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Volumn 35, Issue , 2017, Pages 32-42

Anti-diabetic and anti-hyperlipidemic properties of Capparis spinosa L.: In vivo and in vitro evaluation of its nutraceutical potential

Author keywords

Capparis spinosa L; Diabetes; Flavonoids; HPLC; Nutraceuticals; Polyphenols; Amylase; Glucosidase

Indexed keywords


EID: 85019859084     PISSN: 17564646     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jff.2017.05.001     Document Type: Article
Times cited : (134)

References (52)
  • 1
    • 0035106922 scopus 로고    scopus 로고
    • Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats
    • Ahmed, I., Lakhani, M., Gillett, M., John, A., Raza, H., Hypotriglyceridemic and hypocholesterolemic effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced diabetic rats. Diabetes Research and Clinical Practice 51:3 (2001), 155–161.
    • (2001) Diabetes Research and Clinical Practice , vol.51 , Issue.3 , pp. 155-161
    • Ahmed, I.1    Lakhani, M.2    Gillett, M.3    John, A.4    Raza, H.5
  • 4
    • 84984891528 scopus 로고    scopus 로고
    • Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt
    • Bakr, R.O., El Bishbishy, M.H., Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt. Revista Brasileira de Farmacognosia 26 (2016), 514–520.
    • (2016) Revista Brasileira de Farmacognosia , vol.26 , pp. 514-520
    • Bakr, R.O.1    El Bishbishy, M.H.2
  • 5
    • 23744505354 scopus 로고    scopus 로고
    • Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes
    • Cameron, N.E., Gibson, T.M., Nangle, M.R., Cotter, M.A., Inhibitors of advanced glycation end product formation and neurovascular dysfunction in experimental diabetes. Annals of the New York Academy of Sciences 1043:1 (2005), 784–792.
    • (2005) Annals of the New York Academy of Sciences , vol.1043 , Issue.1 , pp. 784-792
    • Cameron, N.E.1    Gibson, T.M.2    Nangle, M.R.3    Cotter, M.A.4
  • 7
    • 85019885121 scopus 로고    scopus 로고
    • Response to cellular injury Ultrastructural Pathology
    • Willey-Blackwell Ames, Iowa, USA
    • Cheville, N., Response to cellular injury Ultrastructural Pathology. 2000, Willey-Blackwell, Ames, Iowa, USA.
    • (2000)
    • Cheville, N.1
  • 8
    • 3242688023 scopus 로고    scopus 로고
    • Caraway and caper: Potential anti-hyperglycaemic plants in diabetic rats
    • Eddouks, M., Lemhadri, A., Michel, J.-B., Caraway and caper: Potential anti-hyperglycaemic plants in diabetic rats. Journal of Ethnopharmacology 94:1 (2004), 143–148.
    • (2004) Journal of Ethnopharmacology , vol.94 , Issue.1 , pp. 143-148
    • Eddouks, M.1    Lemhadri, A.2    Michel, J.-B.3
  • 9
    • 16244379577 scopus 로고    scopus 로고
    • Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats
    • Eddouks, M., Lemhadri, A., Michel, J.-B., Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats. Journal of Ethnopharmacology 98:3 (2005), 345–350.
    • (2005) Journal of Ethnopharmacology , vol.98 , Issue.3 , pp. 345-350
    • Eddouks, M.1    Lemhadri, A.2    Michel, J.-B.3
  • 11
    • 84885927912 scopus 로고    scopus 로고
    • Blood glucose levels and pathology of organs in alloxan-induced diabetic rats treated with hydro-ethanol extracts of Allium sativum and Capparis spinosa
    • Hashemnia, M., Oryan, A., Hamidi, A.-R., Mohammadalipour, A., Blood glucose levels and pathology of organs in alloxan-induced diabetic rats treated with hydro-ethanol extracts of Allium sativum and Capparis spinosa. African Journal of Pharmacy and Pharmacology 6:21 (2012), 1559–1564.
    • (2012) African Journal of Pharmacy and Pharmacology , vol.6 , Issue.21 , pp. 1559-1564
    • Hashemnia, M.1    Oryan, A.2    Hamidi, A.-R.3    Mohammadalipour, A.4
  • 12
  • 13
    • 33645103657 scopus 로고    scopus 로고
    • Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats
    • Kamalakkannan, N., Prince, P.S.M., Antihyperglycaemic and antioxidant effect of rutin, a polyphenolic flavonoid, in streptozotocin-induced diabetic wistar rats. Basic & Clinical Pharmacology & Toxicology 98:1 (2006), 97–103.
    • (2006) Basic & Clinical Pharmacology & Toxicology , vol.98 , Issue.1 , pp. 97-103
    • Kamalakkannan, N.1    Prince, P.S.M.2
  • 17
    • 84992199659 scopus 로고    scopus 로고
    • Multicomponent pattern and biological activities of seven Asphodeline taxa: Potential sources of natural-functional ingredients for bioactive formulations
    • Locatelli, M., Zengin, G., Uysal, A., Carradori, S., De Luca, E., Bellagamba, G., Lazarova, I., Multicomponent pattern and biological activities of seven Asphodeline taxa: Potential sources of natural-functional ingredients for bioactive formulations. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1 (2017), 60–67.
    • (2017) Journal of Enzyme Inhibition and Medicinal Chemistry , vol.32 , Issue.1 , pp. 60-67
    • Locatelli, M.1    Zengin, G.2    Uysal, A.3    Carradori, S.4    De Luca, E.5    Bellagamba, G.6    Lazarova, I.7
  • 18
    • 84896458495 scopus 로고    scopus 로고
    • Chemical standardization studies on Capparis spinosa L.
    • Manikandaselvi, S., Brindha, P., Chemical standardization studies on Capparis spinosa L., 6, 2014, 47–54.
    • (2014) , vol.6 , pp. 47-54
    • Manikandaselvi, S.1    Brindha, P.2
  • 19
    • 84975029644 scopus 로고    scopus 로고
    • Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties
    • Mocan, A., Zengin, G., Uysal, A., Gunes, E., Mollica, A., Degirmenci, N.S., Aktumsek, A., Biological and chemical insights of Morina persica L.: A source of bioactive compounds with multifunctional properties. Journal of Functional Foods 25 (2016), 94–109.
    • (2016) Journal of Functional Foods , vol.25 , pp. 94-109
    • Mocan, A.1    Zengin, G.2    Uysal, A.3    Gunes, E.4    Mollica, A.5    Degirmenci, N.S.6    Aktumsek, A.7
  • 20
    • 84940352357 scopus 로고    scopus 로고
    • Effects of hydroalcoholic extract of Capparis spinosa on histomorphological changes of pancreas in diabetic rats model
    • Mohammadi, J., Mirzaei, A., Delaviz, H., Mohammadi, B., Effects of hydroalcoholic extract of Capparis spinosa on histomorphological changes of pancreas in diabetic rats model. Journal of Birjand University of Medical Sciences 19:3 (2012), 235–244.
    • (2012) Journal of Birjand University of Medical Sciences , vol.19 , Issue.3 , pp. 235-244
    • Mohammadi, J.1    Mirzaei, A.2    Delaviz, H.3    Mohammadi, B.4
  • 24
    • 84903792466 scopus 로고    scopus 로고
    • Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines
    • Niture, N.T., Ansari, A.A., Naik, S.R., Anti-hyperglycemic activity of Rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines. Antioxidants and Lipid Biomarkers 52 (2014), 720–727.
    • (2014) Antioxidants and Lipid Biomarkers , vol.52 , pp. 720-727
    • Niture, N.T.1    Ansari, A.A.2    Naik, S.R.3
  • 25
    • 84881096817 scopus 로고    scopus 로고
    • OECD guidelines for the testing of chemicals: Organization for economic
    • OECD (2008). OECD guidelines for the testing of chemicals: Organization for economic.
    • (2008)
    • OECD1
  • 26
    • 84858952669 scopus 로고    scopus 로고
    • Ocimum Gratissimum Linn causes dose dependent hepatotoxicity in streptozotocin-induced diabetic Wistar rats
    • Onaolapo, A., Onaolapo, O., Ocimum Gratissimum Linn causes dose dependent hepatotoxicity in streptozotocin-induced diabetic Wistar rats. Macedonian Journal of Medical Sciences 5:1 (2012), 17–25.
    • (2012) Macedonian Journal of Medical Sciences , vol.5 , Issue.1 , pp. 17-25
    • Onaolapo, A.1    Onaolapo, O.2
  • 27
    • 83755183909 scopus 로고    scopus 로고
    • Ethanolic extract of Ocimum grattissimum leaves (Linn.) rapidly lowers blood glucose levels in diabetic Wistar rats. Macedonian
    • Onaolapo, A., Onaolapo, O., Adewole, S., Ethanolic extract of Ocimum grattissimum leaves (Linn.) rapidly lowers blood glucose levels in diabetic Wistar rats. Macedonian. Journal of Medical Sciences 4:4 (2011), 351–357.
    • (2011) Journal of Medical Sciences , vol.4 , Issue.4 , pp. 351-357
    • Onaolapo, A.1    Onaolapo, O.2    Adewole, S.3
  • 28
    • 84871627803 scopus 로고    scopus 로고
    • Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats
    • Onaolapo, A.Y., Onaolapo, O.J., Adewole, S.O., Ocimum Gratissimum Linn Worsens Streptozotocin-Induced Nephrotoxicity in Diabetic Wistar Rats. Macedonian Journal of Medical Sciences 5:4 (2012), 382–388.
    • (2012) Macedonian Journal of Medical Sciences , vol.5 , Issue.4 , pp. 382-388
    • Onaolapo, A.Y.1    Onaolapo, O.J.2    Adewole, S.O.3
  • 29
    • 85019904613 scopus 로고    scopus 로고
    • Antioxidant and antidiabetic effect of Capparis spinosa linn. In streptozotocin induced diabetic rats
    • Patel, V., Sharma, V., Antioxidant and antidiabetic effect of Capparis spinosa linn. In streptozotocin induced diabetic rats. European Journal of Biomedical and Pharmaceutical Sciences 2 (2015), 308–318.
    • (2015) European Journal of Biomedical and Pharmaceutical Sciences , vol.2 , pp. 308-318
    • Patel, V.1    Sharma, V.2
  • 30
    • 77952548706 scopus 로고    scopus 로고
    • The role of vitamin E and oxidative stress in diabetes complications
    • Pazdro, R., Burgess, J.R., The role of vitamin E and oxidative stress in diabetes complications. Mechanisms of Ageing and Development 131:4 (2010), 276–286.
    • (2010) Mechanisms of Ageing and Development , vol.131 , Issue.4 , pp. 276-286
    • Pazdro, R.1    Burgess, J.R.2
  • 31
    • 85019932130 scopus 로고    scopus 로고
    • An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats
    • Paper presented at the Veterinary Research Forum.
    • Pournaghi, P., Sadrkhanlou, R. -A., Hasanzadeh, S., & Foroughi, A. (2012). An investigation on body weights, blood glucose levels and pituitary-gonadal axis hormones in diabetic and metformin-treated diabetic female rats. Paper presented at the Veterinary Research Forum.
    • (2012)
    • Pournaghi, P.1    Sadrkhanlou, R.-A.2    Hasanzadeh, S.3    Foroughi, A.4
  • 32
    • 84949815754 scopus 로고    scopus 로고
    • Effect of hydroalcoholic extract of Capparis spinosa fruit on blood sugar and lipid profile of diabetic and normal rats
    • Rahmani, R., Mahmoodi, M., Salehi, M., Effect of hydroalcoholic extract of Capparis spinosa fruit on blood sugar and lipid profile of diabetic and normal rats. Zahedan Journal of Research in Medical Sciences 15:11 (2013), 34–38.
    • (2013) Zahedan Journal of Research in Medical Sciences , vol.15 , Issue.11 , pp. 34-38
    • Rahmani, R.1    Mahmoodi, M.2    Salehi, M.3
  • 33
    • 85019552260 scopus 로고    scopus 로고
    • A review on the medical effects of Capparis spinosa L
    • Rahnavard, R., Razavi, N., A review on the medical effects of Capparis spinosa L. Advanced Herbal Medicine 2:1 (2016), 44–53.
    • (2016) Advanced Herbal Medicine , vol.2 , Issue.1 , pp. 44-53
    • Rahnavard, R.1    Razavi, N.2
  • 34
    • 85019889441 scopus 로고    scopus 로고
    • Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: A virtual screening perspective for the treatment of obesity and diabetes
    • Rasouli, H., Hosseini-Ghazvini, S.M.-B., Adibi, H., Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: A virtual screening perspective for the treatment of obesity and diabetes. Food & Function, 2017, 10.1039/C7FO00220C.
    • (2017) Food & Function
    • Rasouli, H.1    Hosseini-Ghazvini, S.M.-B.2    Adibi, H.3
  • 35
    • 84856449758 scopus 로고    scopus 로고
    • Inhibition of aldose reductase and sorbitol accumulation by dietary rutin
    • Reddy, G.B., Muthenna, P., Akileshwari, C., Saraswat, M., Petrash, J.M., Inhibition of aldose reductase and sorbitol accumulation by dietary rutin. Current Science 101:9 (2011), 1191–1197.
    • (2011) Current Science , vol.101 , Issue.9 , pp. 1191-1197
    • Reddy, G.B.1    Muthenna, P.2    Akileshwari, C.3    Saraswat, M.4    Petrash, J.M.5
  • 36
    • 0842284799 scopus 로고    scopus 로고
    • Β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
    • Robertson, R.P., Harmon, J., Tran, P.O.T., Poitout, V., Β-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53:suppl 1 (2004), S119–S124.
    • (2004) Diabetes , vol.53 , pp. S119-S124
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.T.3    Poitout, V.4
  • 37
    • 84905676608 scopus 로고    scopus 로고
    • Nutraceuticals: Beyond the diet before the drugs
    • Santini, A., Novellino, E., Nutraceuticals: Beyond the diet before the drugs. Current Bioactive Compounds 10:1 (2014), 1–12.
    • (2014) Current Bioactive Compounds , vol.10 , Issue.1 , pp. 1-12
    • Santini, A.1    Novellino, E.2
  • 38
    • 0033989790 scopus 로고    scopus 로고
    • Quercetin triglycoside from Capparis spinosa
    • Sharaf, M., El-Ansari, M., Saleh, N., Quercetin triglycoside from Capparis spinosa. Fitoterapia 71:1 (2000), 46–49.
    • (2000) Fitoterapia , vol.71 , Issue.1 , pp. 46-49
    • Sharaf, M.1    El-Ansari, M.2    Saleh, N.3
  • 39
    • 0037375210 scopus 로고    scopus 로고
    • Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits
    • Sharma, S., Nasir, A., Prabhu, K., Murthy, P., Dev, G., Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. Journal of Ethnopharmacology 85:2 (2003), 201–206.
    • (2003) Journal of Ethnopharmacology , vol.85 , Issue.2 , pp. 201-206
    • Sharma, S.1    Nasir, A.2    Prabhu, K.3    Murthy, P.4    Dev, G.5
  • 41
    • 83055196898 scopus 로고    scopus 로고
    • Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L. and Crithmum maritimum L. before and after submission to a two-step in vitro digestion model
    • Siracusa, L., Kulisic-Bilusic, T., Politeo, O., Krause, I., Dejanovic, B., Ruberto, G., Phenolic composition and antioxidant activity of aqueous infusions from Capparis spinosa L. and Crithmum maritimum L. before and after submission to a two-step in vitro digestion model. Journal of Agricultural and Food Chemistry 59:23 (2011), 12453–12459.
    • (2011) Journal of Agricultural and Food Chemistry , vol.59 , Issue.23 , pp. 12453-12459
    • Siracusa, L.1    Kulisic-Bilusic, T.2    Politeo, O.3    Krause, I.4    Dejanovic, B.5    Ruberto, G.6
  • 43
    • 77957131144 scopus 로고    scopus 로고
    • Phenolic compounds and vitamin antioxidants of caper (Capparis spinosa)
    • Tlili, N., Khaldi, A., Triki, S., Munné-Bosch, S., Phenolic compounds and vitamin antioxidants of caper (Capparis spinosa). Plant Foods for Human Nutrition 65:3 (2010), 260–265.
    • (2010) Plant Foods for Human Nutrition , vol.65 , Issue.3 , pp. 260-265
    • Tlili, N.1    Khaldi, A.2    Triki, S.3    Munné-Bosch, S.4
  • 44
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler, M.C., Hardie, D.G., AMP-activated protein kinase in metabolic control and insulin signaling. Circulation Research 100:3 (2007), 328–341.
    • (2007) Circulation Research , vol.100 , Issue.3 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 46
    • 77956629122 scopus 로고    scopus 로고
    • Natural products as α-amylase and α-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: An update
    • Tundis, R., Loizzo, M., Menichini, F., Natural products as α-amylase and α-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: An update. Mini Reviews in Medicinal Chemistry 10:4 (2010), 315–331.
    • (2010) Mini Reviews in Medicinal Chemistry , vol.10 , Issue.4 , pp. 315-331
    • Tundis, R.1    Loizzo, M.2    Menichini, F.3
  • 47
    • 84976415537 scopus 로고    scopus 로고
    • Natural products to counteract the epidemic of cardiovascular and metabolic disorders
    • Waltenberger, B., Mocan, A., Šmejkal, K., Heiss, E.H., Atanasov, A.G., Natural products to counteract the epidemic of cardiovascular and metabolic disorders. Molecules, 21(6), 2016, 807.
    • (2016) Molecules , vol.21 , Issue.6 , pp. 807
    • Waltenberger, B.1    Mocan, A.2    Šmejkal, K.3    Heiss, E.H.4    Atanasov, A.G.5
  • 48
    • 84929090062 scopus 로고    scopus 로고
    • Natural polyphenols and diabetes: Understanding their mechanism of action
    • Xiao, J., Natural polyphenols and diabetes: Understanding their mechanism of action. Current Medicinal Chemistry 22:1 (2014), 2–3.
    • (2014) Current Medicinal Chemistry , vol.22 , Issue.1 , pp. 2-3
    • Xiao, J.1
  • 50
    • 77954180564 scopus 로고    scopus 로고
    • Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: A comparative study
    • Zafar, M., Naqvi, S.N.U.H., Effects of STZ-induced diabetes on the relative weights of kidney, liver and pancreas in albino rats: A comparative study. International Journal of Morphology 28:1 (2010), 135–142.
    • (2010) International Journal of Morphology , vol.28 , Issue.1 , pp. 135-142
    • Zafar, M.1    Naqvi, S.N.U.H.2
  • 51
    • 84951740703 scopus 로고    scopus 로고
    • A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems
    • Zengin, G., A study on in vitro enzyme inhibitory properties of Asphodeline anatolica: New sources of natural inhibitors for public health problems. Industrial Crops and Products 83 (2016), 39–43.
    • (2016) Industrial Crops and Products , vol.83 , pp. 39-43
    • Zengin, G.1
  • 52
    • 84938529496 scopus 로고    scopus 로고
    • Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: Can Asphodeline roots be considered as a new source of natural compounds?
    • Zengin, G., Locatelli, M., Ceylan, R., Aktumsek, A., Anthraquinone profile, antioxidant and enzyme inhibitory effect of root extracts of eight Asphodeline taxa from Turkey: Can Asphodeline roots be considered as a new source of natural compounds?. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5 (2016), 754–759.
    • (2016) Journal of Enzyme Inhibition and Medicinal Chemistry , vol.31 , Issue.5 , pp. 754-759
    • Zengin, G.1    Locatelli, M.2    Ceylan, R.3    Aktumsek, A.4


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