The oncogenic microRNA miR-21 promotes regulated necrosis in mice

Nature Communications

Volumn 6, Issue , 2015, Pages

  Ma, Xiaodong ^a,b   Conklin, Daniel J ^c   Li, Fenge ^c   Dai, Zhongping ^d   Hua, Xiang ^d   Li, Yan ^c   Xu Monette, Zijun Y ^e   Young, Ken H ^e   Xiong, Wei ^f   Wysoczynski, Marcin ^c   Sithu, Srinivas D ^c   Srivastava, Sanjay ^c   Bhatnagar, Aruni ^c   Li, Yong ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b SOUTH CHINA NORMAL UNIVERSITY   (China)

^c University of Louisville School of Medicine   (United States)

^d FOX CHASE CANCER CENTER   (United States)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^f CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CERULETIDE; MICRORNA 21; OLIGONUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA; CASPASE; FAS ANTIGEN; FAS LIGAND; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MICRORNA; MIRN21 MICRORNA, MOUSE; NECROSTATIN-1; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR;

APOPTOSIS; CANCER; GENE EXPRESSION; INJURY; RNA; RODENT;

ACUTE PANCREATITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; GENE DELETION; GENE OVEREXPRESSION; GENE REPRESSION; MOLECULAR PATHOLOGY; MOUSE; NECROPTOSIS; NONHUMAN; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; ANIMAL; APOPTOSIS; BONE MARROW TRANSPLANTATION; C57BL MOUSE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; MALE; METABOLISM; NECROSIS; PANCREATITIS; RNA INTERFERENCE; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

MURINAE; MUS;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; ARGININE; BONE MARROW TRANSPLANTATION; CASPASES; CERULETIDE; FAS LIGAND PROTEIN; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; IMIDAZOLES; INDOLES; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICRORNAS; NECROSIS; OLIGONUCLEOTIDES; PANCREATITIS; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA INTERFERENCE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84930204546     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8151     Document Type: Article

References (47)

1. Vandenabeele, P., Galluzzi, L., Berghe, T. V. & Kroemer, G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat. Rev. Mol. Cell Biol. 11, 700-714 (2010).
2. Linkermann, A. & Green, D. R. Necroptosis. N. Engl. J. Med. 370, 455-465 (2014).
3. He, S. et al. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-a. Cell 137, 1100-1111 (2009).
4. Han, J., Zhong, C.-Q. & Zhang, D.-W. Programmed necrosis: backup to and competitor with apoptosis in the immune system. Nat. Immunol. 12, 1143-1149 (2011).
5. Feoktistova, M. et al. cIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol. Cell 43, 449-463 (2011).
6. Kaiser, W. J. et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471, 368-372 (2011).
7. Gunther, C. et al. Caspase-8 regulates TNF-a-induced epithelial necroptosis and terminal ileitis. Nature 477, 335-339 (2011).
8. Zhang, H. et al. Functional complementation between FADD and RIP1 in embryos and lymphocytes. Nature 471, 373-376 (2011).
9. Welz, P.-S. et al. FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477, 330-334 (2011).
10. Mareninova, O. A. et al. Cell death in pancreatitis: caspases protect from necrotizing pancreatitis. J. Biol. Chem. 281, 3370-3381 (2006).
11. Griffiths-Jones, S., Grocock, R., van Dongen, S., Bateman, A. & Enright, A. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34, D140-D144 (2006).
12. Miranda, K. C. et al. A pattern-based method for the identification of microRNA binding sites and their corresponding heteroduplexes. Cell 126, 1203-1217 (2006).
13. Medina, P. P., Nolde, M. & Slack, F. J. OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467, 86-90 (2010).
14. Hatley, M. E. et al. Modulation of K-Ras-dependent lung tumorigenesis by microRNA-21. Cancer Cell 18, 282-293 (2010).
15. Ma, X. et al. Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc. Natl Acad. Sci. USA 108, 10144-10149 (2011).
16. Jensen, J. N. et al. Recapitulation of elements of embryonic development in adult mouse pancreatic regeneration. Gastroenterology 128, 728-741 (2005).
17. Pandol, S. J., Saluja, A. K., Imrie, C. W. & Banks, P. A. Acute pancreatitis: bench to the bedside. Gastroenterology 132, 1127-1151 (2007).
18. Whitcomb, D. C. Acute pancreatitis. N. Engl. J. Med. 354, 2142-2150 (2006).
19. Lankisch, P. G. et al. Effect of FOY-305 (camostate) on severe acute pancreatitis in two experimental animal models. Gastroenterology 96, 193-199 (1989).
20. Mikami, Y. et al. Do peritoneal macrophages play an essential role in the progression of acute pancreatitis in rats? Pancreas 27, 253-260 (2003).
21. Gea-Sorli, S. & Closa, D. Role of macrophages in the progression of acute pancreatitis. World J. Gastrointest. Pharmacol. Ther. 1, 107-111 (2010).
22. Biswas, S. K. & Mantovani, A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat. Immunol. 11, 889-896 (2010).
23. Gea-Sorli, S. & Closa, D. In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitis. BMC Immunol. 10, 42 (2009).
24. Takeyama, Y. et al. Involvement of peritoneal macrophage in the induction of cytotoxicity due to apoptosis in ascitic fluid associated with severe acute pancreatitis. J. Surg. Res. 82, 163-171 (1999).
25. Yuan, X. J. & Whang, Y. E. PTEN sensitizes prostate cancer cells to death receptor-mediated and drug-induced apoptosis through a FADD-dependent pathway. Oncogene 21, 319-327 (2002).
26. Monnier, P. P. et al. Involvement of caspase-6 and caspase-8 in neuronal apoptosis and the regenerative failure of injured retinal ganglion cells. J. Neurosci. 31, 10494-10505 (2011).
27. Panzarini, E., Inguscio, V. & Dini, L. Timing the multiple cell death pathways initiated by Rose Bengal acetate photodynamic therapy. Cell Death Dis. 2, e169 (2011).
28. Dawra, R. et al. Development of a new mouse model of acute pancreatitis induced by administration of l-arginine. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G1009-G1018 (2007).
29. Tani, S. et al. New model of acute necrotizing pancreatitis induced by excessive doses of arginine in rats. Digest. Dis. Sci. 35, 367-374 (1990).
30. Saka, M. et al. Acute pancreatitis possibly due to arginine use: a case report. Turk. J. Gastroenterol. 15, 56-58 (2004).
31. Duprez, L. et al. RIP kinase-dependent necrosis drives lethal systemic inflammatory response syndrome. Immunity 35, 908-918 (2011).
32. Pardalis, V. et al. Expression of Fas (CD95/APO-1) and Fas ligand (FasL) in experimentally-induced acute pancreatitis. J. Invest. Surg. 27, 65-72 (2014).
33. Endo, S. et al. Soluble Fas and soluble Fas L levels in patients with acute pancreatitis. Res. Commun. Mol. Pathol. Pharmacol. 108, 179-186 (2000).
34. Jeyarajah, D. R., Kielar, M., Gokaslan, S. T., Lindberg, G. & Lu, C. Y. Fas deficiency exacerbates cerulein-induced pancreatitis. J. Invest. Surg. 16, 325-333 (2003).
35. Linkermann, A. et al. Dichotomy between RIP1-and RIP3-mediated necroptosis in tumor necrosis factor-alpha-induced shock. Mol. Med. 18, 577-586 (2012).
36. Cho, Y. S. et al. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 137, 1112-1123 (2009).
37. Berghe, T. V., Linkermann, A., Jouan-Lanhouet, S., Walczak, H. & Vandenabeele, P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat. Rev. Mol. Cell Biol. 15, 135-147 (2014).
38. Buscaglia, L. E. & Li, Y. Apoptosis and the target genes of microRNA-21. Chin. J. Cancer 30, 371-380 (2011).
39. Peacock, J. W. et al. PTEN loss promotes mitochondrially dependent type II Fas-induced apoptosis via PEA-15. Mol. Cell Biol. 29, 1222-1234 (2009).
40. Singh, V. P. et al. Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis. Am. J. Physiol. Gastrointest. Liver Physiol. 296, G1040-G1046 (2009).
41. Van Laethem, J. L. et al. Interleukin 10 prevents necrosis in murine experimental acute pancreatitis. Gastroenterology 108, 1917-1922 (1995).
42. Bhatia, M. et al. Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc. Natl Acad. Sci. USA 95, 4760-4765 (1998).
43. Galluzzi, L. et al. Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ. 19, 107-120 (2012).
44. Kurup, S. & Bhonde, R. R. Analysis and optimization of nutritional set-up for murine pancreatic acinar cells. JOP 3, 8-15 (2002).
45. Gukovskaya, A. S., Gukovsky, I., Jung, Y., Mouria, M. & Pandol, S. J. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells: roles in cell injury processes of pancreatitis. J. Biol. Chem. 277, 22595-22604 (2002).
46. Xu, C. et al. Feeder-free growth of undifferentiated human embryonic stem cells. Nat. Biotechnol. 19, 971-974 (2001).
47. Weischenfeldt, J. & Porse, B. Bone marrow-derived macrophages (BMM): isolation and applications. CSH Protoc. 2008, 5080 (2008).