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Volumn 106, Issue , 2017, Pages 533-546

A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 2): In vitro biological assessment and comparison with different tobacco-heating products

Author keywords

Hybrid tobacco product; In vitro; Tobacco heating products; Toxicology

Indexed keywords

2 BUTANONE; ACETALDEHYDE; ACETONE; ACROLEIN; BUTYRALDEHYDE; CARBONYL DERIVATIVE; CIGARETTE SMOKE; CROTONALDEHYDE; FORMALDEHYDE; NICOTINE; PROPIONALDEHYDE; AEROSOL; FLAVORING AGENT; PARTICULATE MATTER;

EID: 85020190223     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2017.05.023     Document Type: Article
Times cited : (34)

References (68)
  • 1
    • 80052031025 scopus 로고    scopus 로고
    • Assessment of an in vitro whole cigarette smoke exposure system: the Borgwaldt RM20S 8-syringe smoking machine
    • Adamson, J., Azzopardi, D., Errington, G., Dickens, C., McAughey, J., Gaҫa, M.D., Assessment of an in vitro whole cigarette smoke exposure system: the Borgwaldt RM20S 8-syringe smoking machine. Chem. Cent. J., 5, 2011, 50.
    • (2011) Chem. Cent. J. , vol.5 , pp. 50
    • Adamson, J.1    Azzopardi, D.2    Errington, G.3    Dickens, C.4    McAughey, J.5    Gaҫa, M.D.6
  • 4
    • 85002514484 scopus 로고    scopus 로고
    • Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems
    • Adamson, J., Thorne, D., Zainuddin, B., Baxter, A., McAughey, J., Gaça, M., Application of dosimetry tools for the assessment of e-cigarette aerosol and cigarette smoke generated on two different in vitro exposure systems. Chem. Cent., 10, 2016, 74.
    • (2016) Chem. Cent. , vol.10 , pp. 74
    • Adamson, J.1    Thorne, D.2    Zainuddin, B.3    Baxter, A.4    McAughey, J.5    Gaça, M.6
  • 5
    • 84937019857 scopus 로고    scopus 로고
    • Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols
    • Azzopardi, D., Haswell, L.E., Foss-Smith, G., Hewitt, K., Asquith, N., Corke, S., Phillips, G., Evaluation of an air–liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols. Toxicol. In Vitro 29 (2015), 1720–1729.
    • (2015) Toxicol. In Vitro , vol.29 , pp. 1720-1729
    • Azzopardi, D.1    Haswell, L.E.2    Foss-Smith, G.3    Hewitt, K.4    Asquith, N.5    Corke, S.6    Phillips, G.7
  • 8
    • 84926490317 scopus 로고    scopus 로고
    • Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia
    • Baxter, A., Thain, S., Banerjee, A., Haswell, L.E., Parmar, A., Phillips, G., Minet, E.F., Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia. Toxicol. In Vitro 29 (2015), 864–875.
    • (2015) Toxicol. In Vitro , vol.29 , pp. 864-875
    • Baxter, A.1    Thain, S.2    Banerjee, A.3    Haswell, L.E.4    Parmar, A.5    Phillips, G.6    Minet, E.F.7
  • 10
    • 85021005361 scopus 로고    scopus 로고
    • Application of the Bhas 42 Cell Transformation Assay to the Assessment of Novel Tobacco Products
    • (Accessed 23 August 2016)
    • Breheny, D., Oke, O., Camacho, O.M., Pant, K., Bruce, S.W., LaForce, M.K., Celestin, N., Application of the Bhas 42 Cell Transformation Assay to the Assessment of Novel Tobacco Products. 2015 http://www.bat-science.com/groupms/sites/BAT_9GVJXS.nsf/vwPagesWebLive/DOA29DVY/$FILE/EuroTox_DB_2015_(2).pdf?openelement (Accessed 23 August 2016).
    • (2015)
    • Breheny, D.1    Oke, O.2    Camacho, O.M.3    Pant, K.4    Bruce, S.W.5    LaForce, M.K.6    Celestin, N.7
  • 12
    • 33847099316 scopus 로고    scopus 로고
    • The Tobacco Atlas Fifth Edition
    • American Cancer Society (Accessed 26 August 2016)
    • Eriksen, M., Mackay, J., Schluger, N., The Tobacco Atlas Fifth Edition. 2015, American Cancer Society http://www.tobaccoatlas.org/ (Accessed 26 August 2016).
    • (2015)
    • Eriksen, M.1    Mackay, J.2    Schluger, N.3
  • 13
    • 84923967853 scopus 로고    scopus 로고
    • Directive 2014/40/EU of the european parliament and of the council of 3 april 2014
    • European Union, Directive 2014/40/EU of the european parliament and of the council of 3 april 2014. Off. J. Eur. Union L 127 (2014), 1–38.
    • (2014) Off. J. Eur. Union L , vol.127 , pp. 1-38
    • European Union1
  • 14
    • 84959150244 scopus 로고    scopus 로고
    • Special Eurobarometer 429: Attitudes of Europeans towards Tobacco and Electronic Cigarettes
    • (Accessed 23 June 2016)
    • European Commission, Special Eurobarometer 429: Attitudes of Europeans towards Tobacco and Electronic Cigarettes. 2015 http://ec.europa.eu/public_opinion/archives/ebs/ebs_429_en.pdf (Accessed 23 June 2016).
    • (2015)
    • European Commission1
  • 15
    • 84943427430 scopus 로고    scopus 로고
    • Regulation in the face of uncertainty: the evidence on electronic nicotine delivery systems (e-cigarettes)
    • Farsalinos, K.E., Le Houezec, J., Regulation in the face of uncertainty: the evidence on electronic nicotine delivery systems (e-cigarettes). Risk Manag. Healthc. Policy 8 (2015), 157–167.
    • (2015) Risk Manag. Healthc. Policy , vol.8 , pp. 157-167
    • Farsalinos, K.E.1    Le Houezec, J.2
  • 17
    • 85020975703 scopus 로고    scopus 로고
    • Guidance for industry modified risk tobacco product applications
    • (Accessed 23 August 2016)
    • Food and Drug Administration, Guidance for industry modified risk tobacco product applications. Draft Guid., 2012 http://www.fda.gov/downloads/TobaccoProducts/GuidanceComplianceRegulatoryInformation/UCM297751.pdf (Accessed 23 August 2016).
    • (2012) Draft Guid.
    • Food and Drug Administration1
  • 18
    • 84928683914 scopus 로고    scopus 로고
    • An experimental method to study emissions from heated tobacco between 100-200°C
    • Forster, M., Liu, C., Duke, M.G., McAdam, K.G., Proctor, C.J., An experimental method to study emissions from heated tobacco between 100-200°C. Chem. Cent. J., 9, 2015, 20.
    • (2015) Chem. Cent. J. , vol.9 , pp. 20
    • Forster, M.1    Liu, C.2    Duke, M.G.3    McAdam, K.G.4    Proctor, C.J.5
  • 19
    • 4143062086 scopus 로고    scopus 로고
    • Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke
    • Fowles, J., Dybing, E., Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob. Control 12:4 (2003), 424–430.
    • (2003) Tob. Control , vol.12 , Issue.4 , pp. 424-430
    • Fowles, J.1    Dybing, E.2
  • 20
    • 84926088290 scopus 로고    scopus 로고
    • Characterisation of an aerosol exposure system to evaluate the genotoxicity of whole mainstream cigarette smoke using the in vitro γ-H2AX assay by high content screening
    • Garcia-Canton, C., Errington, G., Anadon, A., Meredith, C., Characterisation of an aerosol exposure system to evaluate the genotoxicity of whole mainstream cigarette smoke using the in vitro γ-H2AX assay by high content screening. BMC Pharmacol. Toxicol., 15, 2014, 41.
    • (2014) BMC Pharmacol. Toxicol. , vol.15 , pp. 41
    • Garcia-Canton, C.1    Errington, G.2    Anadon, A.3    Meredith, C.4
  • 21
    • 84913593498 scopus 로고    scopus 로고
    • Application of CE–MS to a metabonomics study of human urine from cigarette smokers and non-smokers
    • Garcia-Perez, I., Lindon, J.C., Minet, E.F., Application of CE–MS to a metabonomics study of human urine from cigarette smokers and non-smokers. Bioanalysis 6 (2014), 2733–2749.
    • (2014) Bioanalysis , vol.6 , pp. 2733-2749
    • Garcia-Perez, I.1    Lindon, J.C.2    Minet, E.F.3
  • 23
    • 84960444701 scopus 로고    scopus 로고
    • Bhas 42 cell transformation activity of cigarette smoke condensate is modulated by selenium and arsenic
    • Han, S.G., Pant, K., Bruce, S.W., Gairola, C.G., Bhas 42 cell transformation activity of cigarette smoke condensate is modulated by selenium and arsenic. Environ. Mol. Mutagen 57 (2016), 220–228.
    • (2016) Environ. Mol. Mutagen , vol.57 , pp. 220-228
    • Han, S.G.1    Pant, K.2    Bruce, S.W.3    Gairola, C.G.4
  • 24
    • 77649185234 scopus 로고    scopus 로고
    • Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia
    • Haswell, L.E., Thorne, D., Richter, A., Hewitt, K., Cigarette smoke total particulate matter increases mucous secreting cell numbers in vitro: a potential model of goblet cell hyperplasia. Toxicol. In Vitro 24 (2010), 981–987.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 981-987
    • Haswell, L.E.1    Thorne, D.2    Richter, A.3    Hewitt, K.4
  • 25
    • 85020959051 scopus 로고    scopus 로고
    • Determination of “tar”, nicotine and carbon monoxide in mainstream tobacco smoke
    • (Accessed 23 August 2016)
    • Health Canada, Determination of “tar”, nicotine and carbon monoxide in mainstream tobacco smoke. Health Can. Method T-115, 1999 http://edge.rit.edu/edge/P10056/public/Health%20Canada%20Nicotine (Accessed 23 August 2016).
    • (1999) Health Can. Method T-115
    • Health Canada1
  • 27
    • 0003803673 scopus 로고    scopus 로고
    • Tobacco and Tobacco Products—atmosphere for Conditioning and Testing
    • ISO 3402:1999 (Accessed 23 August 2016)
    • International Organization for Standardization, Tobacco and Tobacco Products—atmosphere for Conditioning and Testing. ISO 3402:1999, 1999 http://www.iso.org/iso/catalogue_detail.htm?csnumber=28324 (Accessed 23 August 2016).
    • (1999)
    • International Organization for Standardization1
  • 28
    • 13744257040 scopus 로고    scopus 로고
    • Cigarettes—determination of Total and Nicotine-free Dry Particulate Matter Using a Routine Analytical Smoking Machine
    • ISO 4387:2000 (Accessed 23 August 2016)
    • International Organization for Standardization, Cigarettes—determination of Total and Nicotine-free Dry Particulate Matter Using a Routine Analytical Smoking Machine. ISO 4387:2000, 2000 http://www.iso.org/iso/catalogue_detail.htm?csnumber=28323 (Accessed 23 August 2016).
    • (2000)
    • International Organization for Standardization1
  • 29
    • 0003803672 scopus 로고    scopus 로고
    • Routine Analytical Cigarette-smoking Machine—definitions and Standard Conditions
    • ISO 3308:2012 (Accessed 23 August 2016)
    • International Organization for Standardization, Routine Analytical Cigarette-smoking Machine—definitions and Standard Conditions. ISO 3308:2012, 2012 http://www.iso.org/iso/iso_catalogue/catalogue_tc/catalogue_detail.htm?csnumber=60404 (Accessed 23 August 2016).
    • (2012)
    • International Organization for Standardization1
  • 30
    • 84859991085 scopus 로고    scopus 로고
    • A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937Macrophages: implications in oxidative stress in HIV + smokers
    • Jin, M., Earla, R., Shah, A., Earla, R.L., Gupte, R., Mitra, A.K., Kumar, A., Kumar, S., A LC-MS/MS method for concurrent determination of nicotine metabolites and role of CYP2A6 in nicotine metabolism in U937Macrophages: implications in oxidative stress in HIV + smokers. J. Neuroimmune Pharmacol. 7:1 (2012), 289–299.
    • (2012) J. Neuroimmune Pharmacol. , vol.7 , Issue.1 , pp. 289-299
    • Jin, M.1    Earla, R.2    Shah, A.3    Earla, R.L.4    Gupte, R.5    Mitra, A.K.6    Kumar, A.7    Kumar, S.8
  • 31
    • 84988566161 scopus 로고    scopus 로고
    • Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers
    • Kaluarachchi, M.R., Boulangé, C.L., Garcia-Perez, I., Lindon, J.C., Minet, E.F., Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers. Bioanalysis 8 (2016), 2023–2043.
    • (2016) Bioanalysis , vol.8 , pp. 2023-2043
    • Kaluarachchi, M.R.1    Boulangé, C.L.2    Garcia-Perez, I.3    Lindon, J.C.4    Minet, E.F.5
  • 32
    • 85020952610 scopus 로고    scopus 로고
    • University of Kentucky Reference Cigarette 3R4F Preliminary Analysis
    • (Accessed 23 June 2016)
    • Kentucky Tobacco Research & Development Center, University of Kentucky Reference Cigarette 3R4F Preliminary Analysis. 2015 https://ctrp.uky.edu/resources/pdf/webdocs/3R4F%20Preliminary%20Analysis.pdf (Accessed 23 June 2016).
    • (2015)
    • Kentucky Tobacco Research & Development Center1
  • 33
    • 84901612719 scopus 로고    scopus 로고
    • A method for assessment of the genotoxicity of mainstream cigarette-smoke by use of the bacterial reverse-mutation assay and an aerosol-based exposure system
    • Kilford, J., Thorne, D., Payne, R., Dalrymple, A., Clements, J., Meredith, C., Dillon, D., A method for assessment of the genotoxicity of mainstream cigarette-smoke by use of the bacterial reverse-mutation assay and an aerosol-based exposure system. Mutat. Res. Genet. Toxicol. Environ. Mutagen 769 (2014), 20–28.
    • (2014) Mutat. Res. Genet. Toxicol. Environ. Mutagen , vol.769 , pp. 20-28
    • Kilford, J.1    Thorne, D.2    Payne, R.3    Dalrymple, A.4    Clements, J.5    Meredith, C.6    Dillon, D.7
  • 34
    • 84888827144 scopus 로고    scopus 로고
    • Evaluation method for the cytotoxicity of cigarette smoke by in vitro whole smoke exposure
    • Li, X., Nie, C., Shang, P., Xie, F., Liu, H., Xie, J., Evaluation method for the cytotoxicity of cigarette smoke by in vitro whole smoke exposure. Exp. Toxicol. Pathol. 66 (2014), 27–33.
    • (2014) Exp. Toxicol. Pathol. , vol.66 , pp. 27-33
    • Li, X.1    Nie, C.2    Shang, P.3    Xie, F.4    Liu, H.5    Xie, J.6
  • 35
    • 85016321061 scopus 로고    scopus 로고
    • A framework for the assessment of reduced risk tobacco and nicotine products
    • Lowe, F., Fearon, I.M., Camacho, O.M., Minet, E., Murphy, J., A framework for the assessment of reduced risk tobacco and nicotine products. Recent Adv. Tob. Sci. 41 (2015), 51–82.
    • (2015) Recent Adv. Tob. Sci. , vol.41 , pp. 51-82
    • Lowe, F.1    Fearon, I.M.2    Camacho, O.M.3    Minet, E.4    Murphy, J.5
  • 36
    • 84991666710 scopus 로고    scopus 로고
    • Chemical composition of an e-cigarette aerosol: a quantitative comparison with cigarette smoke
    • Published online September 18, 2016
    • Margham, J., McAdam, K., Forster, M., Liu, C., Wright, C., Mariner, D., Proctor, C., Chemical composition of an e-cigarette aerosol: a quantitative comparison with cigarette smoke. Chem. Res. Toxicol., 2016, 10.1021/acs.chemrestox.6b00188 Published online September 18, 2016.
    • (2016) Chem. Res. Toxicol.
    • Margham, J.1    McAdam, K.2    Forster, M.3    Liu, C.4    Wright, C.5    Mariner, D.6    Proctor, C.7
  • 37
    • 84943320459 scopus 로고    scopus 로고
    • E-cigarettes: an Evidence Update a Report Commissioned by Public Health England
    • (Accessed 23 June 2016)
    • McNeill, A., Brose, L.S., Calder, R., Hitchman, S.C., Hajek, P., McRobbie, H., E-cigarettes: an Evidence Update a Report Commissioned by Public Health England., 2015 https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/457102/Ecigarettes_an_evidence_update_A_report_commissioned_by_Public_Health_England_FINAL.pdf (Accessed 23 June 2016).
    • (2015)
    • McNeill, A.1    Brose, L.S.2    Calder, R.3    Hitchman, S.C.4    Hajek, P.5    McRobbie, H.6
  • 38
    • 84926304331 scopus 로고    scopus 로고
    • Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models
    • McQuillan, K., Carr, T., Taylor, M., Bishop, E., Fearon, I.M., Examination of the use of human sera as an exposure agent for in vitro studies investigating the effects of cigarette smoking on cellular cardiovascular disease models. Toxicol. In Vitro 29 (2015), 856–863.
    • (2015) Toxicol. In Vitro , vol.29 , pp. 856-863
    • McQuillan, K.1    Carr, T.2    Taylor, M.3    Bishop, E.4    Fearon, I.M.5
  • 39
    • 84888416010 scopus 로고    scopus 로고
    • Test No. 471: Bacterial Reverse Mutation Test
    • (Accessed 23 August 2016)
    • Organisation for Economic and Cooperative Development, Test No. 471: Bacterial Reverse Mutation Test. 1997 http://www.oecd-ilibrary.org/docserver/download/9747101e.pdf?expires=1471288798&id=id&accname=guest&checksum=9FAE38391CF2402837312CAD703B9197 (Accessed 23 August 2016).
    • (1997)
    • Organisation for Economic and Cooperative Development1
  • 40
    • 0006898158 scopus 로고    scopus 로고
    • Guideline 476, In vitro Mammalian Cell Gene Mutation Test
    • updated and adopted July 21
    • Organisation for Economic and Cooperative Development, Guideline 476, In vitro Mammalian Cell Gene Mutation Test. 1997 updated and adopted July 21.
    • (1997)
    • Organisation for Economic and Cooperative Development1
  • 41
    • 85017829399 scopus 로고    scopus 로고
    • Guidance Document on the In Vitro Bhas 42 Cell Transformation Assay
    • Series on Testing and Assessment. No. 231. Paris (Accessed 03 December 2016)
    • Organisation for Economic and Cooperative Development, Guidance Document on the In Vitro Bhas 42 Cell Transformation Assay. Series on Testing and Assessment. No. 231. Paris, 2016 https://www.oecd.org/env/ehs/testing/ENV_JM_MONO(2016)1.pdf (Accessed 03 December 2016).
    • (2016)
    • Organisation for Economic and Cooperative Development1
  • 42
    • 84877312657 scopus 로고    scopus 로고
    • Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests
    • Series on Testing and Assessment. No. 129. Paris (Accessed 29 May 2016)
    • Organisation for Economic and Cooperative Development, Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests. Series on Testing and Assessment. No. 129. Paris, 2010 http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/cote=env/jm/mono(2010)20&doclanguage=en (Accessed 29 May 2016).
    • (2010)
    • Organisation for Economic and Cooperative Development1
  • 43
    • 84937040476 scopus 로고    scopus 로고
    • Guideline for Testing of Chemicals: In vitro Mammalian Cell Micronucleus Test
    • TG 487. Adopted Sept 2014
    • Organisation for Economic and Cooperative Development, Guideline for Testing of Chemicals: In vitro Mammalian Cell Micronucleus Test. 2014 TG 487. Adopted Sept 2014.
    • (2014)
    • Organisation for Economic and Cooperative Development1
  • 44
    • 80052586257 scopus 로고    scopus 로고
    • Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS
    • Onoue, S., Yamamoto, N., Seto, Y., Yamada, S., Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS. Drug. Metab. Pharmacokinet. 26:4 (2011), 416–422.
    • (2011) Drug. Metab. Pharmacokinet. , vol.26 , Issue.4 , pp. 416-422
    • Onoue, S.1    Yamamoto, N.2    Seto, Y.3    Yamada, S.4
  • 45
    • 21844451174 scopus 로고    scopus 로고
    • Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses
    • Phillips, J., Kluss, B., Richter, A., Massey, E., Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses. Altern. Lab. Anim. 33 (2005), 239–248.
    • (2005) Altern. Lab. Anim. , vol.33 , pp. 239-248
    • Phillips, J.1    Kluss, B.2    Richter, A.3    Massey, E.4
  • 46
    • 85020005010 scopus 로고    scopus 로고
    • A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 1): product operation and preliminary aerosol chemistry assessment
    • Available online 30 May 2017
    • Poynton, S., Sutton, J., Goodall, S., Margham, J., Forster, M., Scott, J., Liu, C., McAdam, K., Murphy, J., Proctor, C., A novel hybrid tobacco product that delivers a tobacco flavour note with vapour aerosol (Part 1): product operation and preliminary aerosol chemistry assessment. Food Chem. Toxicol., 2017 Available online 30 May 2017.
    • (2017) Food Chem. Toxicol.
    • Poynton, S.1    Sutton, J.2    Goodall, S.3    Margham, J.4    Forster, M.5    Scott, J.6    Liu, C.7    McAdam, K.8    Murphy, J.9    Proctor, C.10
  • 47
    • 0003471821 scopus 로고
    • Chemical and Biological Studies: New Cigarette Prototype that Heat Instead of Burn Tobacco
    • R.J. Reynolds Tobacco Co. Winston-Salem, NC
    • R.J. Reynolds Tobacco Company, Chemical and Biological Studies: New Cigarette Prototype that Heat Instead of Burn Tobacco. 1988, R.J. Reynolds Tobacco Co., Winston-Salem, NC.
    • (1988)
    • R.J. Reynolds Tobacco Company1
  • 48
    • 59849088241 scopus 로고    scopus 로고
    • The Chemical Components of Tobacco and Tobacco Smoke
    • second ed. CRC Press Boca Raton
    • Rodgman, A., Perfetti, T.A., The Chemical Components of Tobacco and Tobacco Smoke. second ed., 2013, CRC Press, Boca Raton.
    • (2013)
    • Rodgman, A.1    Perfetti, T.A.2
  • 50
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E.P., Pilch, D.R., Orr, A.H., Ivanova, V.S., Bonner, W.M., DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273 (1998), 5858–5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 51
    • 84879976839 scopus 로고    scopus 로고
    • Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis
    • Salomon, C., Ryan, J., Sobrevia, L., Kobayashi, M., Ashman, K., Mitchell, M., Rice, G.E., Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis. PLoS One, 8, 2013, e6845.
    • (2013) PLoS One , vol.8 , pp. e6845
    • Salomon, C.1    Ryan, J.2    Sobrevia, L.3    Kobayashi, M.4    Ashman, K.5    Mitchell, M.6    Rice, G.E.7
  • 52
    • 84927549632 scopus 로고    scopus 로고
    • Evaluation of e-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells
    • Scheffler, S., Dieken, H., Krischenowski, O., Förster, C., Branscheid, D., Aufderheide, M., Evaluation of e-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells. Int. J. Environ. Res. Public Health 12 (2015), 3915–3925.
    • (2015) Int. J. Environ. Res. Public Health , vol.12 , pp. 3915-3925
    • Scheffler, S.1    Dieken, H.2    Krischenowski, O.3    Förster, C.4    Branscheid, D.5    Aufderheide, M.6
  • 53
    • 84947446046 scopus 로고    scopus 로고
    • Electronic Cigarette Use Amongst Adults
    • NCHS Data Brief No. 217, October 2015 (Accessed 23 June 2016)
    • Schoenborn, C.A., Grindi, R.M., Electronic Cigarette Use Amongst Adults. NCHS Data Brief No. 217, October 2015, 2015 http://www.cdc.gov/nchs/data/databriefs/db217.pdf (Accessed 23 June 2016).
    • (2015)
    • Schoenborn, C.A.1    Grindi, R.M.2
  • 54
    • 84875766056 scopus 로고    scopus 로고
    • The resolving power of in vitro genotoxicity assays for cigarette smoke particulate matter
    • Scott, K., Saul, J., Crooks, I., Camacho, O.M., Dillon, D., Meredith, C., The resolving power of in vitro genotoxicity assays for cigarette smoke particulate matter. Toxicol. In Vitro 27 (2013), 1312–1319.
    • (2013) Toxicol. In Vitro , vol.27 , pp. 1312-1319
    • Scott, K.1    Saul, J.2    Crooks, I.3    Camacho, O.M.4    Dillon, D.5    Meredith, C.6
  • 55
    • 0003989598 scopus 로고    scopus 로고
    • Clearing the Smoke: the Science Base for Tobacco Harm Reduction
    • National Academy Press Washington DC
    • Stratton, K., Shetty, P., Wallace, R., Bondurant, S., Clearing the Smoke: the Science Base for Tobacco Harm Reduction. 2001, National Academy Press, Washington DC.
    • (2001)
    • Stratton, K.1    Shetty, P.2    Wallace, R.3    Bondurant, S.4
  • 56
    • 85006826895 scopus 로고    scopus 로고
    • E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke
    • Taylor, M., Carr, T., Oke, O., Jaunky, J., Breheny, D., Lowe, F., Gaça, M., E-cigarette aerosols induce lower oxidative stress in vitro when compared to tobacco smoke. Toxicol. Mech. Methods 26 (2016), 465–476.
    • (2016) Toxicol. Mech. Methods , vol.26 , pp. 465-476
    • Taylor, M.1    Carr, T.2    Oke, O.3    Jaunky, J.4    Breheny, D.5    Lowe, F.6    Gaça, M.7
  • 57
    • 84964595349 scopus 로고    scopus 로고
    • Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture
    • Teasdale, J.E., Newby, A.C., Timpson, N.J., Munafò, M.R., White, S.J., Cigarette smoke but not electronic cigarette aerosol activates a stress response in human coronary artery endothelial cells in culture. Drug Alcohol Depend. 163 (2016), 256–260.
    • (2016) Drug Alcohol Depend. , vol.163 , pp. 256-260
    • Teasdale, J.E.1    Newby, A.C.2    Timpson, N.J.3    Munafò, M.R.4    White, S.J.5
  • 58
    • 84885849228 scopus 로고    scopus 로고
    • A review of in vitro cigarette smoke exposure systems
    • Thorne, D., Adamson, J., A review of in vitro cigarette smoke exposure systems. Exp. Toxicol. Pathol. 65 (2013), 1183–1193.
    • (2013) Exp. Toxicol. Pathol. , vol.65 , pp. 1183-1193
    • Thorne, D.1    Adamson, J.2
  • 60
    • 84947039500 scopus 로고    scopus 로고
    • A comparative assessment of cigarette smoke aerosols using an in vitro air-liquid interface cytotoxicity test
    • Thorne, D., Dalrymple, A., Dillon, D., Duke, M., Meredith, C., A comparative assessment of cigarette smoke aerosols using an in vitro air-liquid interface cytotoxicity test. Inhal. Toxicol. 27 (2015), 629–640.
    • (2015) Inhal. Toxicol. , vol.27 , pp. 629-640
    • Thorne, D.1    Dalrymple, A.2    Dillon, D.3    Duke, M.4    Meredith, C.5
  • 61
    • 84999028769 scopus 로고    scopus 로고
    • The mutagenic assessment of electronic-cigarettes and tobacco smoke using the Ames assay in strains TA98 and TA100
    • Thorne, D., Crooks, I., Hollings, M., Seymour, A., Meredith, C., Gaҫa, M., The mutagenic assessment of electronic-cigarettes and tobacco smoke using the Ames assay in strains TA98 and TA100. Mutat. Res. 812 (2016), 29–38.
    • (2016) Mutat. Res. , vol.812 , pp. 29-38
    • Thorne, D.1    Crooks, I.2    Hollings, M.3    Seymour, A.4    Meredith, C.5    Gaҫa, M.6
  • 62
    • 85006728977 scopus 로고    scopus 로고
    • The in vitro assessment of e-cigarette aerosol DNA induced damage using the γ-H2AX assay
    • Thorne, D., Larard, S., Baxter, A., Meredith, C., Gaҫa, M., The in vitro assessment of e-cigarette aerosol DNA induced damage using the γ-H2AX assay. Toxicol. Lett. 265 (2016), 170–178.
    • (2016) Toxicol. Lett. , vol.265 , pp. 170-178
    • Thorne, D.1    Larard, S.2    Baxter, A.3    Meredith, C.4    Gaҫa, M.5
  • 63
    • 79952213804 scopus 로고    scopus 로고
    • How Tobacco Smoke Causes Disease: the Biology and Behavioral Basis for Smoking-attributable Disease: a Report of the Surgeon General
    • Centers for Disease Control and Prevention Atlanta, USA
    • US Department of Health and Human Services, How Tobacco Smoke Causes Disease: the Biology and Behavioral Basis for Smoking-attributable Disease: a Report of the Surgeon General., 2010, Centers for Disease Control and Prevention, Atlanta, USA.
    • (2010)
    • US Department of Health and Human Services1
  • 64
    • 84893235639 scopus 로고    scopus 로고
    • The Health Consequences of Smoking 50 Years of Progress: a Report of the Surgeon General, 2014
    • Centers for Disease Control and Prevention (US) Atlanta, USA 2014 (Accessed 26 August 2016)
    • US Department of Health and Human Services, The Health Consequences of Smoking 50 Years of Progress: a Report of the Surgeon General, 2014., 2014, Centers for Disease Control and Prevention (US), Atlanta, USA 2014 http://www.surgeongeneral.gov/library/reports/50-years-of-progress/index.html (Accessed 26 August 2016).
    • (2014)
    • US Department of Health and Human Services1
  • 65
    • 79955880483 scopus 로고    scopus 로고
    • Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
    • Volpi, G., Facchinetti, F., Moretto, N., Civelli, M., Patacchini, R., Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts. Br. J. Pharmacol. 163:3 (2011), 649–661.
    • (2011) Br. J. Pharmacol. , vol.163 , Issue.3 , pp. 649-661
    • Volpi, G.1    Facchinetti, F.2    Moretto, N.3    Civelli, M.4    Patacchini, R.5
  • 66
    • 84881105135 scopus 로고    scopus 로고
    • Cigarette smoke-induced morphological transformation of Bhas 42 cells in vitro
    • Weisensee, D., Poth, A., Roemer, E., Conroy, L.L., Schlage, W.K., Cigarette smoke-induced morphological transformation of Bhas 42 cells in vitro. Altern. Lab. Anim. 41 (2013), 181–189.
    • (2013) Altern. Lab. Anim. , vol.41 , pp. 181-189
    • Weisensee, D.1    Poth, A.2    Roemer, E.3    Conroy, L.L.4    Schlage, W.K.5
  • 67
    • 84992518703 scopus 로고    scopus 로고
    • Trends in electronic cigarette use in England
    • (Accessed 23 June 2016)
    • West, R., Beard, E., Brown, J., Trends in electronic cigarette use in England. Smok. Toolkit Study STS140122, 2015 http://www.smokinginengland.info/latest-statistics/ (Accessed 23 June 2016).
    • (2015) Smok. Toolkit Study STS140122
    • West, R.1    Beard, E.2    Brown, J.3
  • 68
    • 84925826948 scopus 로고    scopus 로고
    • Electronic Nicotine Delivery Systems 2014
    • WHO July 21, Geneva July 21, (Accessed 23 June 2016) July 21
    • WHO Framework Convention on Tobacco Control, Electronic Nicotine Delivery Systems 2014. July 21, 2014, WHO, Geneva http://apps.who.int/gb/fctc/PDF/cop6/FCTC_COP6_10-en.pdf (Accessed 23 June 2016).
    • (2014)
    • WHO Framework Convention on Tobacco Control1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.