Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis

Chemistry and Biology

Volumn 21, Issue 12, 2014, Pages 1610-1617

  Luo, Hong ^a   Hong, Sung Yong ^a   Sgambelluri, R Michael ^a,b   Angelos, Evan ^a   Li, Xuan ^a,c   Walton, Jonathan D ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c KUNMING UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA AMANITIN; AMINO ACID; MACROCYCLIC COMPOUND; PROLYL ENDOPEPTIDASE; SYNTHETIC PEPTIDE; AMANITIN; PHALLOTOXIN; SERINE PROTEINASE;

ARTICLE; BIOSYNTHESIS; CATALYST; CELL MATURATION; CHEMICAL MODIFICATION; COMPARATIVE STUDY; ENZYME ACTIVE SITE; ENZYME KINETICS; FRACTIONATION; GALERINA MARGINATA; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MUSHROOM; MUSHROOM POISONING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PEPTIDE MACROCYCLIZATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; AMANITA; AMINO ACID SEQUENCE; BIOCATALYSIS; CHEMISTRY; CYCLIZATION; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; SPECIES DIFFERENCE;

ALPHA-AMANITIN; AMANITA; AMANITINS; AMINO ACID SEQUENCE; BIOCATALYSIS; CYCLIZATION; KINETICS; MOLECULAR SEQUENCE DATA; MUTATION; SERINE ENDOPEPTIDASES; SPECIES SPECIFICITY;

EID: 84919903118     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.10.015     Document Type: Article

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