Kinetic landscape of a peptide bond-forming prolyl oligopeptidase

Biochemistry

Volumn 56, Issue 15, 2017, Pages 2086-2095

  Czekster, Clarissa M ^a   Naismith, James H ^a,b,c,d  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b SICHUAN UNIVERSITY   (China)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Harwell Campus   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; KINETICS;

BROAD SPECIFICITIES; CONFORMATIONAL RIGIDITY; KINETIC CHARACTERIZATION; MACRO-CYCLIZATION; PRODUCT FORMATION; RATE-LIMITING STEPS; THERAPEUTIC APPLICATION; VISCOSITY EFFECTS;

PEPTIDES;

CYCLOPEPTIDE; PROLYL ENDOPEPTIDASE; PEPTIDE; RECOMBINANT PROTEIN; SERINE PROTEINASE;

ARTICLE; CONTROLLED STUDY; CYCLIZATION; DISSOCIATION; EQUILIBRIUM CONSTANT; INFORMATION PROCESSING; ISOTHERMAL TITRATION CALORIMETRY; KINETIC PARAMETERS; KINETICS; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; STEADY STATE; TURNOVER TIME; VISCOSITY; CALORIMETRY; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; SPECTROFLUOROMETRY; TEMPERATURE;

CALORIMETRY; HYDROGEN-ION CONCENTRATION; KINETICS; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; RECOMBINANT PROTEINS; SERINE ENDOPEPTIDASES; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; TEMPERATURE; VISCOSITY;

EID: 85020057125     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.7b00012     Document Type: Article

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