Biscarbamate cross-linked low molecular weight PEI for delivering IL-1 receptor antagonist gene to synoviocytes for arthritis therapy

Biomaterials

Volumn 33, Issue 27, 2012, Pages 6520-6532

  Xiang, Shengnan ^a   Su, Jing ^b   Tong, Haijun ^a   Yang, Fei ^a   Tong, Wenxue ^a   Yuan, Weien ^b   Wu, Fei ^b   Wang, Chuandong ^a   Jin, Tuo ^b   Dai, Kerong ^a   Zhang, Xiaoling ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Arthritis; Cross linking; Gene transfer; Nanoparticle

Indexed keywords

ANTI-INFLAMMATORIES; ARTHRITIS; CARTILAGE DESTRUCTION; CYTOKINES; CYTOXICITY; DNA CONDENSATION; GENE DELIVERY; INTERLEUKIN-1; LOW MOLECULAR WEIGHT; METALLOPROTEASES; OPTIMAL TARGET; POLYETHYLENE IMINES; POLYETHYLENEIMINE; RECEPTOR ANTAGONISTS; SYNOVIOCYTES; TARGET CELL APOPTOSIS; TRANSFECTION AGENTS;

CELL DEATH; GENE EXPRESSION; GENE TRANSFER; MANGANESE; MOLECULAR BIOLOGY; MOLECULAR WEIGHT; NANOPARTICLES;

GENE THERAPY;

BISCARBAMATE; CARBAMIC ACID DERIVATIVE; COLLAGENASE 3; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; POLYCATION; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTHRITIS; ARTICLE; CELL VIABILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DEGRADATION KINETICS; DNA CONDENSATION; DNA CONFORMATION; GEL ELECTROPHORESIS; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SYNOVIOCYTE;

ANIMALS; ARTHRITIS; CARBAMATES; CELL DEATH; CELLS, CULTURED; CROSS-LINKING REAGENTS; DRUG DELIVERY SYSTEMS; ELECTROPHORESIS, AGAR GEL; GENE THERAPY; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTRACELLULAR SPACE; MAGNETIC RESONANCE SPECTROSCOPY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; PLASMIDS; POLYETHYLENEIMINE; RATS; RATS, SPRAGUE-DAWLEY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SYNOVIAL MEMBRANE; TRANSFECTION;

RATTUS;

EID: 84863584886     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.05.044     Document Type: Article

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