메뉴 건너뛰기




Volumn 8, Issue 4, 2017, Pages

MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; FARNESOID X RECEPTOR; MICRORNA 21; OBETICHOLIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; CELL RECEPTOR; CHENODEOXYCHOLIC ACID; FARNESOID X-ACTIVATED RECEPTOR; MICRORNA; MIRN21 MICRORNA, MOUSE;

EID: 85017474560     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2017.172     Document Type: Article
Times cited : (92)

References (48)
  • 1
    • 56549117448 scopus 로고    scopus 로고
    • Animal models of NASH: Getting both pathology and metabolic context right
    • Larter CZ, Yeh MM. Animal models of NASH: Getting both pathology and metabolic context right. J Gastroenterol Hepatol 2008; 23: 1635-1648.
    • (2008) J Gastroenterol Hepatol , vol.23 , pp. 1635-1648
    • Larter, C.Z.1    Yeh, M.M.2
  • 2
    • 67651099223 scopus 로고    scopus 로고
    • Recent advances in nonalcoholic fatty liver disease
    • Cheung O, Sanyal AJ. Recent advances in nonalcoholic fatty liver disease. Curr Opin Gastroenterol 2009; 25: 230-237.
    • (2009) Curr Opin Gastroenterol , vol.25 , pp. 230-237
    • Cheung, O.1    Sanyal, A.J.2
  • 3
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009; 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 5
    • 58149386462 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression
    • Cheung O, Puri P, Eicken C, Contos MJ, Mirshahi F, Maher JW et al. Nonalcoholic steatohepatitis is associated with altered hepatic microRNA expression. Hepatology 2008; 48: 1810-1820.
    • (2008) Hepatology , vol.48 , pp. 1810-1820
    • Cheung, O.1    Puri, P.2    Eicken, C.3    Contos, M.J.4    Mirshahi, F.5    Maher, J.W.6
  • 6
    • 84940901740 scopus 로고    scopus 로고
    • Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARalpha expression
    • Loyer X, Paradis V, Henique C, Vion AC, Colnot N, Guerin CL et al. Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARalpha expression. Gut 2016; 65: 1882-1894.
    • (2016) Gut , vol.65 , pp. 1882-1894
    • Loyer, X.1    Paradis, V.2    Henique, C.3    Vion, A.C.4    Colnot, N.5    Guerin, C.L.6
  • 7
    • 70350054798 scopus 로고    scopus 로고
    • Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice
    • Wang B, Majumder S, Nuovo G, Kutay H, Volinia S, Patel T et al. Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. Hepatology 2009; 50: 1152-1161.
    • (2009) Hepatology , vol.50 , pp. 1152-1161
    • Wang, B.1    Majumder, S.2    Nuovo, G.3    Kutay, H.4    Volinia, S.5    Patel, T.6
  • 8
    • 84940195131 scopus 로고    scopus 로고
    • MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway
    • Wu H, Ng R, Chen X, Steer CJ, Song G. MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway. Gut 2016; 65: 1850-1860.
    • (2016) Gut , vol.65 , pp. 1850-1860
    • Wu, H.1    Ng, R.2    Chen, X.3    Steer, C.J.4    Song, G.5
  • 9
    • 84973390006 scopus 로고    scopus 로고
    • Stress-activated miR-21/miR-21 in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption
    • Calo N, Ramadori P, Sobolewski C, Romero Y, Maeder C, Fournier M et al. Stress-activated miR-21/miR-21∗in hepatocytes promotes lipid and glucose metabolic disorders associated with high-fat diet consumption. Gut 2016; 65: 1871-1881.
    • (2016) Gut , vol.65 , pp. 1871-1881
    • Calo, N.1    Ramadori, P.2    Sobolewski, C.3    Romero, Y.4    Maeder, C.5    Fournier, M.6
  • 10
    • 65449119905 scopus 로고    scopus 로고
    • Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes
    • Vinciguerra M, Sgroi A, Veyrat-Durebex C, Rubbia-Brandt L, Buhler LH, Foti M. Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes. Hepatology 2009; 49: 1176-1184.
    • (2009) Hepatology , vol.49 , pp. 1176-1184
    • Vinciguerra, M.1    Sgroi, A.2    Veyrat-Durebex, C.3    Rubbia-Brandt, L.4    Buhler, L.H.5    Foti, M.6
  • 11
    • 84859157277 scopus 로고    scopus 로고
    • Roles of PPARs in NAFLD: Potential therapeutic targets
    • Tailleux A, Wouters K, Staels B. Roles of PPARs in NAFLD: Potential therapeutic targets. Biochim Biophys Acta 2012; 1821: 809-818.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 809-818
    • Tailleux, A.1    Wouters, K.2    Staels, B.3
  • 13
    • 84865499656 scopus 로고    scopus 로고
    • Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis
    • Adorini L, Pruzanski M, Shapiro D. Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis. Drug Discov Today 2012; 17: 988-997.
    • (2012) Drug Discov Today , vol.17 , pp. 988-997
    • Adorini, L.1    Pruzanski, M.2    Shapiro, D.3
  • 14
    • 84863427742 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: The bile acid-activated farnesoid x receptor as an emerging treatment target
    • Fuchs M. Non-alcoholic fatty liver disease: The bile acid-activated farnesoid x receptor as an emerging treatment target. J Lipids 2012; 2012: 934396.
    • (2012) J Lipids , vol.2012 , pp. 934396
    • Fuchs, M.1
  • 15
    • 79952227694 scopus 로고    scopus 로고
    • Nuclear receptors in liver disease
    • Wagner M, Zollner G, Trauner M. Nuclear receptors in liver disease. Hepatology 2011; 53: 1023-1034.
    • (2011) Hepatology , vol.53 , pp. 1023-1034
    • Wagner, M.1    Zollner, G.2    Trauner, M.3
  • 16
    • 59149106502 scopus 로고    scopus 로고
    • Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet
    • Kong B, Luyendyk JP, Tawfik O, Guo GL. Farnesoid X receptor deficiency induces nonalcoholic steatohepatitis in low-density lipoprotein receptor-knockout mice fed a high-fat diet. J Pharmacol Exp Ther 2009; 328: 116-122.
    • (2009) J Pharmacol Exp Ther , vol.328 , pp. 116-122
    • Kong, B.1    Luyendyk, J.P.2    Tawfik, O.3    Guo, G.L.4
  • 17
    • 84929266699 scopus 로고    scopus 로고
    • Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial
    • Neuschwander-Tetri BA, Loomba R, Sanyal AJ, Lavine JE, Van Natta ML, Abdelmalek MF et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial. Lancet 2015; 385: 956-965.
    • (2015) Lancet , vol.385 , pp. 956-965
    • Neuschwander-Tetri, B.A.1    Loomba, R.2    Sanyal, A.J.3    Lavine, J.E.4    Van Natta, M.L.5    Abdelmalek, M.F.6
  • 18
    • 84942872734 scopus 로고    scopus 로고
    • Necroptosis is a key pathogenic event in human and experimental murine models of nonalcoholic steatohepatitis
    • Afonso MB, Rodrigues PM, Carvalho T, Caridade M, Borralho P, Cortez-Pinto H et al. Necroptosis is a key pathogenic event in human and experimental murine models of nonalcoholic steatohepatitis. Clin Sci (Lond) 2015; 129: 721-739.
    • (2015) Clin Sci (Lond) , vol.129 , pp. 721-739
    • Afonso, M.B.1    Rodrigues, P.M.2    Carvalho, T.3    Caridade, M.4    Borralho, P.5    Cortez-Pinto, H.6
  • 20
    • 84919465499 scopus 로고    scopus 로고
    • Cell death and cell death responses in liver disease: Mechanisms and clinical relevance
    • Luedde T, Kaplowitz N, Schwabe RF. Cell death and cell death responses in liver disease: Mechanisms and clinical relevance. Gastroenterology 2014; 147: 765-783 e764.
    • (2014) Gastroenterology , vol.147 , pp. 765-783
    • Luedde, T.1    Kaplowitz, N.2    Schwabe, R.F.3
  • 21
    • 84871221881 scopus 로고    scopus 로고
    • MiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease
    • Castro RE, Ferreira DM, Afonso MB, Borralho PM, Machado MV, Cortez-Pinto H et al. miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. J Hepatol 2013; 58: 119-125.
    • (2013) J Hepatol , vol.58 , pp. 119-125
    • Castro, R.E.1    Ferreira, D.M.2    Afonso, M.B.3    Borralho, P.M.4    MacHado, M.V.5    Cortez-Pinto, H.6
  • 22
    • 84933039083 scopus 로고    scopus 로고
    • Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis
    • Machado MV, Michelotti GA, Pereira Tde A, Boursier J, Kruger L, Swiderska-Syn M et al. Reduced lipoapoptosis, hedgehog pathway activation and fibrosis in caspase-2 deficient mice with non-alcoholic steatohepatitis. Gut 2015; 64: 1148-1157.
    • (2015) Gut , vol.64 , pp. 1148-1157
    • MacHado, M.V.1    Michelotti, G.A.2    Pereira Tde, A.3    Boursier, J.4    Kruger, L.5    Swiderska-Syn, M.6
  • 23
    • 79959755613 scopus 로고    scopus 로고
    • Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease
    • Ferreira DM, Castro RE, Machado MV, Evangelista T, Silvestre A, Costa A et al. Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. Diabetologia 2011; 54: 1788-1798.
    • (2011) Diabetologia , vol.54 , pp. 1788-1798
    • Ferreira, D.M.1    Castro, R.E.2    MacHado, M.V.3    Evangelista, T.4    Silvestre, A.5    Costa, A.6
  • 24
    • 84888795580 scopus 로고    scopus 로고
    • Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice
    • Itagaki H, Shimizu K, Morikawa S, Ogawa K, Ezaki T. Morphological and functional characterization of non-alcoholic fatty liver disease induced by a methionine-choline-deficient diet in C57BL/6 mice. Int J Clin Exp Pathol 2013; 6: 2683-2696.
    • (2013) Int J Clin Exp Pathol , vol.6 , pp. 2683-2696
    • Itagaki, H.1    Shimizu, K.2    Morikawa, S.3    Ogawa, K.4    Ezaki, T.5
  • 25
    • 80055026523 scopus 로고    scopus 로고
    • Fast food diet mouse: Novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition
    • Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A et al. Fast food diet mouse: Novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol 2011; 301: G825-G834.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , pp. G825-G834
    • Charlton, M.1    Krishnan, A.2    Viker, K.3    Sanderson, S.4    Cazanave, S.5    McConico, A.6
  • 26
    • 85016277900 scopus 로고    scopus 로고
    • Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis
    • Spahis S, Delvin E, Borys JM, Levy E. Oxidative stress as a critical factor in nonalcoholic fatty liver disease pathogenesis. Antioxid Redox Signal 2017; 26: 519-541.
    • (2017) Antioxid Redox Signal , vol.26 , pp. 519-541
    • Spahis, S.1    Delvin, E.2    Borys, J.M.3    Levy, E.4
  • 29
    • 85048814308 scopus 로고    scopus 로고
    • Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma
    • Afonso MB, Rodrigues PM, Simao AL, Castro RE. Circulating microRNAs as potential biomarkers in non-alcoholic fatty liver disease and hepatocellular carcinoma. J Clin Med 2016; 5: E30.
    • (2016) J Clin Med , vol.5 , pp. E30
    • Afonso, M.B.1    Rodrigues, P.M.2    Simao, A.L.3    Castro, R.E.4
  • 30
    • 84954325304 scopus 로고    scopus 로고
    • Role of microRNAs in NAFLD/NASH
    • Szabo G, Csak T. Role of microRNAs in NAFLD/NASH. Dig Dis Sci 2016; 61: 1314-1324.
    • (2016) Dig Dis Sci , vol.61 , pp. 1314-1324
    • Szabo, G.1    Csak, T.2
  • 31
    • 84901944989 scopus 로고    scopus 로고
    • Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease
    • Ferreira DM, Simao AL, Rodrigues CM, Castro RE. Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease. FEBS J 2014; 281: 2503-2524.
    • (2014) FEBS J , vol.281 , pp. 2503-2524
    • Ferreira, D.M.1    Simao, A.L.2    Rodrigues, C.M.3    Castro, R.E.4
  • 32
    • 73449136157 scopus 로고    scopus 로고
    • Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD
    • Zheng L, Lv GC, Sheng J, Yang YD. Effect of miRNA-10b in regulating cellular steatosis level by targeting PPAR-alpha expression, a novel mechanism for the pathogenesis of NAFLD. J Gastroenterol Hepatol 2010; 25: 156-163.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 156-163
    • Zheng, L.1    Lv, G.C.2    Sheng, J.3    Yang, Y.D.4
  • 33
    • 84940849475 scopus 로고    scopus 로고
    • Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease
    • Ding J, Li M, Wan X, Jin X, Chen S, Yu C et al. Effect of miR-34a in regulating steatosis by targeting PPARalpha expression in nonalcoholic fatty liver disease. Sci Rep 2015; 5: 13729.
    • (2015) Sci Rep , vol.5 , pp. 13729
    • Ding, J.1    Li, M.2    Wan, X.3    Jin, X.4    Chen, S.5    Yu, C.6
  • 35
    • 85017437719 scopus 로고    scopus 로고
    • Corrigendum: Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis
    • Rodrigues PM, Afonso MB, Simao AL, Borralho PM, Rodrigues CM, Castro RE. Corrigendum: Inhibition of NF-kappaB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis. Sci Rep 2016; 6: 27828.
    • (2016) Sci Rep , vol.6 , pp. 27828
    • Rodrigues, P.M.1    Afonso, M.B.2    Simao, A.L.3    Borralho, P.M.4    Rodrigues, C.M.5    Castro, R.E.6
  • 36
    • 84930204546 scopus 로고    scopus 로고
    • The oncogenic microRNA miR-21 promotes regulated necrosis in mice
    • Ma X, Conklin DJ, Li F, Dai Z, Hua X, Li Y et al. The oncogenic microRNA miR-21 promotes regulated necrosis in mice. Nat Commun 2015; 6: 7151.
    • (2015) Nat Commun , vol.6 , pp. 7151
    • Ma, X.1    Conklin, D.J.2    Li, F.3    Dai, Z.4    Hua, X.5    Li, Y.6
  • 37
    • 77949522423 scopus 로고    scopus 로고
    • Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice
    • Ii H, Yokoyama N, Yoshida S, Tsutsumi K, Hatakeyama S, Sato T et al. Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice. PloS ONE 2009; 4: E8089.
    • (2009) PloS ONE , vol.4 , pp. E8089
    • Ii H1    Yokoyama, N.2    Yoshida, S.3    Tsutsumi, K.4    Hatakeyama, S.5    Sato, T.6
  • 38
    • 84959010789 scopus 로고    scopus 로고
    • ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease
    • Kanai S, Ishihara K, Kawashita E, Tomoo T, Nagahira K, Hayashi Y et al. ASB14780, an orally active inhibitor of group IVA phospholipase A2, is a pharmacotherapeutic candidate for nonalcoholic fatty liver disease. J Pharmacol Exp Ther 2016; 356: 604-614.
    • (2016) J Pharmacol Exp Ther , vol.356 , pp. 604-614
    • Kanai, S.1    Ishihara, K.2    Kawashita, E.3    Tomoo, T.4    Nagahira, K.5    Hayashi, Y.6
  • 39
    • 84958942979 scopus 로고    scopus 로고
    • The role of cholesterol in the pathogenesis of NASH
    • Ioannou GN. The role of cholesterol in the pathogenesis of NASH. Trends Endocrinol Metabol 2016; 27: 84-95.
    • (2016) Trends Endocrinol Metabol , vol.27 , pp. 84-95
    • Ioannou, G.N.1
  • 40
    • 79959227567 scopus 로고    scopus 로고
    • The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease
    • Martinez-Clemente M, Claria J, Titos E. The 5-lipoxygenase/leukotriene pathway in obesity, insulin resistance, and fatty liver disease. Curr Opin Clin Nutr Metab Care 2011; 14: 347-353.
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 347-353
    • Martinez-Clemente, M.1    Claria, J.2    Titos, E.3
  • 41
    • 37149001609 scopus 로고    scopus 로고
    • Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies
    • Hwang JH, Stein DT, Barzilai N, Cui MH, Tonelli J, Kishore P et al. Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 2007; 293: E1663-E1669.
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E1663-E1669
    • Hwang, J.H.1    Stein, D.T.2    Barzilai, N.3    Cui, M.H.4    Tonelli, J.5    Kishore, P.6
  • 42
    • 20944450486 scopus 로고    scopus 로고
    • Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms
    • Bugianesi E, Gastaldelli A, Vanni E, Gambino R, Cassader M, Baldi S et al. Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: Sites and mechanisms. Diabetologia 2005; 48: 634-642.
    • (2005) Diabetologia , vol.48 , pp. 634-642
    • Bugianesi, E.1    Gastaldelli, A.2    Vanni, E.3    Gambino, R.4    Cassader, M.5    Baldi, S.6
  • 43
    • 84920459959 scopus 로고    scopus 로고
    • Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways
    • Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S et al. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest 2015; 125: 141-156.
    • (2015) J Clin Invest , vol.125 , pp. 141-156
    • Gomez, I.G.1    MacKenna, D.A.2    Johnson, B.G.3    Kaimal, V.4    Roach, A.M.5    Ren, S.6
  • 44
    • 84981557035 scopus 로고    scopus 로고
    • Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function
    • Han CY, Kim TH, Koo JH, Kim SG. Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function. Arch Pharmacal Res 2016; 39: 1062-1074.
    • (2016) Arch Pharmacal Res , vol.39 , pp. 1062-1074
    • Han, C.Y.1    Kim, T.H.2    Koo, J.H.3    Kim, S.G.4
  • 45
    • 84961848398 scopus 로고    scopus 로고
    • Novel pharmacotherapy options for NASH
    • Ratziu V. Novel pharmacotherapy options for NASH. Dig Dis Sci 2016; 61: 1398-1405.
    • (2016) Dig Dis Sci , vol.61 , pp. 1398-1405
    • Ratziu, V.1
  • 46
    • 84880664792 scopus 로고    scopus 로고
    • Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease
    • e571
    • Mudaliar S, Henry RR, Sanyal AJ, Morrow L, Marschall HU, Kipnes M et al. Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease. Gastroenterology 2013; 145: 574-582 e571.
    • (2013) Gastroenterology , vol.145 , pp. 574-582
    • Mudaliar, S.1    Henry, R.R.2    Sanyal, A.J.3    Morrow, L.4    Marschall, H.U.5    Kipnes, M.6
  • 47
    • 84888285959 scopus 로고    scopus 로고
    • Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt LJ et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology 2013; 58: 1941-1952.
    • (2013) Hepatology , vol.58 , pp. 1941-1952
    • Staels, B.1    Rubenstrunk, A.2    Noel, B.3    Rigou, G.4    Delataille, P.5    Millatt, L.J.6
  • 48
    • 84883124310 scopus 로고    scopus 로고
    • HCV infection and miravirsen
    • Sanchez-Nino MD, Ortiz A. HCV infection and miravirsen. N Engl J Med 2013; 369: 877-878.
    • (2013) N Engl J Med , vol.369 , pp. 877-878
    • Sanchez-Nino, M.D.1    Ortiz, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.