Simvastatin in the acute respiratory distress syndrome

New England Journal of Medicine

Volumn 371, Issue 18, 2014, Pages 1695-1703

  McAuley, Daniel F ^a,b,c   Laffey, John G ^j,k   O'Kane, Cecilia M ^a   Perkins, Gavin D ^e,f   Mullan, Brian ^b   Trinder, T John ^d   Johnston, Paul ^g   Hopkins, Philip A ^h   Johnston, Andrew J ⁱ   McDowell, Cliona ^c   McNally, Christine ^c  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b Regional Intensive Care Unit   (United Kingdom)

^c ROYAL VICTORIA HOSPITAL   (United Kingdom)

^d ULSTER HOSPITAL   (United Kingdom)

^e UNIVERSITY HOSPITALS BIRMINGHAM NHS FOUNDATION TRUST   (United Kingdom)

^f UNIVERSITY OF WARWICK   (United Kingdom)

^g ANTRIM AREA HOSPITAL   (United Kingdom)

^h KING S COLLEGE HOSPITAL   (United Kingdom)

ⁱ CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^j NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^k ST MICHAEL'S HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATINE KINASE; PLACEBO; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ARTIFICIAL VENTILATION; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HUMAN; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORNING DOSAGE; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; SIDE EFFECT; TIDAL VOLUME; TREATMENT DURATION; AGED; CONTROLLED CLINICAL TRIAL; INTENSIVE CARE UNIT; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; TREATMENT FAILURE;

ADULT; AGED; COMBINED MODALITY THERAPY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTENSIVE CARE UNITS; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; RESPIRATION, ARTIFICIAL; RESPIRATORY DISTRESS SYNDROME, ADULT; SIMVASTATIN; TIDAL VOLUME; TREATMENT FAILURE;

EID: 84908434411     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1403285     Document Type: Article

References (19)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000;342: 1334-49.
2. Terblanche M, Almog Y, Rosenson RS, Smith TS, Hackam DG. Statins: Panacea for sepsis? Lancet Infect Dis 2006;6: 242-8.
3. Jacobson JR, Barnard JW, Grigoryev DN, Ma S-F, Tuder RM, Garcia JGN. Simvastatin attenuates vascular leak and inflammation in murine inflammatory lung injury. Am J Physiol Lung Cell Mol Physiol 2005;288: L1026-L1032.
4. Shyamsundar M, McKeown ST, O'Kane CM, et al. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am J Respir Crit Care Med 2009;179: 1107-14.
5. Craig TR, Duffy MJ, Shyamsundar M, et al. A randomized clinical trial of hydroxymethylglutaryl-coenzyme A reductase inhibition for acute lung injury (The HARP Study). Am J Respir Crit Care Med 2011;183: 620-6.
6. McAuley DF, Laffey JG, O'Kane CM, et al. Hydroxymethylglutaryl-CoA reductase inhibition with simvastatin in acute lung injury to reduce pulmonary dysfunction (HARP-2) trial: Study protocol for a randomized controlled trial. Trials 2012;13: 170.
7. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS: Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994;149: 818-24.
8. Felton TW, Sander R, Al-Aloul M, Dark P, Bentley AM. Can a score derived from the Critical Care Minimum Data Set be used as a marker of organ dysfunction?-A pilot study. BMC Res Notes 2009;2: 77.
9. The Acute Respiratory Distress Syndrome Network. Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med 2000;342: 1301-8.
10. Vincent JL, Moreno R, Takala J, et al. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996; 22: 707-10.
11. Harvey S, Harrison DA, Singer M, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial. Lancet 2005;366: 472-7.
12. The National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med 2014;370: 2191-200.
13. Al Harbi SA, Tamim HM, Arabi YM. Association between statin therapy and outcomes in critically ill patients: A nested cohort study. BMC Clin Pharmacol 2011; 11: 12.
14. Shah AI, Sobnosky S, Shen AY, Jorgensen MB. High dose statins are associated with a reduced all cause mortality in patients hospitalized with sepsis and severe sepsis. Crit Care Med 2008; 36: A15. abstract.
15. Drage SM, Simpkin AL, Neuvonen PJ, Watkinson PJ, Barber VS, Young JD. Plasma simvastatin concentrations in critically ill septic patients. J Intensive Care Soc 2009;10: 61.
16. Chiarla C, Giovannini I, Giuliante F, et al. Severe hypocholesterolemia in surgical patients, sepsis, and critical illness. J Crit Care 2010;25(2): 361.e7-361.e12.
17. Calfee CS, Delucchi K, Parsons PE, Thompson BT, Ware LB, Matthay MA. Subphenotypes in acute respiratory distress syndrome: Latent class analysis of data from two randomised controlled trials. Lancet Respir Med 2014;2: 611-20.
18. Jaswal DS, Leung JM, Sun J, et al. Tidal volume and plateau pressure use for acute lung injury from 2000 to present: A systematic literature review. Crit Care Med 2014 August 5 (Epub ahead of print).
19. Papazian L, Roch A, Charles PE, et al. Effect of statin therapy on mortality in patients with ventilator-associated pneumonia: A randomized clinical trial. JAMA 2013;310: 1692-700.