Heterologous production of α-farnesene in metabolically engineered strains of Yarrowia lipolytica

Bioresource Technology

Volumn 216, Issue , 2016, Pages 1040-1048

  Yang, Xia ^a   Nambou, Komi ^b   Wei, Liujing ^a   Hua, Qiang ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANGHAI COLLABORATIVE INNOVATION CENTER FOR BIOMANUFACTURING TECHNOLOGY   (China)

Author keywords

Biofuels; Fed batch; Metabolic engineering; Terpene synthases; Yarrowia lipolytica

Indexed keywords

BIOFUELS; INDUSTRIAL RESEARCH; METABOLISM; STRAIN;

BIOREACTOR SCALE-UP; BIOTECHNOLOGICAL APPLICATIONS; ENGINEERED STRAINS; FED BATCHES; HETEROLOGOUS PRODUCTION; INDUSTRIAL PRODUCTION; SYNTHASES; YARROWIA LIPOLYTICA;

METABOLIC ENGINEERING;

ALPHA FARNESENE; DNA FRAGMENT; MEVALONIC ACID; SESQUITERPENE; UNCLASSIFIED DRUG; ALPHA-FARNESENE;

BIOFUEL; CHEMICAL COMPOUND; GENE EXPRESSION; GENETIC ENGINEERING; GENOME; INDUSTRIAL PRODUCTION; LABORATORY METHOD; METABOLISM; TERPENE; YEAST;

ALPHA FARNESENE SYNTHASE GENE; ARTICLE; BIOMASS; BIOMASS PRODUCTION; BIOREACTOR; BIOSYNTHESIS; CELL GROWTH; CODON; FED BATCH FERMENTATION; GENE; GENE EXPRESSION; GENOME; INDUSTRIAL PRODUCTION; METABOLIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; SYNTHESIS; YARROWIA LIPOLYTICA; GENETICS; METABOLISM; MICROBIOLOGY; PROCEDURES; YARROWIA;

YARROWIA LIPOLYTICA;

BIOREACTORS; METABOLIC ENGINEERING; SESQUITERPENES; YARROWIA;

EID: 84975508641     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2016.06.028     Document Type: Article

References (37)

1. Albertsen L., Chen Y., Bach L.S., Rattleff S., Maury J., Brix S., Nielsen J., Mortensen U.H. Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes. Appl. Environ. Microbiol. 2011, 77:1033-1040.
2. Asadollahi M.A., Maury J., Patil K.R., Schalk M., Clark A., Nielsen J. Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering. Metab. Eng. 2009, 11:328-334.
3. Asadollahi M.A., Maury J., Schalk M., Clark A., Nielsen J. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. Biotechnol. Bioeng. 2010, 106:86-96.
4. Barth G., Gaillardin C. Physiology and genetics of the dimorphic fungus Yarrowia lipolytica. FEMS Microbiol. Rev. 1997, 19:219-237.
5. Chandran S.S., Kealey J.T., Reeves C.D. Microbial production of isoprenoids. Process Biochem. 2011, 46:1703-1710.
6. Du F.L., Yu H.L., Xu J.H., Li C.X. Enhanced limonene production by optimizing the expression of limonene biosynthesis and MEP pathway genes in E. coli. Bioresour. Bioprocess. 2014, 1:1-10.
7. Faulkner A., Chen X., Rush J., Horazdovsky B., Waechter C.J., Carman G.M., Sternweis P.C. The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae. J. Biol. Chem. 1999, 274:14831-14837.
8. Groenewald M., Boekhout T., Neuveglise C., Gaillardin C., van Dijck P.W., Wyss M. Yarrowia lipolytica: safety assessment of an oleaginous yeast with a great industrial potential. Crit. Rev. Microbiol. 2014, 40:187-206.
9. Groussin A.L., Antoniotti S. Valuable chemicals by the enzymatic modification of molecules of natural origin: terpenoids, steroids, phenolics and related compounds. Bioresour. Technol. 2012, 115:237-243.
10. Howes M.-J.R., Simmonds M.S.J., Kite G.C. Evaluation of the quality of sandalwood essential oils by gas chromatography-mass spectrometry. J. Chromatogr. A 2004, 1028:307-312.
11. Janssens L., De Pooter H.L., Schamp N.M., Vandamme E.J. Production of flavours by microorganisms. Process Biochem. 1992, 27:195-215.
12. Kollner T.G., Gershenzon J., Degenhardt J. Molecular and biochemical evolution of maize terpene synthase 10, an enzyme of indirect defense. Phytochemistry 2009, 70:1139-1145.
13. Madzak C., Gaillardin C., Beckerich J.M. Heterologous protein expression and secretion in the non-conventional yeast Yarrowia lipolytica: a review. J. Biotechnol. 2004, 109:63-81.
14. Madzak C., Tréton B., Blanchinroland S. Strong hybrid promoters and integrative expression/secretion vectors for quasi-constitutive expression of heterologous proteins in the yeast Yarrowia lipolytica. J. Microbiol. Biotechnol. 2000, 2:207-216.
15. Matthaus F., Ketelhot M., Gatter M., Barth G. Production of lycopene in the non-carotenoid-producing yeast Yarrowia lipolytica. Appl. Environ. Microbiol. 2014, 80:1660-1669.
16. Mirzaee H., Sharafi A., Hashemi Sohi H. In vitro regeneration and transient expression of recombinant sesquiterpene cyclase (SQC) in Artemisia annua L. South Afr. J. Bot. 2016, 104:225-231.
17. Nambou K., Jian X., Zhang X., Wei L., Lou J., Madzak C., Hua Q. Flux balance analysis inspired bioprocess upgrading for lycopene production by a metabolically engineered strain of Yarrowia lipolytica. Metabolites 2015, 5:794-813.
18. Nambou K., Zhao C., Wei L., Chen J., Imanaka T., Hua Q. Designing of a "cheap to run" fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel. Bioresour. Technol. 2014, 173:324-333.
19. Nieuwenhuizen N.J., Green S., Atkinson R.G. Floral sesquiterpenes and their synthesis in dioecious kiwifruit. Plant Signaling Behav. 2014, 5:61-63.
20. Papanikolaou S., Aggelis G. Lipid production by Yarrowia lipolytica growing on industrial glycerol in a single-stage continuous culture. Bioresour. Technol. 2002, 82:43-49.
21. Pechous S.W., Whitaker B.D. Cloning and functional expression of an (E,E)-alpha-farnesene synthase cDNA from peel tissue of apple fruit. Planta 2004, 219:84-94.
22. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:2002-2007.
23. Plácido J., Capareda S. Ligninolytic enzymes: a biotechnological alternative for bioethanol production. Bioresour. Bioprocess. 2015, 2:1-12.
24. Renninger, N.S., McPhee, D.J., 2010. Fuel compositions comprising farnesane and farnesane derivatives and method of making and using same.
25. Ro D.-K., Paradise E.M., Ouellet M., Fisher K.J., Newman K.L., Ndungu J.M., Ho K.A., Eachus R.A., Ham T.S., Kirby J., Chang M.C.Y., Withers S.T., Shiba Y., Sarpong R., Keasling J.D. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 2006, 440:940-943.
26. Scalcinati G., Knuf C., Partow S., Chen Y., Maury J., Schalk M., Daviet L., Nielsen J., Siewers V. Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode. Metab. Eng. 2012, 14:91-103.
27. Šobotník J., Hanus R., Kalinová B., Piskorski R., Cvačka J., Bourguignon T., Roisin Y. (E, E)-α-Farnesene, an alarm pheromone of the termite prorhinotermes canalifrons. J. Chem. Ecol. 2008, 34:478-486.
28. Suckling D.M., Stringer L.D., Bunn B., El-Sayed A.M., Meer R.K.V. Trail pheromone disruption of red imported fire ant. J. Chem. Ecol. 2010, 36:744-750.
29. Takahashi S., Yeo Y., Greenhagen B.T., McMullin T., Song L., Maurina-Brunker J., Rosson R., Noel J.P., Chappell J. Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol. Bioeng. 2007, 97:170-181.
30. Tippmann S., Scalcinati G., Siewers V., Nielsen J. Production of farnesene and santalene by Saccharomyces cerevisiae using fed-batch cultivations with RQ -controlled feed. J. Chem. Ecol. 2015, 113:72-81.
31. Verwaal R., Paalman J.W.G., Hogenkamp A., Verkleij A.J., Verrips C.T., Boonstra J. HXT5 expression is determined by growth rates in Saccharomyces cerevisiae. Yeast 2002, 19:1029-1038.
32. Wallaart T., Pras N., Ac Quax W. Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes. Planta Med. 2000, 66:57-62.
33. Wang C., Yoon S.H., Jang H.J., Chung Y.R., Kim J.Y., Choi E.S., Kim S.W. Metabolic engineering of Escherichia coli for alpha-farnesene production. Metab. Eng. 2011, 13:648-655.
34. Withers S.T., Keasling J.D. Biosynthesis and engineering of isoprenoid small molecules. Appl. Microbiol. Biotechnol. 2007, 73:980-990.
35. Yang T., Stoopen G., Yalpani N., Vervoort J., Vos R.D., Voster A., Verstappen F.W.A., Bouwmeester H.J., Jongsma M.A. Metabolic engineering of geranic acid in maize to achieve fungal resistance is compromised by novel glycosylation patterns. Metab. Eng. 2011, 13:414-425.
36. Zhou Y.J., Gao W., Rong Q., Jin G., Chu H., Liu W., Yang W., Zhu Z., Li G., Zhu G., Huang L., Zhao Z.K. Modular pathway engineering of diterpenoid synthases and the mevalonic acid pathway for miltiradiene production. J. Am. Chem. Soc. 2012, 134:3234-3241.
37. Zhu F., Zhong X., Hu M., Lu L., Deng Z., Liu T. In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnol. Bioeng. 2014, 111:1396-1405.