메뉴 건너뛰기




Volumn 369, Issue 1, 2017, Pages 105-118

Genetic kidney diseases: Caenorhabditis elegans as model system

Author keywords

Aging; Caenorhabditis elegans; Cilia; Genetic kidney disease; Podocyte morphogenesis

Indexed keywords

AUTOSOMAL RECESSIVE DISORDER; AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE; BARDET BIEDL SYNDROME; CAENORHABDITIS ELEGANS; CILIOPATHY; DISEASE ASSOCIATION; DISEASE MODEL; GENETIC DISORDER; GENETIC KIDNEY DISEASE; GENOTYPE PHENOTYPE CORRELATION; HEREDITARY TUMOR SYNDROME; HUMAN; KIDNEY CARCINOMA; KIDNEY DEVELOPMENT; KIDNEY DISEASE; KIDNEY POLYCYSTIC DISEASE; KIDNEY TUBULE EXCRETION; NEPHRONOPHTHISIS; NEPHROTIC SYNDROME; NONHUMAN; PATHOGENESIS; PENETRANCE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; METABOLISM;

EID: 85019027989     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-017-2622-z     Document Type: Review
Times cited : (15)

References (99)
  • 2
    • 40849084015 scopus 로고    scopus 로고
    • The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD1cXjs1artbg%3D, PID: 18245347
    • Bacaj T, Lu Y, Shaham S (2008) The conserved proteins CHE-12 and DYF-11 are required for sensory cilium function in Caenorhabditis elegans. Genetics 178:989–1002
    • (2008) Genetics , vol.178 , pp. 989-1002
    • Bacaj, T.1    Lu, Y.2    Shaham, S.3
  • 3
    • 33750490373 scopus 로고    scopus 로고
    • General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia
    • COI: 1:CAS:528:DC%2BD28XhtFyms7%2FJ, PID: 16943275
    • Bae YK, Qin H, Knobel KM, Hu J, Rosenbaum JL, Barr MM (2006) General and cell-type specific mechanisms target TRPP2/PKD-2 to cilia. Development 133:3859–3870
    • (2006) Development , vol.133 , pp. 3859-3870
    • Bae, Y.K.1    Qin, H.2    Knobel, K.M.3    Hu, J.4    Rosenbaum, J.L.5    Barr, M.M.6
  • 4
    • 0033598394 scopus 로고    scopus 로고
    • A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans
    • COI: 1:CAS:528:DyaK1MXmsFensr0%3D, PID: 10517638
    • Barr MM, Sternberg PW (1999) A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans. Nature 401:386–389
    • (1999) Nature , vol.401 , pp. 386-389
    • Barr, M.M.1    Sternberg, P.W.2
  • 5
    • 0035806961 scopus 로고    scopus 로고
    • The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway
    • COI: 1:CAS:528:DC%2BD3MXmvVyrurg%3D, PID: 11553327
    • Barr MM, DeModena J, Braun D, Nguyen CQ, Hall DH, Sternberg PW (2001) The Caenorhabditis elegans autosomal dominant polycystic kidney disease gene homologs lov-1 and pkd-2 act in the same pathway. Curr Biol 11:1341–1346
    • (2001) Curr Biol , vol.11 , pp. 1341-1346
    • Barr, M.M.1    DeModena, J.2    Braun, D.3    Nguyen, C.Q.4    Hall, D.H.5    Sternberg, P.W.6
  • 6
    • 0025997389 scopus 로고
    • Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans
    • COI: 1:CAS:528:DyaK3sXhvVWguw%3D%3D, PID: 1756579
    • Barstead RJ, Kleiman L, Waterston RH (1991) Cloning, sequencing, and mapping of an alpha-actinin gene from the nematode Caenorhabditis elegans. Cell Motil Cytoskeleton 20:69–78
    • (1991) Cell Motil Cytoskeleton , vol.20 , pp. 69-78
    • Barstead, R.J.1    Kleiman, L.2    Waterston, R.H.3
  • 7
    • 84868561161 scopus 로고    scopus 로고
    • Genetic causes and mechanisms of distal renal tubular acidosis
    • COI: 1:CAS:528:DC%2BC38Xhs1CqsLbJ, PID: 23114896
    • Batlle D, Haque SK (2012) Genetic causes and mechanisms of distal renal tubular acidosis. Nephrol Dial Transplant 27:3691–3704
    • (2012) Nephrol Dial Transplant , vol.27 , pp. 3691-3704
    • Batlle, D.1    Haque, S.K.2
  • 10
    • 0034034757 scopus 로고    scopus 로고
    • NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
    • COI: 1:CAS:528:DC%2BD3cXisVCjsb4%3D, PID: 10742096
    • Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24:349–354
    • (2000) Nat Genet , vol.24 , pp. 349-354
    • Boute, N.1    Gribouval, O.2    Roselli, S.3    Benessy, F.4    Lee, H.5    Fuchshuber, A.6    Dahan, K.7    Gubler, M.C.8    Niaudet, P.9    Antignac, C.10
  • 12
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • COI: 1:STN:280:DyaE2c3ntFWlsw%3D%3D, PID: 4366476
    • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77:71–94
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 14
    • 0033214947 scopus 로고    scopus 로고
    • Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell
    • COI: 1:CAS:528:DyaK1MXlvFagtrk%3D, PID: 10491271
    • Buechner M, Hall DH, Bhatt H, Hedgecock EM (1999) Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell. Dev Biol 214:227–241
    • (1999) Dev Biol , vol.214 , pp. 227-241
    • Buechner, M.1    Hall, D.H.2    Bhatt, H.3    Hedgecock, E.M.4
  • 15
    • 84892742828 scopus 로고    scopus 로고
    • Local F-actin network links synapse formation and axon branching
    • COI: 1:CAS:528:DC%2BC2cXhtFyqtL4%3D, PID: 24439377
    • Chia PH, Chen B, Li P, Rosen MK, Shen K (2014) Local F-actin network links synapse formation and axon branching. Cell 156:208–220
    • (2014) Cell , vol.156 , pp. 208-220
    • Chia, P.H.1    Chen, B.2    Li, P.3    Rosen, M.K.4    Shen, K.5
  • 16
    • 34548044548 scopus 로고    scopus 로고
    • Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination
    • COI: 1:CAS:528:DC%2BD2sXptVaju7Y%3D, PID: 17626846
    • Ding M, Chao D, Wang G, Shen K (2007) Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination. Science 317:947–951
    • (2007) Science , vol.317 , pp. 947-951
    • Ding, M.1    Chao, D.2    Wang, G.3    Shen, K.4
  • 20
    • 33750478660 scopus 로고    scopus 로고
    • A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels
    • COI: 1:CAS:528:DC%2BD28Xht1Wgtb%2FF, PID: 17081982
    • Feng Z, Li W, Ward A, Piggott BJ, Larkspur ER, Sternberg PW, Xu XZ (2006) A C. elegans model of nicotine-dependent behavior: regulation by TRP-family channels. Cell 127:621–633
    • (2006) Cell , vol.127 , pp. 621-633
    • Feng, Z.1    Li, W.2    Ward, A.3    Piggott, B.J.4    Larkspur, E.R.5    Sternberg, P.W.6    Xu, X.Z.7
  • 22
    • 0037186523 scopus 로고    scopus 로고
    • MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation
    • COI: 1:CAS:528:DC%2BD38XhvVWjtr0%3D, PID: 11875573
    • Goodman MB, Ernstrom GG, Chelur DS, O'Hagan R, Yao CA, Chalfie M (2002) MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature 415:1039–1042
    • (2002) Nature , vol.415 , pp. 1039-1042
    • Goodman, M.B.1    Ernstrom, G.G.2    Chelur, D.S.3    O'Hagan, R.4    Yao, C.A.5    Chalfie, M.6
  • 23
    • 84925546346 scopus 로고    scopus 로고
    • VHL, the story of a tumour suppressor gene
    • COI: 1:CAS:528:DC%2BC2cXitFKlu73E, PID: 25533676
    • Gossage L, Eisen T, Maher ER (2015) VHL, the story of a tumour suppressor gene. Nat Rev Cancer 15:55–64
    • (2015) Nat Rev Cancer , vol.15 , pp. 55-64
    • Gossage, L.1    Eisen, T.2    Maher, E.R.3
  • 24
    • 84884670045 scopus 로고    scopus 로고
    • The podocyte slit diaphragm—from a thin grey line to a complex signalling hub
    • COI: 1:CAS:528:DC%2BC3sXhsVWqsrnP, PID: 23999399
    • Grahammer F, Schell C, Huber TB (2013) The podocyte slit diaphragm—from a thin grey line to a complex signalling hub. Nat Rev Nephrol 9:587–598
    • (2013) Nat Rev Nephrol , vol.9 , pp. 587-598
    • Grahammer, F.1    Schell, C.2    Huber, T.B.3
  • 25
    • 68249132212 scopus 로고    scopus 로고
    • The Caenorhabditis elegans HNF4alpha homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase
    • PID: 19668342
    • Hahn-Windgassen A, Van Gilst MR (2009) The Caenorhabditis elegans HNF4alpha homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase. PLoS Genet 5:e1000553
    • (2009) PLoS Genet , vol.5
    • Hahn-Windgassen, A.1    Van Gilst, M.R.2
  • 27
    • 0034987372 scopus 로고    scopus 로고
    • The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms
    • COI: 1:CAS:528:DC%2BD3MXktVWlsL4%3D, PID: 11290289
    • Haycraft CJ, Swoboda P, Taulman PD, Thomas JH, Yoder BK (2001) The C. elegans homolog of the murine cystic kidney disease gene Tg737 functions in a ciliogenic pathway and is disrupted in osm-5 mutant worms. Development 128:1493–1505
    • (2001) Development , vol.128 , pp. 1493-1505
    • Haycraft, C.J.1    Swoboda, P.2    Taulman, P.D.3    Thomas, J.H.4    Yoder, B.K.5
  • 28
  • 30
    • 37849001774 scopus 로고    scopus 로고
    • Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity
    • COI: 1:CAS:528:DC%2BD1cXhvFKlsA%3D%3D, PID: 18049475
    • Hisamoto N, Moriguchi T, Urushiyama S, Mitani S, Shibuya H, Matsumoto K (2008) Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep 9:70–75
    • (2008) EMBO Rep , vol.9 , pp. 70-75
    • Hisamoto, N.1    Moriguchi, T.2    Urushiyama, S.3    Mitani, S.4    Shibuya, H.5    Matsumoto, K.6
  • 31
    • 77951743346 scopus 로고    scopus 로고
    • Reconstructing the evolutionary history of the centriole from protein components
    • COI: 1:CAS:528:DC%2BC3cXnt1Kmt7k%3D, PID: 20388734
    • Hodges ME, Scheumann N, Wickstead B, Langdale JA, Gull K (2010) Reconstructing the evolutionary history of the centriole from protein components. J Cell Sci 123:1407–1413
    • (2010) J Cell Sci , vol.123 , pp. 1407-1413
    • Hodges, M.E.1    Scheumann, N.2    Wickstead, B.3    Langdale, J.A.4    Gull, K.5
  • 32
    • 79959794426 scopus 로고    scopus 로고
    • TRPP channels and polycystins
    • COI: 1:CAS:528:DC%2BC38XpsVKls7s%3D, PID: 21290302
    • Hofherr A, Kottgen M (2011) TRPP channels and polycystins. Adv Exp Med Biol 704:287–313
    • (2011) Adv Exp Med Biol , vol.704 , pp. 287-313
    • Hofherr, A.1    Kottgen, M.2
  • 34
    • 84861356212 scopus 로고    scopus 로고
    • Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms
    • COI: 1:CAS:528:DC%2BC38XmtlKhsL4%3D, PID: 21996733
    • Hsu T (2012) Complex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms. Oncogene 31:2247–2257
    • (2012) Oncogene , vol.31 , pp. 2247-2257
    • Hsu, T.1
  • 35
    • 12844254280 scopus 로고    scopus 로고
    • ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling
    • COI: 1:CAS:528:DC%2BD2MXhtVGit78%3D, PID: 15563610
    • Hu J, Barr MM (2005) ATP-2 interacts with the PLAT domain of LOV-1 and is involved in Caenorhabditis elegans polycystin signaling. Mol Biol Cell 16:458–469
    • (2005) Mol Biol Cell , vol.16 , pp. 458-469
    • Hu, J.1    Barr, M.M.2
  • 36
    • 0028839194 scopus 로고
    • A stomatin-like protein necessary for mechanosensation in C. elegans
    • COI: 1:CAS:528:DyaK2MXpsVylsbc%3D, PID: 7477350
    • Huang M, Gu G, Ferguson EL, Chalfie M (1995) A stomatin-like protein necessary for mechanosensation in C. elegans. Nature 378:292–295
    • (1995) Nature , vol.378 , pp. 292-295
    • Huang, M.1    Gu, G.2    Ferguson, E.L.3    Chalfie, M.4
  • 39
    • 38449122706 scopus 로고    scopus 로고
    • The sensory cilia of Caenorhabditis elegans
    • Inglis PN, Ou G, Leroux MR, Scholey JM (2007) The sensory cilia of Caenorhabditis elegans. WormBook 2007: 1-22. DOI: 10.1895/wormbook.1.126.2
    • (2007) WormBook , vol.2007 , pp. 1-22
    • Inglis, P.N.1    Ou, G.2    Leroux, M.R.3    Scholey, J.M.4
  • 40
    • 79953032655 scopus 로고    scopus 로고
    • Ciliogenesis: building the cell's antenna
    • COI: 1:CAS:528:DC%2BC3MXjs1Cqt7k%3D, PID: 21427764
    • Ishikawa H, Marshall WF (2011) Ciliogenesis: building the cell's antenna. Nat Rev Mol Cell Biol 12:222–234
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 222-234
    • Ishikawa, H.1    Marshall, W.F.2
  • 41
    • 16244368744 scopus 로고    scopus 로고
    • Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors
    • COI: 1:CAS:528:DC%2BD2MXjt1KiurY%3D, PID: 15817158
    • Jauregui AR, Barr MM (2005) Functional characterization of the C. elegans nephrocystins NPHP-1 and NPHP-4 and their role in cilia and male sensory behaviors. Exp Cell Res 305:333–342
    • (2005) Exp Cell Res , vol.305 , pp. 333-342
    • Jauregui, A.R.1    Barr, M.M.2
  • 42
    • 40849097592 scopus 로고    scopus 로고
    • The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure
    • COI: 1:CAS:528:DC%2BD1cXjtlKmur4%3D, PID: 18316409
    • Jauregui AR, Nguyen KC, Hall DH, Barr MM (2008) The Caenorhabditis elegans nephrocystins act as global modifiers of cilium structure. J Cell Biol 180:973–988
    • (2008) J Cell Biol , vol.180 , pp. 973-988
    • Jauregui, A.R.1    Nguyen, K.C.2    Hall, D.H.3    Barr, M.M.4
  • 43
    • 84944411248 scopus 로고    scopus 로고
    • Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance
    • COI: 1:CAS:528:DC%2BC2MXhsFajurbO, PID: 26392567
    • Jensen VL, Li C, Bowie RV, Clarke L, Mohan S, Blacque OE, Leroux MR (2015) Formation of the transition zone by Mks5/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance. EMBO J 34:2537–2556
    • (2015) EMBO J , vol.34 , pp. 2537-2556
    • Jensen, V.L.1    Li, C.2    Bowie, R.V.3    Clarke, L.4    Mohan, S.5    Blacque, O.E.6    Leroux, M.R.7
  • 44
    • 77953879123 scopus 로고    scopus 로고
    • The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia
    • COI: 1:CAS:528:DC%2BC3cXovFarur4%3D, PID: 20603001
    • Jin H, White SR, Shida T, Schulz S, Aguiar M, Gygi SP, Bazan JF, Nachury MV (2010) The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell 141:1208–1219
    • (2010) Cell , vol.141 , pp. 1208-1219
    • Jin, H.1    White, S.R.2    Shida, T.3    Schulz, S.4    Aguiar, M.5    Gygi, S.P.6    Bazan, J.F.7    Nachury, M.V.8
  • 45
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism
    • COI: 1:CAS:528:DC%2BD28XktVGmtr8%3D, PID: 16672925
    • Kaletta T, Hengartner MO (2006) Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov 5:387–398
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 46
    • 4444245789 scopus 로고    scopus 로고
    • Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD2cXnsVyqu7g%3D, PID: 15355798
    • Kariya K, Bui YK, Gao X, Sternberg PW, Kataoka T (2004) Phospholipase Cepsilon regulates ovulation in Caenorhabditis elegans. Dev Biol 274:201–210
    • (2004) Dev Biol , vol.274 , pp. 201-210
    • Kariya, K.1    Bui, Y.K.2    Gao, X.3    Sternberg, P.W.4    Kataoka, T.5
  • 48
    • 18844393668 scopus 로고    scopus 로고
    • Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis
    • COI: 1:CAS:528:DC%2BD2MXktlShsLs%3D, PID: 15790966
    • Kramer-Zucker AG, Olale F, Haycraft CJ, Yoder BK, Schier AF, Drummond IA (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development 132:1907–1921
    • (2005) Development , vol.132 , pp. 1907-1921
    • Kramer-Zucker, A.G.1    Olale, F.2    Haycraft, C.J.3    Yoder, B.K.4    Schier, A.F.5    Drummond, I.A.6
  • 50
    • 84855179325 scopus 로고    scopus 로고
    • Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants
    • COI: 1:CAS:528:DC%2BC38XhsFWjsA%3D%3D, PID: 22180729
    • Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K (2011) Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol 9:e1001219
    • (2011) PLoS Biol , vol.9
    • Lee, B.H.1    Liu, J.2    Wong, D.3    Srinivasan, S.4    Ashrafi, K.5
  • 53
    • 79951868152 scopus 로고    scopus 로고
    • Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL
    • COI: 1:CAS:528:DC%2BC3MXjs1yksLo%3D, PID: 21155973
    • Li M, Kim WY (2011) Two sides to every story: the HIF-dependent and HIF-independent functions of pVHL. J Cell Mol Med 15:187–195
    • (2011) J Cell Mol Med , vol.15 , pp. 187-195
    • Li, M.1    Kim, W.Y.2
  • 54
    • 84996590429 scopus 로고    scopus 로고
    • Genetic testing in steroid-resistant nephrotic syndrome: when and how?
    • PID: 26507970
    • Lovric S, Ashraf S, Tan W, Hildebrandt F (2016) Genetic testing in steroid-resistant nephrotic syndrome: when and how? Nephrol Dial Transplant 31:1802–1813
    • (2016) Nephrol Dial Transplant , vol.31 , pp. 1802-1813
    • Lovric, S.1    Ashraf, S.2    Tan, W.3    Hildebrandt, F.4
  • 55
    • 33644616841 scopus 로고    scopus 로고
    • Polygenic control of Caenorhabditis elegans fat storage
    • COI: 1:CAS:528:DC%2BD28XhslCjtrg%3D, PID: 16462744
    • Mak HY, Nelson LS, Basson M, Johnson CD, Ruvkun G (2006) Polygenic control of Caenorhabditis elegans fat storage. Nat Genet 38:363–368
    • (2006) Nat Genet , vol.38 , pp. 363-368
    • Mak, H.Y.1    Nelson, L.S.2    Basson, M.3    Johnson, C.D.4    Ruvkun, G.5
  • 58
    • 80055070334 scopus 로고    scopus 로고
    • Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC3MXhsVWqsb7P, PID: 22022287
    • Mok CA, Healey MP, Shekhar T, Leroux MR, Heon E, Zhen M (2011) Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans. PLoS Genet 7:e1002335
    • (2011) PLoS Genet , vol.7
    • Mok, C.A.1    Healey, M.P.2    Shekhar, T.3    Leroux, M.R.4    Heon, E.5    Zhen, M.6
  • 59
    • 34250894981 scopus 로고    scopus 로고
    • Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans
    • COI: 1:CAS:528:DC%2BD2sXms1Wnt7Y%3D, PID: 17510633
    • Mukhopadhyay S, Lu Y, Qin H, Lanjuin A, Shaham S, Sengupta P (2007) Distinct IFT mechanisms contribute to the generation of ciliary structural diversity in C. elegans. EMBO J 26:2966–2980
    • (2007) EMBO J , vol.26 , pp. 2966-2980
    • Mukhopadhyay, S.1    Lu, Y.2    Qin, H.3    Lanjuin, A.4    Shaham, S.5    Sengupta, P.6
  • 63
    • 84982102705 scopus 로고    scopus 로고
    • The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BC28XhtlCit7fE, PID: 27515926
    • Niwa S (2016) The nephronophthisis-related gene ift-139 is required for ciliogenesis in Caenorhabditis elegans. Sci Rep 6:31544
    • (2016) Sci Rep , vol.6 , pp. 31544
    • Niwa, S.1
  • 64
    • 84946491886 scopus 로고    scopus 로고
    • Bardet-Biedl syndrome: is it only cilia dysfunction?
    • COI: 1:CAS:528:DC%2BC2MXht1Crt7fI, PID: 26231314
    • Novas R, Cardenas-Rodriguez M, Irigoin F, Badano JL (2015) Bardet-Biedl syndrome: is it only cilia dysfunction? FEBS Lett 589:3479–3491
    • (2015) FEBS Lett , vol.589 , pp. 3479-3491
    • Novas, R.1    Cardenas-Rodriguez, M.2    Irigoin, F.3    Badano, J.L.4
  • 65
    • 16644397827 scopus 로고    scopus 로고
    • The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    • PID: 15580270
    • O'Hagan R, Chalfie M, Goodman MB (2005) The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat Neurosci 8:43–50
    • (2005) Nat Neurosci , vol.8 , pp. 43-50
    • O'Hagan, R.1    Chalfie, M.2    Goodman, M.B.3
  • 66
    • 23144445446 scopus 로고    scopus 로고
    • Functional coordination of intraflagellar transport motors
    • COI: 1:CAS:528:DC%2BD2MXmsFCgsL4%3D, PID: 16049494
    • Ou G, Blacque OE, Snow JJ, Leroux MR, Scholey JM (2005) Functional coordination of intraflagellar transport motors. Nature 436:583–587
    • (2005) Nature , vol.436 , pp. 583-587
    • Ou, G.1    Blacque, O.E.2    Snow, J.J.3    Leroux, M.R.4    Scholey, J.M.5
  • 67
    • 0034735526 scopus 로고    scopus 로고
    • Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella
    • COI: 1:CAS:528:DC%2BD3cXnsl2lsbg%3D, PID: 11062270
    • Pazour GJ, Dickert BL, Vucica Y, Seeley ES, Rosenbaum JL, Witman GB, Cole DG (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella. J Cell Biol 151:709–718
    • (2000) J Cell Biol , vol.151 , pp. 709-718
    • Pazour, G.J.1    Dickert, B.L.2    Vucica, Y.3    Seeley, E.S.4    Rosenbaum, J.L.5    Witman, G.B.6    Cole, D.G.7
  • 68
    • 0037019017 scopus 로고    scopus 로고
    • Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease
    • COI: 1:CAS:528:DC%2BD38XksFOjt70%3D, PID: 12062067
    • Pazour GJ, San Agustin JT, Follit JA, Rosenbaum JL, Witman GB (2002) Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease. Curr Biol 12:R378–R380
    • (2002) Curr Biol , vol.12 , pp. R378-R380
    • Pazour, G.J.1    San Agustin, J.T.2    Follit, J.A.3    Rosenbaum, J.L.4    Witman, G.B.5
  • 69
    • 0022792740 scopus 로고
    • Mutant sensory cilia in the nematode Caenorhabditis elegans
    • COI: 1:STN:280:DyaL2s%2FgsFGluw%3D%3D, PID: 2428682
    • Perkins LA, Hedgecock EM, Thomson JN, Culotti JG (1986) Mutant sensory cilia in the nematode Caenorhabditis elegans. Dev Biol 117:456–487
    • (1986) Dev Biol , vol.117 , pp. 456-487
    • Perkins, L.A.1    Hedgecock, E.M.2    Thomson, J.N.3    Culotti, J.G.4
  • 70
    • 15544367400 scopus 로고    scopus 로고
    • A physiological view of the primary cilium
    • COI: 1:CAS:528:DC%2BD2MXjsFeksrY%3D, PID: 15709968
    • Praetorius HA, Spring KR (2005) A physiological view of the primary cilium. Annu Rev Physiol 67:515–529
    • (2005) Annu Rev Physiol , vol.67 , pp. 515-529
    • Praetorius, H.A.1    Spring, K.R.2
  • 71
    • 0035916823 scopus 로고    scopus 로고
    • An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons
    • COI: 1:CAS:528:DC%2BD3MXis1Sjt7w%3D, PID: 11301258
    • Qin H, Rosenbaum JL, Barr MM (2001) An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons. Curr Biol 11:457–461
    • (2001) Curr Biol , vol.11 , pp. 457-461
    • Qin, H.1    Rosenbaum, J.L.2    Barr, M.M.3
  • 72
    • 84989819635 scopus 로고    scopus 로고
    • Precision medicine from the renal cancer genome
    • COI: 1:CAS:528:DC%2BC28Xhs1aqtb7I, PID: 27694978
    • Riazalhosseini Y, Lathrop M (2016) Precision medicine from the renal cancer genome. Nat Rev Nephrol 12:655–666
    • (2016) Nat Rev Nephrol , vol.12 , pp. 655-666
    • Riazalhosseini, Y.1    Lathrop, M.2
  • 75
    • 84925370956 scopus 로고    scopus 로고
    • The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons
    • COI: 1:CAS:528:DC%2BC2MXksVaisLg%3D, PID: 25771894
    • Shaye DD, Greenwald I (2015) The disease-associated formin INF2/EXC-6 organizes lumen and cell outgrowth during tubulogenesis by regulating F-actin and microtubule cytoskeletons. Dev Cell 32:743–755
    • (2015) Dev Cell , vol.32 , pp. 743-755
    • Shaye, D.D.1    Greenwald, I.2
  • 76
    • 0037423919 scopus 로고    scopus 로고
    • The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans
    • COI: 1:CAS:528:DC%2BD3sXitFykurg%3D, PID: 12628183
    • Shen K, Bargmann CI (2003) The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans. Cell 112:619–630
    • (2003) Cell , vol.112 , pp. 619-630
    • Shen, K.1    Bargmann, C.I.2
  • 77
    • 1642634997 scopus 로고    scopus 로고
    • Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1
    • COI: 1:CAS:528:DC%2BD2cXivVyksL0%3D, PID: 15035988
    • Shen K, Fetter RD, Bargmann CI (2004) Synaptic specificity is generated by the synaptic guidepost protein SYG-2 and its receptor, SYG-1. Cell 116:869–881
    • (2004) Cell , vol.116 , pp. 869-881
    • Shen, K.1    Fetter, R.D.2    Bargmann, C.I.3
  • 78
    • 20144362749 scopus 로고    scopus 로고
    • Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans
    • COI: 1:CAS:528:DC%2BD2MXktlCls7s%3D, PID: 15781453
    • Shen C, Nettleton D, Jiang M, Kim SK, Powell-Coffman JA (2005) Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. J Biol Chem 280:20580–20588
    • (2005) J Biol Chem , vol.280 , pp. 20580-20588
    • Shen, C.1    Nettleton, D.2    Jiang, M.3    Kim, S.K.4    Powell-Coffman, J.A.5
  • 79
    • 62149117660 scopus 로고    scopus 로고
    • Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region
    • COI: 1:CAS:528:DC%2BD1MXhtlCmtbc%3D, PID: 19050042
    • Shiba D, Yamaoka Y, Hagiwara H, Takamatsu T, Hamada H, Yokoyama T (2009) Localization of Inv in a distinctive intraciliary compartment requires the C-terminal ninein-homolog-containing region. J Cell Sci 122:44–54
    • (2009) J Cell Sci , vol.122 , pp. 44-54
    • Shiba, D.1    Yamaoka, Y.2    Hagiwara, H.3    Takamatsu, T.4    Hamada, H.5    Yokoyama, T.6
  • 80
    • 7944222301 scopus 로고    scopus 로고
    • Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons
    • COI: 1:CAS:528:DC%2BD2cXptFentLo%3D, PID: 15489852
    • Snow JJ, Ou G, Gunnarson AL, Walker MR, Zhou HM, Brust-Mascher I, Scholey JM (2004) Two anterograde intraflagellar transport motors cooperate to build sensory cilia on C. elegans neurons. Nat Cell Biol 6:1109–1113
    • (2004) Nat Cell Biol , vol.6 , pp. 1109-1113
    • Snow, J.J.1    Ou, G.2    Gunnarson, A.L.3    Walker, M.R.4    Zhou, H.M.5    Brust-Mascher, I.6    Scholey, J.M.7
  • 81
    • 84908417266 scopus 로고    scopus 로고
    • CLC channel function and dysfunction in health and disease
    • PID: 25339907
    • Stolting G, Fischer M, Fahlke C (2014) CLC channel function and dysfunction in health and disease. Front Physiol 5:378
    • (2014) Front Physiol , vol.5 , pp. 378
    • Stolting, G.1    Fischer, M.2    Fahlke, C.3
  • 82
    • 84979917597 scopus 로고    scopus 로고
    • The Caenorhabditis elegans excretory system: a model for tubulogenesis, cell fate specification, and plasticity
    • PID: 27183565
    • Sundaram MV, Buechner M (2016) The Caenorhabditis elegans excretory system: a model for tubulogenesis, cell fate specification, and plasticity. Genetics 203:35–63
    • (2016) Genetics , vol.203 , pp. 35-63
    • Sundaram, M.V.1    Buechner, M.2
  • 83
    • 34047276812 scopus 로고    scopus 로고
    • Autosomal dominant polycystic kidney disease
    • PID: 17434405
    • Torres VE, Harris PC, Pirson Y (2007) Autosomal dominant polycystic kidney disease. Lancet 369:1287–1301
    • (2007) Lancet , vol.369 , pp. 1287-1301
    • Torres, V.E.1    Harris, P.C.2    Pirson, Y.3
  • 84
    • 84961201778 scopus 로고    scopus 로고
    • Ciliary extracellular vesicles: txt Msg organelles
    • COI: 1:CAS:528:DC%2BC28XksVyns7w%3D, PID: 26983828
    • Wang J, Barr MM (2016) Ciliary extracellular vesicles: txt Msg organelles. Cell Mol Neurobiol 36:449–457
    • (2016) Cell Mol Neurobiol , vol.36 , pp. 449-457
    • Wang, J.1    Barr, M.M.2
  • 85
    • 84897606897 scopus 로고    scopus 로고
    • C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication
    • COI: 1:CAS:528:DC%2BC2cXisFCjsbg%3D, PID: 24530063
    • Wang J, Silva M, Haas LA, Morsci NS, Nguyen KC, Hall DH, Barr MM (2014) C. elegans ciliated sensory neurons release extracellular vesicles that function in animal communication. Curr Biol 24:519–525
    • (2014) Curr Biol , vol.24 , pp. 519-525
    • Wang, J.1    Silva, M.2    Haas, L.A.3    Morsci, N.S.4    Nguyen, K.C.5    Hall, D.H.6    Barr, M.M.7
  • 87
    • 80051705567 scopus 로고    scopus 로고
    • Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis
    • COI: 1:CAS:528:DC%2BC3MXhtFGktrvN, PID: 21858180
    • Wanner N, Noutsou F, Baumeister R, Walz G, Huber TB, Neumann-Haefelin E (2011) Functional and spatial analysis of C. elegans SYG-1 and SYG-2, orthologs of the Neph/nephrin cell adhesion module directing selective synaptogenesis. PLoS One 6:e23598
    • (2011) PLoS One , vol.6
    • Wanner, N.1    Noutsou, F.2    Baumeister, R.3    Walz, G.4    Huber, T.B.5    Neumann-Haefelin, E.6
  • 88
    • 84863332430 scopus 로고    scopus 로고
    • Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins
    • COI: 1:CAS:528:DC%2BC38Xht1OrsrzJ, PID: 22393243
    • Warburton-Pitt SR, Jauregui AR, Li C, Wang J, Leroux MR, Barr MM (2012) Ciliogenesis in Caenorhabditis elegans requires genetic interactions between ciliary middle segment localized NPHP-2 (inversin) and transition zone-associated proteins. J Cell Sci 125:2592–2603
    • (2012) J Cell Sci , vol.125 , pp. 2592-2603
    • Warburton-Pitt, S.R.1    Jauregui, A.R.2    Li, C.3    Wang, J.4    Leroux, M.R.5    Barr, M.M.6
  • 89
    • 84919608436 scopus 로고    scopus 로고
    • The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans
    • PID: 25501555
    • Warburton-Pitt SR, Silva M, Nguyen KC, Hall DH, Barr MM (2014) The nphp-2 and arl-13 genetic modules interact to regulate ciliogenesis and ciliary microtubule patterning in C. elegans. PLoS Genet 10:e1004866
    • (2014) PLoS Genet , vol.10
    • Warburton-Pitt, S.R.1    Silva, M.2    Nguyen, K.C.3    Hall, D.H.4    Barr, M.M.5
  • 90
    • 0042667181 scopus 로고    scopus 로고
    • From cilia to cyst
    • COI: 1:CAS:528:DC%2BD3sXmt1SktbY%3D, PID: 12923538
    • Watnick T, Germino G (2003) From cilia to cyst. Nat Genet 34:355–356
    • (2003) Nat Genet , vol.34 , pp. 355-356
    • Watnick, T.1    Germino, G.2
  • 91
    • 84865803552 scopus 로고    scopus 로고
    • The BBSome controls IFT assembly and turnaround in cilia
    • PID: 22922713
    • Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J (2012) The BBSome controls IFT assembly and turnaround in cilia. Nat Cell Biol 14:950–957
    • (2012) Nat Cell Biol , vol.14 , pp. 950-957
    • Wei, Q.1    Zhang, Y.2    Li, Y.3    Zhang, Q.4    Ling, K.5    Hu, J.6
  • 92
    • 48249132000 scopus 로고    scopus 로고
    • Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis
    • COI: 1:CAS:528:DC%2BD1cXlslelsLc%3D, PID: 18337471
    • Williams CL, Winkelbauer ME, Schafer JC, Michaud EJ, Yoder BK (2008) Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell 19:2154–2168
    • (2008) Mol Biol Cell , vol.19 , pp. 2154-2168
    • Williams, C.L.1    Winkelbauer, M.E.2    Schafer, J.C.3    Michaud, E.J.4    Yoder, B.K.5
  • 93
    • 77952561092 scopus 로고    scopus 로고
    • Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4
    • COI: 1:CAS:528:DC%2BC3cXmvFOjsL8%3D, PID: 20150540
    • Williams CL, Masyukova SV, Yoder BK (2010) Normal ciliogenesis requires synergy between the cystic kidney disease genes MKS-3 and NPHP-4. J Am Soc Nephrol 21:782–793
    • (2010) J Am Soc Nephrol , vol.21 , pp. 782-793
    • Williams, C.L.1    Masyukova, S.V.2    Yoder, B.K.3
  • 95
    • 30544454640 scopus 로고    scopus 로고
    • The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception
    • COI: 1:CAS:528:DC%2BD28XjvFOhuw%3D%3D, PID: 16291722
    • Winkelbauer ME, Schafer JC, Haycraft CJ, Swoboda P, Yoder BK (2005) The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception. J Cell Sci 118:5575–5587
    • (2005) J Cell Sci , vol.118 , pp. 5575-5587
    • Winkelbauer, M.E.1    Schafer, J.C.2    Haycraft, C.J.3    Swoboda, P.4    Yoder, B.K.5
  • 96
    • 84922263988 scopus 로고    scopus 로고
    • Nephronophthisis and related syndromes
    • COI: 1:CAS:528:DC%2BC2MXksFyltbY%3D, PID: 25635582
    • Wolf MT (2015) Nephronophthisis and related syndromes. Curr Opin Pediatr 27:201–211
    • (2015) Curr Opin Pediatr , vol.27 , pp. 201-211
    • Wolf, M.T.1
  • 97
    • 84936108939 scopus 로고    scopus 로고
    • BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors
    • PID: 26150102
    • Xu Q, Zhang Y, Wei Q, Huang Y, Li Y, Ling K, Hu J (2015) BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors. Sci Rep 5:11855
    • (2015) Sci Rep , vol.5 , pp. 11855
    • Xu, Q.1    Zhang, Y.2    Wei, Q.3    Huang, Y.4    Li, Y.5    Ling, K.6    Hu, J.7
  • 99
    • 0036785149 scopus 로고    scopus 로고
    • The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia
    • COI: 1:CAS:528:DC%2BD38XntVyntr0%3D, PID: 12239239
    • Yoder BK, Hou X, Guay-Woodford LM (2002) The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia. J Am Soc Nephrol 13:2508–2516
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2508-2516
    • Yoder, B.K.1    Hou, X.2    Guay-Woodford, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.