Pharmacokinetic study of nicotine and its metabolite cotinine to clarify possible association between smoking and voiding dysfunction in rats using UPLC/ESI-MS

Drug Metabolism and Pharmacokinetics

Volumn 26, Issue 4, 2011, Pages 416-422

  Onoue, Satomi ^a   Yamamoto, Noriyuki ^a   Seto, Yoshiki ^a   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Cigarette smoking; Cotinine; Nicotine; UPLC; Urinary excretion

Indexed keywords

COTININE; NICOTINE TARTRATE; NICOTINIC RECEPTOR;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLADDER DYSFUNCTION; CIGARETTE SMOKING; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; METABOLITE; MICTURITION; NONHUMAN; PRACTICE GUIDELINE; PROCESS OPTIMIZATION; PROTEIN EXPRESSION; RAT; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 80052586257     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-11-RG-019     Document Type: Article

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