Clinical grade allogeneic human mesenchymal stem cells restore alveolar fluid clearance in human lungs rejected for transplantation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 306, Issue 9, 2014, Pages

  McAuley, D F ^a   Curley, G F ^b,c   Hamid, U I ^a   Laffey, J G ^b,c   Abbott, J ^d   McKenna, D H ^e   Fang, X ^d   Matthay, M A ^d   Lee, J W ^d  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c ST MICHAEL'S HOSPITAL   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Ex vivo lung perfusion; Lung transplantation; Pulmonary edema

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ELECTROLYTE; KERATINOCYTE GROWTH FACTOR; NEUTRALIZING ANTIBODY;

ADULT; ALVEOLAR FLUID CLEARANCE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; FLUID TRANSPORT; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG ARTERY PRESSURE; LUNG COMPLIANCE; LUNG EDEMA; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG PERFUSION; LUNG TRANSPLANTATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; PARACRINE SIGNALING; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; RESPIRATORY TRACT PARAMETERS; TISSUE OXYGENATION;

EX VIVO LUNG PERFUSION; LUNG TRANSPLANTATION; PULMONARY EDEMA;

ADULT; CELLS, CULTURED; FEMALE; FIBROBLAST GROWTH FACTOR 7; GRAFT REJECTION; HUMANS; LUNG DISEASES; LUNG TRANSPLANTATION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; PROGNOSIS; PULMONARY ALVEOLI; PULMONARY EDEMA; TRANSPLANTATION, HOMOLOGOUS;

EID: 84900547816     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00358.2013     Document Type: Article

References (40)

1. Bastarache JA, Ong T, Matthay MA, Ware LB. Alveolar fluid clearance is faster in women with acute lung injury compared to men. J Criti Care 26: 249-256, 2011.
2. Berthiaume Y, Staub NC, Matthay MA. Beta-adrenergic agonists increase lung liquid clearance in anesthetized sheep. J Clin Invest 79: 335-343, 1987.
3. Botha P, Trivedi D, Weir CJ, Searl CP, Corris PA, Dark JH, Schueler SV. Extended donor criteria in lung transplantation: impact on organ allocation. J Thorac Cardiovasc Surg 131: 1154-1160, 2006.
4. Briot R, Frank JA, Uchida T, Lee JW, Calfee CS, Matthay MA. Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs. Chest 135: 269-275, 2009.
5. Calfee CS, Budev MM, Matthay MA, Church G, Brady S, Uchida T, Ishizaka A, Lara A, Ranes JL, deCamp MM, Arroliga AC. Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation. J Heart Lung Transplant 26: 675-680, 2007.
6. Christie JD, Bavaria JE, Palevsky HI, Litzky L, Blumenthal NP, Kaiser LR, Kotloff RM. Primary graft failure following lung transplantation. Chest 114: 51-60, 1998.
7. Christie JD, Sager JS, Kimmel SE, Ahya VN, Gaughan C, Blumenthal NP, Kotloff RM. Impact of primary graft failure on outcomes following lung transplantation. Chest 127: 161-165, 2005.
8. Cross LJ, O'Kane CM, McDowell C, Elborn JJ, Matthay MA, McAuley DF. Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction-a randomised placebo-controlled trial (KARE): study protocol (Abstract). Trials 14: 51, 2013.
9. Curley GF, Contreras M, Higgins B, O'Kane C, McAuley DF, O'Toole D, Laffey JG. Evolution of the inflammatory and fibroproliferative responses during resolution and repair after ventilator-induced lung injury in the rat. Anesthesiology 115: 1022-1032, 2011.
10. Curley GF, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O'Brien T, O'Toole D, Laffey JG. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax 67: 496-501, 2012.
11. Cypel M, Yeung JC, Liu M, Anraku M, Chen F, Karolak W, Sato M, Laratta J, Azad S, Madonik M, Chow CW, Chaparro C, Hutcheon M, Singer LG, Slutsky AS, Yasufuku K, de Perrot M, Pierre AF, Waddell TK, Keshavjee S. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 364: 1431-1440, 2011.
12. De Meester J, Smits JM, Persijn GG, Haverich A. Listing for lung transplantation: life expectancy and transplant effect, stratified by type of end-stage lung disease, the Eurotransplant experience. J Heart Lung Transplant 20: 518-524, 2001.
13. de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusioninduced lung injury. Am J Respir Crit Care Med 167: 490-511, 2003.
14. Esteban A, Fernandez-Segoviano P, Frutos-Vivar F, Aramburu JA, Najera L, Ferguson ND, Alia I, Gordo F, Rios F. Comparison of clinical criteria for the acute respiratory distress syndrome with autopsy findings. Ann Intern Med 141: 440-445, 2004.
15. Fischer UM, Harting MT, Jimenez F, Monzon-Posadas WO, Xue H, Savitz SI, Laine GA, Cox CS Jr. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first-pass effect. Stem Cells Dev 18: 683-692, 2009.
16. Fisher AJ, Donnelly SC, Pritchard G, Dark JH, Corris PA. Objective assessment of criteria for selection of donor lungs suitable for transplantation. Thorax 59: 434-437, 2004.
17. Frank JA, Briot R, Lee JW, Ishizaka A, Uchida T, Matthay MA. Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol 293: L52-L59, 2007.
18. Gao Smith F, Perkins GD, Gates S, Young D, McAuley DF, Tunnicliffe W, Khan Z, Lamb SE. Effect of intravenous beta-2 agonist treatment on clinical outcomes in acute respiratory distress syndrome (BALTI-2): a multicentre, randomised controlled trial. Lancet 379: 229-235, 2012.
19. Hornby K, Ross H, Keshavjee S, Rao V, Shemie SD. Non-utilization of hearts and lungs after consent for donation: a Canadian multicentre study. Can J Anaesth 53: 831-837, 2006.
20. Keshavjee SH, Yamazaki F, Cardoso PF, McRitchie DI, Patterson GA, Cooper JD. A method for safe twelve-hour pulmonary preservation. J Thorac Cardiovasc Surg 98: 529-534, 1989.
21. Krasnodembskaya A, Song Y, Fang X, Gupta N, Serikov V, Lee JW, Matthay MA. Antibacterial effect of human mesenchymal stem cells is mediated in part from secretion of the antimicrobial peptide LL-37. Stem Cells 28: 2229-2238, 2010.
22. Lee JW, Fang X, Gupta N, Serikov V, Matthay MA. Allogeneic human mesenchymal stem cells for treatment of E. coli endotoxin-induced acute lung injury in the ex vivo perfused human lung. Proc Natl Acad Sci USA 106: 16357-16362, 2009.
23. Lee JW, Krasnodembskaya A, McKenna DH, Song Y, Abbott J, Matthay MA. Therapeutic effects of human mesenchymal stem cells in ex vivo human lungs injured with live bacteria. Am J Respir Crit Care Med 187: 751-7760, 2013.
24. Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized beta(2)-agonist for treatment of acute lung injury. Am J Respir Crit Care Med 184: 561-568, 2011.
25. Matthay MA, Folkesson HG, Clerici C. Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol Rev 82: 569-600, 2002.
26. Matthay MA, Folkesson HG, Verkman AS. Salt and water transport across alveolar and distal airway epithelia in the adult lung. Am J Physiol Lung Cell Mol Physiol 270: L487-L503, 1996.
27. Matthay MA, Goolaerts A, Howard JP, Lee JW. Mesenchymal stem cells for acute lung injury: preclinical evidence. Crit Care Med 38: S569-573, 2010.
28. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 138: 720-723, 1988.
29. Orens JB, Garrity ER Jr. General overview of lung transplantation and review of organ allocation. Proc Am Thorac Soc 6: 13-19, 2009.
30. Pomfret EA, Sung RS, Allan J, Kinkhabwala M, Melancon JK, Roberts JP. Solving the organ shortage crisis: the 7th annual American Society of Transplant Surgeons' State-of-the-Art Winter Symposium. Am J Transplant 8: 745-752, 2008.
31. Sugita M, Ferraro P, Dagenais A, Clermont ME, Barbry P, Michel RP, Berthiaume Y. Alveolar liquid clearance and sodium channel expression are decreased in transplanted canine lungs. Am J Respir Crit Care Med 167: 1440-1450, 2003.
32. Thabut G, Mal H, Cerrina J, Dartevelle P, Dromer C, Velly JF, Stern M, Loirat P, Leseche G, Bertocchi M, Mornex JF, Haloun A, Despins P, Pison C, Blin D, Reynaud-Gaubert M. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med 171: 786-791, 2005.
33. Wang Y, Folkesson HG, Jayr C, Ware LB, Matthay MA. Alveolar epithelial fluid transport can be simultaneously upregulated by both KGF and β-agonist therapy. J Appl Physiol 87: 1852-1860, 1999.
34. Ware L, Landeck M, Koyama T, Zhao Z, Singer J, Kern R, Johnson E, Janz D, Bernard G, Lee J, Matthay M, Network CTD. A randomized trial of nebulized albuterol to enhance resolution of pulmonary edema in 506 brain dead organ donors. Am J Transplant 14: 621-628, 2014.
35. Ware LB, Golden JA, Finkbeiner WE, Matthay MA. Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation. Am J Respir Crit Care Med 159: 980-988, 1999.
36. Ware LB, Koyama T, Billheimer D, Landeck M, Johnson E, Brady S, Bernard GR, Matthay MA. Advancing donor management research: design and implementation of a large, randomized, placebo-controlled trial (Abstract). Ann Intensive Care 1: 20, 2011.
37. Ware LB, Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.
38. Ware LB, Wang Y, Fang X, Warnock M, Sakuma T, Hall TS, Matthay M. Assessment of lungs rejected for transplantation and implications for donor selection. Lancet 360: 619-620, 2002.
39. Yano T, Deterding RR, Simonet WS, Shannon JM, Mason RJ. Keratinocyte growth factor reduces lung damage due to acid instillation in rats. Am J Respir Cell Mol Biol 15: 433-442, 1996.
40. Yeung JC, Wagnetz D, Cypel M, Rubacha M, Koike T, Chun YM, Hu J, Waddell TK, Hwang DM, Liu M, Keshavjee S. Ex vivo adenoviral vector gene delivery results in decreased vector-associated inflammation pre-and post-lung transplantation in the pig. Mol Ther 20: 1204-1211, 2012.