Lack of association between IL-15 genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 73, Issue 4, 2014, Pages 784-785

  Yoshida, Shinji ^a,b   Ikari, Katsunori ^a   Yano, Koichiro ^a   Toyama, Yoshiaki ^b   Taniguchi, Atsuo ^a   Yamanaka, Hisashi ^a   Momohara, Shigeki ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; INTERLEUKIN 15;

ADULT; COHORT ANALYSIS; DISEASE COURSE; DISEASE DURATION; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE MAP; HUMAN; JAPANESE; JOINT DESTRUCTION; LETTER; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

CYTOKINES; GENE POLYMORPHISM; RHEUMATOID ARTHRITIS;

ARTHRITIS, RHEUMATOID; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-15; MALE;

EID: 84895421568     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-203921     Document Type: Letter

References (10)

1. Knevel R, Krabben A, Brouwer E, et al. Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study. Ann Rheum Dis 2012;71:1651-7.
2. Kuca-Warnawin E, Burakowski T, Kurowska W, et al. Elevated number of recently activated T cells in bone marrow of patients with rheumatoid arthritis: a role for interleukin 15? Ann Rheum Dis 2011;70:227-33.
3. Ruckert R, Brandt K, Ernst M, et al. Interleukin-15 stimulates macrophages to activate CD4+ T cells: a role in the pathogenesis of rheumatoid arthritis? Immunology 2009;126:63-73.
4. Okada Y, Terao C, Ikari K, et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics 2012;44:511-16.
5. Ikari K, Momohara S, Inoue E, et al. Haplotype analysis revealed no association between the PTPN22 gene and RA in a Japanese population. Rheumatology (Oxford) 2006;45:1345-8. (Pubitemid 44605467)
6. Suzuki T, Ikari K, Yano K, et al. PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. PLoS ONE 2013;8:e61045.
7. Eyre S, Bowes J, Diogo D, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012;44:1336-40.
8. Stahl EA, Raychaudhuri S, Remmers EF, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet 2010;42:508-14.
9. Park MK, Her YM, Cho ML, et al. IL-15 promotes osteoclastogenesis via the PLD pathway in rheumatoid arthritis. Immunol Lett 2011;139:42-51.
10. Djaafar S, Pierroz DD, Chicheportiche R, et al. Inhibition of T cell-dependent and RANKL-dependent osteoclastogenic processes associated with high levels of bone mass in interleukin-15 receptor-deficient mice. Arthritis Rheum 2010;62:3300-10.