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Volumn 79, Issue 9, 2005, Pages 5863-5869

Characterization of herpes simplex virus type 1 thymidine kinase mutants selected under a single round of high-dose brivudin

Author keywords

[No Author keywords available]

Indexed keywords

5 (2 BROMOVINYL) 2' DEOXYURIDINE; ALANINE; ARGININE; CYTOSINE; GLYCINE; GUANINE; SERINE; THREONINE; THYMIDINE KINASE; TRYPTOPHAN; TYROSINE;

EID: 17444409992     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.9.5863-5869.2005     Document Type: Article
Times cited : (46)

References (47)
  • 1
    • 0033952542 scopus 로고    scopus 로고
    • Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene
    • Andrei, G., R. Snoeck, E. De Clercq, R. Esnouf, P. Fiten, and G. Opdenakker. 2000. Resistance of herpes simplex virus type 1 against different phosphonylmethoxyalkyl derivatives of purines and pyrimidines due to specific mutations in the viral DNA polymerase gene. J. Gen. Virol. 81:639-648.
    • (2000) J. Gen. Virol. , vol.81 , pp. 639-648
    • Andrei, G.1    Snoeck, R.2    De Clercq, E.3    Esnouf, R.4    Fiten, P.5    Opdenakker, G.6
  • 2
    • 0037244124 scopus 로고    scopus 로고
    • Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy
    • Bacon, T. H., M. J. Levin, J. J. Leary, R. T. Sarisky, and D. Sutton. 2003. Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin. Microbiol. Rev. 16:114-128.
    • (2003) Clin. Microbiol. Rev. , vol.16 , pp. 114-128
    • Bacon, T.H.1    Levin, M.J.2    Leary, J.J.3    Sarisky, R.T.4    Sutton, D.5
  • 3
    • 0034085553 scopus 로고    scopus 로고
    • Resistance to antiviral drugs in herpes simplex virus infections among allogeneic stem cell transplant recipients: Risk factors and prognostic significance
    • Chakrabarti, S, D. Pillay, D. Ratcliffe, P. A. Cane, K. E. Collinghan, and D. W. Milligan. 2000. Resistance to antiviral drugs in herpes simplex virus infections among allogeneic stem cell transplant recipients: risk factors and prognostic significance. J. Infect. Dis. 181:2055-2058.
    • (2000) J. Infect. Dis. , vol.181 , pp. 2055-2058
    • Chakrabarti, S.1    Pillay, D.2    Ratcliffe, D.3    Cane, P.A.4    Collinghan, K.E.5    Milligan, D.W.6
  • 7
    • 0344304750 scopus 로고    scopus 로고
    • Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus
    • Chibo, D., J. Druce, J. Sasadeusz, and C. Birch. 2004. Molecular analysis of clinical isolates of acyclovir resistant herpes simplex virus. Antivir. Res. 61:83-91.
    • (2004) Antivir. Res. , vol.61 , pp. 83-91
    • Chibo, D.1    Druce, J.2    Sasadeusz, J.3    Birch, C.4
  • 9
    • 0019904116 scopus 로고
    • Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1
    • Coen, D. M., P. A. Schaffer, P. A. Furman, P. M. Keller, and M. H. St. Clair. 1982. Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1. Am. J. Med. 73:351-360.
    • (1982) Am. J. Med. , vol.73 , pp. 351-360
    • Coen, D.M.1    Schaffer, P.A.2    Furman, P.A.3    Keller, P.M.4    St. Clair, M.H.5
  • 11
    • 0027985004 scopus 로고
    • Acyclovir-resistant, pathogenic herpesviruses
    • Coen, D. M. 1994. Acyclovir-resistant, pathogenic herpesviruses. Trends Microbiol. 2:481-485.
    • (1994) Trends Microbiol. , vol.2 , pp. 481-485
    • Coen, D.M.1
  • 12
    • 0001835821 scopus 로고
    • Laboratory studies of herpes simplex virus strains resistant to acyclovir
    • Collins, P., and G. Darby. 1991. Laboratory studies of herpes simplex virus strains resistant to acyclovir. Rev. Med. Virol. 1:19-28.
    • (1991) Rev. Med. Virol. , vol.1 , pp. 19-28
    • Collins, P.1    Darby, G.2
  • 13
    • 0024520120 scopus 로고
    • Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir
    • Collins, P., B. A. Larder, N. M. Oliver, S. Kemp, I. W., Smith, and G. Darby. 1989. Characterization of a DNA polymerase mutant of herpes simplex virus from a severely immunocompromised patient receiving acyclovir. J. Gen. Virol. 70:375-382.
    • (1989) J. Gen. Virol. , vol.70 , pp. 375-382
    • Collins, P.1    Larder, B.A.2    Oliver, N.M.3    Kemp, S.4    Smith, I.W.5    Darby, G.6
  • 14
    • 0024337663 scopus 로고
    • Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence
    • Chrisp, C. E., J. C. Sunstrum, D. R. Averill, Jr., M. Levine, and J. C. Glorioso. 1989. Characterization of encephalitis in adult mice induced by intracerebral inoculation of herpes simplex virus type 1 (KOS) and comparison with mutants showing decreased virulence. Lab. Investig. 60:822-830.
    • (1989) Lab. Investig. , vol.60 , pp. 822-830
    • Chrisp, C.E.1    Sunstrum, J.C.2    Averill Jr., D.R.3    Levine, M.4    Glorioso, J.C.5
  • 15
    • 0019350295 scopus 로고
    • Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance
    • Darby, G., H. J. Field, and S. A. Salisbury. 1981. Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance. Nature 289:81-83.
    • (1981) Nature , vol.289 , pp. 81-83
    • Darby, G.1    Field, H.J.2    Salisbury, S.A.3
  • 16
    • 0021278114 scopus 로고
    • Cooperative effects between two acyclovir resistance loci in herpes simplex virus
    • Darby, G., M. J. Churcher, and B. A. Larder. 1984. Cooperative effects between two acyclovir resistance loci in herpes simplex virus. J. Virol. 50: 838-846.
    • (1984) J. Virol. , vol.50 , pp. 838-846
    • Darby, G.1    Churcher, M.J.2    Larder, B.A.3
  • 17
    • 0022550413 scopus 로고
    • Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide
    • Darby, G., B. A. Larder, and M. M. Inglis. 1986. Evidence that the 'active centre' of the herpes simplex virus thymidine kinase involves an interaction between three distinct regions of the polypeptide. J. Gen. Virol. 67:753-758.
    • (1986) J. Gen. Virol. , vol.67 , pp. 753-758
    • Darby, G.1    Larder, B.A.2    Inglis, M.M.3
  • 18
    • 18544405495 scopus 로고    scopus 로고
    • Bystander effect of purine nucleoside analogues in HSV-1 tk gene therapy is superior to that of pyrimidine nucleoside analogues
    • Degrève, B., E. De Clercq, and J. Balzarini. 1999. Bystander effect of purine nucleoside analogues in HSV-1 tk gene therapy is superior to that of pyrimidine nucleoside analogues. Gene Ther. 6:162-170.
    • (1999) Gene Ther. , vol.6 , pp. 162-170
    • Degrève, B.1    De Clercq, E.2    Balzarini, J.3
  • 19
    • 0025873255 scopus 로고
    • Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(bromovinyl)-2′-deoxyuridine
    • Docherty, J. J., A. T. Dobson, J. J. Trimble, and B. A. Jennings. 1991. Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(bromovinyl)-2′-deoxyuridine. Intervirology 32:308-315.
    • (1991) Intervirology , vol.32 , pp. 308-315
    • Docherty, J.J.1    Dobson, A.T.2    Trimble, J.J.3    Jennings, B.A.4
  • 20
    • 0024598849 scopus 로고
    • The role of herpes simplex virus type 1 thymidine kinase in pathogenesis
    • Efstathiou, S., S. Kemp, G. Darby, and A. C. Minson. 1989. The role of herpes simplex virus type 1 thymidine kinase in pathogenesis. J. Gen. Virol. 70:869-879.
    • (1989) J. Gen. Virol. , vol.70 , pp. 869-879
    • Efstathiou, S.1    Kemp, S.2    Darby, G.3    Minson, A.C.4
  • 22
    • 0018834367 scopus 로고
    • Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo
    • Field, H. J., and G. Darby. 1980. Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo. Antimicrob. Agents Chemother. 17:209-216.
    • (1980) Antimicrob. Agents Chemother. , vol.17 , pp. 209-216
    • Field, H.J.1    Darby, G.2
  • 23
    • 0020362360 scopus 로고
    • Isolation of bromovinyldeoxyuridine-resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir
    • Field, H. J., and J. Neden. 1982. Isolation of bromovinyldeoxyuridine- resistant strains of herpes simplex virus and successful chemotherapy of mice infected with one such strain by using acyclovir. Antiviral Res. 2:243-254.
    • (1982) Antiviral Res. , vol.2 , pp. 243-254
    • Field, H.J.1    Neden, J.2
  • 24
    • 0022533838 scopus 로고
    • Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene
    • Field, H. J., and D. M. Coen. 1986. Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene. J. Virol. 60:286-288.
    • (1986) J. Virol. , vol.60 , pp. 286-288
    • Field, H.J.1    Coen, D.M.2
  • 25
    • 0020066676 scopus 로고
    • Differential phosphorylation of (E)-5-(2-bromovinyl)-2′- deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus
    • Fyfe, J. A. 1982. Differential phosphorylation of (E)-5-(2-bromovinyl)- 2′-deoxyuridine monophosphate by thymidylate kinases from herpes simplex viruses types 1 and 2 and varicella zoster virus. Mol. Pharmacol. 21:432-437.
    • (1982) Mol. Pharmacol. , vol.21 , pp. 432-437
    • Fyfe, J.A.1
  • 26
    • 0031821936 scopus 로고    scopus 로고
    • Phenotypic and genotyic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients
    • Gaudreau, A., E. Hill, H. H. Balfour, Jr., A. Erice, and G. Boivin. 1998. Phenotypic and genotyic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 178:297-303.
    • (1998) J. Infect. Dis. , vol.178 , pp. 297-303
    • Gaudreau, A.1    Hill, E.2    Balfour Jr., H.H.3    Erice, A.4    Boivin, G.5
  • 27
    • 0038210262 scopus 로고    scopus 로고
    • Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to acyclovir
    • Harris, W., P. Collins, F. J. Fenton, W. Snowden, M. Sowa, and G. Darby. 2003. Phenotypic and genotypic characterization of clinical isolates of herpes simplex virus resistant to acyclovir. J. Gen. Virol. 84:1393-1401.
    • (2003) J. Gen. Virol. , vol.84 , pp. 1393-1401
    • Harris, W.1    Collins, P.2    Fenton, F.J.3    Snowden, W.4    Sowa, M.5    Darby, G.6
  • 28
    • 0026063125 scopus 로고
    • In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus
    • Hill, E. L., G. A. Hunter, and M. N. Ellis. 1991. In vitro and in vivo characterization of herpes simplex virus clinical isolates recovered from patients infected with human immunodeficiency virus. Antimicrob. Agents Chemother. 35:2322-2328.
    • (1991) Antimicrob. Agents Chemother. , vol.35 , pp. 2322-2328
    • Hill, E.L.1    Hunter, G.A.2    Ellis, M.N.3
  • 29
    • 0026562712 scopus 로고
    • A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance
    • Hwang, C. B. C., K. L. Ruffner, and D. M. Coen. 1992. A point mutation within a distinct conserved region of the herpes simplex virus DNA polymerase gene confers drug resistance. J. Virol. 66:1774-1776.
    • (1992) J. Virol. , vol.66 , pp. 1774-1776
    • Hwang, C.B.C.1    Ruffner, K.L.2    Coen, D.M.3
  • 30
    • 0028898550 scopus 로고
    • An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase
    • Hwang, C. B. C., and H. J. H. Chen. 1995. An altered spectrum of herpes simplex virus mutations mediated by an antimutator DNA polymerase. Gene 152:191-193.
    • (1995) Gene , vol.152 , pp. 191-193
    • Hwang, C.B.C.1    Chen, H.J.H.2
  • 32
    • 0032528262 scopus 로고    scopus 로고
    • Drug resistance of herpes simplex virus type 1-structural considerations at the molecular level of the thymidine kinase
    • Kussmann-Gerber, S., O. Kuonen, G. Folkers, B. D. Pilger, and L. Scapozza. 1998. Drug resistance of herpes simplex virus type 1-structural considerations at the molecular level of the thymidine kinase. Eur. J. Biochem. 255:472-481.
    • (1998) Eur. J. Biochem. , vol.255 , pp. 472-481
    • Kussmann-Gerber, S.1    Kuonen, O.2    Folkers, G.3    Pilger, B.D.4    Scapozza, L.5
  • 33
    • 0020633163 scopus 로고
    • Characterization of abnormal thymidine kinases induced by drug-resistant strains of herpes simplex virus type 1
    • Larder, B. A., Y. C. Cheng, and G. Darby. 1983. Characterization of abnormal thymidine kinases induced by drug-resistant strains of herpes simplex virus type 1. J. Gen. Virol. 64:523-532.
    • (1983) J. Gen. Virol. , vol.64 , pp. 523-532
    • Larder, B.A.1    Cheng, Y.C.2    Darby, G.3
  • 34
  • 35
    • 0033913918 scopus 로고    scopus 로고
    • Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients
    • Morfin, F., G. Souillet, K. Bilger, T. Ooka, M. Aymard, and D. Thouvenot. 2000. Genetic characterization of thymidine kinase from acyclovir-resistant and -susceptible herpes simplex virus type 1 isolated from bone marrow transplant recipients. J. Infect. Dis. 182:290-293.
    • (2000) J. Infect. Dis. , vol.182 , pp. 290-293
    • Morfin, F.1    Souillet, G.2    Bilger, K.3    Ooka, T.4    Aymard, M.5    Thouvenot, D.6
  • 36
    • 0026575343 scopus 로고
    • Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: Report on a two-year sensitivity screening survey
    • Nugier, F., J. N. Colin, M. Aymard, and M. Langlois. 1992. Occurrence and characterization of acyclovir-resistant herpes simplex virus isolates: report on a two-year sensitivity screening survey. J. Med. Virol. 36:1-12.
    • (1992) J. Med. Virol. , vol.36 , pp. 1-12
    • Nugier, F.1    Colin, J.N.2    Aymard, M.3    Langlois, M.4
  • 37
    • 0031984781 scopus 로고    scopus 로고
    • Penciclovir and pathogenesis phenotypes of drug-resistant herpes simplex virus mutants
    • Pelosi, E., G. B. Mulamba, and D. M. Coen. 1998. Penciclovir and pathogenesis phenotypes of drug-resistant herpes simplex virus mutants. Antivir. Res. 37:17-28.
    • (1998) Antivir. Res. , vol.37 , pp. 17-28
    • Pelosi, E.1    Mulamba, G.B.2    Coen, D.M.3
  • 38
    • 0032567301 scopus 로고    scopus 로고
    • A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice
    • Pelosi, E., F. Rozenberg, D. M. Coen, and K. L. Tyler. 1998. A herpes simplex virus DNA polymerase mutation that specifically attenuates neurovirulence in mice. Virology 252:364-372.
    • (1998) Virology , vol.252 , pp. 364-372
    • Pelosi, E.1    Rozenberg, F.2    Coen, D.M.3    Tyler, K.L.4
  • 39
    • 0033527750 scopus 로고    scopus 로고
    • Substrate diversity of herpes simplex virus thymidine kinase. Impact of the kinematics of the enzyme
    • Pilger, B. D., R. Perozzo, F. Alber, C. Wurth, G. Folkers, L. Scapozza. 1999. Substrate diversity of herpes simplex virus thymidine kinase. Impact of the kinematics of the enzyme. J. Biol. Chem. 274:31967-31973.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31967-31973
    • Pilger, B.D.1    Perozzo, R.2    Alber, F.3    Wurth, C.4    Folkers, G.5    Scapozza, L.6
  • 40
    • 0029092805 scopus 로고
    • Herpes simplex virus resistance to acyclovir: Clinical relevance
    • Pottage, J. C., Jr., and H. A. Kessler. 1995. Herpes simplex virus resistance to acyclovir: clinical relevance. Infect. Agents Dis. 4:115-124.
    • (1995) Infect. Agents Dis. , vol.4 , pp. 115-124
    • Pottage Jr., J.C.1    Kessler, H.A.2
  • 41
    • 33745158157 scopus 로고
    • A simple method of estimating fifty percent endpoints
    • 40a. Reed, J. H., and H. Muench. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. 27:493-497.
    • (1938) Am. J. Hyg. , vol.27 , pp. 493-497
    • Reed, J.H.1    Muench, H.2
  • 42
    • 0024354415 scopus 로고
    • Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity?
    • Sacks, S. L., R. J. Wanklin, D. E. Reece, K. A. Hicks, K. L. Tyler, and D. M. Coen. 1989. Progressive esophagitis from acyclovir-resistant herpes simplex. Clinical roles for DNA polymerase mutants and viral heterogeneity? Ann. Intern. Med. 111:893-899.
    • (1989) Ann. Intern. Med. , vol.111 , pp. 893-899
    • Sacks, S.L.1    Wanklin, R.J.2    Reece, D.E.3    Hicks, K.A.4    Tyler, K.L.5    Coen, D.M.6
  • 46
    • 0020625176 scopus 로고
    • Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1
    • Tenser, R. B. 1983. Intracerebral inoculation of newborn and adult mice with thymidine kinase-deficient mutants of herpes simplex virus type 1. J. Infect. Dis. 147:956.
    • (1983) J. Infect. Dis. , vol.147 , pp. 956
    • Tenser, R.B.1
  • 47
    • 0028334052 scopus 로고
    • Analysis of the thymidine kinase of herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine
    • Wilber, B. A., and J. J. Docherty. 1994. Analysis of the thymidine kinase of herpes simplex virus type 1 isolate that exhibits resistance to (E)-5-(2-bromovinyl)-2′-deoxyuridine. J. Gen. Virol. 75:1743-1747.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1743-1747
    • Wilber, B.A.1    Docherty, J.J.2


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