Role of residues W228 and Y233 in the structure and activity of metallo-β-lactamase GIM-1

Antimicrobial Agents and Chemotherapy

Volumn 60, Issue 2, 2016, Pages 990-1002

  Skagseth, Susann ^a   Carlsen, Trine Josefine ^a   Bjerga, Gro Elin Kjæreng ^a,b   Spencer, James ^c   Samuelsen, Ørjan ^a,d   Leiros, Hanna Kirsti S ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b Uni Research AS   (Norway)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; CEFOXITIN; CEFTAZIDIME; HYDROLASE; IMIPENEM; MEROPENEM; METALLO BETA LACTAMASE GIM 1; PENICILLIN G; UNCLASSIFIED DRUG; BETA LACTAMASE; BETA-LACTAMASE GIM-1, PSEUDOMONAS AERUGINOSA;

ARTICLE; COMPUTER MODEL; ENZYME ASSAY; ENZYME KINETICS; ENZYME PURIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; STEADY STATE; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENETICS; HYDROLYSIS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR GENETICS; MOLECULAR MODEL; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMPICILLIN; BETA-LACTAMASES; CATALYTIC DOMAIN; CEFTAZIDIME; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HYDROLYSIS; IMIPENEM; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84957928408     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02017-15     Document Type: Article

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