A comparative assessment of cigarette smoke aerosols using an in vitro air-liquid interface cytotoxicity test

Inhalation Toxicology

Volumn 27, Issue 12, 2015, Pages 629-640

  Thorne, David ^a   Dalrymple, Annette ^a   Dillon, Deborah ^a   Duke, Martin ^a   Meredith, Clive ^a  

^a BRITISH AMERICAN TOBACCO   (United Kingdom)

Author keywords

3R4F; Aerosol; BALB c 3T3; cigarette comparison; neutral red; tobacco smoke; vapor phase; whole smoke

Indexed keywords

CARBON MONOXIDE; CIGARETTE SMOKE; NICOTINE; TOBACCO SMOKE; AEROSOL; SMOKE;

AEROSOL; AIR CONDITIONING; ANIMAL CELL; ARTICLE; BLEND; CELL VIABILITY; CHEMICAL ANALYSIS; CIGARETTE SMOKE AEROSOL; COMPARATIVE STUDY; CYTOTOXICITY; CYTOTOXICITY TEST; IC50; MOUSE; NONHUMAN; PARTICULATE MATTER; PRESSURE DROP; PRIORITY JOURNAL; PUFF NUMBER; TOBACCO; VAPOR; 3T3 CELL LINE; ADVERSE EFFECTS; ANIMAL; CELL SURVIVAL; DRUG EFFECTS; MUTAGEN TESTING; PHYSIOLOGY; PROCEDURES; SMOKE; SMOKING; TOXICITY;

AEROSOLS; ANIMALS; BALB 3T3 CELLS; CELL SURVIVAL; MICE; MUTAGENICITY TESTS; SMOKE; SMOKING; TOBACCO PRODUCTS;

EID: 84947039500     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2015.1080773     Document Type: Article

References (41)

1. Adamson J, Thorne D, Dalrymple A, et al. (2013). Assessment of cigarette smoke particle deposition within the Vitrocell- exposure module using quartz crystal microbalances. Chem Cent J 7:50.
2. Adamson J, Thorne D, Errington G, et al. (2014). An inter-machine comparison of tobacco smoke particle deposition in vitro from six independent smoke exposure systems. Toxicol In Vitro 28:1320-28.
3. Andreoli C, Gigante D, Nunziata A. (2003). A review of in vitro methods to assess the biological activity of tobacco smoke with the aim of reducing the toxicology of smoke. Toxicol In Vitro 17:587-94.
4. Azzopardi D, Haswell L, Foss-Smith G, et al. (2015). Evaluation of an air-liquid interface cell culture model for studies on the inflammatory and cytotoxic responses to tobacco smoke aerosols. Toxicol In Vitro 29:1720-8.
5. Bombick D, Bombick R, Ayres P, et al. (1997). Evaluation of the genotoxic and cytotoxic potential of mainstream whole smoke and smoke condensate from a cigarette containing a novel carbon filter. Fund Appl Toxicol 39:11-7.
6. Branton P, McAdam K, Winter D, et al. (2011a). Reduction of aldehydes and hydrogen cyanide yields in mainstream cigarette smoke using an amine functionalised ion exchange resin. Chem Cent J 5:15.
7. Branton P, McAdam K, Duke M, et al. (2011b). Use of classical adsorption theory to understand the dynamic filtration of volatile toxicants in cigarette smoke by active carbons. Adsorp Sci Technol 29:117-38.
8. Burns D, Dybing E, Gray N, et al. (2008). Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal. Tobacco Control 2008;17:132-41.
9. Coggins C, Gaworski C. (2008). Could charcoal filtration of cigarette smoke reduce smoking-induced disease? A review of the literature. Regul Toxicol Pharmacol 50:359-65.
10. Dittrich D, Fieblekorn R, Bevan M, et al. (2014). Approaches for the design of reduced toxicant emission cigarettes. SpringerPlus 3:374.
11. Doolittle D, Lee C, Ivett J, et al. (1990). Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco. Environ Mol Mutagenesis 15: 93-105.
12. Fowles J, Dybing E. (2003). Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke. Tob Control 12:424-30.
13. Fukano Y, Ogura M, Eguchi K, et al. (2004). Modified procedure of a direct in vitro exposure system for mammalian cells to whole tobacco smoke. Exp Toxicol Pathol 55:317-23.
14. Goniewicz M, Knysak J, Gawron M, et al. (2014). Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tobacco Control 23:133-9.
15. Hoffmann D, Hoffmann I. (1997). The changing cigarette, 1950-1995. J Toxicol Environ Health 50:307-64.
16. IARC. (2004). Monograph on the evaluation of carcinogenic risks to humans. Tobacco smoke and involuntary smoking, vol. 83. France, Lyon: IARC.
17. IARC. (2008). Monograph on the evaluation of carcinogenic risks to humans. 1, 3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide), vol. 97. Lyon: IARC.
18. IARC. (2012). Monograph on the evaluation of carcinogenic risks to humans. Chemical Agents and Related Occupations, vol. 100F. Lyon, France: IARC.
19. Institute of Medicine. (2011) Scientific standards for studies on modified risk tobacco products. Washington, DC: National Academies Press.
20. International Organization for Standardization. (1999). Tobacco and tobacco products - Atmosphere for conditioning and testing. ISO 3402:1999. International Organization for Standardization, Geneva.
21. International Organization for Standardization. (2012). Routine analytical cigarette-smoking machine - Definitions and standard conditions. ISO 3308:2012. International Organization for Standardization, Geneva.
22. International Conference on Harmonization (ICH). Guidance on genotoxicity testing and data interpretation for pharmaceuticals intended for human use. Available from: http://www.ich.org/ products/guidelines/safety/safety-single/article/guidance-on-genotoxicity- testing-anddatainterpretation-for-pharmaceuticals-intendedfor- human-use.html. [Last accessed: 25 Aug 2015].
23. Lewis R, Jack A, Morris J, et al. (2008). RNA interference (RNAi)- induced suppression of nicotine demethylase activity reduces levels of a key carcinogen in cured tobacco leaves. Plant Biotechnol J 6: 346-54.
24. Liu C, DeGrandpre Y, Porter A, et al. (2011). The use of a novel treatment process to reduce toxicant yields in cigarette smoke. Food Chem Toxicol 49:1904-17.
25. Majeed S, Frentzel S, Wagner S, et al. (2014). Characterization of the Vitrocell- 24/48 in vitro aerosol exposure system using mainstream cigarette smoke. Chem Cent J 8:62.
26. McAdam K, Gregg E, Liu C, et al. (2011). The use of a novel tobaccosubstitute sheet and smoke dilution to reduce toxicant yields in cigarette smoke. Food Chem Toxicol 49:1684-96.
27. Norman A. (1999). Cigarette design and materials. In: Davis DL, Nielsen MT. (eds.) Tobacco production, chemistry, and technology 1999. Malden, MA: Blackwell Science, 353-87.
28. Phillips J, Kluss B, Richter A, Massey D. (2005). Exposure of bronchial epithelial cells to whole cigarette smoke: assessment of cellular responses. Altern Lab Animals 33:239-48.
29. Rodgman A, Perfetti T. (2013). The chemical components of Tobacco and Tobacco smoke. 2nd edition. Chapter 28. ISBN: 978-1-4200-7883-1.
30. Roemer E, Schramke H, Weiler H, et al. (2012). Mainstream smoke chemistry and in vitro and in vivo toxicity of reference cigarettes 3R4F and 2R4F. Beiträge zur Tabakforschung International/Contrib Tob Res 25:316-35.
31. Shin H-J, Sohn H-O, Han J-H, et al. (2009). Effect of cigarette filters on the chemical composition and in vitro biological activity of cigarette mainstream smoke. Food Chem Toxicol 47:192-7.
32. Stratton K, Shetty P, Wallace R. (2001). Clearing the smoke: assessing the science base for tobacco harm reduction. In: Institute of Medicine (eds). Washington, DC: National Academies Press.
33. Smith C, McKams S, Davis R, et al. (1996). Human urine mutagenicity study comparing cigarettes which burn or primarily heat tobacco. Mutat Res Environ Mutagenesis Relat Sub 361:1-9.
34. Thorne D, Adamson J. (2013a). A review of cigarette smoke exposure systems. Exp Toxicol Pathol 65:1183-93.
35. Thorne D, Kilford K, Payne R, et al. (2013b). Characterisation of a Vitrocell- VC 10 in vitro smoke exposure system using dose tools and biological analysis. Chem Cent J 7:146.
36. Thorne D, Kilford J, Payne R, et al. (2014). Development of a BALB/c 3T3 neutral red uptake cytotoxicity test using a mainstream cigarette smoke exposure system. BMC Res Notes 7:367.
37. The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM test method method evaluation report. In vitro cytotoxicity test methods for estimating starting doses for acute oral systemic cytotoxicity. Available from: http://ntp.niehs.nih.gov/iccvam/docs/acutetox-docs/brd-tmer/at-tmercomplete.pdf. [Last accessed: 25 Aug 2015].
38. Tokida A, Atobe I, Maeda K. (1985). Adsorption of the vapor phase components in cigarette smoke by activated carbon in vented cigarettes. Agric Biol Chem 49:3109-13.
39. Von Blücher H, Böhringer B, Giebelhausen J-M (2006). Pat. No. EP1918022 - High performance adsorbents based on active carbon with high micro-porosity.
40. Witschi H, Espiritu I, Maronpot R, et al. (1997). The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis 11:2035-42.
41. Wright C. (2015). Standardized methods for the regulation of cigarettesmoke constituents. Trends Anal Chem 66:118-27.