Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 339-346

  Goh, Eddy T H ^a   Arthur, J Simon C ^a   Cheung, Peter C F ^b   Akira, Shizuo ^c   Toth, Rachel ^a   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Inhibitor of nuclear factor B kinase (IKK); Interleukin 1 receptor associated kinase (IRAK); TANK TRAF (tumour Necrosis factor receptor associated factor) associated nuclear factor B activator binding kinase 1 (TBK1); Toll like receptor (TLR); Tumour necrosis factor (TNF )

Indexed keywords

BETA INTERFERON; I KAPPA B KINASE INHIBITOR; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE; MYELOID DIFFERENTIATION FACTOR 88; PELLINO 1 PROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ANIMALS; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIGANDS; MACROPHAGES; MICE; MYELOID DIFFERENTIATION FACTOR 88; NUCLEAR PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84055219427     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20111415     Document Type: Article

References (22)

1. Grosshans, J., Schnorrer, F. and Nusslein-Volhard, C. (1999) Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal. Mech. Dev. 81, 127-138 (Pubitemid 29183051)
2. Strelow, A., Kollewe, C. and Wesche, H. (2003) Characterization of Pellino2, a substrate of IRAK1 and IRAK4. FEBS Lett. 547, 157-161 (Pubitemid 36829397)
3. Schauvliege, R., Janssens, S. and Beyaert, R. (2006) Pellino proteins are more than scaffold proteins in TLP/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases. FEBS Lett. 580, 4697-4702 (Pubitemid 44189391)
4. Butler, M. P., Hanly, J. A. and Moynagh, P. N. (2007) Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. J. Biol. Chem. 282, 29729-29737 (Pubitemid 350035285)
5. Ordureau, A., Smith, H., Windheim, M., Peggie, M., Carrick, E., Morrice, N. and Cohen, P. (2008) The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem. J. 409, 43-52
6. Smith, H., Peggie, M., Campbell, D. G., Vandermoere, F., Carrick, E. and Cohen, P. (2009) Identification of the phosphorylation sites on the E3 ubiquitin ligase Pellino that are critical for activation by IRAK1 and IRAK4. Proc. Natl. Acad. Sci. U.S.A. 106, 4584-4590
7. Smith, H., Liu, X. Y., Dai, L., Goh, E. T., Chan, A. T., Xi, J., Seh, C. C., Qureshi, I. A., Lescar, J., Ruedl, C. et al. (2011) The role of TBK1 and IKKε in the expression and activation of Pellino 1. Biochem. J. 434, 537-548
8. Ninomiya-Tsuji, J., Kajino, T., Ono, K., Ohtomo, T., Matsumoto, M., Shiina, M., Mihara, M., Tsuchiya, M. and Matsumoto, K. (2003) A resorcylic acid lactone, 5Z-7-oxozeaenol, prevents inflammation by inhibiting the catalytic activity of TAK1 MAPK kinase kinase. J. Biol. Chem. 278, 18485-18490 (Pubitemid 36799472)
9. Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R., Madwed, J. B., Hough, J., McIver, E. G. and Cohen, P. (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem. J. 434, 93-104
10. Zhang, T., Inesta-Vaquera, F., Niepal, M., Zhang, J., Ficaro, S., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T. et al. (2011) Discovery of potent and selective covalent inhibitors of JNK. Chem. Biol., in the press
11. Handoyo, H., Stafford, M. J., McManus, E., Baltzis, D., Peggie, M. and Cohen, P. (2009) IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2. Biochem. J. 424, 109-118
12. Wiggin, G. R., Soloaga, A., Foster, J. M., Murray-Tait, V., Cohen, P. and Arthur, J. S. (2002) MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts. Mol. Cell. Biol. 22, 2871-2881 (Pubitemid 34263007)
13. Sato, S., Sanjo, H., Takeda, K., Ninomiya-Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O. and Akira, S. (2005) Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat. Immunol. 6, 1087-1095 (Pubitemid 41541786)
14. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K. and Akira, S. (2004) The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J. Exp. Med. 199, 1641-1650
15. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
16. Li, X., Commane, M., Burns, C., Vithalani, K., Cao, Z. and Stark, G. R. (1999) Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase. Mol. Cell. Biol. 19, 4643-4652 (Pubitemid 29289502)
17. Lin, C.-C., Huoh, Y.-S., Schmitz, K. R., Jensen, L. E. and Ferguson, K. (2008) Pellino proteins contain a cryptic FHA domain that mediates interaction with phosphorylated IRAK1. Cell Struct. 16, 1806-1816
18. Durocher, D., Taylor, I. A., Sarbassova, D., Haire, L. F., Westcott, S. L., Jackson, S. P., Smerdon, S. J. and Yaffe, M. B. (2000) The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6, 1169-1182
19. Clark, K., Plater, L., Peggie, M. and Cohen, P. (2009) Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation. J. Biol. Chem. 284, 14136-14146
20. Haghayeghi, A., Sarac, A., Czerniecki, S., Grosshans, J. and Schock, F. (2010) Pellino enhances innate immunity in Drosophila . Mech. Dev. 127, 301-307
21. Clark, K., Takeuchi, O., Akira, S. and Cohen, P. (2011) TANK couples the canonical IKKs and the IKK-related kinases in TLR signaling. Proc. Natl. Acad. Sci. U.S.A., 10.1073/pnas.1114194108
22. Kawagoe, T., Takeuchi, O., Takabatake, Y., Kato, H., Isaka, Y., Tsujimura, T. and Akira, S. (2009) TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis. Nat. Immunol. 10, 965-972