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Volumn 39, Issue 4, 2017, Pages 395-408

Genetics of rheumatoid arthritis susceptibility, severity, and treatment response

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; C REACTIVE PROTEIN; TUMOR NECROSIS FACTOR INHIBITOR; BIOLOGICAL MARKER;

EID: 85019692719     PISSN: 18632297     EISSN: 18632300     Source Type: Journal    
DOI: 10.1007/s00281-017-0630-4     Document Type: Review
Times cited : (80)

References (139)
  • 1
    • 0024290113 scopus 로고
    • Symmetrical erosive peripheral polyarthritis in the Late Archaic Period of Alabama
    • COI: 1:STN:280:DyaL1czjs1yrsQ%3D%3D, PID: 3047874
    • Rothschild BM, Turner KR, DeLuca MA (1988) Symmetrical erosive peripheral polyarthritis in the Late Archaic Period of Alabama. Science 241:1498–1501
    • (1988) Science , vol.241 , pp. 1498-1501
    • Rothschild, B.M.1    Turner, K.R.2    DeLuca, M.A.3
  • 2
    • 0025119354 scopus 로고
    • Skeletal palaeopathology and the rheumatic diseases: where are we now?
    • COI: 1:STN:280:DyaK3M%2Fns1KjsQ%3D%3D, PID: 2256733
    • Rogers J, Dieppe P (1990) Skeletal palaeopathology and the rheumatic diseases: where are we now? Ann Rheum Dis 49:885–886
    • (1990) Ann Rheum Dis , vol.49 , pp. 885-886
    • Rogers, J.1    Dieppe, P.2
  • 3
    • 0035071010 scopus 로고    scopus 로고
    • The first description of rheumatoid arthritis. Unabridged text of the doctoral dissertation presented in 1800
    • COI: 1:STN:280:DC%2BD3MvpsVGiuw%3D%3D, PID: 11324929
    • Landre-Beauvais AJ (2001) The first description of rheumatoid arthritis. Unabridged text of the doctoral dissertation presented in 1800. Joint Bone Spine 68:130–143
    • (2001) Joint Bone Spine , vol.68 , pp. 130-143
    • Landre-Beauvais, A.J.1
  • 4
    • 0002253558 scopus 로고
    • On the tendency of species to form varieties; and on the perpetuation of varieties and species by natural means of selection
    • Darwin CR, Wallace AR (1858) On the tendency of species to form varieties; and on the perpetuation of varieties and species by natural means of selection. J Proc Linn Soc, Zool 3:45–62
    • (1858) J Proc Linn Soc, Zool , vol.3 , pp. 45-62
    • Darwin, C.R.1    Wallace, A.R.2
  • 5
    • 0002781574 scopus 로고
    • Versuche über Pflanzenhybriden
    • Mendel G (1866) Versuche über Pflanzenhybriden. Verh Nat forsch Ver Brünn 4:3–47
    • (1866) Verh Nat forsch Ver Brünn , vol.4 , pp. 3-47
    • Mendel, G.1
  • 6
    • 13144259698 scopus 로고    scopus 로고
    • Friedrich Miescher and the discovery of DNA
    • COI: 1:CAS:528:DC%2BD2MXos1Kgsw%3D%3D, PID: 15680349
    • Dahm R (2005) Friedrich Miescher and the discovery of DNA. Dev Biol 278:274–288. doi:10.1016/j.ydbio.2004.11.028
    • (2005) Dev Biol , vol.278 , pp. 274-288
    • Dahm, R.1
  • 7
    • 0014620885 scopus 로고
    • Altered reactivity in mixed lymphocyte culture of lymphocytes from patients with rheumatoid arthritis
    • COI: 1:STN:280:DyaE3c%2FnvVSitQ%3D%3D, PID: 5363253
    • Astorga GP, Williams RC Jr (1969) Altered reactivity in mixed lymphocyte culture of lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum 12:547–554
    • (1969) Arthritis Rheum , vol.12 , pp. 547-554
    • Astorga, G.P.1    Williams, R.C.2
  • 8
    • 0017157626 scopus 로고
    • Mixed lymphocyte cultures in rheumatoid arthritis
    • COI: 1:STN:280:DyaE287mslyrtQ%3D%3D, PID: 1262462
    • Stastny P (1976) Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest 57:1148–1157. doi:10.1172/JCI108382
    • (1976) J Clin Invest , vol.57 , pp. 1148-1157
    • Stastny, P.1
  • 9
    • 0017605318 scopus 로고
    • HLA-Dw4 in adult and juvenile rheumatoid arthritis
    • COI: 1:STN:280:DyaE1c%2FpslGltA%3D%3D, PID: 146287
    • Stastny P, Fink CW (1977) HLA-Dw4 in adult and juvenile rheumatoid arthritis. Transplant Proc 9:1863–1866
    • (1977) Transplant Proc , vol.9 , pp. 1863-1866
    • Stastny, P.1    Fink, C.W.2
  • 10
    • 0017878054 scopus 로고
    • Association of the B-cell alloantigen DRw4 with rheumatoid arthritis
    • COI: 1:CAS:528:DyaE1cXhvVOgtbs%3D, PID: 147420
    • Stastny P (1978) Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298:869–871. doi:10.1056/NEJM197804202981602
    • (1978) N Engl J Med , vol.298 , pp. 869-871
    • Stastny, P.1
  • 11
    • 85021181776 scopus 로고    scopus 로고
    • http://www.ebi.ac.uk/ipd/imgt/hla/. 2017. -
    • (2017)
  • 13
    • 85021074837 scopus 로고    scopus 로고
    • http://hla.alleles.org/nomenclature/. 2017. -
    • (2017)
  • 14
    • 84964409165 scopus 로고    scopus 로고
    • Family history of rheumatoid arthritis: an old concept with new developments
    • COI: 1:CAS:528:DC%2BC28XmsFChu7o%3D, PID: 27098907
    • Frisell T, Saevarsdottir S, Askling J (2016) Family history of rheumatoid arthritis: an old concept with new developments. Nat Rev Rheumatol 12:335–343. doi:10.1038/nrrheum.2016.52
    • (2016) Nat Rev Rheumatol , vol.12 , pp. 335-343
    • Frisell, T.1    Saevarsdottir, S.2    Askling, J.3
  • 15
    • 0026020217 scopus 로고
    • The familial nature of rheumatoid arthritis
    • COI: 1:STN:280:DyaK3M7js1ehuw%3D%3D, PID: 1994873
    • Deighton CM, Walker DJ (1991) The familial nature of rheumatoid arthritis. Ann Rheum Dis 50:62–65
    • (1991) Ann Rheum Dis , vol.50 , pp. 62-65
    • Deighton, C.M.1    Walker, D.J.2
  • 16
    • 0021363322 scopus 로고
    • The familial aggregation of rheumatoid arthritis and its relationship to the HLA-DR4 association
    • del JD, Luthra HS, Annegers JF, Worthington JW, Kurland LT (1984) The familial aggregation of rheumatoid arthritis and its relationship to the HLA-DR4 association. Am J Epidemiol 119:813–829
    • (1984) Am J Epidemiol , vol.119 , pp. 813-829
    • del, J.D.1    Luthra, H.S.2    Annegers, J.F.3    Worthington, J.W.4    Kurland, L.T.5
  • 18
    • 61649085373 scopus 로고    scopus 로고
    • Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions
    • PID: 19248111
    • Hemminki K, Li X, Sundquist J, Sundquist K (2009) Familial associations of rheumatoid arthritis with autoimmune diseases and related conditions. Arthritis Rheum 60:661–668. doi:10.1002/art.24328
    • (2009) Arthritis Rheum , vol.60 , pp. 661-668
    • Hemminki, K.1    Li, X.2    Sundquist, J.3    Sundquist, K.4
  • 19
    • 0014822605 scopus 로고
    • Heberden Oration, 1969. Rheumatoid arthritis—nature or nurture?
    • COI: 1:STN:280:DyaE3c3nvVyisw%3D%3D, PID: 4916766
    • Lawrence JS (1970) Heberden Oration, 1969. Rheumatoid arthritis—nature or nurture? Ann Rheum Dis 29:357–379
    • (1970) Ann Rheum Dis , vol.29 , pp. 357-379
    • Lawrence, J.S.1
  • 20
    • 0023740498 scopus 로고
    • Prevalence of familial occurrence in patients with rheumatoid arthritis
    • PID: 3401648
    • Wolfe F, Kleinheksel SM, Khan MA (1988) Prevalence of familial occurrence in patients with rheumatoid arthritis. Br J Rheumatol 27(Suppl 2):150–152
    • (1988) Br J Rheumatol , vol.27 , pp. 150-152
    • Wolfe, F.1    Kleinheksel, S.M.2    Khan, M.A.3
  • 21
    • 0023024826 scopus 로고
    • Occurrence of rheumatoid arthritis in a nationwide series of twins
    • COI: 1:STN:280:DyaL2s7ktV2quw%3D%3D, PID: 3820198
    • Aho K, Koskenvuo M, Tuominen J, Kaprio J (1986) Occurrence of rheumatoid arthritis in a nationwide series of twins. J Rheumatol 13:899–902
    • (1986) J Rheumatol , vol.13 , pp. 899-902
    • Aho, K.1    Koskenvuo, M.2    Tuominen, J.3    Kaprio, J.4
  • 22
    • 0034121235 scopus 로고    scopus 로고
    • Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins
    • COI: 1:STN:280:DC%2BD3c7gs1Cqsw%3D%3D, PID: 10643697
    • MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, Silman AJ (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43:30–37. doi:10.1002/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B
    • (2000) Arthritis Rheum , vol.43 , pp. 30-37
    • MacGregor, A.J.1    Snieder, H.2    Rigby, A.S.3    Koskenvuo, M.4    Kaprio, J.5    Aho, K.6    Silman, A.J.7
  • 23
    • 0037006252 scopus 로고    scopus 로고
    • Relative importance of genetic effects in rheumatoid arthritis: historical cohort study of Danish nationwide twin population
    • PID: 11823356
    • Svendsen AJ, Holm NV, Kyvik K, Petersen PH, Junker P (2002) Relative importance of genetic effects in rheumatoid arthritis: historical cohort study of Danish nationwide twin population. BMJ 324:264–266
    • (2002) BMJ , vol.324 , pp. 264-266
    • Svendsen, A.J.1    Holm, N.V.2    Kyvik, K.3    Petersen, P.H.4    Junker, P.5
  • 24
    • 84874521997 scopus 로고    scopus 로고
    • On the origin of rheumatoid arthritis: the impact of environment and genes—a population based twin study
    • COI: 1:CAS:528:DC%2BC3sXjvFKhsrg%3D, PID: 23468964
    • Svendsen AJ, Kyvik KO, Houen G, Junker P, Christensen K, Christiansen L, Nielsen C et al (2013) On the origin of rheumatoid arthritis: the impact of environment and genes—a population based twin study. PLoS One 8:e57304. doi:10.1371/journal.pone.0057304
    • (2013) PLoS One , vol.8
    • Svendsen, A.J.1    Kyvik, K.O.2    Houen, G.3    Junker, P.4    Christensen, K.5    Christiansen, L.6    Nielsen, C.7
  • 25
    • 84886780720 scopus 로고    scopus 로고
    • Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age
    • COI: 1:CAS:528:DC%2BC3sXhslSqurfI, PID: 23897126
    • Frisell T, Holmqvist M, Kallberg H, Klareskog L, Alfredsson L, Askling J (2013) Familial risks and heritability of rheumatoid arthritis: role of rheumatoid factor/anti-citrullinated protein antibody status, number and type of affected relatives, sex, and age. Arthritis Rheum 65:2773–2782. doi:10.1002/art.38097
    • (2013) Arthritis Rheum , vol.65 , pp. 2773-2782
    • Frisell, T.1    Holmqvist, M.2    Kallberg, H.3    Klareskog, L.4    Alfredsson, L.5    Askling, J.6
  • 26
    • 78650856517 scopus 로고    scopus 로고
    • GCTA: a tool for genome-wide complex trait analysis
    • COI: 1:CAS:528:DC%2BC3MXktVejtg%3D%3D, PID: 21167468
    • Yang J, Lee SH, Goddard ME, Visscher PM (2011) GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 88:76–82. doi:10.1016/j.ajhg.2010.11.011
    • (2011) Am J Hum Genet , vol.88 , pp. 76-82
    • Yang, J.1    Lee, S.H.2    Goddard, M.E.3    Visscher, P.M.4
  • 27
    • 77954140531 scopus 로고    scopus 로고
    • Common SNPs explain a large proportion of the heritability for human height
    • COI: 1:CAS:528:DC%2BC3cXns1GisL8%3D, PID: 20562875
    • Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA et al (2010) Common SNPs explain a large proportion of the heritability for human height. Nat Genet 42:565–569. doi:10.1038/ng.608
    • (2010) Nat Genet , vol.42 , pp. 565-569
    • Yang, J.1    Benyamin, B.2    McEvoy, B.P.3    Gordon, S.4    Henders, A.K.5    Nyholt, D.R.6    Madden, P.A.7
  • 28
    • 84870919039 scopus 로고    scopus 로고
    • Improved heritability estimation from genome-wide SNPs
    • COI: 1:CAS:528:DC%2BC38XhvVWis7bP, PID: 23217325
    • Speed D, Hemani G, Johnson MR, Balding DJ (2012) Improved heritability estimation from genome-wide SNPs. Am J Hum Genet 91:1011–1021. doi:10.1016/j.ajhg.2012.10.010
    • (2012) Am J Hum Genet , vol.91 , pp. 1011-1021
    • Speed, D.1    Hemani, G.2    Johnson, M.R.3    Balding, D.J.4
  • 29
    • 84952907851 scopus 로고    scopus 로고
    • New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis
    • PID: 26286434
    • Lee SH, Byrne EM, Hultman CM, Kahler A, Vinkhuyzen AA, Ripke S, Andreassen OA et al (2015) New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Int J Epidemiol 44:1706–1721. doi:10.1093/ije/dyv136
    • (2015) Int J Epidemiol , vol.44 , pp. 1706-1721
    • Lee, S.H.1    Byrne, E.M.2    Hultman, C.M.3    Kahler, A.4    Vinkhuyzen, A.A.5    Ripke, S.6    Andreassen, O.A.7
  • 30
    • 84859515219 scopus 로고    scopus 로고
    • Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study
    • PID: 22219137
    • Knevel R, Grondal G, Huizinga TW, Visser AW, Jonsson H, Vikingsson A, Geirsson AJ et al (2012) Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study. Ann Rheum Dis 71:707–709. doi:10.1136/annrheumdis-2011-200627
    • (2012) Ann Rheum Dis , vol.71 , pp. 707-709
    • Knevel, R.1    Grondal, G.2    Huizinga, T.W.3    Visser, A.W.4    Jonsson, H.5    Vikingsson, A.6    Geirsson, A.J.7
  • 31
    • 84901928838 scopus 로고    scopus 로고
    • Genetic and epigenetic predictors of responsiveness to treatment in RA
    • COI: 1:CAS:528:DC%2BC2cXivFyjt7k%3D, PID: 24535543
    • Plant D, Wilson AG, Barton A (2014) Genetic and epigenetic predictors of responsiveness to treatment in RA. Nat Rev Rheumatol 10:329–337. doi:10.1038/nrrheum.2014.16
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 329-337
    • Plant, D.1    Wilson, A.G.2    Barton, A.3
  • 32
    • 84954242997 scopus 로고    scopus 로고
    • Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis
    • Umicevic MM, Janss L, Vermeulen SH, van de Laar MA, van Riel PL, Guchelaar HJ, Brunner HG et al (2015) Estimation of heritability of different outcomes for genetic studies of TNFi response in patients with rheumatoid arthritis. Ann Rheum Dis 74:2183–2187. doi:10.1136/annrheumdis-2014-205541
    • (2015) Ann Rheum Dis , vol.74 , pp. 2183-2187
    • Umicevic, M.M.1    Janss, L.2    Vermeulen, S.H.3    van de Laar, M.A.4    van Riel, P.L.5    Guchelaar, H.J.6    Brunner, H.G.7
  • 33
    • 84984705713 scopus 로고    scopus 로고
    • Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC28XhsVSrsbnJ, PID: 27549343
    • Sieberts SK, Zhu F, Garcia-Garcia J, Stahl E, Pratap A, Pandey G, Pappas D et al (2016) Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis. Nat Commun 7:12460. doi:10.1038/ncomms12460
    • (2016) Nat Commun , vol.7 , pp. 12460
    • Sieberts, S.K.1    Zhu, F.2    Garcia-Garcia, J.3    Stahl, E.4    Pratap, A.5    Pandey, G.6    Pappas, D.7
  • 34
    • 84994126498 scopus 로고    scopus 로고
    • Update on the genetic architecture of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC28XhslOqtr7N, PID: 27811914
    • Kim K, Bang SY, Lee HS, Bae SC (2017) Update on the genetic architecture of rheumatoid arthritis. Nat Rev Rheumatol 13:13–24. doi:10.1038/nrrheum.2016.176
    • (2017) Nat Rev Rheumatol , vol.13 , pp. 13-24
    • Kim, K.1    Bang, S.Y.2    Lee, H.S.3    Bae, S.C.4
  • 35
    • 84855283714 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis: GWAS and beyond
    • PID: 27790002
    • McAllister K, Eyre S, Orozco G (2011) Genetics of rheumatoid arthritis: GWAS and beyond. Open Access Rheumatol 3:31–46. doi:10.2147/OARRR.S14725
    • (2011) Open Access Rheumatol , vol.3 , pp. 31-46
    • McAllister, K.1    Eyre, S.2    Orozco, G.3
  • 36
    • 84984863636 scopus 로고    scopus 로고
    • Recent advances in defining the genetic basis of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC28XosVegsL8%3D, PID: 27216775
    • Terao C, Raychaudhuri S, Gregersen PK (2016) Recent advances in defining the genetic basis of rheumatoid arthritis. Annu Rev Genomics Hum Genet 17:273–301. doi:10.1146/annurev-genom-090314-045919
    • (2016) Annu Rev Genomics Hum Genet , vol.17 , pp. 273-301
    • Terao, C.1    Raychaudhuri, S.2    Gregersen, P.K.3
  • 37
    • 84874721851 scopus 로고    scopus 로고
    • Genetics and epigenetics of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXjsFartrw%3D, PID: 23381558
    • Viatte S, Plant D, Raychaudhuri S (2013) Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol 9:141–153. doi:10.1038/nrrheum.2012.237
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 141-153
    • Viatte, S.1    Plant, D.2    Raychaudhuri, S.3
  • 38
    • 84930376747 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis in Asia—present and future
    • COI: 1:CAS:528:DC%2BC2MXisVyjsbg%3D, PID: 25668139
    • Yamamoto K, Okada Y, Suzuki A, Kochi Y (2015) Genetics of rheumatoid arthritis in Asia—present and future. Nat Rev Rheumatol 11:375–379. doi:10.1038/nrrheum.2015.7
    • (2015) Nat Rev Rheumatol , vol.11 , pp. 375-379
    • Yamamoto, K.1    Okada, Y.2    Suzuki, A.3    Kochi, Y.4
  • 39
    • 84961905801 scopus 로고    scopus 로고
    • The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA
    • Yarwood A, Huizinga TW, Worthington J (2016) The genetics of rheumatoid arthritis: risk and protection in different stages of the evolution of RA. Rheumatology (Oxford) 55:199–209. doi:10.1093/rheumatology/keu323
    • (2016) Rheumatology (Oxford) , vol.55 , pp. 199-209
    • Yarwood, A.1    Huizinga, T.W.2    Worthington, J.3
  • 40
    • 84978872739 scopus 로고    scopus 로고
    • Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery
    • COI: 1:CAS:528:DC%2BC28Xps1Wltbw%3D, PID: 27267163
    • Yarwood A, Eyre S, Worthington J (2016) Genetic susceptibility to rheumatoid arthritis and its implications for novel drug discovery. Expert Opin Drug Discov 11:805–813. doi:10.1080/17460441.2016.1195366
    • (2016) Expert Opin Drug Discov , vol.11 , pp. 805-813
    • Yarwood, A.1    Eyre, S.2    Worthington, J.3
  • 41
    • 84894288992 scopus 로고    scopus 로고
    • Genetics of rheumatoid arthritis contributes to biology and drug discovery
    • COI: 1:CAS:528:DC%2BC2cXivVCjs78%3D, PID: 24390342
    • Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y et al (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506:376–381. doi:10.1038/nature12873
    • (2014) Nature , vol.506 , pp. 376-381
    • Okada, Y.1    Wu, D.2    Trynka, G.3    Raj, T.4    Terao, C.5    Ikari, K.6    Kochi, Y.7
  • 43
    • 84862776511 scopus 로고    scopus 로고
    • Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC38XhtlOmurk%3D, PID: 22286218
    • Raychaudhuri S, Sandor C, Stahl EA, Freudenberg J, Lee HS, Jia X, Alfredsson L et al (2012) Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet 44:291–296. doi:10.1038/ng.1076
    • (2012) Nat Genet , vol.44 , pp. 291-296
    • Raychaudhuri, S.1    Sandor, C.2    Stahl, E.A.3    Freudenberg, J.4    Lee, H.S.5    Jia, X.6    Alfredsson, L.7
  • 44
    • 0036222676 scopus 로고    scopus 로고
    • Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67–74 of the HLA-DRB1 molecule
    • PID: 11953968
    • de Vries N, Tijssen H, van Riel PL, van de Putte LB (2002) Reshaping the shared epitope hypothesis: HLA-associated risk for rheumatoid arthritis is encoded by amino acid substitutions at positions 67–74 of the HLA-DRB1 molecule. Arthritis Rheum 46:921–928. doi:10.1002/art.10210
    • (2002) Arthritis Rheum , vol.46 , pp. 921-928
    • de Vries, N.1    Tijssen, H.2    van Riel, P.L.3    van de Putte, L.B.4
  • 45
    • 84928731411 scopus 로고    scopus 로고
    • Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response
    • PID: 25919528
    • Viatte S, Plant D, Han B, Fu B, Yarwood A, Thomson W, Symmons DP et al (2015) Association of HLA-DRB1 haplotypes with rheumatoid arthritis severity, mortality, and treatment response. JAMA 313:1645–1656. doi:10.1001/jama.2015.3435
    • (2015) JAMA , vol.313 , pp. 1645-1656
    • Viatte, S.1    Plant, D.2    Han, B.3    Fu, B.4    Yarwood, A.5    Thomson, W.6    Symmons, D.P.7
  • 46
    • 84897992288 scopus 로고    scopus 로고
    • Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity
    • COI: 1:CAS:528:DC%2BC2cXks1Orsrg%3D, PID: 24656864
    • Han B, Diogo D, Eyre S, Kallberg H, Zhernakova A, Bowes J, Padyukov L et al (2014) Fine mapping seronegative and seropositive rheumatoid arthritis to shared and distinct HLA alleles by adjusting for the effects of heterogeneity. Am J Hum Genet 94:522–532. doi:10.1016/j.ajhg.2014.02.013
    • (2014) Am J Hum Genet , vol.94 , pp. 522-532
    • Han, B.1    Diogo, D.2    Eyre, S.3    Kallberg, H.4    Zhernakova, A.5    Bowes, J.6    Padyukov, L.7
  • 47
    • 84888116736 scopus 로고    scopus 로고
    • A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXhvVKjsbfN, PID: 24190431
    • Scally SW, Petersen J, Law SC, Dudek NL, Nel HJ, Loh KL, Wijeyewickrema LC et al (2013) A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. J Exp Med 210:2569–2582. doi:10.1084/jem.20131241
    • (2013) J Exp Med , vol.210 , pp. 2569-2582
    • Scally, S.W.1    Petersen, J.2    Law, S.C.3    Dudek, N.L.4    Nel, H.J.5    Loh, K.L.6    Wijeyewickrema, L.C.7
  • 48
    • 85027928051 scopus 로고    scopus 로고
    • A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides
    • COI: 1:STN:280:DC%2BC2cvlsVyjug%3D%3D, PID: 24532677
    • Bossini-Castillo L, de KC, Kallberg H, van ‘t Slot R, Italiaander A, Coenen M, Tak PP et al (2015) A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides. Ann Rheum Dis 74:e15. doi:10.1136/annrheumdis-2013-204591
    • (2015) Ann Rheum Dis , vol.74
    • Bossini-Castillo, L.1    de, K.C.2    Kallberg, H.3    van ‘t Slot, R.4    Italiaander, A.5    Coenen, M.6    Tak, P.P.7
  • 49
    • 3242713277 scopus 로고    scopus 로고
    • A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD2cXlvFehs74%3D, PID: 15208781
    • Begovich AB, Carlton VE, Honigberg LA, Schrodi SJ, Chokkalingam AP, Alexander HC, Ardlie KG et al (2004) A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 75:330–337. doi:10.1086/422827
    • (2004) Am J Hum Genet , vol.75 , pp. 330-337
    • Begovich, A.B.1    Carlton, V.E.2    Honigberg, L.A.3    Schrodi, S.J.4    Chokkalingam, A.P.5    Alexander, H.C.6    Ardlie, K.G.7
  • 50
    • 84862809846 scopus 로고    scopus 로고
    • Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
    • COI: 1:CAS:528:DC%2BC38XksVehsLo%3D, PID: 22446963
    • Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T et al (2012) Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nat Genet 44:511–516. doi:10.1038/ng.2231
    • (2012) Nat Genet , vol.44 , pp. 511-516
    • Okada, Y.1    Terao, C.2    Ikari, K.3    Kochi, Y.4    Ohmura, K.5    Suzuki, A.6    Kawaguchi, T.7
  • 51
    • 77952888454 scopus 로고    scopus 로고
    • Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
    • COI: 1:CAS:528:DC%2BC3cXlsl2jsrw%3D, PID: 20453842
    • Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y et al (2010) Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 42:508–514. doi:10.1038/ng.582
    • (2010) Nat Genet , vol.42 , pp. 508-514
    • Stahl, E.A.1    Raychaudhuri, S.2    Remmers, E.F.3    Xie, G.4    Eyre, S.5    Thomson, B.P.6    Li, Y.7
  • 52
    • 84888988248 scopus 로고    scopus 로고
    • Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data
    • COI: 1:CAS:528:DC%2BC3sXhvVGrsbzI, PID: 24022229
    • McAllister K, Yarwood A, Bowes J, Orozco G, Viatte S, Diogo D, Hocking LJ et al (2013) Identification of BACH2 and RAD51B as rheumatoid arthritis susceptibility loci in a meta-analysis of genome-wide data. Arthritis Rheum 65:3058–3062. doi:10.1002/art.38183
    • (2013) Arthritis Rheum , vol.65 , pp. 3058-3062
    • McAllister, K.1    Yarwood, A.2    Bowes, J.3    Orozco, G.4    Viatte, S.5    Diogo, D.6    Hocking, L.J.7
  • 53
    • 84897018997 scopus 로고    scopus 로고
    • Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study
    • COI: 1:CAS:528:DC%2BC2cXhsVSqsrzJ, PID: 24449572
    • Orozco G, Viatte S, Bowes J, Martin P, Wilson AG, Morgan AW, Steer S et al (2014) Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. Arthritis Rheumatol. 66:24–30. doi:10.1002/art.38196
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 24-30
    • Orozco, G.1    Viatte, S.2    Bowes, J.3    Martin, P.4    Wilson, A.G.5    Morgan, A.W.6    Steer, S.7
  • 54
    • 84899756990 scopus 로고    scopus 로고
    • Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans
    • COI: 1:CAS:528:DC%2BC2cXhtlyktLbK, PID: 24782177
    • Jiang L, Yin J, Ye L, Yang J, Hemani G, Liu AJ, Zou H et al (2014) Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. Arthritis Rheumatol. 66:1121–1132. doi:10.1002/art.38353
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 1121-1132
    • Jiang, L.1    Yin, J.2    Ye, L.3    Yang, J.4    Hemani, G.5    Liu, A.J.6    Zou, H.7
  • 55
    • 84974817803 scopus 로고    scopus 로고
    • A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis
    • Julia A, Gonzalez I, Fernandez-Nebro A, Blanco F, Rodriguez L, Gonzalez A, Canete JD et al (2016) A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis. Rheumatology (Oxford) 55:1106–1111. doi:10.1093/rheumatology/kew035
    • (2016) Rheumatology (Oxford) , vol.55 , pp. 1106-1111
    • Julia, A.1    Gonzalez, I.2    Fernandez-Nebro, A.3    Blanco, F.4    Rodriguez, L.5    Gonzalez, A.6    Canete, J.D.7
  • 56
    • 78751705333 scopus 로고    scopus 로고
    • A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis
    • PID: 21156761
    • Padyukov L, Seielstad M, Ong RT, Ding B, Ronnelid J, Seddighzadeh M, Alfredsson L et al (2011) A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis. Ann Rheum Dis 70:259–265. doi:10.1136/ard.2009.126821
    • (2011) Ann Rheum Dis , vol.70 , pp. 259-265
    • Padyukov, L.1    Seielstad, M.2    Ong, R.T.3    Ding, B.4    Ronnelid, J.5    Seddighzadeh, M.6    Alfredsson, L.7
  • 57
    • 84929298327 scopus 로고    scopus 로고
    • Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population
    • PID: 25927497
    • Terao C, Ohmura K, Kochi Y, Ikari K, Okada Y, Shimizu M, Nishina N et al (2015) Anti-citrullinated peptide/protein antibody (ACPA)-negative RA shares a large proportion of susceptibility loci with ACPA-positive RA: a meta-analysis of genome-wide association study in a Japanese population. Arthritis Res. Ther. 17:104. doi:10.1186/s13075-015-0623-4
    • (2015) Arthritis Res. Ther. , vol.17 , pp. 104
    • Terao, C.1    Ohmura, K.2    Kochi, Y.3    Ikari, K.4    Okada, Y.5    Shimizu, M.6    Nishina, N.7
  • 58
    • 84870531924 scopus 로고    scopus 로고
    • High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC38Xhs1Ckt77E, PID: 23143596
    • Eyre S, Bowes J, Diogo D, Lee A, Barton A, Martin P, Zhernakova A et al (2012) High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 44:1336–1340. doi:10.1038/ng.2462
    • (2012) Nat Genet , vol.44 , pp. 1336-1340
    • Eyre, S.1    Bowes, J.2    Diogo, D.3    Lee, A.4    Barton, A.5    Martin, P.6    Zhernakova, A.7
  • 59
    • 84976579799 scopus 로고    scopus 로고
    • Replication of associations of genetic loci outside the HLA region with susceptibility to anti-cyclic citrullinated peptide-negative rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC28XhtVCltrvJ, PID: 26895230
    • Viatte S, Massey J, Bowes J, Duffus K, Eyre S, Barton A, Worthington J (2016) Replication of associations of genetic loci outside the HLA region with susceptibility to anti-cyclic citrullinated peptide-negative rheumatoid arthritis. Arthritis Rheumatol. 68:1603–1613. doi:10.1002/art.39619
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 1603-1613
    • Viatte, S.1    Massey, J.2    Bowes, J.3    Duffus, K.4    Eyre, S.5    Barton, A.6    Worthington, J.7
  • 60
    • 84878739093 scopus 로고    scopus 로고
    • Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
    • COI: 1:CAS:528:DC%2BC3sXmt1SrtLg%3D, PID: 23603761
    • Hinks A, Cobb J, Marion MC, Prahalad S, Sudman M, Bowes J, Martin P et al (2013) Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis. Nat Genet 45:664–669. doi:10.1038/ng.2614
    • (2013) Nat Genet , vol.45 , pp. 664-669
    • Hinks, A.1    Cobb, J.2    Marion, M.C.3    Prahalad, S.4    Sudman, M.5    Bowes, J.6    Martin, P.7
  • 61
    • 84874779411 scopus 로고    scopus 로고
    • Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk
    • COI: 1:CAS:528:DC%2BC3sXlt1Wlsrk%3D, PID: 23315543
    • Lill CM, Schjeide BM, Graetz C, Liu T, Damotte V, Akkad DA, Blaschke P et al (2013) Genome-wide significant association of ANKRD55 rs6859219 and multiple sclerosis risk. J Med Genet 50:140–143. doi:10.1136/jmedgenet-2012-101411
    • (2013) J Med Genet , vol.50 , pp. 140-143
    • Lill, C.M.1    Schjeide, B.M.2    Graetz, C.3    Liu, T.4    Damotte, V.5    Akkad, D.A.6    Blaschke, P.7
  • 62
    • 84868502721 scopus 로고    scopus 로고
    • Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients
    • COI: 1:CAS:528:DC%2BC3sXosVKhtw%3D%3D, PID: 22661644
    • Viatte S, Plant D, Bowes J, Lunt M, Eyre S, Barton A, Worthington J (2012) Genetic markers of rheumatoid arthritis susceptibility in anti-citrullinated peptide antibody negative patients. Ann Rheum Dis 71:1984–1990. doi:10.1136/annrheumdis-2011-201225
    • (2012) Ann Rheum Dis , vol.71 , pp. 1984-1990
    • Viatte, S.1    Plant, D.2    Bowes, J.3    Lunt, M.4    Eyre, S.5    Barton, A.6    Worthington, J.7
  • 64
    • 77955463306 scopus 로고    scopus 로고
    • A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3cXhtVykt7fL, PID: 19734133
    • Skinningsrud B, Lie BA, Husebye ES, Kvien TK, Forre O, Flato B, Stormyr A et al (2010) A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-cyclic citrullinated peptide antibody negative rheumatoid arthritis. Ann Rheum Dis 69:1471–1474
    • (2010) Ann Rheum Dis , vol.69 , pp. 1471-1474
    • Skinningsrud, B.1    Lie, B.A.2    Husebye, E.S.3    Kvien, T.K.4    Forre, O.5    Flato, B.6    Stormyr, A.7
  • 65
    • 34547492359 scopus 로고    scopus 로고
    • Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BD2sXovFSgtrc%3D, PID: 17599733
    • Sigurdsson S, Padyukov L, Kurreeman FA, Liljedahl U, Wiman AC, Alfredsson L, Toes R et al (2007) Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis. Arthritis Rheum 56:2202–2210
    • (2007) Arthritis Rheum , vol.56 , pp. 2202-2210
    • Sigurdsson, S.1    Padyukov, L.2    Kurreeman, F.A.3    Liljedahl, U.4    Wiman, A.C.5    Alfredsson, L.6    Toes, R.7
  • 66
    • 84864032178 scopus 로고    scopus 로고
    • A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA—negative RA in a large Asian cohort
    • COI: 1:CAS:528:DC%2BC38XhtV2mtrbN, PID: 22829930
    • Guo J, Wu X, Too CL, Yin F, Lu X, He J, Li R et al (2012) A replication study confirms the association of dendritic cell immunoreceptor (DCIR) polymorphisms with ACPA—negative RA in a large Asian cohort. PLoS One 7:e41228
    • (2012) PLoS One , vol.7
    • Guo, J.1    Wu, X.2    Too, C.L.3    Yin, F.4    Lu, X.5    He, J.6    Li, R.7
  • 68
    • 84902316871 scopus 로고    scopus 로고
    • Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis
    • PID: 24779919
    • Li C, Mu R, Guo J, Wu X, Tu X, Liu X, Hu F et al (2014) Genetic variant in IL33 is associated with susceptibility to rheumatoid arthritis. Arthritis Res. Ther. 16:R105. doi:10.1186/ar4554
    • (2014) Arthritis Res. Ther. , vol.16 , pp. R105
    • Li, C.1    Mu, R.2    Guo, J.3    Wu, X.4    Tu, X.5    Liu, X.6    Hu, F.7
  • 69
    • 77951976129 scopus 로고    scopus 로고
    • Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis
    • COI: 1:CAS:528:DC%2BC3cXlsVSqt7Y%3D, PID: 20234359
    • Kochi Y, Suzuki A, Yamada R, Yamamoto K (2010) Ethnogenetic heterogeneity of rheumatoid arthritis-implications for pathogenesis. Nat Rev Rheumatol 6:290–295. doi:10.1038/nrrheum.2010.23
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 290-295
    • Kochi, Y.1    Suzuki, A.2    Yamada, R.3    Yamamoto, K.4
  • 70
    • 84911495256 scopus 로고    scopus 로고
    • Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations
    • COI: 1:CAS:528:DC%2BC2MXitl2msrc%3D, PID: 25070946
    • Okada Y, Kim K, Han B, Pillai NE, Ong RT, Saw WY, Luo M et al (2014) Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations. Hum Mol Genet 23:6916–6926. doi:10.1093/hmg/ddu387
    • (2014) Hum Mol Genet , vol.23 , pp. 6916-6926
    • Okada, Y.1    Kim, K.2    Han, B.3    Pillai, N.E.4    Ong, R.T.5    Saw, W.Y.6    Luo, M.7
  • 71
    • 84912020278 scopus 로고    scopus 로고
    • HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues
    • COI: 1:CAS:528:DC%2BC2MXislWmug%3D%3D, PID: 25524867
    • Reynolds RJ, Ahmed AF, Danila MI, Hughes LB, Gregersen PK, Raychaudhuri S, Plenge RM et al (2014) HLA-DRB1-associated rheumatoid arthritis risk at multiple levels in African Americans: hierarchical classification systems, amino acid positions, and residues. Arthritis Rheumatol. 66:3274–3282. doi:10.1002/art.38855
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 3274-3282
    • Reynolds, R.J.1    Ahmed, A.F.2    Danila, M.I.3    Hughes, L.B.4    Gregersen, P.K.5    Raychaudhuri, S.6    Plenge, R.M.7
  • 72
    • 84961927084 scopus 로고    scopus 로고
    • Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets
    • COI: 1:CAS:528:DC%2BC28XkvFGrs7g%3D, PID: 27019110
    • Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48:481–487. doi:10.1038/ng.3538
    • (2016) Nat Genet , vol.48 , pp. 481-487
    • Zhu, Z.1    Zhang, F.2    Hu, H.3    Bakshi, A.4    Robinson, M.R.5    Powell, J.E.6    Montgomery, G.W.7
  • 73
    • 80955126044 scopus 로고    scopus 로고
    • Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets
    • COI: 1:CAS:528:DC%2BC3MXhsVKhu7zL, PID: 27880885
    • Hu X, Kim H, Stahl E, Plenge R, Daly M, Raychaudhuri S (2011) Integrating autoimmune risk loci with gene-expression data identifies specific pathogenic immune cell subsets. Am J Hum Genet 89:682. doi:10.1016/j.ajhg.2011.10.010
    • (2011) Am J Hum Genet , vol.89 , pp. 682
    • Hu, X.1    Kim, H.2    Stahl, E.3    Plenge, R.4    Daly, M.5    Raychaudhuri, S.6
  • 74
    • 84873086126 scopus 로고    scopus 로고
    • Chromatin marks identify critical cell types for fine mapping complex trait variants
    • COI: 1:CAS:528:DC%2BC38XhvVOqs7zP, PID: 23263488
    • Trynka G, Sandor C, Han B, Xu H, Stranger BE, Liu XS, Raychaudhuri S (2013) Chromatin marks identify critical cell types for fine mapping complex trait variants. Nat Genet 45:124–130. doi:10.1038/ng.2504
    • (2013) Nat Genet , vol.45 , pp. 124-130
    • Trynka, G.1    Sandor, C.2    Han, B.3    Xu, H.4    Stranger, B.E.5    Liu, X.S.6    Raychaudhuri, S.7
  • 75
    • 84948686586 scopus 로고    scopus 로고
    • Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
    • COI: 1:CAS:528:DC%2BC2MXhvFWksLfE, PID: 26616563
    • Martin P, McGovern A, Orozco G, Duffus K, Yarwood A, Schoenfelder S, Cooper NJ et al (2015) Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci. Nat Commun 6:10069. doi:10.1038/ncomms10069
    • (2015) Nat Commun , vol.6 , pp. 10069
    • Martin, P.1    McGovern, A.2    Orozco, G.3    Duffus, K.4    Yarwood, A.5    Schoenfelder, S.6    Cooper, N.J.7
  • 76
    • 69949176863 scopus 로고    scopus 로고
    • Common regulatory variation impacts gene expression in a cell type-dependent manner
    • COI: 1:CAS:528:DC%2BD1MXhtVOmsrjM, PID: 19644074
    • Dimas AS, Deutsch S, Stranger BE, Montgomery SB, Borel C, Attar-Cohen H, Ingle C et al (2009) Common regulatory variation impacts gene expression in a cell type-dependent manner. Science 325:1246–1250. doi:10.1126/science.1174148
    • (2009) Science , vol.325 , pp. 1246-1250
    • Dimas, A.S.1    Deutsch, S.2    Stranger, B.E.3    Montgomery, S.B.4    Borel, C.5    Attar-Cohen, H.6    Ingle, C.7
  • 77
    • 84923326765 scopus 로고    scopus 로고
    • Genetic and epigenetic fine mapping of causal autoimmune disease variants
    • COI: 1:CAS:528:DC%2BC2cXhvVemtrbP, PID: 25363779
    • Farh KK, Marson A, Zhu J, Kleinewietfeld M, Housley WJ, Beik S, Shoresh N et al (2015) Genetic and epigenetic fine mapping of causal autoimmune disease variants. Nature 518:337–343. doi:10.1038/nature13835
    • (2015) Nature , vol.518 , pp. 337-343
    • Farh, K.K.1    Marson, A.2    Zhu, J.3    Kleinewietfeld, M.4    Housley, W.J.5    Beik, S.6    Shoresh, N.7
  • 78
    • 84900338300 scopus 로고    scopus 로고
    • Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes
    • COI: 1:CAS:528:DC%2BC2cXmvF2mur8%3D, PID: 24786080
    • Raj T, Rothamel K, Mostafavi S, Ye C, Lee MN, Replogle JM, Feng T et al (2014) Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes. Science 344:519–523. doi:10.1126/science.1249547
    • (2014) Science , vol.344 , pp. 519-523
    • Raj, T.1    Rothamel, K.2    Mostafavi, S.3    Ye, C.4    Lee, M.N.5    Replogle, J.M.6    Feng, T.7
  • 79
    • 84928560965 scopus 로고    scopus 로고
    • Super-enhancers delineate disease-associated regulatory nodes in T cells
    • COI: 1:CAS:528:DC%2BC2MXjt1Snur4%3D, PID: 25686607
    • Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR et al (2015) Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature 520:558–562. doi:10.1038/nature14154
    • (2015) Nature , vol.520 , pp. 558-562
    • Vahedi, G.1    Kanno, Y.2    Furumoto, Y.3    Jiang, K.4    Parker, S.C.5    Erdos, M.R.6    Davis, S.R.7
  • 80
    • 84866778111 scopus 로고    scopus 로고
    • The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease
    • Viatte S, Barton A (2012) The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease. European Musculoskeletal Review 7(2):102–107
    • (2012) European Musculoskeletal Review , vol.7 , Issue.2 , pp. 102-107
    • Viatte, S.1    Barton, A.2
  • 81
    • 84992649027 scopus 로고    scopus 로고
    • HLA-DRB1 amino acid positions 11/13, 71, and 74 are associated with inflammation level, disease activity, and the health assessment questionnaire score in patients with inflammatory polyarthritis
    • COI: 1:CAS:528:DC%2BC28XhslGgs77N, PID: 27274008
    • Ling SF, Viatte S, Lunt M, Van Sijl AM, Silva-Fernandez L, Symmons DP, Young A et al (2016) HLA-DRB1 amino acid positions 11/13, 71, and 74 are associated with inflammation level, disease activity, and the health assessment questionnaire score in patients with inflammatory polyarthritis. Arthritis Rheumatol. 68:2618–2628. doi:10.1002/art.39780
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 2618-2628
    • Ling, S.F.1    Viatte, S.2    Lunt, M.3    Van Sijl, A.M.4    Silva-Fernandez, L.5    Symmons, D.P.6    Young, A.7
  • 82
    • 84882543924 scopus 로고    scopus 로고
    • Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2MXjvFehsA%3D%3D, PID: 23956247
    • Knevel R, Klein K, Somers K, Ospelt C, Houwing-Duistermaat JJ, van Nies JA, de Rooy DP et al (2014) Identification of a genetic variant for joint damage progression in autoantibody-positive rheumatoid arthritis. Ann Rheum Dis 73:2038–2046. doi:10.1136/annrheumdis-2013-204050
    • (2014) Ann Rheum Dis , vol.73 , pp. 2038-2046
    • Knevel, R.1    Klein, K.2    Somers, K.3    Ospelt, C.4    Houwing-Duistermaat, J.J.5    van Nies, J.A.6    de Rooy, D.P.7
  • 83
    • 84940658761 scopus 로고    scopus 로고
    • Genetic factors for the severity of ACPA-negative rheumatoid arthritis in 2 cohorts of early disease: a genome-wide study
    • PID: 26077402
    • de Rooy DP, Tsonaka R, Andersson ML, Forslind K, Zhernakova A, Frank-Bertoncelj M, de Kovel CG et al (2015) Genetic factors for the severity of ACPA-negative rheumatoid arthritis in 2 cohorts of early disease: a genome-wide study. J Rheumatol 42:1383–1391. doi:10.3899/jrheum.140741
    • (2015) J Rheumatol , vol.42 , pp. 1383-1391
    • de Rooy, D.P.1    Tsonaka, R.2    Andersson, M.L.3    Forslind, K.4    Zhernakova, A.5    Frank-Bertoncelj, M.6    de Kovel, C.G.7
  • 84
    • 84875985769 scopus 로고    scopus 로고
    • PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study
    • COI: 1:CAS:528:DC%2BC3sXmtlSmu74%3D, PID: 23577190
    • Suzuki T, Ikari K, Yano K, Inoue E, Toyama Y, Taniguchi A, Yamanaka H et al (2013) PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. PLoS One 8:e61045. doi:10.1371/journal.pone.0061045
    • (2013) PLoS One , vol.8
    • Suzuki, T.1    Ikari, K.2    Yano, K.3    Inoue, E.4    Toyama, Y.5    Taniguchi, A.6    Yamanaka, H.7
  • 85
    • 84925745502 scopus 로고    scopus 로고
    • Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies
    • PID: 25580908
    • van Steenbergen HW, Raychaudhuri S, Rodriguez-Rodriguez L, Rantapaa-Dahlqvist S, Berglin E, Toes RE, Huizinga TW et al (2015) Association of valine and leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of anti-citrullinated protein antibodies. Arthritis Rheumatol. 67:877–886. doi:10.1002/art.39018
    • (2015) Arthritis Rheumatol. , vol.67 , pp. 877-886
    • van Steenbergen, H.W.1    Raychaudhuri, S.2    Rodriguez-Rodriguez, L.3    Rantapaa-Dahlqvist, S.4    Berglin, E.5    Toes, R.E.6    Huizinga, T.W.7
  • 86
    • 84940521045 scopus 로고    scopus 로고
    • Do genetic susceptibility variants associate with disease severity in early active rheumatoid arthritis?
    • COI: 1:CAS:528:DC%2BC28XptFWrtrg%3D, PID: 25979711
    • Scott IC, Rijsdijk F, Walker J, Quist J, Spain SL, Tan R, Steer S et al (2015) Do genetic susceptibility variants associate with disease severity in early active rheumatoid arthritis? J Rheumatol 42:1131–1140. doi:10.3899/jrheum.141211
    • (2015) J Rheumatol , vol.42 , pp. 1131-1140
    • Scott, I.C.1    Rijsdijk, F.2    Walker, J.3    Quist, J.4    Spain, S.L.5    Tan, R.6    Steer, S.7
  • 87
    • 85018192721 scopus 로고    scopus 로고
    • A new classification of HLA-DRB1 alleles based on acid-base properties of the amino acids located at positions 13, 70 and 71: impact on ACPA status or structural progression, and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOIR and EAC cohort)
    • PID: 26629363
    • Ruyssen-Witrand A, van Steenbergen HW, van Heemst J, Gourraud PA, Nigon D, Lukas C, Miceli-Richard C et al (2015) A new classification of HLA-DRB1 alleles based on acid-base properties of the amino acids located at positions 13, 70 and 71: impact on ACPA status or structural progression, and meta-analysis on 1235 patients with rheumatoid from two cohorts (ESPOIR and EAC cohort). RMD. Open. 1:e000099. doi:10.1136/rmdopen-2015-000099
    • (2015) RMD. Open. , vol.1
    • Ruyssen-Witrand, A.1    van Steenbergen, H.W.2    van Heemst, J.3    Gourraud, P.A.4    Nigon, D.5    Lukas, C.6    Miceli-Richard, C.7
  • 89
    • 84856016201 scopus 로고    scopus 로고
    • Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population
    • COI: 1:CAS:528:DC%2BC38XhtFWmt74%3D, PID: 22196377
    • Mohamed RH, Pasha HF, El-Shahawy EE (2012) Influence of TRAF1/C5 and STAT4 genes polymorphisms on susceptibility and severity of rheumatoid arthritis in Egyptian population. Cell Immunol 273:67–72
    • (2012) Cell Immunol , vol.273 , pp. 67-72
    • Mohamed, R.H.1    Pasha, H.F.2    El-Shahawy, E.E.3
  • 90
    • 79951715443 scopus 로고    scopus 로고
    • The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register
    • COI: 1:CAS:528:DC%2BC3cXhsFGkurzK
    • Plant D, Thomson W, Lunt M, Flynn E, Martin P, Eyre S, Farragher T et al (2011) The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: results from the Norfolk Arthritis Register. Rheumatology (Oxford) 50:78–84
    • (2011) Rheumatology (Oxford) , vol.50 , pp. 78-84
    • Plant, D.1    Thomson, W.2    Lunt, M.3    Flynn, E.4    Martin, P.5    Eyre, S.6    Farragher, T.7
  • 92
    • 84871114302 scopus 로고    scopus 로고
    • Investigation of rheumatoid arthritis genetic susceptibility markers in the early rheumatoid arthritis study further replicates the TRAF1 association with radiological damage
    • COI: 1:CAS:528:DC%2BC3sXjslSqt70%3D, PID: 23242182
    • Viatte S, Plant D, Lunt M, Fu B, Flynn E, Parker BJ, Galloway J et al (2013) Investigation of rheumatoid arthritis genetic susceptibility markers in the early rheumatoid arthritis study further replicates the TRAF1 association with radiological damage. J Rheumatol 40:144–156
    • (2013) J Rheumatol , vol.40 , pp. 144-156
    • Viatte, S.1    Plant, D.2    Lunt, M.3    Fu, B.4    Flynn, E.5    Parker, B.J.6    Galloway, J.7
  • 93
    • 84866101158 scopus 로고    scopus 로고
    • Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts
    • COI: 1:STN:280:DC%2BC38njtF2ktw%3D%3D, PID: 22586175
    • Knevel R, de Rooy DP, Gregersen PK, Lindqvist E, Wilson AG, Grondal G, Zhernakova A et al (2012) Studying associations between variants in TRAF1-C5 and TNFAIP3-OLIG3 and the progression of joint destruction in rheumatoid arthritis in multiple cohorts. Ann Rheum Dis 71:1753–1755
    • (2012) Ann Rheum Dis , vol.71 , pp. 1753-1755
    • Knevel, R.1    de Rooy, D.P.2    Gregersen, P.K.3    Lindqvist, E.4    Wilson, A.G.5    Grondal, G.6    Zhernakova, A.7
  • 94
    • 84884851276 scopus 로고    scopus 로고
    • Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway
    • COI: 1:CAS:528:DC%2BC3sXhsVClur3E, PID: 24035192
    • Lee JC, Espeli M, Anderson CA, Linterman MA, Pocock JM, Williams NJ, Roberts R et al (2013) Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway. Cell 155:57–69. doi:10.1016/j.cell.2013.08.034
    • (2013) Cell , vol.155 , pp. 57-69
    • Lee, J.C.1    Espeli, M.2    Anderson, C.A.3    Linterman, M.A.4    Pocock, J.M.5    Williams, N.J.6    Roberts, R.7
  • 95
    • 84992618506 scopus 로고    scopus 로고
    • Association between genetic variation in FOXO3 and reductions in inflammation and disease activity in inflammatory polyarthritis
    • COI: 1:CAS:528:DC%2BC28XhslGgs77E, PID: 27214848
    • Viatte S, Lee JC, Fu B, Espeli M, Lunt M, De Wolf JN, Wheeler L et al (2016) Association between genetic variation in FOXO3 and reductions in inflammation and disease activity in inflammatory polyarthritis. Arthritis Rheumatol. 68:2629–2636. doi:10.1002/art.39760
    • (2016) Arthritis Rheumatol. , vol.68 , pp. 2629-2636
    • Viatte, S.1    Lee, J.C.2    Fu, B.3    Espeli, M.4    Lunt, M.5    De Wolf, J.N.6    Wheeler, L.7
  • 97
    • 84885125523 scopus 로고    scopus 로고
    • Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXhsF2htLvN, PID: 23817893
    • Teare MD, Knevel R, Morgan MD, Kleszcz A, Emery P, Moore DJ, Conaghan P et al (2013) Allele-dose association of the C5orf30 rs26232 variant with joint damage in rheumatoid arthritis. Arthritis Rheum 65:2555–2561
    • (2013) Arthritis Rheum , vol.65 , pp. 2555-2561
    • Teare, M.D.1    Knevel, R.2    Morgan, M.D.3    Kleszcz, A.4    Emery, P.5    Moore, D.J.6    Conaghan, P.7
  • 98
    • 84941671291 scopus 로고    scopus 로고
    • C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2MXhsVWgtrvO, PID: 26316022
    • Muthana M, Hawtree S, Wilshaw A, Linehan E, Roberts H, Khetan S, Adeleke G et al (2015) C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis. Proc Natl Acad Sci U S A 112:11618–11623. doi:10.1073/pnas.1501947112
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. 11618-11623
    • Muthana, M.1    Hawtree, S.2    Wilshaw, A.3    Linehan, E.4    Roberts, H.5    Khetan, S.6    Adeleke, G.7
  • 99
    • 84879876338 scopus 로고    scopus 로고
    • Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXhtVKhtrfF, PID: 23529819
    • Knevel R, de Rooy DP, Zhernakova A, Grondal G, Krabben A, Steinsson K, Wijmenga C et al (2013) Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65:1684–1693
    • (2013) Arthritis Rheum , vol.65 , pp. 1684-1693
    • Knevel, R.1    de Rooy, D.P.2    Zhernakova, A.3    Grondal, G.4    Krabben, A.5    Steinsson, K.6    Wijmenga, C.7
  • 102
    • 84865772018 scopus 로고    scopus 로고
    • Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA
    • COI: 1:CAS:528:DC%2BC38XhsFKgurnI, PID: 22798268
    • Maxwell JR, Marinou I, Kuet KP, Orozco G, Moore DJ, Barton A, Worthington J et al (2012) Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA. J Rheumatol 39:1781–1785
    • (2012) J Rheumatol , vol.39 , pp. 1781-1785
    • Maxwell, J.R.1    Marinou, I.2    Kuet, K.P.3    Orozco, G.4    Moore, D.J.5    Barton, A.6    Worthington, J.7
  • 104
    • 84870511681 scopus 로고    scopus 로고
    • Meta-analysis identified the TNFA-308G>A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXitlSgt7s%3D, PID: 23217265
    • Toonen EJ, Barrera P, Fransen J, de Brouwer AP, Eijsbouts AM, Miossec P, Marotte H et al (2012) Meta-analysis identified the TNFA-308G>A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis. Arthritis Res. Ther. 14:R264. doi:10.1186/ar4110
    • (2012) Arthritis Res. Ther. , vol.14 , pp. R264
    • Toonen, E.J.1    Barrera, P.2    Fransen, J.3    de Brouwer, A.P.4    Eijsbouts, A.M.5    Miossec, P.6    Marotte, H.7
  • 105
    • 84889022684 scopus 로고    scopus 로고
    • Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts
    • COI: 1:CAS:528:DC%2BC3sXhvVGrsLbJ, PID: 23983153
    • Krabben A, Wilson AG, de Rooy DP, Zhernakova A, Brouwer E, Lindqvist E, Saxne T et al (2013) Association of genetic variants in the IL4 and IL4R genes with the severity of joint damage in rheumatoid arthritis: a study in seven cohorts. Arthritis Rheum 65:3051–3057
    • (2013) Arthritis Rheum , vol.65 , pp. 3051-3057
    • Krabben, A.1    Wilson, A.G.2    de Rooy, D.P.3    Zhernakova, A.4    Brouwer, E.5    Lindqvist, E.6    Saxne, T.7
  • 107
    • 84875373794 scopus 로고    scopus 로고
    • Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population
    • COI: 1:CAS:528:DC%2BC3sXitVGhs74%3D, PID: 23394902
    • Hussein YM, El-Shal AS, Rezk NA, Abdel Galil SM, Alzahrani SS (2013) Influence of interleukin-4 gene polymorphisms and interleukin-4 serum level on susceptibility and severity of rheumatoid arthritis in Egyptian population. Cytokine 61:849–855
    • (2013) Cytokine , vol.61 , pp. 849-855
    • Hussein, Y.M.1    El-Shal, A.S.2    Rezk, N.A.3    Abdel Galil, S.M.4    Alzahrani, S.S.5
  • 108
    • 84875920469 scopus 로고    scopus 로고
    • Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis
    • PID: 23041840
    • de Rooy DP, Yeremenko NG, Wilson AG, Knevel R, Lindqvist E, Saxne T, Krabben A et al (2013) Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann Rheum Dis 72:769–775. doi:10.1136/annrheumdis-2012-202184
    • (2013) Ann Rheum Dis , vol.72 , pp. 769-775
    • de Rooy, D.P.1    Yeremenko, N.G.2    Wilson, A.G.3    Knevel, R.4    Lindqvist, E.5    Saxne, T.6    Krabben, A.7
  • 109
    • 84899933765 scopus 로고    scopus 로고
    • A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis
    • PID: 23696630
    • de Rooy DP, Zhernakova A, Tsonaka R, Willemze A, Kurreeman BA, Trynka G, van Toorn L et al (2014) A genetic variant in the region of MMP-9 is associated with serum levels and progression of joint damage in rheumatoid arthritis. Ann Rheum Dis 73:1163–1169. doi:10.1136/annrheumdis-2013-203375
    • (2014) Ann Rheum Dis , vol.73 , pp. 1163-1169
    • de Rooy, D.P.1    Zhernakova, A.2    Tsonaka, R.3    Willemze, A.4    Kurreeman, B.A.5    Trynka, G.6    van Toorn, L.7
  • 110
    • 84874441173 scopus 로고    scopus 로고
    • A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXjtlGqsLY%3D, PID: 23440692
    • Knevel R, Krabben A, Wilson AG, Brouwer E, Leijsma MK, Lindqvist E, de Rooy DP et al (2013) A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Rheum 65:582–589
    • (2013) Arthritis Rheum , vol.65 , pp. 582-589
    • Knevel, R.1    Krabben, A.2    Wilson, A.G.3    Brouwer, E.4    Leijsma, M.K.5    Lindqvist, E.6    de Rooy, D.P.7
  • 111
    • 84866937907 scopus 로고    scopus 로고
    • CCR5 gene polymorphism is a genetic risk factor for radiographic severity of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC38XhvV2ntL%2FK, PID: 22924548
    • Han SW, Sa KH, Kim SI, Lee SI, Park YW, Lee SS, Yoo WH et al (2012) CCR5 gene polymorphism is a genetic risk factor for radiographic severity of rheumatoid arthritis. Tissue Antigens 80:416–423. doi:10.1111/j.1399-0039.2012.01955.x
    • (2012) Tissue Antigens , vol.80 , pp. 416-423
    • Han, S.W.1    Sa, K.H.2    Kim, S.I.3    Lee, S.I.4    Park, Y.W.5    Lee, S.S.6    Yoo, W.H.7
  • 112
    • 84862801520 scopus 로고    scopus 로고
    • FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC38Xkt1GgsLg%3D, PID: 22386693
    • Han SW, Sa KH, Kim SI, Lee SI, Park YW, Lee SS, Yoo WH et al (2012) FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis. Hum Immunol 73:537–542. doi:10.1016/j.humimm.2012.02.011
    • (2012) Hum Immunol , vol.73 , pp. 537-542
    • Han, S.W.1    Sa, K.H.2    Kim, S.I.3    Lee, S.I.4    Park, Y.W.5    Lee, S.S.6    Yoo, W.H.7
  • 113
    • 84866062778 scopus 로고    scopus 로고
    • Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study
    • COI: 1:CAS:528:DC%2BC38Xhs1SqurzF, PID: 22440823
    • Knevel R, Krabben A, Brouwer E, Posthumus MD, Wilson AG, Lindqvist E, Saxne T et al (2012) Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study. Ann Rheum Dis 71:1651–1657
    • (2012) Ann Rheum Dis , vol.71 , pp. 1651-1657
    • Knevel, R.1    Krabben, A.2    Brouwer, E.3    Posthumus, M.D.4    Wilson, A.G.5    Lindqvist, E.6    Saxne, T.7
  • 114
    • 84895421568 scopus 로고    scopus 로고
    • Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2cXosVehsL4%3D, PID: 24273077
    • Yoshida S, Ikari K, Yano K, Toyama Y, Taniguchi A, Yamanaka H, Momohara S (2014) Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis. Ann Rheum Dis 73:784–785
    • (2014) Ann Rheum Dis , vol.73 , pp. 784-785
    • Yoshida, S.1    Ikari, K.2    Yano, K.3    Toyama, Y.4    Taniguchi, A.5    Yamanaka, H.6    Momohara, S.7
  • 115
    • 84898669483 scopus 로고    scopus 로고
    • Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2cXhtl2qtbjK, PID: 24757135
    • Du Y, Cui Y, Liu X, Hu F, Yang Y, Wu X, Liu X et al (2014) Contribution of functional LILRA3, but not nonfunctional LILRA3, to sex bias in susceptibility and severity of anti-citrullinated protein antibody-positive rheumatoid arthritis. Arthritis Rheumatol. 66:822–830. doi:10.1002/art.38308
    • (2014) Arthritis Rheumatol. , vol.66 , pp. 822-830
    • Du, Y.1    Cui, Y.2    Liu, X.3    Hu, F.4    Yang, Y.5    Wu, X.6    Liu, X.7
  • 116
    • 84925231407 scopus 로고    scopus 로고
    • SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis
    • PID: 24936586
    • Juge PA, van Steenbergen HW, Constantin A, Tobon GJ, Schaeverbeke T, Gazal S, Combe B et al (2014) SPP1 rs9138 variant contributes to the severity of radiological damage in anti-citrullinated protein autoantibody-negative rheumatoid arthritis. Ann Rheum Dis 73:1840–1843. doi:10.1136/annrheumdis-2014-205539
    • (2014) Ann Rheum Dis , vol.73 , pp. 1840-1843
    • Juge, P.A.1    van Steenbergen, H.W.2    Constantin, A.3    Tobon, G.J.4    Schaeverbeke, T.5    Gazal, S.6    Combe, B.7
  • 117
    • 84901389239 scopus 로고    scopus 로고
    • A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis
    • PID: 24886600
    • Knevel R, de Rooy DP, Saxne T, Lindqvist E, Leijsma MK, Daha NA, Koeleman BP et al (2014) A genetic variant in osteoprotegerin is associated with progression of joint destruction in rheumatoid arthritis. Arthritis Res. Ther. 16:R108. doi:10.1186/ar4558
    • (2014) Arthritis Res. Ther. , vol.16 , pp. R108
    • Knevel, R.1    de Rooy, D.P.2    Saxne, T.3    Lindqvist, E.4    Leijsma, M.K.5    Daha, N.A.6    Koeleman, B.P.7
  • 118
    • 84946401247 scopus 로고    scopus 로고
    • PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts
    • PID: 26538147
    • Rodriguez-Rodriguez L, Ivorra-Cortes J, Carmona FD, Martin J, Balsa A, van Steenbergen HW, van der Helm-van Mil AH et al (2015) PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts. Arthritis Res Ther 17:306. doi:10.1186/s13075-015-0830-z
    • (2015) Arthritis Res Ther , vol.17 , pp. 306
    • Rodriguez-Rodriguez, L.1    Ivorra-Cortes, J.2    Carmona, F.D.3    Martin, J.4    Balsa, A.5    van Steenbergen, H.W.6    van der Helm-van Mil, A.H.7
  • 119
    • 84945452189 scopus 로고    scopus 로고
    • The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2MXht1Kiur7M, PID: 26226010
    • Danila MI, Westfall AO, Raman K, Chen L, Reynolds RJ, Hughes LB, Arnett DK et al (2015) The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis. Genes Immun 16:446–451. doi:10.1038/gene.2015.24
    • (2015) Genes Immun , vol.16 , pp. 446-451
    • Danila, M.I.1    Westfall, A.O.2    Raman, K.3    Chen, L.4    Reynolds, R.J.5    Hughes, L.B.6    Arnett, D.K.7
  • 120
    • 77949495704 scopus 로고    scopus 로고
    • Genetic influences modulating the radiological severity of rheumatoid arthritis
    • COI: 1:STN:280:DC%2BC3c7ns1Wluw%3D%3D, PID: 20124360
    • Marinou I, Maxwell JR, Wilson AG (2010) Genetic influences modulating the radiological severity of rheumatoid arthritis. Ann Rheum Dis 69:476–482. doi:10.1136/ard.2009.117721
    • (2010) Ann Rheum Dis , vol.69 , pp. 476-482
    • Marinou, I.1    Maxwell, J.R.2    Wilson, A.G.3
  • 121
    • 33751416149 scopus 로고    scopus 로고
    • Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register
    • COI: 1:CAS:528:DC%2BD28Xht1Kns73E
    • Hyrich KL, Watson KD, Silman AJ, Symmons DP (2006) Predictors of response to anti-TNF-alpha therapy among patients with rheumatoid arthritis: results from the British Society for Rheumatology Biologics Register. Rheumatology (Oxford) 45:1558–1565. doi:10.1093/rheumatology/kel149
    • (2006) Rheumatology (Oxford) , vol.45 , pp. 1558-1565
    • Hyrich, K.L.1    Watson, K.D.2    Silman, A.J.3    Symmons, D.P.4
  • 122
    • 84901789226 scopus 로고    scopus 로고
    • Biologic therapies in rheumatoid arthritis and the risk of opportunistic infections: a meta-analysis
    • PID: 24647016
    • Kourbeti IS, Ziakas PD, Mylonakis E (2014) Biologic therapies in rheumatoid arthritis and the risk of opportunistic infections: a meta-analysis. Clin Infect Dis 58:1649–1657. doi:10.1093/cid/ciu185
    • (2014) Clin Infect Dis , vol.58 , pp. 1649-1657
    • Kourbeti, I.S.1    Ziakas, P.D.2    Mylonakis, E.3
  • 123
    • 84960496176 scopus 로고    scopus 로고
    • Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches
    • COI: 1:CAS:528:DC%2BC2sXntFOrtbw%3D, PID: 26620497
    • Shea M, Costa DB, Rangachari D (2016) Management of advanced non-small cell lung cancers with known mutations or rearrangements: latest evidence and treatment approaches. Ther Adv Respir Dis 10:113–129. doi:10.1177/1753465815617871
    • (2016) Ther Adv Respir Dis , vol.10 , pp. 113-129
    • Shea, M.1    Costa, D.B.2    Rangachari, D.3
  • 124
    • 84923856898 scopus 로고    scopus 로고
    • Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases
    • COI: 1:CAS:528:DC%2BC2cXmtlWrtrg%3D, PID: 24709693
    • Cobb J, Cule E, Moncrieffe H, Hinks A, Ursu S, Patrick F, Kassoumeri L et al (2014) Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases. Pharmacogenomics. J. 14:356–364. doi:10.1038/tpj.2014.3
    • (2014) Pharmacogenomics. J. , vol.14 , pp. 356-364
    • Cobb, J.1    Cule, E.2    Moncrieffe, H.3    Hinks, A.4    Ursu, S.5    Patrick, F.6    Kassoumeri, L.7
  • 125
    • 84896394396 scopus 로고    scopus 로고
    • Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation
    • COI: 1:CAS:528:DC%2BC2cXjs1Gqurc%3D, PID: 24583629
    • Senapati S, Singh S, Das M, Kumar A, Gupta R, Kumar U, Jain S et al (2014) Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation. Pharmacogenet Genomics 24:211–219. doi:10.1097/FPC.0000000000000036
    • (2014) Pharmacogenet Genomics , vol.24 , pp. 211-219
    • Senapati, S.1    Singh, S.2    Das, M.3    Kumar, A.4    Gupta, R.5    Kumar, U.6    Jain, S.7
  • 126
    • 84877648835 scopus 로고    scopus 로고
    • GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXntF2jtrk%3D, PID: 23651021
    • Acosta-Colman I, Palau N, Tornero J, Fernandez-Nebro A, Blanco F, Gonzalez-Alvaro I, Canete JD et al (2013) GWAS replication study confirms the association of PDE3A-SLCO1C1 with anti-TNF therapy response in rheumatoid arthritis. Pharmacogenomics 14:727–734. doi:10.2217/pgs.13.60
    • (2013) Pharmacogenomics , vol.14 , pp. 727-734
    • Acosta-Colman, I.1    Palau, N.2    Tornero, J.3    Fernandez-Nebro, A.4    Blanco, F.5    Gonzalez-Alvaro, I.6    Canete, J.D.7
  • 127
    • 84973515323 scopus 로고    scopus 로고
    • Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort
    • COI: 1:CAS:528:DC%2BC28XptFSjt74%3D, PID: 27180831
    • Smith SL, Plant D, Lee XH, Massey J, Hyrich K, Morgan AW, Wilson AG et al (2016) Previously reported PDE3A-SLCO1C1 genetic variant does not correlate with anti-TNF response in a large UK rheumatoid arthritis cohort. Pharmacogenomics 17:715–720. doi:10.2217/pgs.16.16
    • (2016) Pharmacogenomics , vol.17 , pp. 715-720
    • Smith, S.L.1    Plant, D.2    Lee, X.H.3    Massey, J.4    Hyrich, K.5    Morgan, A.W.6    Wilson, A.G.7
  • 128
    • 77954241353 scopus 로고    scopus 로고
    • Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy
    • COI: 1:CAS:528:DC%2BC3cXht1aqsL7F, PID: 20309874
    • Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AH, Nititham J, Hughes LB et al (2010) Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy. Arthritis Rheum 62:1849–1861. doi:10.1002/art.27457
    • (2010) Arthritis Rheum , vol.62 , pp. 1849-1861
    • Cui, J.1    Saevarsdottir, S.2    Thomson, B.3    Padyukov, L.4    van der Helm-van Mil, A.H.5    Nititham, J.6    Hughes, L.B.7
  • 129
    • 84928151802 scopus 로고    scopus 로고
    • Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC2MXnsFymt78%3D, PID: 25896535
    • Ferreiro-Iglesias A, Montes A, Perez-Pampin E, Canete JD, Raya E, Magro-Checa C, Vasilopoulos Y et al (2016) Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis. Pharmacogenomics J 16:137–140. doi:10.1038/tpj.2015.29
    • (2016) Pharmacogenomics J , vol.16 , pp. 137-140
    • Ferreiro-Iglesias, A.1    Montes, A.2    Perez-Pampin, E.3    Canete, J.D.4    Raya, E.5    Magro-Checa, C.6    Vasilopoulos, Y.7
  • 130
    • 84857721973 scopus 로고    scopus 로고
    • Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort
    • COI: 1:CAS:528:DC%2BC38XivVGjtb4%3D, PID: 21952740
    • Plant D, Prajapati R, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A (2012) Replication of association of the PTPRC gene with response to anti-tumor necrosis factor therapy in a large UK cohort. Arthritis Rheum 64:665–670. doi:10.1002/art.33381
    • (2012) Arthritis Rheum , vol.64 , pp. 665-670
    • Plant, D.1    Prajapati, R.2    Hyrich, K.L.3    Morgan, A.W.4    Wilson, A.G.5    Isaacs, J.D.6    Barton, A.7
  • 131
    • 84925307951 scopus 로고    scopus 로고
    • TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy
    • PID: 25834819
    • Canhao H, Rodrigues AM, Santos MJ, Carmona-Fernandes D, Bettencourt BF, Cui J, Rocha FL et al (2015) TRAF1/C5 but not PTPRC variants are potential predictors of rheumatoid arthritis response to anti-tumor necrosis factor therapy. Biomed Res Int 2015:490295. doi:10.1155/2015/490295
    • (2015) Biomed Res Int , vol.2015 , pp. 490295
    • Canhao, H.1    Rodrigues, A.M.2    Santos, M.J.3    Carmona-Fernandes, D.4    Bettencourt, B.F.5    Cui, J.6    Rocha, F.L.7
  • 132
    • 84883816559 scopus 로고    scopus 로고
    • Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population
    • COI: 1:CAS:528:DC%2BC3sXhsVyrsbrI, PID: 24040234
    • Zervou MI, Myrthianou E, Flouri I, Plant D, Chlouverakis G, Castro-Giner F, Rapsomaniki P et al (2013) Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population. PLoS One 8:e74375. doi:10.1371/journal.pone.0074375
    • (2013) PLoS One , vol.8
    • Zervou, M.I.1    Myrthianou, E.2    Flouri, I.3    Plant, D.4    Chlouverakis, G.5    Castro-Giner, F.6    Rapsomaniki, P.7
  • 133
    • 84875993860 scopus 로고    scopus 로고
    • Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis
    • COI: 1:CAS:528:DC%2BC3sXlvVyjsrY%3D, PID: 23555300
    • Cui J, Stahl EA, Saevarsdottir S, Miceli C, Diogo D, Trynka G, Raj T et al (2013) Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis. PLoS Genet 9:e1003394. doi:10.1371/journal.pgen.1003394
    • (2013) PLoS Genet , vol.9
    • Cui, J.1    Stahl, E.A.2    Saevarsdottir, S.3    Miceli, C.4    Diogo, D.5    Trynka, G.6    Raj, T.7
  • 134
    • 84941616276 scopus 로고    scopus 로고
    • Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort
    • Bluett J, Morgan C, Thurston L, Plant D, Hyrich KL, Morgan AW, Wilson AG et al (2015) Impact of inadequate adherence on response to subcutaneously administered anti-tumour necrosis factor drugs: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort. Rheumatology (Oxford) 54:494–499. doi:10.1093/rheumatology/keu358
    • (2015) Rheumatology (Oxford) , vol.54 , pp. 494-499
    • Bluett, J.1    Morgan, C.2    Thurston, L.3    Plant, D.4    Hyrich, K.L.5    Morgan, A.W.6    Wilson, A.G.7
  • 135
    • 84988353382 scopus 로고    scopus 로고
    • Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes
    • PID: 26848403
    • Hope HF, Bluett J, Barton A, Hyrich KL, Cordingley L, Verstappen SM (2016) Psychological factors predict adherence to methotrexate in rheumatoid arthritis; findings from a systematic review of rates, predictors and associations with patient-reported and clinical outcomes. RMD Open 2:e000171. doi:10.1136/rmdopen-2015-000171
    • (2016) RMD Open , vol.2
    • Hope, H.F.1    Bluett, J.2    Barton, A.3    Hyrich, K.L.4    Cordingley, L.5    Verstappen, S.M.6
  • 136
    • 84883822462 scopus 로고    scopus 로고
    • Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation
    • PID: 23300118
    • van Schouwenburg PA, Krieckaert CL, Rispens T, Aarden L, Wolbink GJ, Wouters D (2013) Long-term measurement of anti-adalimumab using pH-shift-anti-idiotype antigen binding test shows predictive value and transient antibody formation. Ann Rheum Dis 72:1680–1686. doi:10.1136/annrheumdis-2012-202407
    • (2013) Ann Rheum Dis , vol.72 , pp. 1680-1686
    • van Schouwenburg, P.A.1    Krieckaert, C.L.2    Rispens, T.3    Aarden, L.4    Wolbink, G.J.5    Wouters, D.6
  • 137
    • 84898669486 scopus 로고    scopus 로고
    • Development and validation of modified disease activity scores in rheumatoid arthritis: superior correlation with magnetic resonance imaging-detected synovitis and radiographic progression
    • PID: 24757132
    • Baker JF, Conaghan PG, Smolen JS, Aletaha D, Shults J, Emery P, Baker DG et al (2014) Development and validation of modified disease activity scores in rheumatoid arthritis: superior correlation with magnetic resonance imaging-detected synovitis and radiographic progression. Arthritis Rheumatol 66:794–802. doi:10.1002/art.38304
    • (2014) Arthritis Rheumatol , vol.66 , pp. 794-802
    • Baker, J.F.1    Conaghan, P.G.2    Smolen, J.S.3    Aletaha, D.4    Shults, J.5    Emery, P.6    Baker, D.G.7
  • 138
    • 84917734196 scopus 로고    scopus 로고
    • Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients
    • PID: 25504080
    • MacIsaac KD, Baumgartner R, Kang J, Loboda A, Peterfy C, DiCarlo J, Riek J et al (2014) Pre-treatment whole blood gene expression is associated with 14-week response assessed by dynamic contrast enhanced magnetic resonance imaging in infliximab-treated rheumatoid arthritis patients. PLoS One 9:e113937. doi:10.1371/journal.pone.0113937
    • (2014) PLoS One , vol.9
    • MacIsaac, K.D.1    Baumgartner, R.2    Kang, J.3    Loboda, A.4    Peterfy, C.5    DiCarlo, J.6    Riek, J.7
  • 139
    • 84918554994 scopus 로고    scopus 로고
    • A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk
    • PID: 24092415
    • Yarwood A, Han B, Raychaudhuri S, Bowes J, Lunt M, Pappas DA, Kremer J et al (2015) A weighted genetic risk score using all known susceptibility variants to estimate rheumatoid arthritis risk. Ann Rheum Dis 74:170–176. doi:10.1136/annrheumdis-2013-204133
    • (2015) Ann Rheum Dis , vol.74 , pp. 170-176
    • Yarwood, A.1    Han, B.2    Raychaudhuri, S.3    Bowes, J.4    Lunt, M.5    Pappas, D.A.6    Kremer, J.7


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