Development of dextran microparticles loaded with IL-1Ra of high-encapsulation efficiency and high-bioactivity by a novel method without exposing IL-1Ra to water-oil interfaces

Powder Technology

Volumn 235, Issue , 2013, Pages 299-302

  Liang, Di ^a,b   Fu, Xiujuan ^a   Liao, Meiling ^c   Yuan, Weien ^c   Su, Jing ^c  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Bioactivity; Dextran microparticle; Interleukin 1 receptor antagonist; Stability

Indexed keywords

ACTIVITY LOSS; CONTINUOUS PHASE; CONTROL METHODS; DISPERSED PHASE; FREEZING PROCESS; FROZEN SAMPLE; IN-VITRO; INTERLEUKIN-1; MICRO PARTICLES; OIL/WATER INTERFACES; PATIENT COMPLIANCE; PREPARATION PROCESS; PROTEIN STABILIZATION; RECEPTOR ANTAGONISTS; RHEUMATOID ARTHRITIS; SEPARATION METHODS; THERAPEUTIC EFFICACY; WATER OIL INTERFACE; WATER SOLUTIONS; WATER-IN-OIL-IN-WATER;

BIOACTIVITY; CELL PROLIFERATION; CONVERGENCE OF NUMERICAL METHODS; DICHLOROMETHANE; DISEASES; ENCAPSULATION; FREEZING; PHASE SEPARATION; POLYETHYLENE GLYCOLS;

DEXTRAN;

DEXTRAN; DICHLOROMETHANE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; MACROGOL; OIL; WATER;

ARTICLE; CELL PROLIFERATION; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; FREEZE DRYING; FREEZING; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MICROENCAPSULATION; PATIENT COMPLIANCE; PHASE PARTITIONING; PHASE SEPARATION; SCANNING ELECTRON MICROSCOPY;

EID: 84871525209     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.10.036     Document Type: Article

References (20)

1. Campion G.V., Lebsack M.E., Lookabaugh J., Gordon G. Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis and Rheumatism 1996, 39:1092-1101.
2. McKenzie R.C., Oran A., Dinarello C.A., Sauder D.N. Interleukin-1 receptor antagonist inhibits subcutaneous B16 melanoma growth in vivo. Anticancer Research 1996, 16:437-441.
3. Vidal-Vanaclocha F., Alvarez A., Asumendi A., Urcelay B., Tonino P., Dinarello C.A. Interleukin 1 (IL-1)-dependent melanoma hepatic metastasis in vivo; increased endothelial adherence by IL-1-induced mannose receptors and growth factor production in vitro. Journal of the National Cancer Institute 1996, 88:198-205.
4. Vidal-Vanaclocha F., Amézaga C., Asumendi A., Kaplanski G., Dinarello C.A. Interleukin-1 receptor blockade reduces the number and size of murine B16 melanoma hepatic metastases. Cancer Research 1994, 54:2667-2672.
5. Lavi G., Dinarello C.A., Apte R.N., Cohen S. Sustained release of IL-1Ra from biodegradable microspheres prolongs its IL-1 neutralizing effects. Israel Journal of Chemistry 2005, 45:457-465.
6. Lavi G., Voronov E., Dinarello C.A., Apte R.N., Cohen S. Sustained delivery of IL-1 Ra from biodegradable microspheres reduces the number of murine B16 melanoma lung metastases. Journal of Controlled Release 2007, 123:123-130.
7. Yuan W., Wu F., Geng Y., Xu S., Jin T. Preparation of dextran glassy particles through freezing-induced phase separation. International Journal of Pharmaceutics 2007, 339:76-83.
8. Yuan W., Geng Y., Wu F., Liu Y., Guo M., Zhao H., Jin T. Preparation of polysaccharide glassy microparticles with stabilization of proteins. International Journal of Pharmaceutics 2009, 366:154-159.
9. Yuan W., Liu Z. Controlled-release and preserved bioactivity of proteins from (self-assembled) core-shell double-walled microspheres. International Journal of Nanomedicine 2012, 7:257-270.
10. Yuan W., Liu Z. Surgical wound healing using hemostatic gauze scaffold loaded with microparticles containing sustained-release granulocyte colony-stimulating factor. International Journal of Nanomedicine 2011, 6:3139-3149.
11. Jin T., Zhu J., Wu F., Yuan W., Geng L.L., Zhu H. Preparing polymer-based sustained-release systems without exposing proteins to water-oil or water-air interfaces and cross-linking reagents. Journal of Controlled Release 2008, 128:50-59.
12. Zaslavsky B.Y. Aqueous Two-Phase Partitioning: Physical Chemistry and Biological Applications 1995, 153-285. Marcel Dekker, New York.
13. Bar D., Apte R.N., Voronov E., Dinarello C.A., Cohen S. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. The FASEB Journal 2003, 17:161-163.
14. Cleland J.L., Jones J.S. Stable formulations of recombinant human growth hormone and interferon-gamma for microencapsulation in biodegradable microspheres. Pharmaceutical Research 1996, 13:1464-1475.
15. Yang S., Yuan W., Jin T. Formulating protein therapeutics into particulate forms. Expert Opinion on Drug Delivery 2009, 6:1123-1133.
16. Xu D., Hu H., Su J., Wu F., Yuan W. Micro and Nanotechnology for Intracellular Delivery Therapy Protein. Nano-Micro Letters 2012, 4:118-123.
17. 2+ nanoparticles under mild conditions. Nanotechnology 2007, 18. no. 145601.
18. Yuan W., Zhang Y., Wu F., Li H., Cai Y., Zhang Y., Han M., Jin T. Preparation of protein-loaded sustained-release microspheres via 'solid-in-oil-in-hydrophilic oil-in-ethanol (S/O/hO/E)' emulsification. Colloids and Surfaces. B, Biointerfaces 2010, 79:326-333.
19. Ren T., Yuan W., Zhao H., Jin T. Sustained-release polylactide-co-glycolide microspheres loaded with pre-formulated protein polysaccharide nanoparticles. Micro & Nano Letters 2011, 6:70-74.
20. Rong X., Mo X., Ren T., Yang S., Yuan W., Dong J., Wang Y., Wang X. Neuroprotective effect of erythropoietin-loaded composite microspheres on retinal ganglion cells in rats. European Journal of Pharmaceutical Sciences 2011, 43:334-342.