Effects of mutations on herpes simplex virus 1 thymidine kinase functionality: An in vitro assay based on detection of monophosphate forms of acyclovir and thymidine using HPLC/DAD

Antiviral Research

Volumn 95, Issue 3, 2012, Pages 224-228

  Malartre, Nicolas ^a   Boulieu, Roselyne ^b,c   Falah, Nisrine ^d   Cortay, Jean Claude ^d   Lina, Bruno ^a,d   Morfin, Florence ^a,d   Frobert, Emilie ^a,d  

^a HOSPICES CIVILS DE LYON   (France)

^b EDOUARD HERRIOT HOSPITAL   (France)

^c Clinical and Therapeutic Aspects of the Skin Barrier Function   (France)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

ACV resistance; Genotyping; HPLC DAD; HSV1; Thymidine kinase

Indexed keywords

ACICLOVIR; ACICLOVIR PHOSPHATE; THYMIDINE KINASE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANTIVIRAL RESISTANCE; ARTICLE; DIODE ARRAY DETECTION; GENE MUTATION; GENOTYPE; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; VIRUS GENE;

ACYCLOVIR; ANTIVIRAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENOTYPE; HERPESVIRUS 1, HUMAN; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTANT PROTEINS; MUTATION, MISSENSE; THYMIDINE; THYMIDINE KINASE; VIRAL PROTEINS;

HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 84864415229     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.07.001     Document Type: Article

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