Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Science Translational Medicine

Volumn 9, Issue 392, 2017, Pages

  Jensen, Dane D ^a   Lieu, Tina Marie ^a   Halls, Michelle L ^a   Veldhuis, Nicholas A ^a   Imlach, Wendy L ^b   Mai, Quynh N ^a   Poole, Daniel P ^a   Quach, Tim ^a   Aurelio, Luigi ^a   Conner, Joshua ^a   Herenbrink, Carmen Klein ^a   Barlow, Nicholas ^a   Simpson, Jamie S ^a   Scanlon, Martin J ^a   Graham, Bimbil ^a   McCluskey, Adam ^c   Robinson, Phillip J ^b   Escriou, Virginie ^d   Nassini, Romina ^e   Materazzi, Serena ^e   Geppetti, Pierangelo ^e   Hicks, Gareth A ^f   Christie, MacDonald J ^b   Porter, Christopher J H ^a   Canals, Meritxell ^a   Bunnett, Nigel W ^a,g,h   more..

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF NEWCASTLE   (Australia)

^d Centre National de la Recherche Scientifique   (France)

^e UNIVERSITY OF FLORENCE   (Italy)

^f TAKEDA PHARMACEUTICALS   (United States)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; BETA ARRESTIN; CHOLESTANOL; CLATHRIN; DYNAMIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PROTEIN KINASE C; GUANINE NUCLEOTIDE BINDING PROTEIN; LIPID; PROTEIN BINDING; SUBSTANCE P;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG TARGETING; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVATION; GENE DISRUPTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NERVE CELL EXCITABILITY; NOCICEPTION; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL CORD NERVE CELL; SPINAL CORD SLICE; TRANSCRIPTION REGULATION; ANIMAL; BIOLOGICAL MODEL; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CHEMISTRY; DRUG EFFECTS; METABOLISM; MOLECULARLY TARGETED THERAPY; NERVE CELL; PATHOLOGY; SPINAL CORD;

ANIMALS; BETA-ARRESTINS; CELL COMPARTMENTATION; CLATHRIN; DYNAMINS; ENDOCYTOSIS; ENDOSOMES; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; LIPIDS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NEUROKININ-1 RECEPTOR ANTAGONISTS; NEURONS; NOCICEPTION; PAIN; PROTEIN BINDING; RATS; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; SPINAL CORD; SUBCELLULAR FRACTIONS; SUBSTANCE P;

EID: 85020248318     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aal3447     Document Type: Article

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