Hypolipidemic activity of aqueous extract of Capparis spinosa L. in normal and diabetic rats

Journal of Ethnopharmacology

Volumn 98, Issue 3, 2005, Pages 345-350

  Eddouks, M ^a   Lemhadri, A ^a   Michel, J B ^b  

^a MOULAY ISMAIL UNIVERSITY   (Morocco)

^b BICHAT HOSPITAL   (France)

Author keywords

Aqueous extract; Body weight; Capparis spinosa L.; Cholesterol; Hypolipidemic; Oral administration; Triglycerides

Indexed keywords

ANTIDIABETIC AGENT; CAPPARIS EXTRACT; CAPPARIS SPINOSA EXTRACT; CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CAPPARIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; HYPOLIPEMIA; LIPID METABOLISM; MALE; MEDICINAL PLANT; NONHUMAN; RAT; SPECIES COMPARISON; STREPTOZOCIN DIABETES; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT REDUCTION;

EID: 16244379577     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.01.053     Document Type: Article

References (31)

1. I. Ahmed, M.S. Lakhani, M. Gillet, A. John, and H. Raza Hypotriglyceridemic and hypocholesterolemic effects of antidiabetic Momordica charantia (Karela) fruit extract in streptozotocin-induced diabetic rats Diabetes Research and Clinical Practice 51 2001 155 161
2. M.S. Ali-Shtayeh, and S.L. Abu Ghdeib Antifungal activity of plant extracts against dermatophytes Mycoses 42 1999 665 672
3. M.S. Al-Said, E.A. Abdelsattar, S.I. Khalifa, and F.S. El-feraly Isolation and identification of an anti-inflammatory principle from Capparis spinosa Pharmazie 43 1988 640 641
4. L. Anila, and N.R. Vijayalakshmi Flavonoids from Embilica officinalis and Mangifera indica, effectiveness for dyslipidemia Journal of Ethnopharmacology 79 2002 81 87
5. K.N. Bopanna, J. Kannan, S. Gadgil, E.R. Balaraman, and S.P. Rathore Antidiabetic and antihyperglycaemic effects of neem seed kernel powder on alloxan diabetic rabbits Indian Journal of Pharmacology 29 1997 162 167
6. H. Brevard, M. Brambilla, A. Chaintreau, and J.P. Marison Occurrence of elements sulphur in capers (Capparis spinosa L.) and first investigation of the flavour profile. Flavour Fragrance Journal 7 1992 313 321
7. I. Calis, A. Kuruuzum-Uz, P.A. Lorenzetto, and P. Ruedi (6S)-Hydroxy-3-oxalpha-ionol glucosides from Capparis spinosa fruits Phytochemistry 59 2002 451 457
8. M.S. Chi Effects of garlic products on lipids metabolism in cholesterol fed rats Proceedings of Society of Experimental Biology and Medicine, vol. 171 1982 174 178
9. J.S. Choi, T. Yokozawa, and H. Oura Improvement of hyperglycemia and hyperlipidemia in streptozotocin-diabetic rats by a methanolic extract of Prunus davidiana stems and its main component, pruning Planta Medica 57 1991 208 211
10. M. Eddouks, M. Maghrani, A. Lemhadri, M.-L. Ouahidi, and H. Jouad Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet) Journal of Ethnopharmacology 82 2002 97 103
11. M. Eddouks, A. Lemhadri, and J.-B. Michel Caraway and caper: a potential anti-hyperglycaemic plants in diabetic rats Journal of Ethnopharmacology 94 2004 143 148
12. C. Gadgoli, and S.H. Mishra Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa Journal of Ethnopharmacology 66 1999 187 192
13. M.P. Germano, R. De Pasquale, V. D'Angelo, S. Catania, V. Silvari, and C. Costa Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source Journal of Agriculture and Food Chemistry 27 2002 1168 1171
14. H.N. Gingsberg Lipoprotein metabolism and its relationship to atherosclerosis Medicinal and Clinical North America 78 1994 1 20
15. D. Gupta, J. Raju, J. Prakash, and N.-Z. Baquer Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate Diabetes Research and Clinical Practice 46 1999 1 7
16. H. Jouad, M. Haloui, H. Rhiouani, J. El Hilaly, and M. Eddouks Ethnopharmacological survey of medicinal plants used or the treatment of diabetes, cardiac and renal diseases in the North centre region of Morocco (Fez-Boulemane) Journal of Ethnopharmacology 77 2001 175 182
17. W.B. Kannel, and D.L. Mc Gee Diabetes and cardiovascular risk factors: the Framingham study Circulation 59 1979 8 13
18. P. Kedar, and C.H. Chakrabarti Effects of bittergourd (Momordica charantia) seed and glibenclamide in streptozotocin induced diabetes mellitus Indian Journal of Experimental Biology 20 1982 232 235
19. J.J. Kelly, and A.C. Tsai Effect of pectin, gum Arabic and agar on cholesterol absorption, synthesis and turnover in rats Journal of Nutrition 108 1978 630 639
20. K. Khanna, F. Rizvi, and R. Chander Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats Journal of Ethnopharmacology 82 2002 19 22
21. A.S. Koshy, L. Anila, and N.R. Vijayalakshmi Flavonoids from Garcinia cambogia lower lipid levels in hypocholesterolemic rats Food Chemistry 72 2001 289 294
22. D. Kritchevsky Fiber, lipids and atherosclerosis American Journal of Clinical Nutrition 31S 1978 65 74
23. M.F. Mc Carty Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantetheine Medical Hypotheses 56 2001 314 317
24. D. Rajlakshmi, and D.K. Sharma Hypolipidemic effect of different extracts of Clerodendron colebrookranum in normal and high-fat diet fed rats Journal of Ethnopharmacology 90 2004 63 68
25. A. Riyad, S. Abdul-Ghani Abdul-Salam, and S.M. Suleiman Effect of fenugreek and lupine seeds on the development of experimental diabetes in rats Planta Medica 54 1988 286 290
26. M. Sharaf, M.A. El-Ansari, and N.A. Saleh Quercetin triglycoside from Capparis spinosa Fitoterapia 71 2000 46 49
27. S.B. Sharma, A. Nasir, K.M. Prabhu, P.S. Murthy, and G. Dev Hypoglycaemic and hypolipidemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits Journal of Ethnopharmacology 85 2003 201 206
28. H.R. Slater, C.J. Packard, S. Bicker, and Shephered Effects of cholestyramine on receptor mediated plasma clearance and tissue uptake of humain low dnsity lipoprotein in the rabbit Journal of Biological Chemistry 255 1980 10210 10213
29. E. Tsiani, E. Bogdanovic, A. Sorisky, L. Nagy, and I.-G. Fantus Tyrosine phosphatase inhibitors, vanadate and pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol 3-kinase and protein kinase C Diabetes 47 1998 1676 1686
30. Z. Yaniv, A. Dafni, J. Friedman, and D. Palevitch Plants used for the treatment of diabetes in Israel Journal of Ethnopharmacology 19 1987 145 151
31. A. Ziyyat, A. Legssyer, H. Mekhfi, A. Dassouli, M. Serhrouchni, and W. Benjelloun Phytotherapy of hypertension and diabetes in oriental Morocco Journal of Ethnopharmacology 58 1997 45 54