCIATED KINASE (IRAK); INTERLEUKIN RECEPTOR-ASSOCIATED KINASE 4 (IRAK4); PROTEIN KINASES; PROTEIN PHOSPHORYLATION; TOLL-LIKE RECEPTORS (TLR);

AMINO ACID SEQUENCE; ANIMALS; CELL-FREE SYSTEM; CLONING, MOLECULAR; CYTOKINES; ENZYME INHIBITORS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INSECTS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MOLECULAR SEQUENCE DATA; MONOCYTES; MUTATION; NF-KAPPA B; OPEN READING FRAMES; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; SKIN; TOLL-LIKE RECEPTORS;

EID: 84898655870     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.544809     Document Type: Article

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