메뉴 건너뛰기




Volumn 52, Issue 8, 2017, Pages 1751-1759

Identification of angiotensin converting enzyme inhibitory and antioxidant peptides in a whey protein concentrate hydrolysate produced at semi-pilot scale

Author keywords

Angiotensin converting enzyme inhibition; antioxidant; ESI MS MS; food protein hydrolysate; mass spectrometry; oxygen radical absorbance capacity assay; peptide identification; whey protein concentrate

Indexed keywords

ANTIOXIDANTS; ENZYMES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; INTEGRATED CIRCUITS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PEPTIDES; PROTEINS; SCALES (WEIGHING INSTRUMENTS); ULTRAFILTRATION;

EID: 85019270258     PISSN: 09505423     EISSN: 13652621     Source Type: Journal    
DOI: 10.1111/ijfs.13448     Document Type: Article
Times cited : (39)

References (45)
  • 1
    • 0002494352 scopus 로고
    • A review of food hydrolysis specific areas
    • In, (edited by, J. Adler-Nissen, New York, Elsevier Applied Science Publishers
    • Adler-Nissen, J. (1986). A review of food hydrolysis specific areas. In: Enzymatic Hydrolysis of Food Proteins (edited by J. Adler-Nissen). Pp. 57–109. New York: Elsevier Applied Science Publishers.
    • (1986) Enzymatic Hydrolysis of Food Proteins , pp. 57-109
    • Adler-Nissen, J.1
  • 2
    • 84882833723 scopus 로고    scopus 로고
    • Casein hydrolysis by Bifidobacterium longum KACC91563 and antioxidant activities of peptides derived there from
    • Chang, O.K., Seol, K.H., Jeong, S.G. et al. (2013). Casein hydrolysis by Bifidobacterium longum KACC91563 and antioxidant activities of peptides derived there from. Journal of Dairy Science, 96, 5544–5555.
    • (2013) Journal of Dairy Science , vol.96 , pp. 5544-5555
    • Chang, O.K.1    Seol, K.H.2    Jeong, S.G.3
  • 3
    • 0026518272 scopus 로고
    • Effects of synthetic antioxidants (BHA, BHT and PG) on the mutagenicity of IQ-like compounds
    • Chen, C., Pearson, A.M. & Gray, J.I. (1992). Effects of synthetic antioxidants (BHA, BHT and PG) on the mutagenicity of IQ-like compounds. Food Chemistry, 43, 177–183.
    • (1992) Food Chemistry , vol.43 , pp. 177-183
    • Chen, C.1    Pearson, A.M.2    Gray, J.I.3
  • 4
    • 77956875053 scopus 로고    scopus 로고
    • Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin: optimization by response surface methodology
    • Contreras, M.D., Hernandez-Ledesma, B., Amigo, L., Martin-Alvarez, P.J. & Recio, I. (2011a). Production of antioxidant hydrolyzates from a whey protein concentrate with thermolysin: optimization by response surface methodology. LWT-Food Science and Technology, 44, 9–15.
    • (2011) LWT-Food Science and Technology , vol.44 , pp. 9-15
    • Contreras, M.D.1    Hernandez-Ledesma, B.2    Amigo, L.3    Martin-Alvarez, P.J.4    Recio, I.5
  • 5
    • 79955549808 scopus 로고    scopus 로고
    • Food-grade production of an antihypertensive casein hydrolysate and resistance of active peptides to drying and storage
    • Contreras, M.d.M, Sevilla, M.A, Monroy-Ruiz, J. et al. (2011b). Food-grade production of an antihypertensive casein hydrolysate and resistance of active peptides to drying and storage. International Dairy Journal, 21, 470–476.
    • (2011) International Dairy Journal , vol.21 , pp. 470-476
    • Contreras, M.D.M.1    Sevilla, M.A.2    Monroy-Ruiz, J.3
  • 6
    • 0033547645 scopus 로고    scopus 로고
    • Treatment of hypertension with ascorbic acid
    • Duffy, S., Gokce, N., Holbrook, M. et al. (1999). Treatment of hypertension with ascorbic acid. The Lancet, 354, 2048–2049.
    • (1999) The Lancet , vol.354 , pp. 2048-2049
    • Duffy, S.1    Gokce, N.2    Holbrook, M.3
  • 9
    • 34247153806 scopus 로고    scopus 로고
    • Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation
    • Foltz, M., Meynen, E.E., Bianco, V., van Platerink, C., Koning, T.M.M.G. & Kloek, J. (2007). Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation. Journal of Nutrition, 137, 953–958.
    • (2007) Journal of Nutrition , vol.137 , pp. 953-958
    • Foltz, M.1    Meynen, E.E.2    Bianco, V.3    van Platerink, C.4    Koning, T.M.M.G.5    Kloek, J.6
  • 10
    • 13244277961 scopus 로고    scopus 로고
    • Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS
    • Hernandez-Ledesma, B., Davalos, A., Bartolome, B. & Amigo, L. (2005). Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS. Journal of Agricultural and Food Chemistry, 53, 588–593.
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , pp. 588-593
    • Hernandez-Ledesma, B.1    Davalos, A.2    Bartolome, B.3    Amigo, L.4
  • 11
    • 34249339084 scopus 로고    scopus 로고
    • ACE-inhibitory and radical-scavenging activity of peptides derived from -lactoglobulin f(19−25). Interactions with ascorbic acid
    • Hernández-Ledesma, B., Amigo, L., Recio, I. & Bartolomé, B. (2007a). ACE-inhibitory and radical-scavenging activity of peptides derived from -lactoglobulin f(19−25). Interactions with ascorbic acid. Journal of Agricultural and Food Chemistry, 55, 3392–3397.
    • (2007) Journal of Agricultural and Food Chemistry , vol.55 , pp. 3392-3397
    • Hernández-Ledesma, B.1    Amigo, L.2    Recio, I.3    Bartolomé, B.4
  • 12
    • 33846015834 scopus 로고    scopus 로고
    • Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin
    • Hernández-Ledesma, B., Quirós, A., Amigo, L. & Recio, I. (2007b). Identification of bioactive peptides after digestion of human milk and infant formula with pepsin and pancreatin. International Dairy Journal, 17, 42–49.
    • (2007) International Dairy Journal , vol.17 , pp. 42-49
    • Hernández-Ledesma, B.1    Quirós, A.2    Amigo, L.3    Recio, I.4
  • 13
    • 84860278737 scopus 로고    scopus 로고
    • Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials
    • Juraschek, S.P., Guallar, E., Appel, L.J. & Miller, E.R. (2012). Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition, 95, 1079–1088.
    • (2012) The American Journal of Clinical Nutrition , vol.95 , pp. 1079-1088
    • Juraschek, S.P.1    Guallar, E.2    Appel, L.J.3    Miller, E.R.4
  • 14
    • 84920736150 scopus 로고    scopus 로고
    • Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes
    • Kleekayai, T., Harnedy, P.A., O'Keeffe, M.B. et al. (2015). Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes. Food Chemistry, 176, 441–447.
    • (2015) Food Chemistry , vol.176 , pp. 441-447
    • Kleekayai, T.1    Harnedy, P.A.2    O'Keeffe, M.B.3
  • 15
    • 84870322164 scopus 로고    scopus 로고
    • Characterization of structure–antioxidant activity relationship of peptides in free radical systems using QSAR models: key sequence positions and their amino acid properties
    • Li, Y.-W. & Li, B. (2013). Characterization of structure–antioxidant activity relationship of peptides in free radical systems using QSAR models: key sequence positions and their amino acid properties. Journal of Theoretical Biology, 318, 29–43.
    • (2013) Journal of Theoretical Biology , vol.318 , pp. 29-43
    • Li, Y.-W.1    Li, B.2
  • 16
    • 41849144523 scopus 로고    scopus 로고
    • Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides
    • López-Expósito, I., Quirós, A., Amigo, L. & Recio, I. (2007). Casein hydrolysates as a source of antimicrobial, antioxidant and antihypertensive peptides. Le Lait, 87, 241–249.
    • (2007) Le Lait , vol.87 , pp. 241-249
    • López-Expósito, I.1    Quirós, A.2    Amigo, L.3    Recio, I.4
  • 17
    • 84886552524 scopus 로고    scopus 로고
    • Biologically active food proteins and peptides in health: an overview
    • &, In, (edited by, Y. Mine, E. Li-Chan, &, B. Jiang, Oxford, Wiley-Blackwell
    • Mine, Y., Li-Chan, E.C.Y. & Jiang, B. (2010). Biologically active food proteins and peptides in health: an overview. In: Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals (edited by Y. Mine, E. Li-Chan & B. Jiang). Pp. 3–11. Oxford: Wiley-Blackwell.
    • (2010) Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals , pp. 3-11
    • Mine, Y.1    Li-Chan, E.C.Y.2    Jiang, B.3
  • 19
    • 84879481214 scopus 로고    scopus 로고
    • Insulinotropic properties of whey protein hydrolysates and impact of peptide fractionation on insulinotropic response
    • Nongonierma, A.B., Gaudel, C., Murray, B.A. et al. (2013). Insulinotropic properties of whey protein hydrolysates and impact of peptide fractionation on insulinotropic response. International Dairy Journal, 32, 163–168.
    • (2013) International Dairy Journal , vol.32 , pp. 163-168
    • Nongonierma, A.B.1    Gaudel, C.2    Murray, B.A.3
  • 20
    • 84956766460 scopus 로고    scopus 로고
    • Milk protein hydrolysates and bioactive peptides
    • &, In, (edited by, P.L.H. McSweeney, &, J.A. O'Mahony, New York, Springer
    • Nongonierma, A.B., O'Keeffe, M.B. & FitzGerald, R.J. (2016). Milk protein hydrolysates and bioactive peptides. In: Advanced Dairy Chemistry (edited by P.L.H. McSweeney & J.A. O'Mahony). Pp. 417–482. New York: Springer.
    • (2016) Advanced Dairy Chemistry , pp. 417-482
    • Nongonierma, A.B.1    O'Keeffe, M.B.2    FitzGerald, R.J.3
  • 21
    • 84883803444 scopus 로고    scopus 로고
    • Antihypertensive Peptides from Food Proteins
    • &, In, (edited by, B. Hernandez-Ledesma, &, C.C. Hsieh, Rijeka, Croatia, InTech
    • Norris, R. & FitzGerald, R.J. (2013). Antihypertensive Peptides from Food Proteins. In: Bioactive Food Peptides in Health and Disease (edited by B. Hernandez-Ledesma & C.C. Hsieh). Pp. 45–72. Rijeka, Croatia: InTech.
    • (2013) Bioactive Food Peptides in Health and Disease , pp. 45-72
    • Norris, R.1    FitzGerald, R.J.2
  • 22
    • 84859791745 scopus 로고    scopus 로고
    • Predictive modelling of angiotensin converting enzyme inhibitory dipeptides
    • Norris, R., Casey, F., FitzGerald, R.J., Shields, D. & Mooney, C. (2012). Predictive modelling of angiotensin converting enzyme inhibitory dipeptides. Food Chemistry, 133, 1349–1354.
    • (2012) Food Chemistry , vol.133 , pp. 1349-1354
    • Norris, R.1    Casey, F.2    FitzGerald, R.J.3    Shields, D.4    Mooney, C.5
  • 23
    • 84894242430 scopus 로고    scopus 로고
    • Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity
    • Norris, R., Poyarkov, A., O'Keeffe, M.B. & FitzGerald, R.J. (2014). Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity. Food Chemistry, 156, 29–36.
    • (2014) Food Chemistry , vol.156 , pp. 29-36
    • Norris, R.1    Poyarkov, A.2    O'Keeffe, M.B.3    FitzGerald, R.J.4
  • 24
    • 84928905272 scopus 로고    scopus 로고
    • Peptide identification and angiotensin converting enzyme (ACE) inhibitory activity in prolyl endoproteinase digests of bovine αs-casein
    • Norris, R., O'Keeffe, M.B., Poyarkov, A. & FitzGerald, R.J. (2015). Peptide identification and angiotensin converting enzyme (ACE) inhibitory activity in prolyl endoproteinase digests of bovine αs-casein. Food Chemistry, 188, 210–217.
    • (2015) Food Chemistry , vol.188 , pp. 210-217
    • Norris, R.1    O'Keeffe, M.B.2    Poyarkov, A.3    FitzGerald, R.J.4
  • 25
    • 84896878189 scopus 로고    scopus 로고
    • Antioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells
    • O'Keeffe, M.B. & FitzGerald, R.J. (2014). Antioxidant effects of enzymatic hydrolysates of whey protein concentrate on cultured human endothelial cells. International Dairy Journal, 36, 128–135.
    • (2014) International Dairy Journal , vol.36 , pp. 128-135
    • O'Keeffe, M.B.1    FitzGerald, R.J.2
  • 26
    • 84926168802 scopus 로고    scopus 로고
    • Identification of short peptide sequences in complex milk protein hydrolysates
    • O'Keeffe, M.B. & FitzGerald, R.J. (2015). Identification of short peptide sequences in complex milk protein hydrolysates. Food Chemistry, 184, 140–146.
    • (2015) Food Chemistry , vol.184 , pp. 140-146
    • O'Keeffe, M.B.1    FitzGerald, R.J.2
  • 27
    • 84883787354 scopus 로고    scopus 로고
    • Pilot-scale production of hydrolysates with altered bio-functionalities based on thermally-denatured whey protein isolate
    • O'Loughlin, I.B., Murray, B.A., FitzGerald, R.J., Brodkorb, A. & Kelly, P.M. (2014). Pilot-scale production of hydrolysates with altered bio-functionalities based on thermally-denatured whey protein isolate. International Dairy Journal, 34, 146–152.
    • (2014) International Dairy Journal , vol.34 , pp. 146-152
    • O'Loughlin, I.B.1    Murray, B.A.2    FitzGerald, R.J.3    Brodkorb, A.4    Kelly, P.M.5
  • 28
    • 33748319573 scopus 로고    scopus 로고
    • Antioxidative peptides derived from milk proteins
    • Pihlanto, A. (2006). Antioxidative peptides derived from milk proteins. International Dairy Journal, 16, 1306–1314.
    • (2006) International Dairy Journal , vol.16 , pp. 1306-1314
    • Pihlanto, A.1
  • 29
    • 39149099961 scopus 로고    scopus 로고
    • ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum)
    • Pihlanto, A., Akkanen, S. & Korhonen, H.J. (2008). ACE-inhibitory and antioxidant properties of potato (Solanum tuberosum). Food Chemistry, 109, 104–112.
    • (2008) Food Chemistry , vol.109 , pp. 104-112
    • Pihlanto, A.1    Akkanen, S.2    Korhonen, H.J.3
  • 30
    • 84878368347 scopus 로고    scopus 로고
    • Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides
    • Power, O., Jakeman, P. & FitzGerald, R.J. (2013). Antioxidative peptides: enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides. Amino Acids, 44, 797–820.
    • (2013) Amino Acids , vol.44 , pp. 797-820
    • Power, O.1    Jakeman, P.2    FitzGerald, R.J.3
  • 31
    • 84902689746 scopus 로고    scopus 로고
    • Selective enrichment of bioactive properties during ultrafiltration of a tryptic digest of β-lactoglobulin
    • Power, O., Fernández, A., Norris, R., Riera, F.A. & FitzGerald, R.J. (2014). Selective enrichment of bioactive properties during ultrafiltration of a tryptic digest of β-lactoglobulin. Journal of Functional Foods, 9, 38–47.
    • (2014) Journal of Functional Foods , vol.9 , pp. 38-47
    • Power, O.1    Fernández, A.2    Norris, R.3    Riera, F.A.4    FitzGerald, R.J.5
  • 33
    • 77951432631 scopus 로고    scopus 로고
    • The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy
    • Ralph, S.J., Rodríguez-Enríquez, S., Neuzil, J., Saavedra, E. & Moreno-Sánchez, R. (2010). The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy. Molecular Aspects of Medicine, 31, 145–170.
    • (2010) Molecular Aspects of Medicine , vol.31 , pp. 145-170
    • Ralph, S.J.1    Rodríguez-Enríquez, S.2    Neuzil, J.3    Saavedra, E.4    Moreno-Sánchez, R.5
  • 34
    • 0035136024 scopus 로고    scopus 로고
    • Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition
    • Rival, S.G., Boeriu, C.G. & Wichers, H.J. (2001). Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. Journal of Agricultural and Food Chemistry, 49, 295–302.
    • (2001) Journal of Agricultural and Food Chemistry , vol.49 , pp. 295-302
    • Rival, S.G.1    Boeriu, C.G.2    Wichers, H.J.3
  • 35
    • 60949087943 scopus 로고    scopus 로고
    • Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats
    • Rivera, L., Morón, R., Zarzuelo, A. & Galisteo, M. (2009). Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochemical Pharmacology, 77, 1053–1063.
    • (2009) Biochemical Pharmacology , vol.77 , pp. 1053-1063
    • Rivera, L.1    Morón, R.2    Zarzuelo, A.3    Galisteo, M.4
  • 36
    • 13944264258 scopus 로고    scopus 로고
    • Aggregation properties of whey protein hydrolysates generated with Bacillus licheniformis proteinase activities
    • Spellman, D., Kenny, P., O'Cuinn, G. & FitzGerald, R.J. (2005). Aggregation properties of whey protein hydrolysates generated with Bacillus licheniformis proteinase activities. Journal of Agricultural and Food Chemistry, 53, 1258–1265.
    • (2005) Journal of Agricultural and Food Chemistry , vol.53 , pp. 1258-1265
    • Spellman, D.1    Kenny, P.2    O'Cuinn, G.3    FitzGerald, R.J.4
  • 37
    • 0034817211 scopus 로고    scopus 로고
    • Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis
    • Suetsuna, K. & Chen, J.-R. (2001). Identification of antihypertensive peptides from peptic digest of two microalgae, Chlorella vulgaris and Spirulina platensis. Marine Biotechnology, 3, 305–309.
    • (2001) Marine Biotechnology , vol.3 , pp. 305-309
    • Suetsuna, K.1    Chen, J.-R.2
  • 38
    • 79955468271 scopus 로고    scopus 로고
    • Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes
    • Tavares, T., del Mar Contreras, M., Amorim, M., Pintado, M., Recio, I. & Malcata, F.X. (2011). Novel whey-derived peptides with inhibitory effect against angiotensin-converting enzyme: in vitro effect and stability to gastrointestinal enzymes. Peptides, 32, 1013–1019.
    • (2011) Peptides , vol.32 , pp. 1013-1019
    • Tavares, T.1    del Mar Contreras, M.2    Amorim, M.3    Pintado, M.4    Recio, I.5    Malcata, F.X.6
  • 40
    • 84958214206 scopus 로고    scopus 로고
    • Antioxidant and ACE-inhibitory activities of hemp (Cannabis sativa L.) protein hydrolysates produced by the proteases AFP, HT, Pro-G, actinidin and zingibain
    • Teh, S.-S., Bekhit, A.E.-D.A., Carne, A. & Birch, J. (2016). Antioxidant and ACE-inhibitory activities of hemp (Cannabis sativa L.) protein hydrolysates produced by the proteases AFP, HT, Pro-G, actinidin and zingibain. Food Chemistry, 203, 199–206.
    • (2016) Food Chemistry , vol.203 , pp. 199-206
    • Teh, S.-S.1    Bekhit, A.E.-D.A.2    Carne, A.3    Birch, J.4
  • 41
    • 8644277006 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: implications in hypertension
    • Touyz, R.M. & Schiffrin, E.L. (2004). Reactive oxygen species in vascular biology: implications in hypertension. Histochemistry and Cell Biology, 122, 339–352.
    • (2004) Histochemistry and Cell Biology , vol.122 , pp. 339-352
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 43
    • 84967045459 scopus 로고    scopus 로고
    • Factsheet 317. Updated January 2015
    • WHO (2015). Cardiovascular Diseases (CVDs). Factsheet No. 317. Updated January 2015. URL: www.who.int/mediacentre/factsheets/fs317/en/
    • (2015) Cardiovascular Diseases (CVDs)
  • 44
    • 33750333538 scopus 로고    scopus 로고
    • Structural requirements of angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship modeling of peptides containing 4-10 amino acid residues
    • Wu, J., Aluko, R.E. & Nakai, S. (2006a). Structural requirements of angiotensin I-converting enzyme inhibitory peptides: quantitative structure-activity relationship modeling of peptides containing 4-10 amino acid residues. QSAR & Combinatorial Science, 25, 873–880.
    • (2006) QSAR & Combinatorial Science , vol.25 , pp. 873-880
    • Wu, J.1    Aluko, R.E.2    Nakai, S.3
  • 45
    • 33244488716 scopus 로고    scopus 로고
    • Structural requirements of angiotensin I-converting enzyme inhibitory peptides: quantitative structure−activity relationship study of di- and tripeptides
    • Wu, J., Aluko, R.E. & Nakai, S. (2006b). Structural requirements of angiotensin I-converting enzyme inhibitory peptides: quantitative structure−activity relationship study of di- and tripeptides. Journal of Agricultural and Food Chemistry, 54, 732–738.
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , pp. 732-738
    • Wu, J.1    Aluko, R.E.2    Nakai, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.