The role of rheumatoid arthritis genetic susceptibility markers in the prediction of erosive disease in patients with early inflammatory polyarthritis: Results from the Norfolk Arthritis Register

Rheumatology

Volumn 50, Issue 1, 2011, Pages 78-84

  Plant, Darren ^a   Thomson, Wendy ^a   Lunt, Mark ^a   Flynn, Edward ^a   Martin, Paul ^a   Eyre, Steven ^a   Farragher, Tracey ^a   Bunn, Diane ^b,c   Worthington, Jane ^a   Symmons, Deborah ^a   Barton, Anne ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b Norfolk Arthritis Register   (United Kingdom)

^c NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Erosions; Genetic association; Inflammatory polyarthritis; Rheumatoid arthritis

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY;

ADULT; AGED; ARTICLE; CLINICAL ASSESSMENT; CLINICAL STUDY; CONTROLLED STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE REGISTRY; DISEASE SEVERITY; FEMALE; FOLLOW UP; GENE FREQUENCY; GENE LOCUS; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; POLYARTHRITIS; PREDICTION; PRIMARY MEDICAL CARE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SEROLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGE OF ONSET; ARTHRITIS; ARTHRITIS, RHEUMATOID; COHORT STUDIES; DISEASE PROGRESSION; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; REGISTRIES; REGRESSION ANALYSIS; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 79951715443     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/keq032     Document Type: Article

References (25)

1. Bukhari M, Thomson W, Naseem H et al. The performance of anti-cyclic citrullinated peptide antibodies in predicting the severity of radiologic damage in inflammatory polyarthritis: results from the Norfolk Arthritis Register. Arthritis Rheum 2007;56:2929-35.
2. De RL, Peene I, Hoffman IE et al. Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis 2004;63:1587-93.
3. Forslind K, Ahlmen M, Eberhardt K, Hafstrom I, Svensson B. Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP). Ann Rheum Dis 2004; 63:1090-5.
4. Inanc N, Dalkilic E, Kamali S et al. Anti-CCP antibodies in rheumatoid arthritis and psoriatic arthritis. Clin Rheumatol 2007;26:17-23.
5. Quinn MA, Gough AK, Green MJ et al. Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome. Rheumatology 2006;45:478-80.
6. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
7. Begovich AB, Carlton VE, Honigberg LA et al. A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis. Am J Hum Genet 2004;75:330-7.
8. Harrison B, Thomson W, Symmons D et al. The influence of HLA-DRB1 alleles and rheumatoid factor on disease outcome in an inception cohort of patients with early inflammatory arthritis. Arthritis Rheum 1999;42:2174-83.
9. Naseem H, Thomson W, Silman A, Worthington J, Symmons D, Barton A. The PTPN22*C1858T functional polymorphism is associated with susceptibility to inflammatory polyarthritis but neither this nor other variants spanning the gene is associated with disease outcome. Ann Rheum Dis 2008;67:251-5.
10. Barton A, Thomson W, Ke X et al. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet 2008;40:1156-9.
11. Barton A, Thomson W, Ke X et al. Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility. Hum Mol Genet 2008;17:2274-9.
12. Barton A, Eyre S, Ke X et al. Identification of AF4/FMR2 family, member 3 (AFF3) as a novel rheumatoid arthritis susceptibility locus and confirmation of two further pan-autoimmune susceptibility genes. Hum Mol Genet 2009;18:2518-22.
13. Bowes J, Barton A. Recent advances in the genetics of RA susceptibility. Rheumatology 2008;47:399-402.
14. Hafler JP, Maier LM, Cooper JD et al. CD226 Gly307Ser association with multiple autoimmune diseases. Genes Immun 2008;10:5-10.
15. Plenge RM, Seielstad M, Padyukov L et al. TRAF1-C5 as a risk locus for rheumatoid arthritis-a genomewide study. N Engl J Med 2007;357:1199-209.
16. Plenge RM, Cotsapas C, Davies L et al. Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. Nat Genet 2007;39:1477-82.
17. Raychaudhuri S, Remmers EF, Lee AT et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 2008;40:1216-23.
18. Thomson W, Barton A, Ke X et al. Rheumatoid arthritis association at 6q23. Nat Genet 2007;39:1431-3.
19. Zhernakova A, Alizadeh BZ, Bevova M et al. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet 2007;81:1284-8.
20. Symmons DP, Silman AJ. The Norfolk Arthritis Register (NOAR). Clin Exp Rheumatol 2003;21:S94-9.
21. Larsen A, Dale K, Eek M. Radiographic evaluation of rheumatoid arthritis and related conditions by standard reference films. Acta Radiol Diagn 1977;18:481-91.
22. Lunt M, Symmons DP, Silman AJ. An evaluation of the decision tree format of the American College of Rheumatology 1987 classification criteria for rheumatoid arthritis: performance over five years in a primary care-based prospective study. Arthritis Rheum 2005;52: 2277-83.
23. Patsopoulos NA, Ioannidis JP. Susceptibility variants for rheumatoid arthritis in the TRAF1-C5 and 6q23 loci: a meta-analysis. Ann Rheum Dis. Advance Access published May 15, 2009, doi:10.1136/ard.2009. 109447.
24. International HapMap Project. HapMap Genome Browser. http://hapmap.ncbi.nlm.nih.gov/(9 March 2009, date last accessed).
25. Kurreeman FA, Padyukov L, Marques RB et al. A candidate gene approach identifies the TRAF1/C5 region as a risk factor for rheumatoid arthritis. PLoS Med 2007;4:e278.