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Volumn 5, Issue 6, 2017, Pages 512-523

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; BIOLOGICAL MARKER; GENOMIC DNA; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RNA;

EID: 85019686560     PISSN: 22132600     EISSN: 22132619     Source Type: Journal    
DOI: 10.1016/S2213-2600(17)30187-X     Document Type: Review
Times cited : (61)

References (107)
  • 2
    • 0343893748 scopus 로고    scopus 로고
    • Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network
    • Network, ARDS, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med 342 (2000), 1301–1308.
    • (2000) N Engl J Med , vol.342 , pp. 1301-1308
    • Network, A.R.D.S.1
  • 3
    • 84873714375 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    • Dellinger, RP, Levy, MM, Rhodes, A, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 39 (2013), 165–228.
    • (2013) Intensive Care Med , vol.39 , pp. 165-228
    • Dellinger, R.P.1    Levy, M.M.2    Rhodes, A.3
  • 4
    • 85009804040 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016
    • Rhodes, A, Evans, LE, Alhazzani, W, et al. Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock: 2016. Crit Care Med 45 (2017), 486–552.
    • (2017) Crit Care Med , vol.45 , pp. 486-552
    • Rhodes, A.1    Evans, L.E.2    Alhazzani, W.3
  • 5
    • 85009760484 scopus 로고    scopus 로고
    • Liberation from mechanical ventilation in critically ill adults: an official American College of Chest Physicians/American Thoracic Society clinical practice guideline: inspiratory pressure augmentation during spontaneous breathing trials, protocols minimizing sedation, and noninvasive ventilation immediately after extubation
    • Ouellette, DR, Patel, S, Girard, TD, et al. Liberation from mechanical ventilation in critically ill adults: an official American College of Chest Physicians/American Thoracic Society clinical practice guideline: inspiratory pressure augmentation during spontaneous breathing trials, protocols minimizing sedation, and noninvasive ventilation immediately after extubation. Chest 151 (2017), 166–180.
    • (2017) Chest , vol.151 , pp. 166-180
    • Ouellette, D.R.1    Patel, S.2    Girard, T.D.3
  • 6
    • 85008600505 scopus 로고    scopus 로고
    • An official American Thoracic Society/American College of Chest Physicians clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests
    • Girard, TD, Alhazzani, W, Kress, JP, et al. An official American Thoracic Society/American College of Chest Physicians clinical practice guideline: liberation from mechanical ventilation in critically ill adults. Rehabilitation protocols, ventilator liberation protocols, and cuff leak tests. Am J Respir Crit Care Med 195 (2017), 120–133.
    • (2017) Am J Respir Crit Care Med , vol.195 , pp. 120-133
    • Girard, T.D.1    Alhazzani, W.2    Kress, J.P.3
  • 7
    • 84959277025 scopus 로고    scopus 로고
    • Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries
    • Bellani, G, Laffey, JG, Pham, T, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA 315 (2016), 788–800.
    • (2016) JAMA , vol.315 , pp. 788-800
    • Bellani, G.1    Laffey, J.G.2    Pham, T.3
  • 8
    • 84862490519 scopus 로고    scopus 로고
    • Acute respiratory distress syndrome: the Berlin Definition
    • Ranieri, VM, Rubenfeld, GD, Thompson, BT, et al., for the ARDS Definition Task Force. Acute respiratory distress syndrome: the Berlin Definition. JAMA 307 (2012), 2526–2533.
    • (2012) JAMA , vol.307 , pp. 2526-2533
    • Ranieri, V.M.1    Rubenfeld, G.D.2    Thompson, B.T.3
  • 9
    • 77956671058 scopus 로고    scopus 로고
    • Neuromuscular blockers in early acute respiratory distress syndrome
    • Papazian, L, Forel, JM, Gacouin, A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med 363 (2010), 1107–1116.
    • (2010) N Engl J Med , vol.363 , pp. 1107-1116
    • Papazian, L.1    Forel, J.M.2    Gacouin, A.3
  • 10
    • 84901759539 scopus 로고    scopus 로고
    • Rosuvastatin for sepsis-associated acute respiratory distress syndrome
    • Truwit, JD, Bernard, GR, Steingrub, J, et al., for the National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med 370 (2014), 2191–2200.
    • (2014) N Engl J Med , vol.370 , pp. 2191-2200
    • Truwit, J.D.1    Bernard, G.R.2    Steingrub, J.3
  • 11
    • 84908434411 scopus 로고    scopus 로고
    • Simvastatin in the acute respiratory distress syndrome
    • McAuley, DF, Laffey, JG, O'Kane, CM, et al. Simvastatin in the acute respiratory distress syndrome. N Engl J Med 371 (2014), 1695–1703.
    • (2014) N Engl J Med , vol.371 , pp. 1695-1703
    • McAuley, D.F.1    Laffey, J.G.2    O'Kane, C.M.3
  • 12
    • 84856102590 scopus 로고    scopus 로고
    • Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial
    • Smith, FG, Perkins, GD, Gates, S, et al., for the BALTI-2 study investigators. Effect of intravenous β-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet 379 (2012), 229–235.
    • (2012) Lancet , vol.379 , pp. 229-235
    • Smith, F.G.1    Perkins, G.D.2    Gates, S.3
  • 13
    • 79960430979 scopus 로고    scopus 로고
    • Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury
    • Matthay, MA, Brower, RG, Carson, S, et al., for the National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network. Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury. Am J Respir Crit Care Med 184 (2011), 561–568.
    • (2011) Am J Respir Crit Care Med , vol.184 , pp. 561-568
    • Matthay, M.A.1    Brower, R.G.2    Carson, S.3
  • 14
    • 3943106162 scopus 로고    scopus 로고
    • Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study
    • Zeiher, BG, Artigas, A, Vincent, JL, et al. Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med 32 (2004), 1695–1702.
    • (2004) Crit Care Med , vol.32 , pp. 1695-1702
    • Zeiher, B.G.1    Artigas, A.2    Vincent, J.L.3
  • 15
    • 84905502770 scopus 로고    scopus 로고
    • Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials
    • Calfee, CS, Delucchi, K, Parsons, PE, Thompson, BT, Ware, LB, Matthay, MA, for the NHLBI ARDS Network. Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2 (2014), 611–620.
    • (2014) Lancet Respir Med , vol.2 , pp. 611-620
    • Calfee, C.S.1    Delucchi, K.2    Parsons, P.E.3    Thompson, B.T.4    Ware, L.B.5    Matthay, M.A.6
  • 17
    • 85014772016 scopus 로고    scopus 로고
    • Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy
    • Famous, KR, Delucchi, K, Ware, LB, et al. Acute respiratory distress syndrome subphenotypes respond differently to randomized fluid management strategy. Am J Respir Crit Care Med 195 (2017), 331–338.
    • (2017) Am J Respir Crit Care Med , vol.195 , pp. 331-338
    • Famous, K.R.1    Delucchi, K.2    Ware, L.B.3
  • 18
    • 84962195226 scopus 로고    scopus 로고
    • Personalized medicine for ARDS: the 2035 research agenda
    • Beitler, JR, Goligher, EC, Schmidt, M, et al. Personalized medicine for ARDS: the 2035 research agenda. Intensive Care Med 42 (2016), 756–767.
    • (2016) Intensive Care Med , vol.42 , pp. 756-767
    • Beitler, J.R.1    Goligher, E.C.2    Schmidt, M.3
  • 19
    • 84988945607 scopus 로고    scopus 로고
    • Toward smarter lumping and smarter splitting: rethinking strategies for sepsis and acute respiratory distress syndrome clinical trial design
    • Prescott, HC, Calfee, CS, Thompson, BT, Angus, DC, Liu, VX, Toward smarter lumping and smarter splitting: rethinking strategies for sepsis and acute respiratory distress syndrome clinical trial design. Am J Respir Crit Care Med 194 (2016), 147–155.
    • (2016) Am J Respir Crit Care Med , vol.194 , pp. 147-155
    • Prescott, H.C.1    Calfee, C.S.2    Thompson, B.T.3    Angus, D.C.4    Liu, V.X.5
  • 20
    • 0345436055 scopus 로고    scopus 로고
    • Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial
    • Ranieri, VM, Suter, PM, Tortorella, C, et al. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA 282 (1999), 54–61.
    • (1999) JAMA , vol.282 , pp. 54-61
    • Ranieri, V.M.1    Suter, P.M.2    Tortorella, C.3
  • 21
    • 12244305569 scopus 로고    scopus 로고
    • Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    • Parsons, PE, Eisner, MD, Thompson, BT, et al. Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury. Crit Care Med 33 (2005), 1–6.
    • (2005) Crit Care Med , vol.33 , pp. 1-6
    • Parsons, P.E.1    Eisner, M.D.2    Thompson, B.T.3
  • 22
    • 0028898380 scopus 로고
    • Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time
    • Meduri, GU, Headley, S, Kohler, G, et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS. Plasma IL-1 beta and IL-6 levels are consistent and efficient predictors of outcome over time. Chest 107 (1995), 1062–1073.
    • (1995) Chest , vol.107 , pp. 1062-1073
    • Meduri, G.U.1    Headley, S.2    Kohler, G.3
  • 23
    • 0028860550 scopus 로고
    • Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome
    • Meduri, GU, Kohler, G, Headley, S, Tolley, E, Stentz, F, Postlethwaite, A, Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest 108 (1995), 1303–1314.
    • (1995) Chest , vol.108 , pp. 1303-1314
    • Meduri, G.U.1    Kohler, G.2    Headley, S.3    Tolley, E.4    Stentz, F.5    Postlethwaite, A.6
  • 24
    • 0017098562 scopus 로고
    • Diffuse alveolar damage—the role of oxygen, shock, and related factors. A review
    • Katzenstein, AL, Bloor, CM, Leibow, AA, Diffuse alveolar damage—the role of oxygen, shock, and related factors. A review. Am J Pathol 85 (1976), 209–228.
    • (1976) Am J Pathol , vol.85 , pp. 209-228
    • Katzenstein, A.L.1    Bloor, C.M.2    Leibow, A.A.3
  • 25
    • 0025988234 scopus 로고
    • Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin
    • Wiener-Kronish, JP, Albertine, KH, Matthay, MA, Differential responses of the endothelial and epithelial barriers of the lung in sheep to Escherichia coli endotoxin. J Clin Invest 88 (1991), 864–875.
    • (1991) J Clin Invest , vol.88 , pp. 864-875
    • Wiener-Kronish, J.P.1    Albertine, K.H.2    Matthay, M.A.3
  • 27
    • 84909632775 scopus 로고    scopus 로고
    • Beyond single-nucleotide polymorphisms: genetics, genomics, and other ‘omic approaches to acute respiratory distress syndrome’
    • Meyer, NJ, Beyond single-nucleotide polymorphisms: genetics, genomics, and other ‘omic approaches to acute respiratory distress syndrome’. Clin Chest Med 35 (2014), 673–684.
    • (2014) Clin Chest Med , vol.35 , pp. 673-684
    • Meyer, N.J.1
  • 28
    • 84959196247 scopus 로고    scopus 로고
    • A pathophysiologic approach to biomarkers in acute respiratory distress syndrome
    • Blondonnet, R, Constantin, JM, Sapin, V, Jabaudon, M, A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers, 2016, 2016, 3501373.
    • (2016) Dis Markers , vol.2016 , pp. 3501373
    • Blondonnet, R.1    Constantin, J.M.2    Sapin, V.3    Jabaudon, M.4
  • 29
    • 84963706241 scopus 로고    scopus 로고
    • Biomarkers of ARDS: what's new?
    • Ware, LB, Calfee, CS, Biomarkers of ARDS: what's new?. Intensive Care Med 42 (2016), 797–799.
    • (2016) Intensive Care Med , vol.42 , pp. 797-799
    • Ware, L.B.1    Calfee, C.S.2
  • 30
    • 84925628291 scopus 로고    scopus 로고
    • Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome
    • Brown, SM, Grissom, CK, Rondina, MT, et al. Polymorphisms in key pulmonary inflammatory pathways and the development of acute respiratory distress syndrome. Exp Lung Res 41 (2015), 155–162.
    • (2015) Exp Lung Res , vol.41 , pp. 155-162
    • Brown, S.M.1    Grissom, C.K.2    Rondina, M.T.3
  • 31
    • 84910664406 scopus 로고    scopus 로고
    • Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by Exome-Seq
    • Shortt, K, Chaudhary, S, Grigoryev, D, et al. Identification of novel single nucleotide polymorphisms associated with acute respiratory distress syndrome by Exome-Seq. PLoS One, 9, 2014, e111953.
    • (2014) PLoS One , vol.9 , pp. e111953
    • Shortt, K.1    Chaudhary, S.2    Grigoryev, D.3
  • 32
    • 84969560171 scopus 로고    scopus 로고
    • Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome
    • Sapru, A, Liu, KD, Wiemels, J, et al. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care, 20, 2016, 151.
    • (2016) Crit Care , vol.20 , pp. 151
    • Sapru, A.1    Liu, K.D.2    Wiemels, J.3
  • 33
    • 84959264724 scopus 로고    scopus 로고
    • Gene control of tyrosine kinase TIE2 and vascular manifestations of infections
    • Ghosh, CC, David, S, Zhang, R, et al. Gene control of tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci USA 113 (2016), 2472–2477.
    • (2016) Proc Natl Acad Sci USA , vol.113 , pp. 2472-2477
    • Ghosh, C.C.1    David, S.2    Zhang, R.3
  • 34
    • 84893854125 scopus 로고    scopus 로고
    • Untargeted LC–MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health
    • Evans, CR, Karnovsky, A, Kovach, MA, Standiford, TJ, Burant, CF, Stringer, KA, Untargeted LC–MS metabolomics of bronchoalveolar lavage fluid differentiates acute respiratory distress syndrome from health. J Proteome Res 13 (2014), 640–649.
    • (2014) J Proteome Res , vol.13 , pp. 640-649
    • Evans, C.R.1    Karnovsky, A.2    Kovach, M.A.3    Standiford, T.J.4    Burant, C.F.5    Stringer, K.A.6
  • 35
    • 78650668101 scopus 로고    scopus 로고
    • Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis
    • Stringer, KA, Serkova, NJ, Karnovsky, A, Guire, K, Paine, R, Standiford, TJ, Metabolic consequences of sepsis-induced acute lung injury revealed by plasma 1H-nuclear magnetic resonance quantitative metabolomics and computational analysis. Am J Physiol Lung Cell Mol Physiol 300 (2011), L4–11.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , pp. L4-11
    • Stringer, K.A.1    Serkova, N.J.2    Karnovsky, A.3    Guire, K.4    Paine, R.5    Standiford, T.J.6
  • 36
    • 84930883815 scopus 로고    scopus 로고
    • Distinct molecular phenotypes of direct versus indirect ARDS in single-center and multicenter studies
    • Calfee, CS, Janz, DR, Bernard, GR, et al. Distinct molecular phenotypes of direct versus indirect ARDS in single-center and multicenter studies. Chest 147 (2015), 1539–1548.
    • (2015) Chest , vol.147 , pp. 1539-1548
    • Calfee, C.S.1    Janz, D.R.2    Bernard, G.R.3
  • 37
    • 84959196247 scopus 로고    scopus 로고
    • A pathophysiologic approach to biomarkers in acute respiratory distress syndrome
    • Blondonnet, R, Constantin, JM, Sapin, V, Jabaudon, M, A pathophysiologic approach to biomarkers in acute respiratory distress syndrome. Dis Markers, 2016, 2016, 20.
    • (2016) Dis Markers , vol.2016 , pp. 20
    • Blondonnet, R.1    Constantin, J.M.2    Sapin, V.3    Jabaudon, M.4
  • 38
    • 84917743754 scopus 로고    scopus 로고
    • Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation
    • Forel, JM, Guervilly, C, Hraiech, S, et al. Type III procollagen is a reliable marker of ARDS-associated lung fibroproliferation. Intensive Care Med 41 (2015), 1–11.
    • (2015) Intensive Care Med , vol.41 , pp. 1-11
    • Forel, J.M.1    Guervilly, C.2    Hraiech, S.3
  • 39
    • 84962018413 scopus 로고    scopus 로고
    • The streetlight effect in type 1 diabetes
    • Battaglia, M, Atkinson, MA, The streetlight effect in type 1 diabetes. Diabetes 64 (2015), 1081–1090.
    • (2015) Diabetes , vol.64 , pp. 1081-1090
    • Battaglia, M.1    Atkinson, M.A.2
  • 40
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, TA, Collins, FS, Cox, NJ, et al. Finding the missing heritability of complex diseases. Nature 461 (2009), 747–753.
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1    Collins, F.S.2    Cox, N.J.3
  • 41
    • 84856278890 scopus 로고    scopus 로고
    • Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma
    • Christie, JD, Wurfel, MM, Feng, R, et al. Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLoS One, 7, 2012, e28268.
    • (2012) PLoS One , vol.7 , pp. e28268
    • Christie, J.D.1    Wurfel, M.M.2    Feng, R.3
  • 42
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus, DC, Linde-Zwirble, WT, Lidicker, J, Clermont, G, Carcillo, J, Pinsky, MR, Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29 (2001), 1303–1310.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 44
    • 84870301161 scopus 로고    scopus 로고
    • Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
    • Tejera, P, Meyer, NJ, Chen, F, et al. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. J Med Genet 49 (2012), 671–680.
    • (2012) J Med Genet , vol.49 , pp. 671-680
    • Tejera, P.1    Meyer, N.J.2    Chen, F.3
  • 45
    • 84855925920 scopus 로고    scopus 로고
    • Rare and common variants: twenty arguments
    • Gibson, G, Rare and common variants: twenty arguments. Nat Rev Genet 13 (2012), 135–145.
    • (2012) Nat Rev Genet , vol.13 , pp. 135-145
    • Gibson, G.1
  • 46
    • 84863556835 scopus 로고    scopus 로고
    • Evolution and functional impact of rare coding variation from deep sequencing of human exomes
    • Tennessen, JA, Bigham, AW, O'Connor, TD, et al. Evolution and functional impact of rare coding variation from deep sequencing of human exomes. Science 337 (2012), 64–69.
    • (2012) Science , vol.337 , pp. 64-69
    • Tennessen, J.A.1    Bigham, A.W.2    O'Connor, T.D.3
  • 47
    • 85008395314 scopus 로고    scopus 로고
    • Resolution of disease phenotypes resulting from multilocus genomic variation
    • Posey, JE, Harel, T, Liu, P, et al. Resolution of disease phenotypes resulting from multilocus genomic variation. N Engl J Med 376 (2017), 21–31.
    • (2017) N Engl J Med , vol.376 , pp. 21-31
    • Posey, J.E.1    Harel, T.2    Liu, P.3
  • 48
    • 84865757142 scopus 로고    scopus 로고
    • Landscape of transcription in human cells
    • Djebali, S, Davis, CA, Merkel, A, et al. Landscape of transcription in human cells. Nature 489 (2012), 101–108.
    • (2012) Nature , vol.489 , pp. 101-108
    • Djebali, S.1    Davis, C.A.2    Merkel, A.3
  • 49
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • Wang, Z, Gerstein, M, Snyder, M, RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 10 (2009), 57–63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 50
    • 84932645923 scopus 로고    scopus 로고
    • Expression quantitative trait locus analysis for translational medicine
    • Gibson, G, Powell, JE, Marigorta, UM, Expression quantitative trait locus analysis for translational medicine. Genome Med, 7, 2015, 60.
    • (2015) Genome Med , vol.7 , pp. 60
    • Gibson, G.1    Powell, J.E.2    Marigorta, U.M.3
  • 51
    • 84942557691 scopus 로고    scopus 로고
    • Which patients with ARDS benefit from lung biopsy?
    • Palakshappa, JA, Meyer, NJ, Which patients with ARDS benefit from lung biopsy?. Chest 148 (2015), 1073–1082.
    • (2015) Chest , vol.148 , pp. 1073-1082
    • Palakshappa, J.A.1    Meyer, N.J.2
  • 52
    • 84927731344 scopus 로고    scopus 로고
    • Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome
    • Kovach, MA, Stringer, KA, Bunting, R, et al. Microarray analysis identifies IL-1 receptor type 2 as a novel candidate biomarker in patients with acute respiratory distress syndrome. Respir Res, 16, 2015, 29.
    • (2015) Respir Res , vol.16 , pp. 29
    • Kovach, M.A.1    Stringer, K.A.2    Bunting, R.3
  • 53
    • 84900528114 scopus 로고    scopus 로고
    • Diverse macrophage populations mediate acute lung inflammation and resolution
    • Aggarwal, NR, King, LS, D'Alessio, FR, Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol 306 (2014), L709–L725.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , pp. L709-L725
    • Aggarwal, N.R.1    King, L.S.2    D'Alessio, F.R.3
  • 54
    • 84930842760 scopus 로고    scopus 로고
    • Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS
    • Kangelaris, KN, Prakash, A, Liu, KD, et al. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Am J Physiol Lung Cell Mol Physiol 308 (2015), L1102–L1113.
    • (2015) Am J Physiol Lung Cell Mol Physiol , vol.308 , pp. L1102-L1113
    • Kangelaris, K.N.1    Prakash, A.2    Liu, K.D.3
  • 55
    • 66149092331 scopus 로고    scopus 로고
    • Discovery of the gene signature for acute lung injury in patients with sepsis
    • Howrylak, JA, Dolinay, T, Lucht, L, et al. Discovery of the gene signature for acute lung injury in patients with sepsis. Physiol Genomics 37 (2009), 133–139.
    • (2009) Physiol Genomics , vol.37 , pp. 133-139
    • Howrylak, J.A.1    Dolinay, T.2    Lucht, L.3
  • 56
    • 84901698040 scopus 로고    scopus 로고
    • Applying metabolomics to uncover novel biology in ARDS
    • Rogers, AJ, Matthay, MA, Applying metabolomics to uncover novel biology in ARDS. Am J Physiol Lung Cell Mol Physiol 306 (2014), L957–L961.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , pp. L957-L961
    • Rogers, A.J.1    Matthay, M.A.2
  • 57
    • 84907743151 scopus 로고    scopus 로고
    • Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors
    • Bhargava, M, Becker, TL, Viken, KJ, et al. Proteomic profiles in acute respiratory distress syndrome differentiates survivors from non-survivors. PLoS One, 9, 2014, e109713.
    • (2014) PLoS One , vol.9 , pp. e109713
    • Bhargava, M.1    Becker, T.L.2    Viken, K.J.3
  • 58
    • 84887490947 scopus 로고    scopus 로고
    • Quantitative proteomic analysis by iTRAQ for identification of candidate biomarkers in plasma from acute respiratory distress syndrome patients
    • Chen, X, Shan, Q, Jiang, L, Zhu, B, Xi, X, Quantitative proteomic analysis by iTRAQ for identification of candidate biomarkers in plasma from acute respiratory distress syndrome patients. Biochem Biophys Res Commun 441 (2013), 1–6.
    • (2013) Biochem Biophys Res Commun , vol.441 , pp. 1-6
    • Chen, X.1    Shan, Q.2    Jiang, L.3    Zhu, B.4    Xi, X.5
  • 59
    • 49049098527 scopus 로고    scopus 로고
    • Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs
    • Gerszten, RE, Accurso, F, Bernard, GR, et al. Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs. Am J Physiol Lung Cell Mol Physiol 295 (2008), 16–22.
    • (2008) Am J Physiol Lung Cell Mol Physiol , vol.295 , pp. 16-22
    • Gerszten, R.E.1    Accurso, F.2    Bernard, G.R.3
  • 60
    • 84903850983 scopus 로고    scopus 로고
    • Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome
    • Bos, LDJ, Weda, H, Wang, Y, et al. Exhaled breath metabolomics as a noninvasive diagnostic tool for acute respiratory distress syndrome. Eur Respir J 44 (2014), 188–197.
    • (2014) Eur Respir J , vol.44 , pp. 188-197
    • Bos, L.D.J.1    Weda, H.2    Wang, Y.3
  • 61
    • 78650060535 scopus 로고    scopus 로고
    • Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study
    • Gajic, O, Dabbagh, O, Park, PK, et al. Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med Medicine 183 (2011), 462–470.
    • (2011) Am J Respir Crit Care Med Medicine , vol.183 , pp. 462-470
    • Gajic, O.1    Dabbagh, O.2    Park, P.K.3
  • 62
    • 78650065752 scopus 로고    scopus 로고
    • Acute lung injury prediction score: derivation and validation in a population-based sample
    • Trillo-Alvarez, C, Cartin-Ceba, R, Kor, DJ, et al. Acute lung injury prediction score: derivation and validation in a population-based sample. Eur Respir J 37 (2011), 604–609.
    • (2011) Eur Respir J , vol.37 , pp. 604-609
    • Trillo-Alvarez, C.1    Cartin-Ceba, R.2    Kor, D.J.3
  • 63
    • 84988919563 scopus 로고    scopus 로고
    • Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome
    • Dickson, RP, Singer, BH, Newstead, MW, et al. Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome. Nat Microbiol, 1, 2016, 16113.
    • (2016) Nat Microbiol , vol.1 , pp. 16113
    • Dickson, R.P.1    Singer, B.H.2    Newstead, M.W.3
  • 64
    • 0028267785 scopus 로고
    • The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination
    • Bernard, GR, Artigas, A, Brigham, KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149 (1994), 818–824.
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 818-824
    • Bernard, G.R.1    Artigas, A.2    Brigham, K.L.3
  • 65
    • 84896905926 scopus 로고    scopus 로고
    • The circulating glycosaminoglycan signature of respiratory failure in critically ill adults
    • Schmidt, EP, Li, G, Li, L, et al. The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem 289 (2014), 8194–8202.
    • (2014) J Biol Chem , vol.289 , pp. 8194-8202
    • Schmidt, E.P.1    Li, G.2    Li, L.3
  • 66
    • 84994391665 scopus 로고    scopus 로고
    • Elevated plasma levels of sRAGE are associated with nonfocal CT-based lung imaging in patients with ARDS: a prospective multicenter study
    • Mrozek, S, Jabaudon, M, Jaber, S, et al. Elevated plasma levels of sRAGE are associated with nonfocal CT-based lung imaging in patients with ARDS: a prospective multicenter study. Chest 150 (2016), 998–1007.
    • (2016) Chest , vol.150 , pp. 998-1007
    • Mrozek, S.1    Jabaudon, M.2    Jaber, S.3
  • 67
    • 34748870199 scopus 로고    scopus 로고
    • Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders
    • Calfee, CS, Eisner, MD, Ware, LB, et al. Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders. Crit Care Med 35 (2007), 2243–2250.
    • (2007) Crit Care Med , vol.35 , pp. 2243-2250
    • Calfee, C.S.1    Eisner, M.D.2    Ware, L.B.3
  • 68
    • 77950218712 scopus 로고    scopus 로고
    • Lung morphology predicts response to recruitment maneuver in patients with acute respiratory distress syndrome
    • Constantin, JM, Grasso, S, Chanques, G, et al. Lung morphology predicts response to recruitment maneuver in patients with acute respiratory distress syndrome. Crit Care Med 38 (2010), 1108–1117.
    • (2010) Crit Care Med , vol.38 , pp. 1108-1117
    • Constantin, J.M.1    Grasso, S.2    Chanques, G.3
  • 69
    • 48249085691 scopus 로고    scopus 로고
    • Cluster analysis and clinical asthma phenotypes
    • Haldar, P, Pavord, ID, Shaw, DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 178 (2008), 218–224.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 218-224
    • Haldar, P.1    Pavord, I.D.2    Shaw, D.E.3
  • 70
    • 76149146032 scopus 로고    scopus 로고
    • Identification of asthma phenotypes using cluster analysis in the severe asthma research program
    • Moore, WC, Meyers, DA, Wenzel, SE, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med 181 (2010), 315–323.
    • (2010) Am J Respir Crit Care Med , vol.181 , pp. 315-323
    • Moore, W.C.1    Meyers, D.A.2    Wenzel, S.E.3
  • 71
    • 70349239233 scopus 로고    scopus 로고
    • Identification of pediatric septic shock subclasses based on genome-wide expression profiling
    • Wong, HR, Cvijanovich, N, Lin, R, et al. Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med, 7, 2009, 34.
    • (2009) BMC Med , vol.7 , pp. 34
    • Wong, H.R.1    Cvijanovich, N.2    Lin, R.3
  • 72
    • 84922311029 scopus 로고    scopus 로고
    • Developing a clinically feasible personalized medicine approach to pediatric septic shock
    • Wong, HR, Cvijanovich, NZ, Anas, N, et al. Developing a clinically feasible personalized medicine approach to pediatric septic shock. Am J Respir Crit Care Med 191 (2015), 309–315.
    • (2015) Am J Respir Crit Care Med , vol.191 , pp. 309-315
    • Wong, H.R.1    Cvijanovich, N.Z.2    Anas, N.3
  • 73
    • 0035375137 scopus 로고    scopus 로고
    • Computational analysis of microarray data
    • Quackenbush, J, Computational analysis of microarray data. Nat Rev Genet 2 (2001), 418–427.
    • (2001) Nat Rev Genet , vol.2 , pp. 418-427
    • Quackenbush, J.1
  • 74
    • 84908546013 scopus 로고    scopus 로고
    • NbClust: an R package for determining the relevant number of clusters in a data set
    • Charrad, M, Ghazzali, N, Boiteau, V, Niknafs, A, NbClust: an R package for determining the relevant number of clusters in a data set. J Stat Softw, 61, 2014, 36.
    • (2014) J Stat Softw , vol.61 , pp. 36
    • Charrad, M.1    Ghazzali, N.2    Boiteau, V.3    Niknafs, A.4
  • 75
    • 84954349720 scopus 로고    scopus 로고
    • Multicenter comparison of machine learning methods and conventional regression for predicting clinical deterioration on the wards
    • Churpek, MM, Yuen, TC, Winslow, C, Meltzer, DO, Kattan, MW, Edelson, DP, Multicenter comparison of machine learning methods and conventional regression for predicting clinical deterioration on the wards. Crit Care Med 44 (2016), 368–374.
    • (2016) Crit Care Med , vol.44 , pp. 368-374
    • Churpek, M.M.1    Yuen, T.C.2    Winslow, C.3    Meltzer, D.O.4    Kattan, M.W.5    Edelson, D.P.6
  • 76
    • 84896595576 scopus 로고    scopus 로고
    • A multi-biomarker-based outcome risk stratification model for adult septic shock
    • Wong, HR, Lindsell, CJ, Pettila, V, et al. A multi-biomarker-based outcome risk stratification model for adult septic shock. Crit Care Med 42 (2014), 781–789.
    • (2014) Crit Care Med , vol.42 , pp. 781-789
    • Wong, H.R.1    Lindsell, C.J.2    Pettila, V.3
  • 77
    • 81855161391 scopus 로고    scopus 로고
    • A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation
    • Brown, LM, Calfee, CS, Matthay, MA, Brower, RG, Thompson, BT, Checkley, W, A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation. Crit Care Med 39 (2011), 2645–2651.
    • (2011) Crit Care Med , vol.39 , pp. 2645-2651
    • Brown, L.M.1    Calfee, C.S.2    Matthay, M.A.3    Brower, R.G.4    Thompson, B.T.5    Checkley, W.6
  • 78
    • 84860679595 scopus 로고    scopus 로고
    • Asthma phenotypes: the evolution from clinical to molecular approaches
    • Wenzel, SE, Asthma phenotypes: the evolution from clinical to molecular approaches. Nat Med 18 (2012), 716–725.
    • (2012) Nat Med , vol.18 , pp. 716-725
    • Wenzel, S.E.1
  • 80
    • 84903575388 scopus 로고    scopus 로고
    • Heterogeneous phenotypes of the acute respiratory distress syndrome after major trauma
    • Reilly, JP, Bellamy, S, Shashaty, MGS, et al. Heterogeneous phenotypes of the acute respiratory distress syndrome after major trauma. Ann Am Thorac Soc 11 (2014), 728–736.
    • (2014) Ann Am Thorac Soc , vol.11 , pp. 728-736
    • Reilly, J.P.1    Bellamy, S.2    Shashaty, M.G.S.3
  • 81
    • 84875865632 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients
    • Agrawal, A, Matthay, MA, Kangelaris, KN, et al. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med 187 (2013), 736–742.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. 736-742
    • Agrawal, A.1    Matthay, M.A.2    Kangelaris, K.N.3
  • 82
    • 84861513903 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance
    • Calfee, CS, Gallagher, D, Abbott, J, Thompson, BT, Matthay, MA, Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance. Crit Care Med 40 (2012), 1731–1737.
    • (2012) Crit Care Med , vol.40 , pp. 1731-1737
    • Calfee, C.S.1    Gallagher, D.2    Abbott, J.3    Thompson, B.T.4    Matthay, M.A.5
  • 83
    • 77952280855 scopus 로고    scopus 로고
    • Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis
    • Fremont, RD, Koyama, T, Calfee, CS, et al. Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis. J Trauma 68 (2010), 1121–1127.
    • (2010) J Trauma , vol.68 , pp. 1121-1127
    • Fremont, R.D.1    Koyama, T.2    Calfee, C.S.3
  • 84
    • 79956207348 scopus 로고    scopus 로고
    • ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio
    • Meyer, NJ, Li, M, Feng, R, et al. ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio. Am J Respir Crit Care Med 183 (2011), 1344–1353.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 1344-1353
    • Meyer, N.J.1    Li, M.2    Feng, R.3
  • 85
    • 84885018609 scopus 로고    scopus 로고
    • Systematic identification of trans-eQTLs as putative drivers of known disease associations
    • Westra, HJ, Peters, MJ, Esko, T, et al. Systematic identification of trans-eQTLs as putative drivers of known disease associations. Nat Genet 45 (2013), 1238–1243.
    • (2013) Nat Genet , vol.45 , pp. 1238-1243
    • Westra, H.J.1    Peters, M.J.2    Esko, T.3
  • 86
    • 78650085125 scopus 로고    scopus 로고
    • A general approach to causal mediation analysis
    • Imai, K, Keele, L, Tingley, D, A general approach to causal mediation analysis. Psychol Methods 15 (2010), 309–334.
    • (2010) Psychol Methods , vol.15 , pp. 309-334
    • Imai, K.1    Keele, L.2    Tingley, D.3
  • 87
    • 84924854841 scopus 로고    scopus 로고
    • Platelet count mediates the contribution of a genetic variant in LRRC 16A to ARDS risk
    • Wei, Y, Wang, Z, Su, L, et al. Platelet count mediates the contribution of a genetic variant in LRRC 16A to ARDS risk. Chest 147 (2015), 607–617.
    • (2015) Chest , vol.147 , pp. 607-617
    • Wei, Y.1    Wang, Z.2    Su, L.3
  • 88
    • 85019876144 scopus 로고    scopus 로고
    • A missense genetic variant in LRRC16A/CAMIL1 improves ARDS survival by attenuating platelet count decline
    • published online Oct 21.
    • Wei, Y, Tejera, P, Wang, Z, et al. A missense genetic variant in LRRC16A/CAMIL1 improves ARDS survival by attenuating platelet count decline. Am J Respir Crit Care Med, 2016, 10.1164/rccm.201605-0946OC published online Oct 21.
    • (2016) Am J Respir Crit Care Med
    • Wei, Y.1    Tejera, P.2    Wang, Z.3
  • 89
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen, J, Pertsemlidis, A, Kotowski, IK, Graham, R, Garcia, CK, Hobbs, HH, Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 37 (2005), 161–165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 90
    • 84877578553 scopus 로고    scopus 로고
    • Emerging LDL therapies: using human genetics to discover new therapeutic targets for plasma lipids
    • Cohen, JC, Emerging LDL therapies: using human genetics to discover new therapeutic targets for plasma lipids. J Clin Lipidol 7:suppl 3 (2013), S1–S5.
    • (2013) J Clin Lipidol , vol.7 , pp. S1-S5
    • Cohen, J.C.1
  • 91
    • 84869126274 scopus 로고    scopus 로고
    • A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice
    • Huh, D, Leslie, DC, Matthews, BD, et al. A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice. Sci Transl Med, 4, 2012, 159ra147.
    • (2012) Sci Transl Med , vol.4 , pp. 159ra147
    • Huh, D.1    Leslie, D.C.2    Matthews, B.D.3
  • 92
    • 79954566390 scopus 로고    scopus 로고
    • Normothermic ex vivo lung perfusion in clinical lung transplantation
    • Cypel, M, Yeung, JC, Liu, M, et al. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 364 (2011), 1431–1440.
    • (2011) N Engl J Med , vol.364 , pp. 1431-1440
    • Cypel, M.1    Yeung, J.C.2    Liu, M.3
  • 94
    • 84900547816 scopus 로고    scopus 로고
    • Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation
    • McAuley, DF, Curley, GF, Hamid, UI, et al. Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation. Am J Physiol Lung Cell Mol Physiol 306 (2014), L809–L815.
    • (2014) Am J Physiol Lung Cell Mol Physiol , vol.306 , pp. L809-L815
    • McAuley, D.F.1    Curley, G.F.2    Hamid, U.I.3
  • 96
    • 84904678816 scopus 로고    scopus 로고
    • Plasma angiopoietin-2 concentrations are related to impaired lung function, and organ failure in a clinical cohort receiving high dose interleukin-2 therapy
    • Gores, KM, Delsing, AS, Kraus, SJ, et al. Plasma angiopoietin-2 concentrations are related to impaired lung function, and organ failure in a clinical cohort receiving high dose interleukin-2 therapy. Shock 42 (2014), 115–120.
    • (2014) Shock , vol.42 , pp. 115-120
    • Gores, K.M.1    Delsing, A.S.2    Kraus, S.J.3
  • 97
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek, M, Chylinski, K, Fonfara, I, Hauer, M, Doudna, JA, Charpentier, E, A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337 (2012), 816–821.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 98
    • 84999652028 scopus 로고    scopus 로고
    • A mouse model for MERS coronavirus-induced acute respiratory distress syndrome
    • Cockrell, AS, Yount, BL, Scobey, T, et al. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol, 2, 2016, 16226.
    • (2016) Nat Microbiol , vol.2 , pp. 16226
    • Cockrell, A.S.1    Yount, B.L.2    Scobey, T.3
  • 99
    • 84863673204 scopus 로고    scopus 로고
    • Improved survival with MEK inhibition in BRAF-mutated melanoma
    • Flaherty, KT, Robert, C, Hersey, P, et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367 (2012), 107–114.
    • (2012) N Engl J Med , vol.367 , pp. 107-114
    • Flaherty, K.T.1    Robert, C.2    Hersey, P.3
  • 100
    • 84900829967 scopus 로고    scopus 로고
    • Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
    • Kris, MG, Johnson, BE, Berry, LD, et al. Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs. JAMA 311 (2014), 1998–2006.
    • (2014) JAMA , vol.311 , pp. 1998-2006
    • Kris, M.G.1    Johnson, B.E.2    Berry, L.D.3
  • 101
    • 84907424177 scopus 로고    scopus 로고
    • Mepolizumab treatment in patients with severe eosinophilic asthma
    • Ortega, HG, Liu, MC, Pavord, ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med 371 (2014), 1198–1207.
    • (2014) N Engl J Med , vol.371 , pp. 1198-1207
    • Ortega, H.G.1    Liu, M.C.2    Pavord, I.D.3
  • 102
    • 84895905845 scopus 로고    scopus 로고
    • Biomarker enrichment strategies: matching trial design to biomarker credentials
    • Freidlin, B, Korn, EL, Biomarker enrichment strategies: matching trial design to biomarker credentials. Nat Rev Clin Oncol 11 (2014), 81–90.
    • (2014) Nat Rev Clin Oncol , vol.11 , pp. 81-90
    • Freidlin, B.1    Korn, E.L.2
  • 103
    • 84907890908 scopus 로고    scopus 로고
    • Biomarker driven population enrichment for adaptive oncology trials with time to event endpoints
    • Mehta, C, Schafer, H, Daniel, H, Irle, S, Biomarker driven population enrichment for adaptive oncology trials with time to event endpoints. Stat Med 33 (2014), 4515–4531.
    • (2014) Stat Med , vol.33 , pp. 4515-4531
    • Mehta, C.1    Schafer, H.2    Daniel, H.3    Irle, S.4
  • 104
    • 40449100030 scopus 로고    scopus 로고
    • Direct multiplexed measurement of gene expression with color-coded probe pairs
    • Geiss, GK, Bumgarner, RE, Birditt, B, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nat Biotechnol 26 (2008), 317–325.
    • (2008) Nat Biotechnol , vol.26 , pp. 317-325
    • Geiss, G.K.1    Bumgarner, R.E.2    Birditt, B.3
  • 105
    • 84876666943 scopus 로고    scopus 로고
    • Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients
    • Cuenca, AG, Gentile, LF, Lopez, MC, et al. Development of a genomic metric that can be rapidly used to predict clinical outcome in severely injured trauma patients. Crit Care Med 41 (2013), 1175–1185.
    • (2013) Crit Care Med , vol.41 , pp. 1175-1185
    • Cuenca, A.G.1    Gentile, L.F.2    Lopez, M.C.3
  • 106
    • 57149101367 scopus 로고    scopus 로고
    • Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury
    • Calfee, CS, Ware, LB, Eisner, MD, et al. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax 63 (2008), 1083–1089.
    • (2008) Thorax , vol.63 , pp. 1083-1089
    • Calfee, C.S.1    Ware, L.B.2    Eisner, M.D.3
  • 107
    • 85019746232 scopus 로고    scopus 로고
    • Clinical trials in ARDS: challenges and opportunities
    • Matthay, MA, McAuley, DF, Ware, LB, Clinical trials in ARDS: challenges and opportunities. Lancet Respir Med 5 (2017), 524–534.
    • (2017) Lancet Respir Med , vol.5 , pp. 524-534
    • Matthay, M.A.1    McAuley, D.F.2    Ware, L.B.3


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