Stepwise characterization of non-synonymous mutations in the HSV-1 thymidine kinase gene by different functional assays

Journal of Virological Methods

Volumn 247, Issue , 2017, Pages 51-57

  Kaspar, Marisa ^a   Bohn Wippert, Kathrin ^b   Bellstedt, Peter ^a   Häfner, Sabine ^c   Görlach, Matthias ^c   Sauerbrei, Andreas ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b University of Illinois at Urbana Champaign   (United States)

^c FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

Functional assay; HSV 1; Resistance; Thymidine kinase

Indexed keywords

ACICLOVIR; THYMIDINE; THYMIDINE KINASE; BROXURIDINE;

AMINO ACID SUBSTITUTION; ANTIVIRAL RESISTANCE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ESCHERICHIA COLI; GENE MUTATION; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS; THYMIDINE KINASE GENE; ULTRAVIOLET SPECTROSCOPY; VIRUS GENE; WESTERN BLOTTING; ENZYMOLOGY; GENETICS; HUMAN ALPHAHERPESVIRUS 1; METABOLISM; MISSENSE MUTATION; PHOSPHORYLATION;

ACYCLOVIR; AMINO ACID SUBSTITUTION; BROMODEOXYURIDINE; DRUG RESISTANCE, VIRAL; HERPESVIRUS 1, HUMAN; MUTATION, MISSENSE; PHOSPHORYLATION; THYMIDINE; THYMIDINE KINASE;

EID: 85019992637     PISSN: 01660934     EISSN: 18790984     Source Type: Journal    
DOI: 10.1016/j.jviromet.2017.05.013     Document Type: Article

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