Evaluation of e-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells

International Journal of Environmental Research and Public Health

Volumn 12, Issue 4, 2015, Pages 3915-3925

  Scheffler, Stefanie ^a   Dieken, Hauke ^a   Krischenowski, Olaf ^a   Förster, Christine ^b   Branscheid, Detlev ^c   Aufderheide, Michaela ^a  

^a Cultex Laboratories GmbH   (Germany)

^b NORDSTADT HOSPITAL   (Germany)

^c EVANGELISCHES KRANKENHAUS   (Germany)

Author keywords

Air liquid interface; CULTEX RFS; Cytotoxicity; Electronic cigarette; Health; Nicotine; Normal bronchial epithelial cells; Public; Smoking; Tobacco

Indexed keywords

CIGARETTE SMOKE; ELECTRONIC CIGARETTE; GLYCEROL; NICOTINE; PROPYLENE GLYCOL; SMOKE;

HEALTH IMPACT; QUALITATIVE ANALYSIS; SAFETY; SMOKING; TECHNOLOGY ADOPTION; TOXICITY TEST;

AGED; ARTICLE; BRONCHUS MUCOSA; CASE REPORT; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; EPITHELIUM CELL; EXPOSURE; HUMAN; HUMAN CELL; LIQUID; MALE; OXIDATIVE STRESS; TOXICITY TESTING; VAPOR; ADVERSE EFFECTS; BRONCHUS; DRUG EFFECTS; ELECTRONIC CIGARETTE; SMOKE;

NICOTIANA TABACUM;

BRONCHI; ELECTRONIC CIGARETTES; EPITHELIAL CELLS; HUMANS; NICOTINE; SMOKE;

EID: 84927549632     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph120403915     Document Type: Article

References (15)

1. Zhu, S.H.; Sun, J.Y.; Bonnevie, E.; Cummins, S.E.; Gamst, A.; Yin, L.; Lee, M. Four hundred and sixty brands of e-cigarettes and counting: Implications for product regulation. Tob. Control 2014, 23, iii3-iii9.
2. Polosa, R.; Caponnetto, P.; Morjaria, J.B.; Papale, G.; Campagna, D.; Russo, C. Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: A prospective 6-month pilot study. BMC Public Health 2011, 11, doi:10.1186/1471-2458-11-786.
3. Polosa, R.; Morjaria, J.; Caponnetto, P.; Campagna, D.; Russo, C.; Alamo, A.; Amaradio, M.; Fisichella, A. Effectiveness and tolerability of electronic cigarette in real-life: A 24-month prospective observational study. Int. Emerg. Med. 2014, 9, 537-546.
4. Ku Leuven. E-Cigarettes Significantly Reduce Tobacco Cravings. Available online: http://www.kuleuven.be/english/news/e-cigarettes-significantly-reduce-tobacco-cravings (assessed on 27 February 2015).
5. Westenberger, B.J. Evaluation of E-Cigarettes. Available online: http://www.fda.gov/downloads/ drugs/scienceresearch/ucm173250.pdf (assessed on 27 February 2015).
6. Hadwiger, M.E.; Trehy, M.L.; Ye, W.; Moore, T.; Allgire, J.; Westenberger, B. Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. J. Chromatogr. A 2010, 1217, 7547-7555.
7. Trehy, M.L.; Ye, W.; Hadwiger, M.E.; Moore, T.W.; Allgire, J.F.; Woodruff, J.T.; Ahadi, S.S.; Black, J.C.; Westenberger, B.J. Analysis of electronic cigarette cartridges, refill solutions, and smoke for nicotine and nicotine related impurities. J. Liq. Chromatogr. Related Technol. 2011, 34, 1442-1458.
8. BBC News Tyne & Wear. E-Cigarette Liquid Bought on Tyneside "Potentially Harmful." Available online: http://www.bbc.com/news/uk-england-tyne-28955590 (assessed on 27 February 2015).
9. Farsalinos, K.E.; Polosa, R. Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: A systematic review. Ther. Adv. Drug Saf. 2014, 5, 67-86.
10. Behar, R.Z.; Davis, B.; Wang, Y.; Bahl, V.; Lin, S.; Talbot, P. Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids. Toxicol. In Vitro 2014, 28, 198-208.
11. Bahl, V.; Lin, S.; Xu, N.; Davis, B.; Wang, Y.H.; Talbot, P. Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod. Toxicol. 2012, 34, 529-537.
12. Farsalinos, K.E.; Romagna, G.; Allifranchini, E.; Ripamonti, E.; Bocchietto, E.; Todeschi, S.; Tsiapras, D.; Kyrzopoulos, S.; Voudris, V. Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells. Int. J. Environ. Res. Public Health 2013, 10, 5146-5162.
13. Romagna, G.; Allifranchini, E.; Bocchietto, E.; Todeschi, S.; Esposito, M.; Farsalinos, K.E. Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE): Comparison with tobacco cigarette smoke extract. Inhal. Toxicol. 2013, 25, 354-361.
14. Farsalinos, K.E.; Romagna, G.; Tsiapras, D.; Kyrzopoulos, S.; Voudris, V. Evaluation of electronic cigarette use (vaping) topography and estimation of liquid consumption: Implications for research protocol standards definition and for public health authorities' regulation. Int. J. Environ. Res. Public Health 2013, 10, 2005-2014.
15. McLaren, N. Big Survey 2014-Initial Findings Eliquid. Available online: http://vaping.com/data/ big-survey-2014-initial-findings-eliquid (assessed on 27 February 2015).