Discovery of Novel Inhibitor Scaffolds against the Metallo-β-lactamase VIM-2 by Surface Plasmon Resonance (SPR) Based Fragment Screening

Journal of Medicinal Chemistry

Volumn 58, Issue 21, 2015, Pages 8671-8682

  Christopeit, Tony ^a   Carlsen, Trine Josefine O ^a   Helland, Ronny ^a   Leiros, Hanna Kirsti S ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CAPTOPRIL; HYDROLASE INHIBITOR; MEROPENEM; METALLO BETA LACTAMASE; METALLO BETA LACTAMASE VIM 2; NITROCEFIN; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBAPENEM DERIVATIVE; MOLECULAR LIBRARY; VIM-2 BETA-LACTAMASE;

ARTICLE; ASSOCIATION CONSTANT; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG BINDING; DRUG DEVELOPMENT; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITION ASSAY; FRAGMENT BASED DRUG DISCOVERY; IC50; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY; ANTIBIOTIC RESISTANCE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MICROBIOLOGY; MOLECULAR LIBRARY; PHARMACOLOGY; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS;

BETA-LACTAMASE INHIBITORS; BETA-LACTAMASES; CARBAPENEMS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; HUMANS; MODELS, MOLECULAR; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; SMALL MOLECULE LIBRARIES; SURFACE PLASMON RESONANCE;

EID: 84947213893     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01289     Document Type: Article

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