The Caenorhabditis elegans HNF4α homolog, NHR-31, mediates excretory tube growth and function through coordinate regulation of the vacuolar ATPase

PLoS Genetics

Volumn 5, Issue 7, 2009, Pages

  Hahn Windgassen, Annett ^a   Van Gilst, Marc R ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CELL NUCLEUS RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; CAENORHABDITIS ELEGANS PROTEIN; CELL RECEPTOR; NHR 31 PROTEIN, C ELEGANS; NHR-31 PROTEIN, C ELEGANS; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

ARTICLE; BINDING SITE; CAENORHABDITIS ELEGANS; CELL NUCLEUS; GENE EXPRESSION; NEMATODE; NONHUMAN; OSMOREGULATION; RNA INTERFERENCE; SEQUENCE ANALYSIS; STRESS; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; KIDNEY; METABOLISM; MULTIGENE FAMILY;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; KIDNEY; MULTIGENE FAMILY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 68249132212     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1000553     Document Type: Article

References (43)

1. Yamamoto KR (1995) Multilayered control of intracellular receptor function. Harvey Lect 91: 1-19.
2. Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, et al. (1995) The nuclear receptor superfamily: the second decade. Cell 83: 835-839. (Pubitemid 126663112)
3. Germain P, Staels B, Dacquet C, Spedding M, Laudet V (2006) Overview of nomenclature of nuclear receptors. Pharmacol Rev 58: 685-704.
4. Van Gilst M, Gissendanner CR, Sluder AE (2002) Diversity and function of orphan nuclear receptors in nematodes. Crit Rev Eukaryot Gene Expr 12: 65-88. (Pubitemid 35239414)
5. Robinson-Rechavi M, Maina CV, Gissendanner CR, Laudet V, Sluder A (2005) Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. J Mol Evol 60: 577-586. (Pubitemid 40896557)
6. Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol 3: e53. doi:10.1371/journal.pbio.0030053. (Pubitemid 40412650)
7. Van Gilst MR, Hadjivassiliou H, Yamamoto KR (2005) A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR- 49. Proc Natl Acad Sci U S A 102: 13496-13501. (Pubitemid 41420876)
8. Sladek FMaSS (2001) Hepatocyte Nuclear Factor 4a. In: McCabe TPBE, ed. Nuclear Receptors and Genetic Disease. London: Academic Press.
9. Gragnoli C, Lindner T, Cockburn BN, Kaisaki PJ, Gragnoli F, et al. (1997) Maturity-onset diabetes of the young due to a mutation in the hepatocyte nuclear factor-4 alpha binding site in the promoter of the hepatocyte nuclear factor-1 alpha gene. Diabetes 46: 1648-1651. (Pubitemid 27411244)
10. Gupta RK, Kaestner KH (2004) HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol Med 10: 521-524. (Pubitemid 39433820)
11. Mitchell SM, Frayling TM (2002) The role of transcription factors in maturityonset diabetes of the young. Mol Genet Metab 77: 35-43. (Pubitemid 35178513)
12. Gonzalez FJ (2008) Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription. Drug Metab Pharmacokinet 23: 2-7.
13. Hayhurst GP, Lee YH, Lambert G, Ward JM, Gonzalez FJ (2001) Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol 21: 1393-1403. (Pubitemid 32114986)
14. Odom DT, Zizlsperger N, Gordon DB, Bell GW, Rinaldi NJ, et al. (2004) Control of pancreas and liver gene expression by HNF transcription factors. Science 303: 1378-1381. (Pubitemid 38269432)
15. Grigo K, Wirsing A, Lucas B, Klein-Hitpass L, Ryffel GU (2008) HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells. Biol Chem 389: 179-187. (Pubitemid 351170657)
16. Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, et al. (1994) Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A 91: 7598-7602. (Pubitemid 24238232)
17. Buechner M (2002) Tubes and the single C. elegans excretory cell. Trends Cell Biol 12: 479-484.
18. Barr MM (2005) Caenorhabditis elegans as a model to study renal development and disease: sexy cilia. J Am Soc Nephrol 16: 305-312. (Pubitemid 41725125)
19. Liegeois S, Benedetto A, Garnier JM, Schwab Y, Labouesse M (2006) The V0-ATPase mediates apical secretion of exosomes containing Hedgehog-related proteins in Caenorhabditis elegans. J Cell Biol 173: 949-961. (Pubitemid 43920702)
20. Oka T, Yamamoto R, Futai M (1998) Multiple genes for vacuolar-type ATPase proteolipids in Caenorhabditis elegans. A new gene, vha-3, has a distinct cellspecific distribution. J Biol Chem 273: 22570-22576. (Pubitemid 28399825)
21. Liegeois S, Benedetto A, Michaux G, Belliard G, Labouesse M (2007) Genes required for osmoregulation and apical secretion in Caenorhabditis elegans. Genetics 175: 709-724. (Pubitemid 46798270)
22. Hisamoto N, Moriguchi T, Urushiyama S, Mitani S, Shibuya H, et al. (2008) Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. EMBO Rep 9: 70-75.
23. Berry KL, Bulow HE, Hall DH, Hobert O (2003) A C. elegans CLIC-like protein required for intracellular tube formation and maintenance. Science 302: 2134-2137.
24. Perens EA, Shaham S (2005) C. elegans daf-6 encodes a patched-related protein required for lumen formation. Dev Cell 8: 893-906.
25. Mah AK, Armstrong KR, Chew DS, Chu JS, Tu DK, et al. (2007) Transcriptional regulation of AQP-8, a Caenorhabditis elegans aquaporin exclusively expressed in the excretory system, by the POU homeobox transcription factor CEH-6. J Biol Chem 282: 28074-28086.
26. Nelson FK, Riddle DL (1984) Functional study of the Caenorhabditis elegans secretory-excretory system using laser microsurgery. J Exp Zool 231: 45-56.
27. Buechner M, Hall DH, Bhatt H, Hedgecock EM (1999) Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell. Dev Biol 214: 227-241. (Pubitemid 29463370)
28. Wormbase.
29. Oka T, Yamamoto R, Futai M (1997) Three vha genes encode proteolipids of Caenorhabditis elegans vacuolar-type ATPase. Gene structures and preferential expression in an H-shaped excretory cell and rectal cells. J Biol Chem 272: 24387-24392. (Pubitemid 27418645)
30. Choi KY, Ji YJ, Dhakal BK, Yu JR, Cho C, et al. (2003) Vacuolar-type H+-ATPase E subunit is required for embryogenesis and yolk transfer in Caenorhabditis elegans. Gene 311: 13-23. (Pubitemid 36830798)
31. Hunt-Newbury R, Viveiros R, Johnsen R, Mah A, Anastas D, et al. (2007) Highthroughput in vivo analysis of gene expression in Caenorhabditis elegans. PLoS Biol 5: e237. doi: 10.1371/journal.pbio.0050237. (Pubitemid 47416596)
32. Oka T, Toyomura T, Honjo K, Wada Y, Futai M (2001) Four subunit a isoforms of Caenorhabditis elegans vacuolar H+-ATPase. Cell-specific expression during development. J Biol Chem 276: 33079-33085. (Pubitemid 37384761)
33. Pujol N, Bonnerot C, Ewbank JJ, Kohara Y, Thierry-Mieg D (2001) The Caenorhabditis elegans unc-32 gene encodes alternative forms of a vacuolar ATPase a subunit. J Biol Chem 276: 11913-11921. (Pubitemid 37385350)
34. Sandelin A, Wasserman WW (2005) Prediction of nuclear hormone receptor response elements. Mol Endocrinol 19: 595-606. (Pubitemid 40349434)
35. Bogan AA, Dallas-Yang Q, Ruse MD Jr, Maeda Y, Jiang G, et al. (2000) Analysis of protein dimerization and ligand binding of orphan receptor HNF4alpha. J Mol Biol 302: 831-851. (Pubitemid 30769043)
36. Khorasanizadeh S, Rastinejad F (2001) Nuclear-receptor interactions on DNAresponse elements. Trends Biochem Sci 26: 384-390.
37. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, et al. (2004) Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes. Proc Natl Acad Sci U S A 101: 15603-15608. (Pubitemid 39473534)
38. Kel AE, Niehof M, Matys V, Zemlin R, Borlak J (2008) Genome wide prediction of HNF4alpha functional binding sites by the use of local and global sequence context. Genome Biol 9: R36. (Pubitemid 351943993)
39. Beyenbach KW, Wieczorek H (2006) The V-type H+ ATPase: molecular structure and function, physiological roles and regulation. J Exp Biol 209: 577-589.
40. Marshansky V, Futai M (2008) The V-type H(+)-ATPase in vesicular trafficking: targeting, regulation and function. Curr Opin Cell Biol.
41. Hertz R, Magenheim J, Berman I, Bar-Tana J (1998) Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4alpha. Nature 392: 512-516. (Pubitemid 28168984)
42. Wisely GB, Miller AB, Davis RG, Thornquest AD Jr., Johnson R, et al. (2002) Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids. Structure 10: 1225-1234. (Pubitemid 35254011)
43. Crooks GE, Hon G, Chandonia JM, Brenner SE (2004) WebLogo: a sequence logo generator. Genome Res 14: 1188-1190.