An sirna screen in pancreatic beta cells reveals a role for Gpr27 in insulin production

PLoS Genetics

Volumn 8, Issue 1, 2012, Pages

  Ku, Gregory M ^a,b   Pappalardo, Zachary ^a   Luo, Chun Chieh ^a   German, Michael S ^a,b   McManus, Michael T ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 27; GLUCOSE; GREEN FLUORESCENT PROTEIN; INOSITOL PHOSPHATE; MESSENGER RNA; RED FLUORESCENT PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; GPR27 PROTEIN, MOUSE; HOMEODOMAIN PROTEIN; INSULIN; PANCREATIC AND DUODENAL HOMEOBOX 1 PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ARTICLE; BASE PAIRING; CELL CLONE; CONTROLLED STUDY; G PROTEIN COUPLED RECEPTOR 27 GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE SILENCING; GENETIC SCREENING; INSULIN RELEASE; INSULIN SYNTHESIS; MOLECULAR LIBRARY; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; PANCREAS ISLET BETA CELL; POSITIVE FEEDBACK; PROCESS DEVELOPMENT; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATOR GENE; ROUS SARCOMA ONCOVIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ANIMAL; CELL LINE; CELL STRAIN HEK293; CYTOLOGY; GENETICS; HUMAN; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; SECRETION;

ROUS SARCOMA VIRUS;

ANIMALS; CELL LINE; DIABETES MELLITUS, TYPE 2; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; INOSITOL PHOSPHATES; INSULIN; INSULIN-SECRETING CELLS; MICE; PROMOTER REGIONS, GENETIC; RECEPTORS, G-PROTEIN-COUPLED; RNA, SMALL INTERFERING; TRANS-ACTIVATORS;

EID: 84857477799     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002449     Document Type: Article

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