A positive allosteric modulator of the adenosine A1 receptor selectively inhibits primary afferent synaptic transmission in a neuropathic pain model

Molecular Pharmacology

Volumn 88, Issue 3, 2015, Pages 460-468

  Imlach, Wendy L ^a   Bhola, Rebecca F ^a   May, Lauren T ^b   Christopoulos, Arthur ^b   Christie, Macdonald J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A1 RECEPTOR ANTAGONIST; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID RECEPTOR; UNCLASSIFIED DRUG; [2 AMINO 4 [3 (TRIFLUOROMETHYL)PHENYL]THIOPHEN 3 YL](PHENYL) METHANONE; (2-AMINO-5-METHYL-4-(3-(TRIFLUOROMETHYL)PHENYL)THIOPHEN-3-YL)(PHENYL)METHANONE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; THIOPHENE DERIVATIVE; XANTHINE DERIVATIVE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GABAERGIC TRANSMISSION; MALE; NERVE INJURY; NEUROPATHIC PAIN; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SPINAL CORD DORSAL HORN; SYNAPSE; SYNAPTIC POTENTIAL; SYNAPTIC TRANSMISSION; ALLOSTERISM; ANIMAL; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; HYPERALGESIA; METABOLISM; NEURALGIA; PHYSIOLOGY; SENSORY NERVE CELL; SPRAGUE DAWLEY RAT;

ADENOSINE A1 RECEPTOR AGONISTS; ALLOSTERIC REGULATION; ANIMALS; EXCITATORY POSTSYNAPTIC POTENTIALS; HYPERALGESIA; MALE; NEURALGIA; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ADENOSINE A1; THIOPHENES; XANTHINES;

EID: 84939802048     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.099499     Document Type: Article

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