Sarilumab plus methotrexate suppresses circulating biomarkers of bone resorption and synovial damage in patients with rheumatoid arthritis and inadequate response to methotrexate: A biomarker study of MOBILITY

Arthritis Research and Therapy

Volumn 18, Issue 1, 2016, Pages

  Boyapati, Anita ^a   Msihid, Jérôme ^b   Fiore, Stefano ^b   van Adelsberg, Janet ^a   Graham, Neil M H ^a   Hamilton, Jennifer D ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b SANOFI   (France)

Author keywords

Biomarker; RANKL OPG; Rheumatoid arthritis; Sarilumab

Indexed keywords

BIOLOGICAL MARKER; C REACTIVE PROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 3; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; METHOTREXATE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PLACEBO; SARILUMAB; STROMELYSIN; ANTIRHEUMATIC AGENT; IL6 PROTEIN, HUMAN; INTERLEUKIN 6; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE DURATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; MULTICENTER STUDY; OSTEOLYSIS; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PROTEIN BLOOD LEVEL; PROTEIN CLEAVAGE; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; TISSUE METABOLISM; TREATMENT RESPONSE; AGED; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; BLOOD; CLINICAL TRIAL; COMBINATION DRUG THERAPY; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; MIDDLE AGED; PATHOLOGY; SYNOVIUM; TREATMENT OUTCOME;

ADULT; AGED; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOMARKERS; BONE RESORPTION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INTERLEUKIN-6; MALE; METHOTREXATE; MIDDLE AGED; SYNOVIAL MEMBRANE; TREATMENT OUTCOME;

EID: 84991666306     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-016-1132-9     Document Type: Article

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