Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts

British Journal of Pharmacology

Volumn 163, Issue 3, 2011, Pages 649-661

  Volpi, Giorgia ^a   Facchinetti, Fabrizio ^a   Moretto, Nadia ^a   Civelli, Maurizio ^a   Patacchini, Riccardo ^a  

^a CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

4 hydroxy 2 nonenal; acrolein; airway smooth muscle cells; COPD; lung fibroblasts; p38 MAPK; VEGF

Indexed keywords

2,3 UNSATURATED ALDEHYDE; 4 HYDROXYNONENAL; ACETYLCYSTEINE; ACROLEIN; ALDEHYDE; ANTIOXIDANT; AP 18; CIGARETTE SMOKE; CROTONALDEHYDE; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; HYDROGEN PEROXIDE; MECAMYLAMINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NICOTINE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PROTEIN INHIBITOR; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1; UNCLASSIFIED DRUG; VASCULOTROPIN;

AIRWAY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EPITHELIUM CELL; EXPOSURE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG PARENCHYMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER;

ACETYLCYSTEINE; ACROLEIN; ALDEHYDES; BRONCHI; CALCIUM CHANNELS; CELLS, CULTURED; COMPLEX MIXTURES; FIBROBLASTS; HUMANS; LUNG; MYOCYTES, SMOOTH MUSCLE; NERVE TISSUE PROTEINS; NICOTINIC ANTAGONISTS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; SMOKE; TOBACCO; TRANSIENT RECEPTOR POTENTIAL CHANNELS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955880483     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01253.x     Document Type: Article

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