Iterative integration of multiple-copy pathway genes in Yarrowia lipolytica for heterologous β-carotene production

Metabolic Engineering

Volumn 41, Issue , 2017, Pages 192-201

  Gao, Shuliang ^a   Tong, Yangyang ^b   Zhu, Li ^c   Ge, Mei ^c   Zhang, Yian ^d   Chen, Daijie ^a,e   Jiang, Yu ^f,g   Yang, Sheng ^f,g,h  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI NORMAL UNIVERSITY   (China)

^c Shanghai Laiyi Center for Biopharmaceuticals RandD   (China)

^d George Stevens Academy   (United States)

^e Shanghai Institute of Pharmaceutical Industry   (China)

^f INSTITUTE OF PLANT PHYSIOLOGY AND ECOLOGY   (China)

^g Shanghai Research and Development Center of Industrial Biotechnology   (China)

^h Institute of Advanced Materials (IAM)   (China)

Author keywords

Metabolic engineering; Terpenoid; Yarrowia lipolytica; carotene

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; GENES; HYDROPHOBICITY; LIPIDS;

BETA CAROTENE; BIOSYNTHETIC PATHWAY; FED-BATCH FERMENTATION; ITERATIVE INTEGRATION; LIPID DROPLETS; MULTIPLE GENES; TERPENOIDS; YARROWIA LIPOLYTICA;

METABOLIC ENGINEERING;

ACETYL COENZYME A; ACETYL COENZYME A ACETYLTRANSFERASE; BETA CAROTENE; DNA FRAGMENT; FARNESYL TRANS TRANSFERASE; FAT DROPLET; LYCOPENE; MEVALONIC ACID; SQUALENE;

ARTICLE; BIOSYNTHESIS; CELL DENSITY; CELL EXPANSION; CONTROLLED STUDY; ENZYME ACTIVE SITE; FED BATCH FERMENTATION; FUNGAL GENE; LIPID STORAGE; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEPLETION; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; YARROWIA LIPOLYTICA; BACTERIAL GENE; GENE DOSAGE; GENETICS; METABOLISM; YARROWIA;

ACETYL COENZYME A; BETA CAROTENE; GENE DOSAGE; GENES, BACTERIAL; YARROWIA;

EID: 85018404578     PISSN: 10967176     EISSN: 10967184     Source Type: Journal    
DOI: 10.1016/j.ymben.2017.04.004     Document Type: Article

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